GREMLIN Database
Q97UV9 - Oxidoreductase
UniProt: Q97UV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (264)
Sequences: 32413 (20856)
Seq/√Len: 1283.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_R272_K3.1701.00
97_E137_K2.9971.00
31_E66_R2.9291.00
69_S104_N2.8351.00
241_L286_D2.7691.00
96_S132_L2.5281.00
35_I70_K2.4981.00
283_R286_D2.4891.00
5_P12_K2.4591.00
93_L131_R2.4241.00
93_L135_E2.4011.00
40_R44_L2.3281.00
240_E289_R2.2171.00
235_S239_K2.0791.00
130_E134_N2.0731.00
35_I66_R2.0601.00
240_E286_D2.0421.00
255_S287_L2.0361.00
98_G102_R1.9971.00
284_D288_R1.9771.00
107_Y139_R1.9731.00
131_R135_E1.9541.00
184_Y188_E1.9491.00
236_S289_R1.9191.00
72_K75_D1.9031.00
268_E272_K1.8891.00
185_M192_L1.8711.00
191_P260_F1.8291.00
17_I48_A1.8101.00
78_I105_T1.8081.00
40_R268_E1.7971.00
89_Y131_R1.7681.00
112_L165_A1.7671.00
131_R134_N1.7461.00
256_K291_D1.7381.00
44_L272_K1.7351.00
243_K280_W1.7211.00
80_T108_I1.7111.00
89_Y93_L1.6531.00
251_N280_W1.6531.00
62_T102_R1.6491.00
44_L275_L1.6401.00
41_A46_I1.6321.00
30_D33_N1.6291.00
233_E236_S1.6211.00
288_R292_E1.6181.00
82_V111_Y1.6161.00
80_T99_S1.6141.00
35_I67_A1.6091.00
35_I39_Q1.6001.00
152_R184_Y1.5981.00
244_T273_E1.5961.00
82_V92_V1.5851.00
96_S111_Y1.5801.00
276_G279_G1.5731.00
40_R43_E1.5691.00
93_L97_E1.5601.00
134_N160_K1.5481.00
79_I112_L1.5451.00
39_Q70_K1.5441.00
128_A131_R1.5411.00
130_E161_T1.5031.00
20_S49_I1.4981.00
11_E140_Y1.4891.00
53_E95_A1.4551.00
108_I138_I1.4461.00
112_L193_L1.4431.00
94_K98_G1.4361.00
243_K247_Q1.4361.00
183_P187_R1.4301.00
42_I76_L1.4171.00
186_L258_N1.4091.00
147_S150_L1.4001.00
97_E101_K1.3971.00
180_E183_P1.3881.00
33_N36_K1.3851.00
133_F161_T1.3601.00
272_K276_G1.3601.00
31_E35_I1.3591.00
38_I67_A1.3541.00
89_Y127_K1.3271.00
168_L192_L1.3251.00
251_N255_S1.3221.00
11_E77_F1.3131.00
39_Q43_E1.2981.00
98_G101_K1.2871.00
289_R292_E1.2861.00
140_Y164_A1.2841.00
93_L128_A1.2811.00
132_L138_I1.2761.00
243_K248_V1.2741.00
138_I141_V1.2671.00
236_S240_E1.2661.00
89_Y128_A1.2641.00
36_K40_R1.2641.00
233_E289_R1.2591.00
77_F110_L1.2271.00
265_T270_H1.2231.00
66_R104_N1.2171.00
244_T247_Q1.2081.00
96_S108_I1.2031.00
265_T271_L1.2011.00
49_I64_I1.1901.00
182_L186_L1.1901.00
148_L184_Y1.1811.00
65_G104_N1.1791.00
103_L108_I1.1791.00
152_R187_R1.1741.00
73_R105_T1.1731.00
269_D272_K1.1721.00
61_E99_S1.1721.00
152_R156_E1.1671.00
73_R107_Y1.1671.00
237_I248_V1.1621.00
110_L165_A1.1551.00
116_P150_L1.1301.00
235_S245_P1.1191.00
62_T66_R1.1171.00
172_V290_L1.1171.00
90_D94_K1.1171.00
9_T140_Y1.1111.00
32_N36_K1.1101.00
130_E160_K1.1071.00
48_A193_L1.1061.00
152_R188_E1.1041.00
88_R91_D1.1041.00
91_D94_K1.1031.00
124_E127_K1.0991.00
97_E135_E1.0971.00
37_A271_L1.0921.00
129_M141_V1.0891.00
232_E236_S1.0751.00
48_A79_I1.0711.00
39_Q67_A1.0691.00
133_F164_A1.0641.00
169_H174_F1.0641.00
130_E133_F1.0481.00
148_L152_R1.0461.00
175_R294_V1.0461.00
236_S239_K1.0381.00
247_Q276_G1.0371.00
47_N77_F1.0351.00
20_S64_I1.0321.00
234_I245_P1.0301.00
8_W164_A1.0291.00
170_Y256_K1.0231.00
232_E235_S1.0221.00
113_V129_M1.0211.00
36_K268_E1.0211.00
254_V277_S1.0151.00
123_R153_E1.0001.00
89_Y124_E0.9971.00
186_L257_D0.9961.00
132_L137_K0.9921.00
62_T101_K0.9901.00
66_R70_K0.9891.00
14_S47_N0.9861.00
5_P10_N0.9771.00
172_V249_V0.9701.00
271_L275_L0.9691.00
183_P186_L0.9671.00
165_A193_L0.9631.00
155_R184_Y0.9611.00
143_L163_V0.9581.00
127_K131_R0.9511.00
14_S46_I0.9471.00
68_I76_L0.9411.00
109_D139_R0.9401.00
61_E102_R0.9311.00
179_K183_P0.9251.00
15_P254_V0.9251.00
273_E276_G0.9221.00
155_R188_E0.9211.00
87_L113_V0.9201.00
132_L135_E0.9191.00
143_L151_M0.9181.00
247_Q273_E0.9181.00
9_T164_A0.9041.00
123_R157_H0.9041.00
269_D273_E0.9031.00
53_E91_D0.9031.00
79_I193_L0.8931.00
128_A132_L0.8921.00
94_K97_E0.8911.00
166_N185_M0.8881.00
288_R291_D0.8861.00
93_L96_S0.8821.00
250_L277_S0.8771.00
38_I49_I0.8721.00
285_S288_R0.8711.00
15_P278_L0.8711.00
255_S281_S0.8671.00
42_I72_K0.8621.00
155_R158_L0.8621.00
130_E141_V0.8571.00
267_K270_H0.8561.00
141_V163_V0.8551.00
285_S289_R0.8521.00
20_S60_S0.8501.00
127_K130_E0.8501.00
36_K39_Q0.8471.00
184_Y187_R0.8391.00
256_K287_L0.8351.00
240_E283_R0.8351.00
145_N195_Y0.8321.00
237_I241_L0.8321.00
93_L132_L0.8311.00
86_H91_D0.8261.00
241_L283_R0.8251.00
79_I110_L0.8231.00
9_T133_F0.8161.00
175_R291_D0.8111.00
18_L41_A0.7971.00
100_L137_K0.7941.00
182_L192_L0.7911.00
251_N277_S0.7861.00
151_M190_I0.7861.00
249_V253_L0.7751.00
255_S284_D0.7701.00
170_Y182_L0.7681.00
115_W145_N0.7671.00
53_E102_R0.7661.00
208_E235_S0.7611.00
53_E86_H0.7611.00
233_E293_A0.7571.00
18_L23_F0.7571.00
80_T111_Y0.7561.00
148_L181_V0.7511.00
126_A154_F0.7481.00
44_L276_G0.7451.00
40_R271_L0.7431.00
51_T64_I0.7391.00
194_A197_A0.7381.00
126_A163_V0.7321.00
17_I263_F0.7281.00
100_L105_T0.7201.00
197_A263_F0.7191.00
53_E98_G0.7171.00
143_L166_N0.7171.00
181_V185_M0.7121.00
175_R178_E0.7071.00
252_W291_D0.7071.00
243_K279_G0.7061.00
32_N35_I0.7061.00
37_A268_E0.7011.00
96_S137_K0.7001.00
92_V132_L0.6991.00
16_L254_V0.6971.00
74_E107_Y0.6961.00
248_V280_W0.6951.00
148_L180_E0.6941.00
46_I275_L0.6931.00
34_A63_I0.6921.00
126_A141_V0.6921.00
185_M190_I0.6891.00
143_L146_F0.6891.00
237_I286_D0.6891.00
209_V232_E0.6891.00
42_I49_I0.6881.00
257_D261_A0.6871.00
241_L248_V0.6851.00
99_S111_Y0.6821.00
92_V125_T0.6801.00
266_T270_H0.6771.00
282_L287_L0.6771.00
234_I249_V0.6741.00
47_N75_D0.6721.00
95_A98_G0.6721.00
239_K242_G0.6701.00
44_L271_L0.6631.00
182_L256_K0.6631.00
234_I290_L0.6621.00
11_E139_R0.6621.00
155_R162_D0.6621.00
38_I42_I0.6601.00
243_K276_G0.6581.00
39_Q72_K0.6581.00
270_H273_E0.6541.00
125_T128_A0.6531.00
246_A273_E0.6531.00
117_N120_V0.6481.00
197_A253_L0.6481.00
54_S83_S0.6441.00
170_Y259_V0.6431.00
248_V282_L0.6431.00
23_F37_A0.6401.00
87_L125_T0.6391.00
178_E183_P0.6391.00
243_K251_N0.6391.00
21_W196_D0.6381.00
130_E158_L0.6371.00
170_Y253_L0.6311.00
133_F140_Y0.6291.00
112_L142_G0.6291.00
25_T63_I0.6281.00
238_A248_V0.6271.00
253_L259_V0.6261.00
193_L260_F0.6241.00
33_N268_E0.6211.00
238_A245_P0.6211.00
237_I289_R0.6201.00
133_F138_I0.6191.00
96_S100_L0.6181.00
129_M133_F0.6151.00
92_V128_A0.6111.00
22_E200_L0.6111.00
13_I260_F0.6101.00
108_I111_Y0.6091.00
72_K76_L0.6081.00
256_K259_V0.6071.00
170_Y192_L0.6061.00
231_I235_S0.6061.00
122_I125_T0.6051.00
208_E232_E0.6051.00
43_E268_E0.6051.00
202_Y231_I0.6031.00
282_L286_D0.5991.00
88_R125_T0.5961.00
175_R179_K0.5951.00
93_L137_K0.5951.00
156_E162_D0.5941.00
37_A265_T0.5941.00
153_E157_H0.5931.00
71_F76_L0.5931.00
6_L191_P0.5911.00
100_L108_I0.5871.00
194_A259_V0.5851.00
286_D289_R0.5821.00
150_L153_E0.5771.00
248_V286_D0.5751.00
123_R127_K0.5751.00
31_E63_I0.5731.00
238_A241_L0.5731.00
170_Y175_R0.5701.00
111_Y138_I0.5681.00
127_K160_K0.5671.00
205_G208_E0.5671.00
100_L107_Y0.5671.00
8_W162_D0.5651.00
155_R160_K0.5621.00
50_D167_E0.5621.00
42_I47_N0.5621.00
17_I262_I0.5601.00
38_I64_I0.5591.00
173_L202_Y0.5581.00
13_I48_A0.5581.00
237_I293_A0.5571.00
53_E83_S0.5551.00
89_Y92_V0.5531.00
23_F34_A0.5531.00
247_Q280_W0.5521.00
42_I75_D0.5511.00
82_V95_A0.5491.00
172_V252_W0.5481.00
8_W189_N0.5451.00
248_V290_L0.5451.00
196_D200_L0.5441.00
149_P152_R0.5421.00
49_I68_I0.5421.00
6_L9_T0.5411.00
111_Y129_M0.5411.00
100_L106_S0.5401.00
113_V125_T0.5391.00
84_I87_L0.5371.00
143_L154_F0.5321.00
82_V87_L0.5311.00
18_L37_A0.5301.00
66_R69_S0.5301.00
204_I207_K0.5301.00
241_L280_W0.5291.00
122_I153_E0.5281.00
182_L259_V0.5281.00
84_I115_W0.5271.00
154_F163_V0.5271.00
48_A77_F0.5271.00
251_N281_S0.5271.00
16_L278_L0.5261.00
64_I67_A0.5261.00
61_E80_T0.5221.00
277_S280_W0.5201.00
122_I150_L0.5191.00
151_M185_M0.5181.00
24_G60_S0.5141.00
96_S128_A0.5141.00
209_V225_K0.5131.00
73_R109_D0.5131.00
168_L181_V0.5121.00
152_R155_R0.5091.00
23_F264_N0.5071.00
268_E271_L0.5071.00
170_Y178_E0.5061.00
141_V161_T0.5061.00
134_N161_T0.5051.00
42_I67_A0.5031.00
68_I72_K0.5031.00
237_I240_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9638 100 0.077 Contact Map
1pz1A 1 0.9901 100 0.085 Contact Map
4xk2A 5 0.9441 100 0.088 Contact Map
3n2tA 1 0.9836 100 0.09 Contact Map
3v0sA 1 0.8618 100 0.095 Contact Map
3eauA 3 0.9803 100 0.101 Contact Map
1lqaA 2 0.9868 100 0.101 Contact Map
3lutA 3 0.977 100 0.108 Contact Map
3erpA 6 0.9309 100 0.109 Contact Map
4r9oA 5 0.9112 100 0.111 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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