GREMLIN Database
Q97UU8 - First ORF in transposon ISC1190
UniProt: Q97UU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (241)
Sequences: 4648 (3511)
Seq/√Len: 226.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V4.8441.00
18_Y92_K3.0981.00
162_S184_E2.8871.00
213_V225_F2.8151.00
76_L95_A2.7081.00
124_I175_E2.5711.00
123_S126_R2.5441.00
14_K25_E2.4731.00
117_W121_T2.4421.00
166_F177_R2.3631.00
220_G224_R2.3551.00
47_A95_A2.3511.00
46_V66_Y2.2851.00
87_S235_V2.2071.00
169_D177_R2.1401.00
221_D224_R2.1381.00
125_V129_N2.1151.00
123_S130_R2.0881.00
237_S242_V2.0671.00
173_R177_R2.0511.00
8_I36_V2.0191.00
194_L197_T2.0111.00
8_I15_L2.0041.00
201_I206_G1.9511.00
60_K108_S1.9101.00
45_K69_R1.9081.00
170_E173_R1.8761.00
115_S212_R1.8651.00
219_F228_Y1.8621.00
48_I68_V1.8441.00
17_V36_V1.8051.00
154_R172_E1.7541.00
117_W182_E1.7271.00
123_S170_E1.7201.00
196_F203_R1.7111.00
182_E185_L1.6751.00
97_L101_M1.6721.00
150_N154_R1.6671.00
120_I178_K1.6501.00
8_I58_L1.6391.00
152_V156_E1.6301.00
61_Y64_K1.6211.00
11_S16_V1.6151.00
131_L171_L1.6001.00
124_I178_K1.5961.00
61_Y65_E1.5921.00
29_N32_G1.5611.00
18_Y93_K1.5581.00
13_D240_K1.5461.00
166_F180_E1.5451.00
16_V25_E1.5301.00
24_Y39_V1.5301.00
85_K235_V1.5261.00
189_V196_F1.5191.00
147_K151_E1.4981.00
184_E187_D1.4931.00
170_E177_R1.4741.00
121_T124_I1.4491.00
226_V232_D1.4361.00
124_I128_K1.4331.00
148_N151_E1.4331.00
171_L175_E1.4321.00
48_I59_A1.4231.00
47_A71_I1.4151.00
124_I171_L1.3911.00
117_W204_T1.3891.00
149_L153_L1.3831.00
168_L172_E1.3831.00
169_D173_R1.3731.00
182_E186_E1.3611.00
131_L164_V1.3571.00
11_S14_K1.3431.00
40_L46_V1.3411.00
55_H70_I1.3311.00
6_A40_L1.3311.00
169_D176_V1.3291.00
179_R182_E1.3211.00
7_G96_E1.3191.00
46_V62_L1.3131.00
201_I205_L1.3111.00
121_T178_K1.3061.00
123_S127_V1.3011.00
150_N153_L1.2911.00
45_K67_D1.2701.00
119_F130_R1.2611.00
126_R129_N1.2561.00
27_Q32_G1.2551.00
74_L78_K1.2511.00
148_N156_E1.2441.00
127_V130_R1.2391.00
142_D146_K1.2161.00
33_F61_Y1.2141.00
148_N152_V1.2111.00
8_I17_V1.1881.00
37_K61_Y1.1861.00
116_Q120_I1.1791.00
187_D191_K1.1751.00
6_A17_V1.1731.00
93_K97_L1.1691.00
122_R126_R1.1671.00
10_V15_L1.1661.00
33_F57_N1.1661.00
71_I76_L1.1581.00
195_I206_G1.1521.00
149_L152_V1.1461.00
213_V216_V1.1201.00
59_A68_V1.1091.00
142_D145_S1.1031.00
175_E179_R1.1011.00
32_G35_G1.0851.00
6_A46_V1.0821.00
153_L156_E1.0801.00
86_K91_D1.0771.00
177_R180_E1.0701.00
19_F96_E1.0681.00
186_E203_R1.0651.00
111_K212_R1.0631.00
121_T125_V1.0581.00
12_K136_I1.0531.00
59_A70_I1.0501.00
150_N156_E1.0481.00
109_E157_D1.0441.00
127_V131_L1.0321.00
5_V100_S1.0321.00
189_V192_D1.0311.00
163_E166_F1.0291.00
69_R99_V1.0231.00
173_R176_V1.0011.00
151_E155_G0.9941.00
176_V180_E0.9871.00
149_L156_E0.9871.00
148_N155_G0.9851.00
117_W178_K0.9771.00
238_S242_V0.9731.00
5_V99_V0.9661.00
17_V39_V0.9651.00
26_F39_V0.9641.00
150_N155_G0.9621.00
84_G227_A0.9591.00
196_F206_G0.9431.00
150_N172_E0.9371.00
6_A44_C0.9321.00
114_T207_C0.9291.00
85_K90_N0.9271.00
10_V48_I0.9241.00
36_V40_L0.9191.00
45_K99_V0.9171.00
113_L181_I0.9161.00
166_F170_E0.9150.99
224_R227_A0.9150.99
161_L165_R0.9140.99
38_Q41_P0.9130.99
31_Q35_G0.9100.99
237_S243_V0.9060.99
184_E188_L0.9030.99
58_L62_L0.8920.99
114_T185_L0.8900.99
116_Q163_E0.8880.99
26_F32_G0.8840.99
50_S73_P0.8790.99
114_T208_I0.8760.99
95_A98_V0.8720.99
53_V136_I0.8670.99
148_N153_L0.8640.99
152_V155_G0.8550.99
48_I95_A0.8550.99
34_E38_Q0.8410.99
11_S15_L0.8380.99
50_S70_I0.8350.99
144_L152_V0.8340.99
106_T191_K0.8310.99
127_V171_L0.8300.99
166_F184_E0.8290.99
37_K65_E0.8270.99
162_S165_R0.8260.99
232_D235_V0.8260.99
7_G92_K0.8210.99
129_N133_R0.8200.99
16_V89_K0.8200.99
174_L177_R0.8140.99
172_E176_V0.8110.99
15_L28_N0.8110.99
79_F101_M0.8100.99
108_S112_E0.8060.99
114_T211_A0.8060.99
176_V179_R0.8050.99
43_G67_D0.8030.99
160_V163_E0.8020.99
72_N75_I0.8000.99
159_I162_S0.7990.99
118_D122_R0.7990.99
17_V26_F0.7970.99
235_V242_V0.7860.98
20_Q100_S0.7820.98
158_N184_E0.7810.98
43_G66_Y0.7790.98
40_L62_L0.7790.98
159_I163_E0.7780.98
37_K41_P0.7760.98
30_K34_E0.7710.98
167_L170_E0.7710.98
147_K150_N0.7710.98
192_D206_G0.7700.98
147_K154_R0.7610.98
128_K171_L0.7530.98
127_V170_E0.7520.98
77_K82_I0.7520.98
201_I209_I0.7510.98
41_P65_E0.7500.98
73_P212_R0.7480.98
116_Q166_F0.7460.98
35_G38_Q0.7410.98
116_Q181_I0.7370.98
175_E178_K0.7330.98
227_A232_D0.7330.98
215_D218_R0.7330.98
33_F39_V0.7320.98
119_F123_S0.7310.98
32_G36_V0.7260.97
146_K150_N0.7260.97
11_S239_G0.7240.97
51_T54_Y0.7210.97
79_F98_V0.7190.97
180_E184_E0.7150.97
48_I70_I0.7140.97
18_Y96_E0.7110.97
188_L191_K0.7110.97
226_V231_L0.7070.97
192_D196_F0.7060.97
47_A76_L0.7020.97
76_L94_L0.7010.97
106_T109_E0.7010.97
208_I212_R0.6980.97
120_I181_I0.6970.97
15_L26_F0.6970.97
234_L245_R0.6940.97
98_V102_G0.6930.97
127_V174_L0.6890.97
172_E175_E0.6880.96
222_K227_A0.6840.96
125_V128_K0.6840.96
32_G39_V0.6810.96
76_L98_V0.6810.96
162_S180_E0.6800.96
6_A62_L0.6740.96
143_S146_K0.6720.96
162_S173_R0.6720.96
88_D238_S0.6690.96
110_A188_L0.6680.96
185_L189_V0.6650.96
38_Q65_E0.6640.96
162_S166_F0.6630.96
127_V167_L0.6630.96
204_T208_I0.6620.96
212_R229_C0.6610.96
87_S237_S0.6580.95
119_F126_R0.6560.95
120_I174_L0.6540.95
10_V54_Y0.6520.95
144_L147_K0.6510.95
166_F169_D0.6500.95
149_L154_R0.6490.95
183_E186_E0.6450.95
19_F100_S0.6410.95
151_E156_E0.6370.95
178_K182_E0.6350.95
214_G218_R0.6330.94
198_I201_I0.6320.94
112_E134_D0.6310.94
186_E190_P0.6290.94
165_R169_D0.6280.94
116_Q119_F0.6270.94
31_Q39_V0.6260.94
37_K66_Y0.6190.94
145_S154_R0.6160.94
131_L161_L0.6150.94
182_E189_V0.6120.93
7_G62_L0.6110.93
124_I168_L0.6100.93
116_Q130_R0.6090.93
145_S149_L0.6090.93
71_I98_V0.6090.93
118_D208_I0.6060.93
225_F229_C0.6060.93
15_L58_L0.6040.93
16_V238_S0.6000.93
145_S150_N0.6000.93
84_G234_L0.5900.92
11_S55_H0.5890.92
116_Q127_V0.5870.92
120_I124_I0.5850.92
109_E188_L0.5850.92
149_L155_G0.5820.92
236_E245_R0.5820.92
236_E241_S0.5800.91
166_F181_I0.5770.91
17_V40_L0.5720.91
112_E160_V0.5710.91
79_F97_L0.5700.91
130_R167_L0.5700.91
73_P76_L0.5700.91
76_L102_G0.5690.91
226_V235_V0.5690.91
170_E174_L0.5670.90
192_D207_C0.5660.90
159_I184_E0.5650.90
174_L178_K0.5630.90
83_R232_D0.5630.90
33_F58_L0.5620.90
34_E61_Y0.5610.90
213_V229_C0.5600.90
120_I177_R0.5600.90
145_S148_N0.5600.90
35_G176_V0.5590.90
194_L198_I0.5550.90
165_R168_L0.5520.89
44_C66_Y0.5510.89
242_V245_R0.5510.89
151_E154_R0.5500.89
130_R133_R0.5500.89
97_L100_S0.5480.89
182_E188_L0.5480.89
34_E122_R0.5450.89
148_N154_R0.5450.89
143_S149_L0.5440.89
48_I58_L0.5420.88
112_E116_Q0.5400.88
55_H59_A0.5380.88
109_E158_N0.5360.88
71_I75_I0.5340.88
186_E189_V0.5330.88
142_D149_L0.5320.88
190_P203_R0.5320.88
119_F163_E0.5320.88
113_L117_W0.5320.88
79_F102_G0.5310.87
147_K153_L0.5290.87
222_K226_V0.5280.87
235_V244_S0.5250.87
209_I225_F0.5250.87
41_P66_Y0.5240.87
145_S152_V0.5230.87
189_V207_C0.5230.87
122_R125_V0.5210.86
157_D160_V0.5200.86
131_L167_L0.5180.86
146_K149_L0.5180.86
230_G239_G0.5180.86
186_E196_F0.5170.86
195_I201_I0.5160.86
23_Y176_V0.5150.86
142_D150_N0.5120.85
34_E65_E0.5100.85
121_T182_E0.5100.85
17_V24_Y0.5090.85
225_F228_Y0.5070.85
75_I78_K0.5070.85
36_V39_V0.5040.85
8_I40_L0.5030.84
219_F225_F0.5020.84
74_L84_G0.5010.84
82_I85_K0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3psfA 1 0.8434 93.7 0.91 Contact Map
3psiA 1 0.8394 93.5 0.91 Contact Map
2csbA 1 0.9157 88.4 0.921 Contact Map
1keaA 2 0.6145 87.4 0.922 Contact Map
1vq8Y 1 0 87 0.923 Contact Map
1pu6A 1 0.6707 86.9 0.923 Contact Map
1z00A 1 0.3012 83.9 0.926 Contact Map
3bzcA 1 0.8273 83.6 0.926 Contact Map
3b0xA 1 0.5823 83.2 0.927 Contact Map
1hjrA 2 0.4217 82.1 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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