GREMLIN Database
Q97UV3 - Third ORF in transposon ISC1225
UniProt: Q97UV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (206)
Sequences: 181 (121)
Seq/√Len: 8.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_T166_Y4.8870.99
66_L165_S4.7830.99
61_V85_V3.7320.96
21_A33_A3.4060.94
164_T167_R2.8510.86
31_L166_Y2.8450.86
142_T160_S2.7740.85
68_A87_G2.6830.82
142_T178_S2.5710.80
67_D159_R2.4380.76
54_I64_V2.3760.74
172_F195_Y2.3570.73
145_D157_K2.3550.73
61_V101_G2.2780.70
37_Q65_T2.1690.66
46_I185_E2.1690.66
186_L190_L2.1520.66
54_I84_F2.0380.61
21_A196_S1.9970.60
20_T189_V1.9880.59
91_G101_G1.8600.54
79_I82_F1.8570.54
71_Y88_V1.8160.52
59_L104_T1.8000.52
47_V50_L1.7830.51
166_Y176_T1.7800.51
31_L192_M1.7660.50
50_L84_F1.7590.50
21_A54_I1.7410.49
19_T50_L1.7350.49
84_F180_K1.7230.48
37_Q47_V1.7100.48
142_T195_Y1.6500.45
41_M85_V1.6070.43
174_P187_I1.6050.43
27_N77_K1.5880.43
183_F187_I1.5810.42
104_T149_R1.5490.41
209_E212_L1.5420.41
30_L105_T1.5380.41
194_F205_M1.5260.40
50_L195_Y1.4930.39
66_L71_Y1.4750.38
86_I144_L1.4610.38
170_K195_Y1.4520.37
143_N169_I1.4300.36
156_N196_S1.4280.36
19_T46_I1.4020.35
62_G191_A1.3960.35
19_T84_F1.3730.34
33_A66_L1.3660.34
219_L224_D1.3630.34
29_V62_G1.3390.33
16_R166_Y1.3350.33
45_E110_H1.3120.32
31_L71_Y1.3100.32
159_R163_E1.3100.32
155_Y162_I1.2930.31
175_F196_S1.2790.31
140_R143_N1.2740.30
33_A51_M1.2510.30
63_L171_A1.2490.30
173_L177_S1.2480.30
75_V162_I1.2400.29
59_L64_V1.2160.28
87_G176_T1.2130.28
202_K206_T1.1840.27
15_T160_S1.1840.27
178_S188_F1.1800.27
137_Y189_V1.1790.27
20_T188_F1.1720.27
21_A51_M1.1680.27
61_V98_E1.1660.27
71_Y164_T1.1650.27
84_F143_N1.1640.27
61_V166_Y1.1540.26
50_L169_I1.1500.26
164_T200_V1.1490.26
59_L82_F1.1320.26
8_W183_F1.1260.25
93_V96_Y1.1190.25
67_D163_E1.1120.25
188_F195_Y1.1060.25
11_Q185_E1.1050.25
13_R31_L1.0770.24
170_K178_S1.0710.24
163_E184_R1.0610.23
161_P191_A1.0610.23
164_T197_L1.0560.23
63_L82_F1.0410.23
51_M76_L1.0380.23
142_T172_F1.0280.22
84_F202_K1.0270.22
18_T79_I1.0250.22
11_Q31_L1.0190.22
120_L208_E1.0140.22
11_Q16_R1.0120.22
173_L185_E1.0090.22
46_I50_L1.0070.22
140_R178_S1.0020.22
28_M62_G0.9980.22
76_L164_T0.9950.22
38_V197_L0.9940.21
85_V155_Y0.9840.21
184_R198_Y0.9810.21
142_T170_K0.9740.21
62_G160_S0.9710.21
160_S178_S0.9680.21
210_F213_L0.9660.21
156_N180_K0.9660.21
14_G85_V0.9640.21
45_E68_A0.9630.21
54_I59_L0.9570.20
29_V167_R0.9540.20
20_T162_I0.9540.20
170_K188_F0.9510.20
51_M186_L0.9400.20
51_M70_F0.9390.20
123_Y156_N0.9370.20
71_Y89_P0.9310.20
143_N188_F0.9220.19
50_L80_S0.9050.19
10_V61_V0.9050.19
16_R91_G0.9040.19
160_S212_L0.9040.19
36_P84_F0.9010.19
47_V54_I0.8960.19
87_G180_K0.8870.19
183_F197_L0.8730.18
48_K132_K0.8710.18
179_T186_L0.8700.18
85_V93_V0.8600.18
156_N161_P0.8560.18
85_V115_Q0.8530.18
18_T118_F0.8530.18
23_T37_Q0.8530.18
76_L86_I0.8480.18
75_V166_Y0.8470.18
67_D70_F0.8470.18
12_P65_T0.8410.17
29_V160_S0.8410.17
58_G88_V0.8400.17
74_E107_S0.8390.17
129_K133_K0.8380.17
12_P210_F0.8380.17
60_K83_K0.8360.17
88_V161_P0.8350.17
30_L108_K0.8260.17
142_T190_L0.8260.17
75_V164_T0.8220.17
168_N191_A0.8210.17
173_L192_M0.8210.17
96_Y99_F0.8180.17
86_I91_G0.8160.17
50_L53_Q0.8130.17
35_V164_T0.8130.17
131_R165_S0.8120.17
66_L160_S0.8040.17
70_F167_R0.7970.16
79_I115_Q0.7970.16
160_S186_L0.7860.16
47_V194_F0.7840.16
42_S72_T0.7830.16
157_K182_I0.7820.16
51_M201_F0.7790.16
190_L201_F0.7760.16
118_F187_I0.7710.16
76_L177_S0.7680.16
31_L203_N0.7670.16
32_L137_Y0.7660.16
18_T124_G0.7640.16
143_N160_S0.7610.16
97_E194_F0.7540.15
21_A69_G0.7520.15
85_V119_R0.7470.15
151_V154_L0.7460.15
28_M207_R0.7460.15
155_Y163_E0.7460.15
34_F43_K0.7450.15
71_Y197_L0.7430.15
18_T148_K0.7420.15
51_M117_K0.7410.15
12_P175_F0.7400.15
72_T179_T0.7400.15
38_V51_M0.7380.15
17_G66_L0.7380.15
12_P131_R0.7320.15
45_E168_N0.7310.15
191_A208_E0.7300.15
18_T76_L0.7290.15
162_I198_Y0.7260.15
199_T202_K0.7250.15
87_G122_V0.7240.15
142_T186_L0.7220.15
27_N81_Q0.7220.15
169_I188_F0.7210.15
43_K174_P0.7190.15
49_L69_G0.7130.15
70_F176_T0.7120.15
169_I203_N0.7100.14
89_P96_Y0.7070.14
172_F225_L0.7060.14
37_Q75_V0.7020.14
18_T68_A0.6960.14
129_K143_N0.6940.14
219_L225_L0.6920.14
100_D195_Y0.6910.14
159_R184_R0.6900.14
48_K178_S0.6900.14
80_S208_E0.6820.14
21_A205_M0.6820.14
68_A185_E0.6800.14
12_P161_P0.6790.14
213_L224_D0.6790.14
112_K151_V0.6750.14
141_A202_K0.6750.14
208_E211_R0.6680.14
75_V143_N0.6570.13
118_F180_K0.6560.13
16_R41_M0.6550.13
59_L102_E0.6540.13
8_W22_T0.6510.13
92_D100_D0.6480.13
99_F197_L0.6450.13
34_F207_R0.6420.13
65_T174_P0.6400.13
22_T133_K0.6380.13
48_K78_F0.6370.13
92_D98_E0.6370.13
96_Y136_V0.6360.13
85_V123_Y0.6350.13
59_L122_V0.6330.13
80_S188_F0.6320.13
70_F166_Y0.6310.13
8_W164_T0.6290.13
122_V165_S0.6270.13
191_A212_L0.6260.13
172_F191_A0.6240.13
13_R51_M0.6210.13
23_T28_M0.6210.13
129_K142_T0.6190.13
12_P199_T0.6160.13
95_I174_P0.6130.13
48_K187_I0.6130.13
25_Y202_K0.6130.13
22_T51_M0.6120.13
19_T75_V0.6080.12
90_V93_V0.6060.12
10_V20_T0.6050.12
35_V49_L0.6050.12
15_T199_T0.6020.12
76_L162_I0.6010.12
16_R55_V0.5990.12
60_K133_K0.5970.12
66_L79_I0.5970.12
96_Y104_T0.5920.12
84_F212_L0.5920.12
180_K193_I0.5880.12
143_N178_S0.5850.12
108_K164_T0.5840.12
86_I191_A0.5820.12
23_T33_A0.5820.12
61_V81_Q0.5800.12
11_Q162_I0.5710.12
69_G153_K0.5690.12
219_L223_S0.5670.12
97_E180_K0.5650.12
174_P177_S0.5640.12
87_G155_Y0.5630.12
59_L68_A0.5620.12
23_T36_P0.5620.12
179_T207_R0.5610.12
212_L225_L0.5610.12
48_K103_Y0.5550.12
95_I98_E0.5550.12
27_N33_A0.5550.12
140_R160_S0.5540.12
11_Q197_L0.5510.11
141_A186_L0.5510.11
25_Y36_P0.5460.11
188_F210_F0.5450.11
30_L135_V0.5430.11
195_Y202_K0.5420.11
69_G197_L0.5390.11
110_H150_E0.5390.11
76_L85_V0.5380.11
98_E101_G0.5380.11
103_Y120_L0.5380.11
20_T32_L0.5370.11
64_V124_G0.5360.11
77_K208_E0.5280.11
68_A176_T0.5270.11
79_I185_E0.5260.11
16_R198_Y0.5250.11
109_R183_F0.5250.11
174_P181_F0.5220.11
171_A191_A0.5170.11
140_R188_F0.5170.11
82_F146_L0.5160.11
104_T174_P0.5110.11
63_L191_A0.5100.11
146_L190_L0.5060.11
106_N199_T0.5050.11
123_Y142_T0.5050.11
102_E164_T0.5040.11
88_V91_G0.5030.11
9_V49_L0.5020.11
140_R202_K0.5010.11
104_T113_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9065 98.7 0.849 Contact Map
2r37A 3 0.2602 8.2 0.965 Contact Map
3uowA 2 0.2967 5 0.969 Contact Map
1v66A 1 0.2602 3.9 0.97 Contact Map
1jvnA 1 0.3496 3.5 0.971 Contact Map
2o8rA 2 0.8374 3.2 0.971 Contact Map
3hbaA 2 0.3455 3.1 0.971 Contact Map
4w22K 1 0.3049 3.1 0.972 Contact Map
3fj1A 2 0.3984 2.7 0.972 Contact Map
2ou2A 1 0.3984 2.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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