GREMLIN Database
Q97UV0 - Oxidoreductase
UniProt: Q97UV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (297)
Sequences: 37072 (25659)
Seq/√Len: 1488.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_P72_K4.0771.00
136_I222_F3.8871.00
3_R25_E3.3601.00
168_I197_Y3.0291.00
81_R257_G2.9411.00
82_T90_K2.8081.00
248_D253_A2.7951.00
134_F166_S2.7851.00
166_S195_K2.6921.00
27_T69_V2.5641.00
186_N190_N2.5621.00
16_I97_V2.5501.00
239_A246_P2.3661.00
3_R94_D2.3601.00
77_M80_N2.3181.00
4_L20_L2.2901.00
3_R27_T2.2471.00
25_E67_K2.1831.00
84_I90_K2.1831.00
93_G96_I2.1521.00
172_K201_V2.1441.00
108_H204_E2.1201.00
95_Y257_G2.0861.00
29_I91_F2.0761.00
240_D244_L2.0431.00
97_V287_I2.0301.00
12_A261_I2.0161.00
103_Q234_G2.0091.00
136_I170_P1.9501.00
206_N213_V1.9461.00
5_V29_I1.9431.00
134_F223_D1.9161.00
5_V91_F1.9031.00
5_V83_I1.8741.00
204_E213_V1.8731.00
168_I195_K1.8501.00
103_Q232_S1.7961.00
197_Y218_E1.7821.00
174_P199_G1.7741.00
78_P258_V1.7721.00
211_Y219_K1.7071.00
75_K84_I1.7041.00
100_T264_A1.6891.00
82_T92_E1.6801.00
206_N211_Y1.6631.00
259_F286_N1.6151.00
200_F216_E1.6071.00
203_Q213_V1.6051.00
95_Y259_F1.5961.00
283_V287_I1.5791.00
97_V261_I1.5611.00
175_P182_S1.5571.00
207_Y210_R1.5521.00
197_Y200_F1.5391.00
253_A256_D1.5271.00
5_V27_T1.5171.00
59_S63_K1.5171.00
213_V219_K1.5151.00
38_Q43_D1.5091.00
39_P43_D1.5011.00
201_V215_T1.4981.00
38_Q42_V1.4951.00
5_V93_G1.4901.00
284_A288_L1.4751.00
206_N219_K1.4731.00
112_G207_Y1.4621.00
7_V73_A1.4591.00
6_V17_A1.4571.00
280_A284_A1.4561.00
72_K86_E1.4411.00
40_G43_D1.4381.00
115_T118_D1.4341.00
74_T84_I1.4321.00
81_R85_S1.4261.00
95_Y287_I1.4221.00
245_I260_V1.3851.00
179_V183_N1.3741.00
9_G30_E1.3701.00
85_S91_F1.3691.00
77_M82_T1.3661.00
136_I212_A1.3621.00
239_A255_K1.3601.00
250_S253_A1.3591.00
282_V286_N1.3471.00
188_K191_E1.3221.00
145_C171_A1.3171.00
39_P42_V1.3151.00
134_F168_I1.3111.00
19_L285_N1.3101.00
170_P220_I1.2991.00
27_T91_F1.2991.00
171_A198_K1.2941.00
12_A276_A1.2931.00
133_S223_D1.2871.00
289_A294_N1.2701.00
4_L97_V1.2651.00
99_A261_I1.2581.00
118_D121_M1.2531.00
23_K285_N1.2511.00
60_S64_P1.2431.00
114_H118_D1.2411.00
38_Q41_L1.2381.00
135_V165_V1.2221.00
188_K192_L1.2111.00
109_S112_G1.2091.00
71_S87_S1.2081.00
253_A257_G1.2071.00
69_V91_F1.2071.00
187_K191_E1.1921.00
7_V100_T1.1911.00
211_Y221_A1.1831.00
43_D46_T1.1791.00
186_N198_K1.1791.00
134_F165_V1.1731.00
247_V265_N1.1711.00
150_W169_V1.1691.00
261_I283_V1.1651.00
125_E165_V1.1581.00
58_T61_L1.1571.00
23_K288_L1.1561.00
252_L265_N1.1541.00
187_K190_N1.1511.00
104_N232_S1.1471.00
205_V225_L1.1441.00
21_A66_V1.1431.00
200_F215_T1.1431.00
183_N186_N1.1381.00
27_T67_K1.1311.00
134_F221_A1.1311.00
135_V160_Y1.1271.00
57_P61_L1.1241.00
247_V260_V1.1171.00
19_L23_K1.1121.00
29_I69_V1.1081.00
69_V89_E1.1031.00
102_G231_I1.1011.00
56_M60_S1.0971.00
203_Q215_T1.0961.00
250_S286_N1.0951.00
135_V224_H1.0941.00
240_D266_S1.0931.00
6_V13_G1.0931.00
245_I264_A1.0881.00
74_T86_E1.0781.00
58_T62_L1.0741.00
77_M84_I1.0741.00
246_P255_K1.0721.00
75_K96_I1.0721.00
214_S218_E1.0681.00
20_L284_A1.0591.00
117_E120_K1.0561.00
7_V98_I1.0561.00
114_H122_I1.0501.00
252_L283_V1.0491.00
77_M81_R1.0421.00
145_C176_P1.0391.00
200_F218_E1.0381.00
175_P179_V1.0381.00
176_P198_K1.0311.00
240_D246_P1.0291.00
16_I283_V1.0151.00
16_I280_A1.0131.00
57_P60_S1.0011.00
19_L281_E0.9951.00
3_R92_E0.9931.00
186_N196_V0.9851.00
16_I261_I0.9841.00
197_Y220_I0.9801.00
114_H119_A0.9771.00
214_S220_I0.9751.00
13_G17_A0.9571.00
98_I264_A0.9561.00
161_P194_I0.9551.00
71_S86_E0.9481.00
254_Y260_V0.9451.00
200_F214_S0.9451.00
161_P166_S0.9411.00
214_S217_G0.9321.00
29_I73_A0.9281.00
260_V264_A0.9261.00
29_I85_S0.9261.00
259_F290_E0.9231.00
175_P186_N0.9211.00
17_A66_V0.9111.00
85_S89_E0.9071.00
241_K246_P0.9051.00
106_P110_L0.9011.00
96_I258_V0.9001.00
150_W303_T0.8971.00
34_Y37_Y0.8921.00
138_S225_L0.8921.00
222_F225_L0.8891.00
39_P44_Y0.8891.00
162_D192_L0.8871.00
136_I220_I0.8751.00
60_S63_K0.8751.00
252_L282_V0.8741.00
95_Y290_E0.8711.00
61_L64_P0.8711.00
57_P62_L0.8681.00
53_K56_M0.8681.00
80_N90_K0.8681.00
122_I224_H0.8611.00
183_N187_K0.8581.00
215_T218_E0.8511.00
113_Y119_A0.8501.00
184_M188_K0.8501.00
138_S229_T0.8481.00
4_L287_I0.8431.00
78_P81_R0.8421.00
97_V283_V0.8401.00
73_A83_I0.8391.00
51_E55_K0.8351.00
159_K163_A0.8341.00
116_I119_A0.8331.00
177_L299_S0.8311.00
132_K165_V0.8281.00
19_L22_D0.8271.00
20_L287_I0.8251.00
168_I222_F0.8231.00
170_P197_Y0.8211.00
149_P171_A0.8201.00
78_P257_G0.8191.00
109_S204_E0.8141.00
259_F283_V0.8111.00
53_K57_P0.8111.00
13_G99_A0.8101.00
283_V286_N0.8031.00
20_L26_V0.7961.00
114_H117_E0.7961.00
260_V265_N0.7951.00
16_I284_A0.7941.00
182_S186_N0.7931.00
253_A286_N0.7901.00
56_M59_S0.7881.00
117_E121_M0.7811.00
54_I57_P0.7791.00
236_S239_A0.7791.00
6_V16_I0.7771.00
153_S169_V0.7711.00
154_F162_D0.7711.00
55_K58_T0.7691.00
120_K123_K0.7671.00
51_E54_I0.7661.00
85_S88_G0.7641.00
30_E68_W0.7641.00
275_A279_Q0.7631.00
138_S227_I0.7571.00
208_N221_A0.7561.00
259_F287_I0.7561.00
50_D53_K0.7551.00
9_G28_V0.7531.00
78_P93_G0.7531.00
18_N22_D0.7511.00
19_L284_A0.7491.00
119_A122_I0.7461.00
184_M187_K0.7441.00
33_E70_R0.7431.00
169_V196_V0.7431.00
55_K59_S0.7421.00
206_N209_E0.7421.00
208_N211_Y0.7401.00
285_N290_E0.7371.00
190_N195_K0.7351.00
76_I90_K0.7341.00
242_S266_S0.7331.00
133_S166_S0.7321.00
181_M184_M0.7311.00
265_N279_Q0.7301.00
285_N289_A0.7291.00
59_S62_L0.7281.00
138_S202_I0.7251.00
43_D48_E0.7221.00
171_A176_P0.7211.00
253_A259_F0.7191.00
137_G153_S0.7171.00
15_L277_H0.7171.00
5_V96_I0.7171.00
44_Y48_E0.7141.00
42_V46_T0.7111.00
170_P200_F0.7091.00
250_S291_I0.7071.00
263_D276_A0.7031.00
150_W189_A0.7021.00
299_S309_Y0.7021.00
121_M125_E0.6991.00
174_P179_V0.6981.00
239_A254_Y0.6981.00
153_S167_V0.6971.00
113_Y117_E0.6951.00
43_D47_G0.6941.00
254_Y258_V0.6921.00
17_A28_V0.6911.00
168_I220_I0.6881.00
93_G257_G0.6881.00
21_A65_S0.6881.00
161_P192_L0.6861.00
113_Y122_I0.6851.00
25_E94_D0.6831.00
153_S194_I0.6811.00
59_S70_R0.6811.00
41_L45_I0.6751.00
15_L280_A0.6751.00
62_L66_V0.6751.00
278_F281_E0.6741.00
261_I280_A0.6741.00
44_Y47_G0.6731.00
289_A293_G0.6731.00
281_E285_N0.6711.00
33_E71_S0.6701.00
15_L19_L0.6691.00
276_A280_A0.6691.00
247_V252_L0.6681.00
118_D122_I0.6651.00
137_G149_P0.6651.00
4_L95_Y0.6611.00
47_G50_D0.6571.00
152_L226_I0.6561.00
107_V110_L0.6531.00
39_P45_I0.6511.00
115_T119_A0.6501.00
15_L18_N0.6501.00
252_L286_N0.6501.00
146_P230_P0.6491.00
95_Y291_I0.6491.00
51_E57_P0.6481.00
171_A174_P0.6461.00
3_R91_F0.6451.00
41_L44_Y0.6431.00
40_G44_Y0.6421.00
145_C149_P0.6411.00
175_P183_N0.6411.00
38_Q44_Y0.6391.00
113_Y118_D0.6381.00
171_A175_P0.6381.00
189_A196_V0.6361.00
80_N92_E0.6361.00
148_A228_D0.6341.00
176_P196_V0.6341.00
244_L271_K0.6321.00
21_A26_V0.6291.00
144_K149_P0.6271.00
71_S85_S0.6251.00
73_A76_I0.6241.00
209_E219_K0.6241.00
203_Q217_G0.6231.00
241_K266_S0.6221.00
53_K58_T0.6191.00
52_N55_K0.6181.00
177_L309_Y0.6161.00
39_P46_T0.6151.00
12_A99_A0.6141.00
290_E293_G0.6131.00
42_V45_I0.6121.00
238_L245_I0.6121.00
31_P234_G0.6061.00
52_N56_M0.6061.00
56_M61_L0.6041.00
83_I86_E0.6021.00
253_A290_E0.6021.00
29_I71_S0.6011.00
35_H38_Q0.5991.00
134_F222_F0.5961.00
179_V182_S0.5951.00
235_F264_A0.5951.00
146_P149_P0.5921.00
78_P238_L0.5921.00
249_K293_G0.5901.00
108_H112_G0.5891.00
15_L281_E0.5871.00
136_I168_I0.5821.00
261_I287_I0.5821.00
150_W196_V0.5821.00
180_P184_M0.5821.00
235_F240_D0.5801.00
75_K236_S0.5791.00
133_S165_V0.5781.00
54_I58_T0.5741.00
135_V226_I0.5721.00
116_I120_K0.5711.00
73_A85_S0.5691.00
75_K81_R0.5691.00
51_E120_K0.5691.00
236_S258_V0.5661.00
245_I254_Y0.5641.00
180_P183_N0.5641.00
150_W176_P0.5631.00
292_E295_R0.5611.00
289_A292_E0.5611.00
51_E58_T0.5591.00
233_T244_L0.5581.00
176_P186_N0.5581.00
103_Q235_F0.5551.00
110_L227_I0.5541.00
30_E70_R0.5531.00
288_L292_E0.5531.00
34_Y55_K0.5531.00
40_G46_T0.5511.00
20_L288_L0.5501.00
67_K70_R0.5471.00
78_P237_E0.5451.00
4_L284_A0.5441.00
176_P182_S0.5441.00
96_I257_G0.5431.00
16_I287_I0.5421.00
28_V68_W0.5401.00
23_K284_A0.5381.00
115_T120_K0.5371.00
55_K62_L0.5351.00
13_G28_V0.5351.00
119_A160_Y0.5341.00
175_P198_K0.5331.00
144_K230_P0.5321.00
149_P228_D0.5321.00
114_H224_H0.5301.00
205_V212_A0.5291.00
56_M62_L0.5281.00
119_A123_K0.5261.00
105_I110_L0.5261.00
106_P109_S0.5251.00
44_Y120_K0.5251.00
154_F192_L0.5251.00
121_M124_N0.5241.00
45_I48_E0.5231.00
120_K124_N0.5211.00
11_N15_L0.5201.00
299_S303_T0.5191.00
108_H111_R0.5171.00
137_G226_I0.5151.00
75_K93_G0.5151.00
41_L117_E0.5151.00
75_K98_I0.5151.00
5_V81_R0.5141.00
11_N273_G0.5141.00
24_L288_L0.5131.00
300_Y303_T0.5121.00
174_P198_K0.5121.00
35_H68_W0.5101.00
113_Y116_I0.5081.00
16_I20_L0.5071.00
28_V62_L0.5061.00
272_T275_A0.5061.00
246_P266_S0.5031.00
41_L46_T0.5021.00
76_I96_I0.5011.00
30_E36_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6hA 2 0.9782 100 0.364 Contact Map
3sx6A 2 0.9591 100 0.388 Contact Map
3hywA 4 0.9755 100 0.396 Contact Map
4nwzA 2 0.9455 100 0.406 Contact Map
3vrdB 1 0.97 100 0.41 Contact Map
3h8lA 2 0.8065 100 0.415 Contact Map
1ojtA 2 0.951 100 0.44 Contact Map
1zmdA 4 0.951 100 0.445 Contact Map
1v59A 2 0.951 100 0.446 Contact Map
1xhcA 1 0.8883 100 0.446 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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