GREMLIN Database
Q97UV2 - Uncharacterized protein
UniProt: Q97UV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (220)
Sequences: 7107 (5755)
Seq/√Len: 388.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_T155_S4.2421.00
56_L67_L3.6161.00
160_D202_K3.2181.00
55_I156_V2.8871.00
30_L52_D2.8311.00
34_I57_T2.7721.00
194_R225_L2.7381.00
132_M140_T2.7181.00
129_G195_L2.7181.00
53_L80_M2.7161.00
134_D140_T2.5531.00
83_N128_E2.3181.00
32_V53_L2.3081.00
143_I154_I2.2491.00
132_M142_K2.2211.00
197_I218_E2.2171.00
78_K125_V2.2081.00
34_I163_F2.1391.00
197_I222_D2.1291.00
143_I156_V2.1291.00
74_Y77_A2.0991.00
153_H165_G2.0501.00
220_H224_M2.0461.00
53_L78_K2.0251.00
244_I247_K2.0161.00
82_K145_Y1.9601.00
222_D226_G1.9281.00
23_Y163_F1.9001.00
80_M125_V1.8911.00
23_Y205_G1.8711.00
82_K154_I1.7751.00
224_M228_E1.7461.00
142_K158_S1.7101.00
185_D188_N1.6861.00
57_T165_G1.6861.00
157_V160_D1.6731.00
161_I205_G1.6701.00
227_K231_D1.6601.00
146_T192_S1.6271.00
195_L198_S1.6101.00
128_E131_E1.5871.00
42_I47_F1.5701.00
221_L225_L1.5661.00
197_I225_L1.5461.00
42_I45_S1.5321.00
125_V131_E1.4981.00
224_M227_K1.4961.00
86_K90_T1.4681.00
36_A54_V1.4661.00
228_E231_D1.4541.00
157_V162_L1.4441.00
85_F152_H1.4411.00
81_I85_F1.4231.00
146_T153_H1.4151.00
127_V154_I1.3781.00
83_N126_E1.3581.00
134_D137_D1.3521.00
26_C31_N1.3421.00
203_V213_S1.3411.00
142_K157_V1.3371.00
80_M127_V1.3321.00
206_L209_G1.3181.00
228_E232_I1.3171.00
194_R198_S1.3071.00
161_I203_V1.2941.00
69_E73_R1.2891.00
118_K121_P1.2781.00
229_S233_G1.2781.00
30_L50_K1.2771.00
43_M47_F1.2721.00
162_L199_L1.2531.00
32_V55_I1.2531.00
157_V201_P1.2371.00
25_V34_I1.2251.00
243_E251_V1.2231.00
148_G192_S1.2221.00
31_N51_L1.2211.00
220_H223_Q1.2131.00
178_P183_P1.2081.00
218_E222_D1.2061.00
167_S196_Q1.1831.00
160_D200_K1.1771.00
142_K199_L1.1761.00
177_I182_P1.1751.00
190_V194_R1.1701.00
194_R197_I1.1671.00
71_L79_V1.1641.00
177_I183_P1.1631.00
245_L249_V1.1581.00
67_L79_V1.1531.00
24_V31_N1.1441.00
163_F205_G1.1371.00
22_I37_G1.1261.00
164_T204_V1.1251.00
225_L229_S1.1231.00
86_K126_E1.1161.00
36_A67_L1.1141.00
32_V141_L1.1141.00
243_E247_K1.1141.00
223_Q227_K1.1021.00
246_R250_E1.0961.00
140_T158_S1.0881.00
141_L156_V1.0711.00
188_N191_N1.0711.00
231_D234_E1.0681.00
190_V229_S1.0671.00
29_K52_D1.0601.00
219_Q223_Q1.0431.00
234_E237_I1.0311.00
44_D47_F1.0261.00
24_V33_M1.0251.00
155_S162_L1.0101.00
27_G137_D1.0091.00
233_G236_D1.0071.00
28_D137_D1.0051.00
34_I156_V1.0031.00
234_E238_G1.0011.00
42_I46_S1.0011.00
69_E72_D0.9921.00
155_S196_Q0.9841.00
140_T159_D0.9721.00
190_V225_L0.9711.00
127_V143_I0.9661.00
180_T183_P0.9651.00
177_I180_T0.9621.00
169_G172_F0.9541.00
130_G142_K0.9521.00
52_D78_K0.9481.00
177_I181_P0.9381.00
129_G145_Y0.9271.00
33_M36_A0.9271.00
58_H166_D0.9241.00
45_S49_E0.9121.00
30_L53_L0.9101.00
220_H228_E0.9101.00
233_G237_I0.9081.00
21_T209_G0.8891.00
178_P181_P0.8891.00
197_I221_L0.8751.00
157_V199_L0.8731.00
54_V77_A0.8691.00
63_H166_D0.8601.00
82_K85_F0.8461.00
44_D73_R0.8401.00
201_P204_V0.8351.00
32_V135_I0.8311.00
25_V141_L0.8291.00
224_M231_D0.8281.00
221_L224_M0.8221.00
178_P182_P0.8211.00
167_S192_S0.8201.00
54_V67_L0.8171.00
144_I157_V0.8151.00
226_G230_F0.8151.00
246_R249_V0.8141.00
189_Y193_L0.8131.00
55_I154_I0.8111.00
58_H63_H0.8091.00
247_K250_E0.8061.00
56_L64_I0.8051.00
22_I36_A0.8021.00
215_N219_Q0.8021.00
43_M48_L0.8001.00
203_V211_L0.7991.00
81_I89_L0.7991.00
64_I67_L0.7971.00
238_G251_V0.7901.00
116_F120_D0.7901.00
84_G87_K0.7871.00
223_Q228_E0.7841.00
231_D238_G0.7841.00
187_D191_N0.7721.00
29_K136_G0.7681.00
42_I48_L0.7661.00
60_H63_H0.7651.00
191_N195_L0.7641.00
22_I33_M0.7631.00
150_A153_H0.7631.00
54_V70_I0.7631.00
200_K218_E0.7621.00
245_L248_Q0.7611.00
191_N194_R0.7601.00
87_K90_T0.7581.00
194_R229_S0.7551.00
85_F150_A0.7551.00
184_L187_D0.7531.00
68_P72_D0.7521.00
248_Q252_N0.7471.00
239_G242_G0.7441.00
220_H227_K0.7431.00
35_D58_H0.7391.00
236_D240_I0.7381.00
31_N48_L0.7371.00
167_S189_Y0.7361.00
243_E248_Q0.7341.00
192_S195_L0.7341.00
226_G229_S0.7291.00
43_M46_S0.7271.00
45_S48_L0.7251.00
153_H167_S0.7241.00
155_S167_S0.7241.00
205_G211_L0.7201.00
217_L228_E0.7121.00
141_L163_F0.7031.00
164_T206_L0.7031.00
110_Y115_E0.7011.00
231_D239_G0.6940.99
57_T156_V0.6930.99
193_L221_L0.6910.99
232_I236_D0.6900.99
174_G177_I0.6810.99
234_E252_N0.6760.99
27_G30_L0.6730.99
53_L125_V0.6730.99
60_H150_A0.6730.99
112_I116_F0.6720.99
116_F119_I0.6720.99
247_K251_V0.6710.99
173_N176_V0.6690.99
230_F234_E0.6680.99
85_F88_F0.6680.99
67_L71_L0.6680.99
33_M51_L0.6670.99
145_Y154_I0.6630.99
222_D225_L0.6630.99
104_K107_G0.6630.99
225_L228_E0.6590.99
33_M70_I0.6560.99
54_V79_V0.6550.99
172_F176_V0.6550.99
71_L76_N0.6550.99
238_G241_G0.6540.99
204_V212_V0.6530.99
62_D208_H0.6510.99
230_F233_G0.6510.99
162_L196_Q0.6500.99
59_I85_F0.6440.99
110_Y114_G0.6400.99
172_F175_A0.6400.99
57_T60_H0.6390.99
87_K91_T0.6390.99
23_Y207_A0.6350.99
44_D48_L0.6320.99
16_F19_L0.6300.99
214_P219_Q0.6250.99
179_T182_P0.6250.99
55_I141_L0.6220.99
235_I239_G0.6210.99
113_Y117_T0.6210.99
148_G153_H0.6200.99
83_N87_K0.6160.99
235_I238_G0.6140.99
20_A207_A0.6140.99
21_T206_L0.6120.99
113_Y119_I0.6090.99
131_E143_I0.6050.99
39_T69_E0.6050.99
219_Q222_D0.6020.99
238_G248_Q0.6020.99
148_G188_N0.5970.98
144_I155_S0.5960.98
112_I115_E0.5950.98
31_N50_K0.5930.98
109_L113_Y0.5860.98
179_T183_P0.5850.98
27_G135_I0.5840.98
32_V51_L0.5810.98
146_T167_S0.5800.98
153_H207_A0.5770.98
89_L92_E0.5760.98
228_E235_I0.5760.98
231_D235_I0.5700.98
58_H62_D0.5690.98
21_T207_A0.5690.98
51_L70_I0.5690.98
31_N47_F0.5650.98
63_H208_H0.5650.98
217_L224_M0.5640.98
31_N52_D0.5620.98
206_L212_V0.5610.98
155_S192_S0.5600.98
127_V130_G0.5590.98
231_D236_D0.5580.98
68_P71_L0.5580.98
223_Q226_G0.5560.98
236_D239_G0.5560.98
41_S69_E0.5540.98
59_I152_H0.5540.98
149_H166_D0.5530.98
51_L77_A0.5530.98
194_R221_L0.5530.98
234_E239_G0.5510.97
230_F235_I0.5480.97
248_Q251_V0.5450.97
244_I248_Q0.5440.97
169_G174_G0.5410.97
127_V131_E0.5370.97
176_V179_T0.5340.97
109_L112_I0.5310.97
38_V64_I0.5280.97
28_D136_G0.5270.97
20_A148_G0.5250.97
88_F91_T0.5250.97
224_M234_E0.5250.97
106_L113_Y0.5250.97
149_H153_H0.5250.97
171_Y210_G0.5240.97
227_K235_I0.5210.96
85_F89_L0.5210.96
86_K89_L0.5210.96
35_D166_D0.5180.96
110_Y113_Y0.5170.96
238_G243_E0.5160.96
26_C48_L0.5160.96
59_I64_I0.5120.96
114_G117_T0.5120.96
241_G251_V0.5110.96
111_Y115_E0.5110.96
106_L109_L0.5100.96
34_I141_L0.5090.96
223_Q231_D0.5080.96
81_I86_K0.5070.96
39_T65_G0.5070.96
127_V156_V0.5060.96
111_Y114_G0.5030.96
32_V136_G0.5020.96
162_L201_P0.5010.96
109_L114_G0.5010.96
186_Y190_V0.5000.96
54_V71_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9513 100 0.351 Contact Map
2yheA 3 0.9663 100 0.377 Contact Map
2cfuA 2 0.9513 100 0.383 Contact Map
4pdxA 2 0.9513 100 0.392 Contact Map
4nurA 2 0.9588 100 0.394 Contact Map
4ad9A 4 0.8727 100 0.401 Contact Map
2vw8A 2 0.9551 100 0.411 Contact Map
3adrA 1 0.9625 100 0.426 Contact Map
2fhxA 2 0.8165 100 0.446 Contact Map
1k07A 1 0.8427 100 0.465 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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