Q97UV0 - SULSO - GREMLIN Contacts

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Q97UV0 - Oxidoreductase

UniProt:	Q97UV0	Sequences: MKRLVVVGGGNAGTLIANLLADKLEVTVIEPNEYHTYQPGLVDYITGEVDENKIKMPTSSLLKPSVKWVRSKATKIMPENRTIISESGEKFEGDYIVIATGGQNIPVHSLRGYHTIEDAKMIKNEVMNPRGKSFVIGSLPGIIKCPAAPWELSFLIKRKYPDANVSVIVPAKQPPPLQVPMSNMFNKKANELGIKVYKGFVIQEVNYNERYAVSTEGEKIAFDHLIIDTPISTGFSELADKSGLIPVDKSTLAYKDGVFVIGDANSTPTPKTGAAAHFQAEVVANNILAEIEGNRSKESYDGTAICAVYSGPNEGMLVWLNYEKSKALGPTSIYRYMKKAFTRLYWASLSGGVDFILKPLVESIRKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (297)
Sequences:	37072 (25659)
Seq/√Len:	1488.9

ECOLI - DHNA RCLA STHA HCAD NORW DLDH GSHR TRXB PRET AHPF
BACSU - YJLD YUMB YUTJ DLDH1 DLDH2 DLDH3 DHNA TRXB FENR1 YPDA FENR2 CZCO
HALSA - Q9HR27 Q9HP48 DLDH Q9HSN0 P82854
SULSO - Q97UV0 Q97VJ3 Q97WG1 Q97WE3 Q97YT2 Q97VD9 Q97XZ3 Q97Z19 Q97U72 Q97Y24 Q97UP4 Q97ZB4 Q97VQ4 Q97W27 Q97V69 FENR Q97Z14

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_P	72_K	4.077	1.00
136_I	222_F	3.887	1.00
3_R	25_E	3.360	1.00
168_I	197_Y	3.029	1.00
81_R	257_G	2.941	1.00
82_T	90_K	2.808	1.00
248_D	253_A	2.795	1.00
134_F	166_S	2.785	1.00
166_S	195_K	2.692	1.00
27_T	69_V	2.564	1.00
186_N	190_N	2.562	1.00
16_I	97_V	2.550	1.00
239_A	246_P	2.366	1.00
3_R	94_D	2.360	1.00
77_M	80_N	2.318	1.00
4_L	20_L	2.290	1.00
3_R	27_T	2.247	1.00
25_E	67_K	2.183	1.00
84_I	90_K	2.183	1.00
93_G	96_I	2.152	1.00
172_K	201_V	2.144	1.00
108_H	204_E	2.120	1.00
95_Y	257_G	2.086	1.00
29_I	91_F	2.076	1.00
240_D	244_L	2.043	1.00
97_V	287_I	2.030	1.00
12_A	261_I	2.016	1.00
103_Q	234_G	2.009	1.00
136_I	170_P	1.950	1.00
206_N	213_V	1.946	1.00
5_V	29_I	1.943	1.00
134_F	223_D	1.916	1.00
5_V	91_F	1.903	1.00
5_V	83_I	1.874	1.00
204_E	213_V	1.873	1.00
168_I	195_K	1.850	1.00
103_Q	232_S	1.796	1.00
197_Y	218_E	1.782	1.00
174_P	199_G	1.774	1.00
78_P	258_V	1.772	1.00
211_Y	219_K	1.707	1.00
75_K	84_I	1.704	1.00
100_T	264_A	1.689	1.00
82_T	92_E	1.680	1.00
206_N	211_Y	1.663	1.00
259_F	286_N	1.615	1.00
200_F	216_E	1.607	1.00
203_Q	213_V	1.605	1.00
95_Y	259_F	1.596	1.00
283_V	287_I	1.579	1.00
97_V	261_I	1.561	1.00
175_P	182_S	1.557	1.00
207_Y	210_R	1.552	1.00
197_Y	200_F	1.539	1.00
253_A	256_D	1.527	1.00
5_V	27_T	1.517	1.00
59_S	63_K	1.517	1.00
213_V	219_K	1.515	1.00
38_Q	43_D	1.509	1.00
39_P	43_D	1.501	1.00
201_V	215_T	1.498	1.00
38_Q	42_V	1.495	1.00
5_V	93_G	1.490	1.00
284_A	288_L	1.475	1.00
206_N	219_K	1.473	1.00
112_G	207_Y	1.462	1.00
7_V	73_A	1.459	1.00
6_V	17_A	1.457	1.00
280_A	284_A	1.456	1.00
72_K	86_E	1.441	1.00
40_G	43_D	1.438	1.00
115_T	118_D	1.434	1.00
74_T	84_I	1.432	1.00
81_R	85_S	1.426	1.00
95_Y	287_I	1.422	1.00
245_I	260_V	1.385	1.00
179_V	183_N	1.374	1.00
9_G	30_E	1.370	1.00
85_S	91_F	1.369	1.00
77_M	82_T	1.366	1.00
136_I	212_A	1.362	1.00
239_A	255_K	1.360	1.00
250_S	253_A	1.359	1.00
282_V	286_N	1.347	1.00
188_K	191_E	1.322	1.00
145_C	171_A	1.317	1.00
39_P	42_V	1.315	1.00
134_F	168_I	1.311	1.00
19_L	285_N	1.310	1.00
170_P	220_I	1.299	1.00
27_T	91_F	1.299	1.00
171_A	198_K	1.294	1.00
12_A	276_A	1.293	1.00
133_S	223_D	1.287	1.00
289_A	294_N	1.270	1.00
4_L	97_V	1.265	1.00
99_A	261_I	1.258	1.00
118_D	121_M	1.253	1.00
23_K	285_N	1.251	1.00
60_S	64_P	1.243	1.00
114_H	118_D	1.241	1.00
38_Q	41_L	1.238	1.00
135_V	165_V	1.222	1.00
188_K	192_L	1.211	1.00
109_S	112_G	1.209	1.00
71_S	87_S	1.208	1.00
253_A	257_G	1.207	1.00
69_V	91_F	1.207	1.00
187_K	191_E	1.192	1.00
7_V	100_T	1.191	1.00
211_Y	221_A	1.183	1.00
43_D	46_T	1.179	1.00
186_N	198_K	1.179	1.00
134_F	165_V	1.173	1.00
247_V	265_N	1.171	1.00
150_W	169_V	1.169	1.00
261_I	283_V	1.165	1.00
125_E	165_V	1.158	1.00
58_T	61_L	1.157	1.00
23_K	288_L	1.156	1.00
252_L	265_N	1.154	1.00
187_K	190_N	1.151	1.00
104_N	232_S	1.147	1.00
205_V	225_L	1.144	1.00
21_A	66_V	1.143	1.00
200_F	215_T	1.143	1.00
183_N	186_N	1.138	1.00
27_T	67_K	1.131	1.00
134_F	221_A	1.131	1.00
135_V	160_Y	1.127	1.00
57_P	61_L	1.124	1.00
247_V	260_V	1.117	1.00
19_L	23_K	1.112	1.00
29_I	69_V	1.108	1.00
69_V	89_E	1.103	1.00
102_G	231_I	1.101	1.00
56_M	60_S	1.097	1.00
203_Q	215_T	1.096	1.00
250_S	286_N	1.095	1.00
135_V	224_H	1.094	1.00
240_D	266_S	1.093	1.00
6_V	13_G	1.093	1.00
245_I	264_A	1.088	1.00
74_T	86_E	1.078	1.00
58_T	62_L	1.074	1.00
77_M	84_I	1.074	1.00
246_P	255_K	1.072	1.00
75_K	96_I	1.072	1.00
214_S	218_E	1.068	1.00
20_L	284_A	1.059	1.00
117_E	120_K	1.056	1.00
7_V	98_I	1.056	1.00
114_H	122_I	1.050	1.00
252_L	283_V	1.049	1.00
77_M	81_R	1.042	1.00
145_C	176_P	1.039	1.00
200_F	218_E	1.038	1.00
175_P	179_V	1.038	1.00
176_P	198_K	1.031	1.00
240_D	246_P	1.029	1.00
16_I	283_V	1.015	1.00
16_I	280_A	1.013	1.00
57_P	60_S	1.001	1.00
19_L	281_E	0.995	1.00
3_R	92_E	0.993	1.00
186_N	196_V	0.985	1.00
16_I	261_I	0.984	1.00
197_Y	220_I	0.980	1.00
114_H	119_A	0.977	1.00
214_S	220_I	0.975	1.00
13_G	17_A	0.957	1.00
98_I	264_A	0.956	1.00
161_P	194_I	0.955	1.00
71_S	86_E	0.948	1.00
254_Y	260_V	0.945	1.00
200_F	214_S	0.945	1.00
161_P	166_S	0.941	1.00
214_S	217_G	0.932	1.00
29_I	73_A	0.928	1.00
260_V	264_A	0.926	1.00
29_I	85_S	0.926	1.00
259_F	290_E	0.923	1.00
175_P	186_N	0.921	1.00
17_A	66_V	0.911	1.00
85_S	89_E	0.907	1.00
241_K	246_P	0.905	1.00
106_P	110_L	0.901	1.00
96_I	258_V	0.900	1.00
150_W	303_T	0.897	1.00
34_Y	37_Y	0.892	1.00
138_S	225_L	0.892	1.00
222_F	225_L	0.889	1.00
39_P	44_Y	0.889	1.00
162_D	192_L	0.887	1.00
136_I	220_I	0.875	1.00
60_S	63_K	0.875	1.00
252_L	282_V	0.874	1.00
95_Y	290_E	0.871	1.00
61_L	64_P	0.871	1.00
57_P	62_L	0.868	1.00
53_K	56_M	0.868	1.00
80_N	90_K	0.868	1.00
122_I	224_H	0.861	1.00
183_N	187_K	0.858	1.00
215_T	218_E	0.851	1.00
113_Y	119_A	0.850	1.00
184_M	188_K	0.850	1.00
138_S	229_T	0.848	1.00
4_L	287_I	0.843	1.00
78_P	81_R	0.842	1.00
97_V	283_V	0.840	1.00
73_A	83_I	0.839	1.00
51_E	55_K	0.835	1.00
159_K	163_A	0.834	1.00
116_I	119_A	0.833	1.00
177_L	299_S	0.831	1.00
132_K	165_V	0.828	1.00
19_L	22_D	0.827	1.00
20_L	287_I	0.825	1.00
168_I	222_F	0.823	1.00
170_P	197_Y	0.821	1.00
149_P	171_A	0.820	1.00
78_P	257_G	0.819	1.00
109_S	204_E	0.814	1.00
259_F	283_V	0.811	1.00
53_K	57_P	0.811	1.00
13_G	99_A	0.810	1.00
283_V	286_N	0.803	1.00
20_L	26_V	0.796	1.00
114_H	117_E	0.796	1.00
260_V	265_N	0.795	1.00
16_I	284_A	0.794	1.00
182_S	186_N	0.793	1.00
253_A	286_N	0.790	1.00
56_M	59_S	0.788	1.00
117_E	121_M	0.781	1.00
54_I	57_P	0.779	1.00
236_S	239_A	0.779	1.00
6_V	16_I	0.777	1.00
153_S	169_V	0.771	1.00
154_F	162_D	0.771	1.00
55_K	58_T	0.769	1.00
120_K	123_K	0.767	1.00
51_E	54_I	0.766	1.00
85_S	88_G	0.764	1.00
30_E	68_W	0.764	1.00
275_A	279_Q	0.763	1.00
138_S	227_I	0.757	1.00
208_N	221_A	0.756	1.00
259_F	287_I	0.756	1.00
50_D	53_K	0.755	1.00
9_G	28_V	0.753	1.00
78_P	93_G	0.753	1.00
18_N	22_D	0.751	1.00
19_L	284_A	0.749	1.00
119_A	122_I	0.746	1.00
184_M	187_K	0.744	1.00
33_E	70_R	0.743	1.00
169_V	196_V	0.743	1.00
55_K	59_S	0.742	1.00
206_N	209_E	0.742	1.00
208_N	211_Y	0.740	1.00
285_N	290_E	0.737	1.00
190_N	195_K	0.735	1.00
76_I	90_K	0.734	1.00
242_S	266_S	0.733	1.00
133_S	166_S	0.732	1.00
181_M	184_M	0.731	1.00
265_N	279_Q	0.730	1.00
285_N	289_A	0.729	1.00
59_S	62_L	0.728	1.00
138_S	202_I	0.725	1.00
43_D	48_E	0.722	1.00
171_A	176_P	0.721	1.00
253_A	259_F	0.719	1.00
137_G	153_S	0.717	1.00
15_L	277_H	0.717	1.00
5_V	96_I	0.717	1.00
44_Y	48_E	0.714	1.00
42_V	46_T	0.711	1.00
170_P	200_F	0.709	1.00
250_S	291_I	0.707	1.00
263_D	276_A	0.703	1.00
150_W	189_A	0.702	1.00
299_S	309_Y	0.702	1.00
121_M	125_E	0.699	1.00
174_P	179_V	0.698	1.00
239_A	254_Y	0.698	1.00
153_S	167_V	0.697	1.00
113_Y	117_E	0.695	1.00
43_D	47_G	0.694	1.00
254_Y	258_V	0.692	1.00
17_A	28_V	0.691	1.00
168_I	220_I	0.688	1.00
93_G	257_G	0.688	1.00
21_A	65_S	0.688	1.00
161_P	192_L	0.686	1.00
113_Y	122_I	0.685	1.00
25_E	94_D	0.683	1.00
153_S	194_I	0.681	1.00
59_S	70_R	0.681	1.00
41_L	45_I	0.675	1.00
15_L	280_A	0.675	1.00
62_L	66_V	0.675	1.00
278_F	281_E	0.674	1.00
261_I	280_A	0.674	1.00
44_Y	47_G	0.673	1.00
289_A	293_G	0.673	1.00
281_E	285_N	0.671	1.00
33_E	71_S	0.670	1.00
15_L	19_L	0.669	1.00
276_A	280_A	0.669	1.00
247_V	252_L	0.668	1.00
118_D	122_I	0.665	1.00
137_G	149_P	0.665	1.00
4_L	95_Y	0.661	1.00
47_G	50_D	0.657	1.00
152_L	226_I	0.656	1.00
107_V	110_L	0.653	1.00
39_P	45_I	0.651	1.00
115_T	119_A	0.650	1.00
15_L	18_N	0.650	1.00
252_L	286_N	0.650	1.00
146_P	230_P	0.649	1.00
95_Y	291_I	0.649	1.00
51_E	57_P	0.648	1.00
171_A	174_P	0.646	1.00
3_R	91_F	0.645	1.00
41_L	44_Y	0.643	1.00
40_G	44_Y	0.642	1.00
145_C	149_P	0.641	1.00
175_P	183_N	0.641	1.00
38_Q	44_Y	0.639	1.00
113_Y	118_D	0.638	1.00
171_A	175_P	0.638	1.00
189_A	196_V	0.636	1.00
80_N	92_E	0.636	1.00
148_A	228_D	0.634	1.00
176_P	196_V	0.634	1.00
244_L	271_K	0.632	1.00
21_A	26_V	0.629	1.00
144_K	149_P	0.627	1.00
71_S	85_S	0.625	1.00
73_A	76_I	0.624	1.00
209_E	219_K	0.624	1.00
203_Q	217_G	0.623	1.00
241_K	266_S	0.622	1.00
53_K	58_T	0.619	1.00
52_N	55_K	0.618	1.00
177_L	309_Y	0.616	1.00
39_P	46_T	0.615	1.00
12_A	99_A	0.614	1.00
290_E	293_G	0.613	1.00
42_V	45_I	0.612	1.00
238_L	245_I	0.612	1.00
31_P	234_G	0.606	1.00
52_N	56_M	0.606	1.00
56_M	61_L	0.604	1.00
83_I	86_E	0.602	1.00
253_A	290_E	0.602	1.00
29_I	71_S	0.601	1.00
35_H	38_Q	0.599	1.00
134_F	222_F	0.596	1.00
179_V	182_S	0.595	1.00
235_F	264_A	0.595	1.00
146_P	149_P	0.592	1.00
78_P	238_L	0.592	1.00
249_K	293_G	0.590	1.00
108_H	112_G	0.589	1.00
15_L	281_E	0.587	1.00
136_I	168_I	0.582	1.00
261_I	287_I	0.582	1.00
150_W	196_V	0.582	1.00
180_P	184_M	0.582	1.00
235_F	240_D	0.580	1.00
75_K	236_S	0.579	1.00
133_S	165_V	0.578	1.00
54_I	58_T	0.574	1.00
135_V	226_I	0.572	1.00
116_I	120_K	0.571	1.00
73_A	85_S	0.569	1.00
75_K	81_R	0.569	1.00
51_E	120_K	0.569	1.00
236_S	258_V	0.566	1.00
245_I	254_Y	0.564	1.00
180_P	183_N	0.564	1.00
150_W	176_P	0.563	1.00
292_E	295_R	0.561	1.00
289_A	292_E	0.561	1.00
51_E	58_T	0.559	1.00
233_T	244_L	0.558	1.00
176_P	186_N	0.558	1.00
103_Q	235_F	0.555	1.00
110_L	227_I	0.554	1.00
30_E	70_R	0.553	1.00
288_L	292_E	0.553	1.00
34_Y	55_K	0.553	1.00
40_G	46_T	0.551	1.00
20_L	288_L	0.550	1.00
67_K	70_R	0.547	1.00
78_P	237_E	0.545	1.00
4_L	284_A	0.544	1.00
176_P	182_S	0.544	1.00
96_I	257_G	0.543	1.00
16_I	287_I	0.542	1.00
28_V	68_W	0.540	1.00
23_K	284_A	0.538	1.00
115_T	120_K	0.537	1.00
55_K	62_L	0.535	1.00
13_G	28_V	0.535	1.00
119_A	160_Y	0.534	1.00
175_P	198_K	0.533	1.00
144_K	230_P	0.532	1.00
149_P	228_D	0.532	1.00
114_H	224_H	0.530	1.00
205_V	212_A	0.529	1.00
56_M	62_L	0.528	1.00
119_A	123_K	0.526	1.00
105_I	110_L	0.526	1.00
106_P	109_S	0.525	1.00
44_Y	120_K	0.525	1.00
154_F	192_L	0.525	1.00
121_M	124_N	0.524	1.00
45_I	48_E	0.523	1.00
120_K	124_N	0.521	1.00
11_N	15_L	0.520	1.00
299_S	303_T	0.519	1.00
108_H	111_R	0.517	1.00
137_G	226_I	0.515	1.00
75_K	93_G	0.515	1.00
41_L	117_E	0.515	1.00
75_K	98_I	0.515	1.00
5_V	81_R	0.514	1.00
11_N	273_G	0.514	1.00
24_L	288_L	0.513	1.00
300_Y	303_T	0.512	1.00
174_P	198_K	0.512	1.00
35_H	68_W	0.510	1.00
113_Y	116_I	0.508	1.00
16_I	20_L	0.507	1.00
28_V	62_L	0.506	1.00
272_T	275_A	0.506	1.00
246_P	266_S	0.503	1.00
41_L	46_T	0.502	1.00
76_I	96_I	0.501	1.00
30_E	36_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g6hA	2	0.9782	100	0.364	Contact Map
3sx6A	2	0.9591	100	0.388	Contact Map
3hywA	4	0.9755	100	0.396	Contact Map
4nwzA	2	0.9455	100	0.406	Contact Map
3vrdB	1	0.97	100	0.41	Contact Map
3h8lA	2	0.8065	100	0.415	Contact Map
1ojtA	2	0.951	100	0.44	Contact Map
1zmdA	4	0.951	100	0.445	Contact Map
1v59A	2	0.951	100	0.446	Contact Map
1xhcA	1	0.8883	100	0.446	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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