Q97UU8 - SULSO - GREMLIN Contacts

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Q97UU8 - First ORF in transposon ISC1190

UniProt:	Q97UU8	Sequences: MEAPVAGIDVSKDKLVVYFQGKYYEFQNNKQGFEGVKQVLPKGCKVAIESTGVYHINLAKYLGKEYDVRIINPLILKKFKDIRGKKSDKNDKKLAELVVSMGSEFTTSEAKELTSQWDFITRSIVRVKNRLRRDLILLGYKDSLSKKNLNEVLRGEDNIVLSEVRFLLDELERLEVRKREIEEELEDLVPKDSLIFTIPGIGRTLGCIILARVGDVKRFGDKKRFVAYCGLDPLVESSGKSVVSRGISR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (241)
Sequences:	4648 (3511)
Seq/√Len:	226.2

SULSO - Q97UU8 Q97WZ5 Q97XK2 Q97Y59 Q97WC0 Q97XM7 Q97ZN4 Q97X07 Q97VS0 Q97X26 Q97UF7 Q97X29 Q97X12 Q97UQ6 Q97YE1 Q97VB2 Q97Y06 Q97XG9 Q97XZ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_A	99_V	4.844	1.00
18_Y	92_K	3.098	1.00
162_S	184_E	2.887	1.00
213_V	225_F	2.815	1.00
76_L	95_A	2.708	1.00
124_I	175_E	2.571	1.00
123_S	126_R	2.544	1.00
14_K	25_E	2.473	1.00
117_W	121_T	2.442	1.00
166_F	177_R	2.363	1.00
220_G	224_R	2.355	1.00
47_A	95_A	2.351	1.00
46_V	66_Y	2.285	1.00
87_S	235_V	2.207	1.00
169_D	177_R	2.140	1.00
221_D	224_R	2.138	1.00
125_V	129_N	2.115	1.00
123_S	130_R	2.088	1.00
237_S	242_V	2.067	1.00
173_R	177_R	2.051	1.00
8_I	36_V	2.019	1.00
194_L	197_T	2.011	1.00
8_I	15_L	2.004	1.00
201_I	206_G	1.951	1.00
60_K	108_S	1.910	1.00
45_K	69_R	1.908	1.00
170_E	173_R	1.876	1.00
115_S	212_R	1.865	1.00
219_F	228_Y	1.862	1.00
48_I	68_V	1.844	1.00
17_V	36_V	1.805	1.00
154_R	172_E	1.754	1.00
117_W	182_E	1.727	1.00
123_S	170_E	1.720	1.00
196_F	203_R	1.711	1.00
182_E	185_L	1.675	1.00
97_L	101_M	1.672	1.00
150_N	154_R	1.667	1.00
120_I	178_K	1.650	1.00
8_I	58_L	1.639	1.00
152_V	156_E	1.630	1.00
61_Y	64_K	1.621	1.00
11_S	16_V	1.615	1.00
131_L	171_L	1.600	1.00
124_I	178_K	1.596	1.00
61_Y	65_E	1.592	1.00
29_N	32_G	1.561	1.00
18_Y	93_K	1.558	1.00
13_D	240_K	1.546	1.00
166_F	180_E	1.545	1.00
16_V	25_E	1.530	1.00
24_Y	39_V	1.530	1.00
85_K	235_V	1.526	1.00
189_V	196_F	1.519	1.00
147_K	151_E	1.498	1.00
184_E	187_D	1.493	1.00
170_E	177_R	1.474	1.00
121_T	124_I	1.449	1.00
226_V	232_D	1.436	1.00
124_I	128_K	1.433	1.00
148_N	151_E	1.433	1.00
171_L	175_E	1.432	1.00
48_I	59_A	1.423	1.00
47_A	71_I	1.415	1.00
124_I	171_L	1.391	1.00
117_W	204_T	1.389	1.00
149_L	153_L	1.383	1.00
168_L	172_E	1.383	1.00
169_D	173_R	1.373	1.00
182_E	186_E	1.361	1.00
131_L	164_V	1.357	1.00
11_S	14_K	1.343	1.00
40_L	46_V	1.341	1.00
55_H	70_I	1.331	1.00
6_A	40_L	1.331	1.00
169_D	176_V	1.329	1.00
179_R	182_E	1.321	1.00
7_G	96_E	1.319	1.00
46_V	62_L	1.313	1.00
201_I	205_L	1.311	1.00
121_T	178_K	1.306	1.00
123_S	127_V	1.301	1.00
150_N	153_L	1.291	1.00
45_K	67_D	1.270	1.00
119_F	130_R	1.261	1.00
126_R	129_N	1.256	1.00
27_Q	32_G	1.255	1.00
74_L	78_K	1.251	1.00
148_N	156_E	1.244	1.00
127_V	130_R	1.239	1.00
142_D	146_K	1.216	1.00
33_F	61_Y	1.214	1.00
148_N	152_V	1.211	1.00
8_I	17_V	1.188	1.00
37_K	61_Y	1.186	1.00
116_Q	120_I	1.179	1.00
187_D	191_K	1.175	1.00
6_A	17_V	1.173	1.00
93_K	97_L	1.169	1.00
122_R	126_R	1.167	1.00
10_V	15_L	1.166	1.00
33_F	57_N	1.166	1.00
71_I	76_L	1.158	1.00
195_I	206_G	1.152	1.00
149_L	152_V	1.146	1.00
213_V	216_V	1.120	1.00
59_A	68_V	1.109	1.00
142_D	145_S	1.103	1.00
175_E	179_R	1.101	1.00
32_G	35_G	1.085	1.00
6_A	46_V	1.082	1.00
153_L	156_E	1.080	1.00
86_K	91_D	1.077	1.00
177_R	180_E	1.070	1.00
19_F	96_E	1.068	1.00
186_E	203_R	1.065	1.00
111_K	212_R	1.063	1.00
121_T	125_V	1.058	1.00
12_K	136_I	1.053	1.00
59_A	70_I	1.050	1.00
150_N	156_E	1.048	1.00
109_E	157_D	1.044	1.00
127_V	131_L	1.032	1.00
5_V	100_S	1.032	1.00
189_V	192_D	1.031	1.00
163_E	166_F	1.029	1.00
69_R	99_V	1.023	1.00
173_R	176_V	1.001	1.00
151_E	155_G	0.994	1.00
176_V	180_E	0.987	1.00
149_L	156_E	0.987	1.00
148_N	155_G	0.985	1.00
117_W	178_K	0.977	1.00
238_S	242_V	0.973	1.00
5_V	99_V	0.966	1.00
17_V	39_V	0.965	1.00
26_F	39_V	0.964	1.00
150_N	155_G	0.962	1.00
84_G	227_A	0.959	1.00
196_F	206_G	0.943	1.00
150_N	172_E	0.937	1.00
6_A	44_C	0.932	1.00
114_T	207_C	0.929	1.00
85_K	90_N	0.927	1.00
10_V	48_I	0.924	1.00
36_V	40_L	0.919	1.00
45_K	99_V	0.917	1.00
113_L	181_I	0.916	1.00
166_F	170_E	0.915	0.99
224_R	227_A	0.915	0.99
161_L	165_R	0.914	0.99
38_Q	41_P	0.913	0.99
31_Q	35_G	0.910	0.99
237_S	243_V	0.906	0.99
184_E	188_L	0.903	0.99
58_L	62_L	0.892	0.99
114_T	185_L	0.890	0.99
116_Q	163_E	0.888	0.99
26_F	32_G	0.884	0.99
50_S	73_P	0.879	0.99
114_T	208_I	0.876	0.99
95_A	98_V	0.872	0.99
53_V	136_I	0.867	0.99
148_N	153_L	0.864	0.99
152_V	155_G	0.855	0.99
48_I	95_A	0.855	0.99
34_E	38_Q	0.841	0.99
11_S	15_L	0.838	0.99
50_S	70_I	0.835	0.99
144_L	152_V	0.834	0.99
106_T	191_K	0.831	0.99
127_V	171_L	0.830	0.99
166_F	184_E	0.829	0.99
37_K	65_E	0.827	0.99
162_S	165_R	0.826	0.99
232_D	235_V	0.826	0.99
7_G	92_K	0.821	0.99
129_N	133_R	0.820	0.99
16_V	89_K	0.820	0.99
174_L	177_R	0.814	0.99
172_E	176_V	0.811	0.99
15_L	28_N	0.811	0.99
79_F	101_M	0.810	0.99
108_S	112_E	0.806	0.99
114_T	211_A	0.806	0.99
176_V	179_R	0.805	0.99
43_G	67_D	0.803	0.99
160_V	163_E	0.802	0.99
72_N	75_I	0.800	0.99
159_I	162_S	0.799	0.99
118_D	122_R	0.799	0.99
17_V	26_F	0.797	0.99
235_V	242_V	0.786	0.98
20_Q	100_S	0.782	0.98
158_N	184_E	0.781	0.98
43_G	66_Y	0.779	0.98
40_L	62_L	0.779	0.98
159_I	163_E	0.778	0.98
37_K	41_P	0.776	0.98
30_K	34_E	0.771	0.98
167_L	170_E	0.771	0.98
147_K	150_N	0.771	0.98
192_D	206_G	0.770	0.98
147_K	154_R	0.761	0.98
128_K	171_L	0.753	0.98
127_V	170_E	0.752	0.98
77_K	82_I	0.752	0.98
201_I	209_I	0.751	0.98
41_P	65_E	0.750	0.98
73_P	212_R	0.748	0.98
116_Q	166_F	0.746	0.98
35_G	38_Q	0.741	0.98
116_Q	181_I	0.737	0.98
175_E	178_K	0.733	0.98
227_A	232_D	0.733	0.98
215_D	218_R	0.733	0.98
33_F	39_V	0.732	0.98
119_F	123_S	0.731	0.98
32_G	36_V	0.726	0.97
146_K	150_N	0.726	0.97
11_S	239_G	0.724	0.97
51_T	54_Y	0.721	0.97
79_F	98_V	0.719	0.97
180_E	184_E	0.715	0.97
48_I	70_I	0.714	0.97
18_Y	96_E	0.711	0.97
188_L	191_K	0.711	0.97
226_V	231_L	0.707	0.97
192_D	196_F	0.706	0.97
47_A	76_L	0.702	0.97
76_L	94_L	0.701	0.97
106_T	109_E	0.701	0.97
208_I	212_R	0.698	0.97
120_I	181_I	0.697	0.97
15_L	26_F	0.697	0.97
234_L	245_R	0.694	0.97
98_V	102_G	0.693	0.97
127_V	174_L	0.689	0.97
172_E	175_E	0.688	0.96
222_K	227_A	0.684	0.96
125_V	128_K	0.684	0.96
32_G	39_V	0.681	0.96
76_L	98_V	0.681	0.96
162_S	180_E	0.680	0.96
6_A	62_L	0.674	0.96
143_S	146_K	0.672	0.96
162_S	173_R	0.672	0.96
88_D	238_S	0.669	0.96
110_A	188_L	0.668	0.96
185_L	189_V	0.665	0.96
38_Q	65_E	0.664	0.96
162_S	166_F	0.663	0.96
127_V	167_L	0.663	0.96
204_T	208_I	0.662	0.96
212_R	229_C	0.661	0.96
87_S	237_S	0.658	0.95
119_F	126_R	0.656	0.95
120_I	174_L	0.654	0.95
10_V	54_Y	0.652	0.95
144_L	147_K	0.651	0.95
166_F	169_D	0.650	0.95
149_L	154_R	0.649	0.95
183_E	186_E	0.645	0.95
19_F	100_S	0.641	0.95
151_E	156_E	0.637	0.95
178_K	182_E	0.635	0.95
214_G	218_R	0.633	0.94
198_I	201_I	0.632	0.94
112_E	134_D	0.631	0.94
186_E	190_P	0.629	0.94
165_R	169_D	0.628	0.94
116_Q	119_F	0.627	0.94
31_Q	39_V	0.626	0.94
37_K	66_Y	0.619	0.94
145_S	154_R	0.616	0.94
131_L	161_L	0.615	0.94
182_E	189_V	0.612	0.93
7_G	62_L	0.611	0.93
124_I	168_L	0.610	0.93
116_Q	130_R	0.609	0.93
145_S	149_L	0.609	0.93
71_I	98_V	0.609	0.93
118_D	208_I	0.606	0.93
225_F	229_C	0.606	0.93
15_L	58_L	0.604	0.93
16_V	238_S	0.600	0.93
145_S	150_N	0.600	0.93
84_G	234_L	0.590	0.92
11_S	55_H	0.589	0.92
116_Q	127_V	0.587	0.92
120_I	124_I	0.585	0.92
109_E	188_L	0.585	0.92
149_L	155_G	0.582	0.92
236_E	245_R	0.582	0.92
236_E	241_S	0.580	0.91
166_F	181_I	0.577	0.91
17_V	40_L	0.572	0.91
112_E	160_V	0.571	0.91
79_F	97_L	0.570	0.91
130_R	167_L	0.570	0.91
73_P	76_L	0.570	0.91
76_L	102_G	0.569	0.91
226_V	235_V	0.569	0.91
170_E	174_L	0.567	0.90
192_D	207_C	0.566	0.90
159_I	184_E	0.565	0.90
174_L	178_K	0.563	0.90
83_R	232_D	0.563	0.90
33_F	58_L	0.562	0.90
34_E	61_Y	0.561	0.90
213_V	229_C	0.560	0.90
120_I	177_R	0.560	0.90
145_S	148_N	0.560	0.90
35_G	176_V	0.559	0.90
194_L	198_I	0.555	0.90
165_R	168_L	0.552	0.89
44_C	66_Y	0.551	0.89
242_V	245_R	0.551	0.89
151_E	154_R	0.550	0.89
130_R	133_R	0.550	0.89
97_L	100_S	0.548	0.89
182_E	188_L	0.548	0.89
34_E	122_R	0.545	0.89
148_N	154_R	0.545	0.89
143_S	149_L	0.544	0.89
48_I	58_L	0.542	0.88
112_E	116_Q	0.540	0.88
55_H	59_A	0.538	0.88
109_E	158_N	0.536	0.88
71_I	75_I	0.534	0.88
186_E	189_V	0.533	0.88
142_D	149_L	0.532	0.88
190_P	203_R	0.532	0.88
119_F	163_E	0.532	0.88
113_L	117_W	0.532	0.88
79_F	102_G	0.531	0.87
147_K	153_L	0.529	0.87
222_K	226_V	0.528	0.87
235_V	244_S	0.525	0.87
209_I	225_F	0.525	0.87
41_P	66_Y	0.524	0.87
145_S	152_V	0.523	0.87
189_V	207_C	0.523	0.87
122_R	125_V	0.521	0.86
157_D	160_V	0.520	0.86
131_L	167_L	0.518	0.86
146_K	149_L	0.518	0.86
230_G	239_G	0.518	0.86
186_E	196_F	0.517	0.86
195_I	201_I	0.516	0.86
23_Y	176_V	0.515	0.86
142_D	150_N	0.512	0.85
34_E	65_E	0.510	0.85
121_T	182_E	0.510	0.85
17_V	24_Y	0.509	0.85
225_F	228_Y	0.507	0.85
75_I	78_K	0.507	0.85
36_V	39_V	0.504	0.85
8_I	40_L	0.503	0.84
219_F	225_F	0.502	0.84
74_L	84_G	0.501	0.84
82_I	85_K	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3psfA	1	0.8434	93.7	0.91	Contact Map
3psiA	1	0.8394	93.5	0.91	Contact Map
2csbA	1	0.9157	88.4	0.921	Contact Map
1keaA	2	0.6145	87.4	0.922	Contact Map
1vq8Y	1	0	87	0.923	Contact Map
1pu6A	1	0.6707	86.9	0.923	Contact Map
1z00A	1	0.3012	83.9	0.926	Contact Map
3bzcA	1	0.8273	83.6	0.926	Contact Map
3b0xA	1	0.5823	83.2	0.927	Contact Map
1hjrA	2	0.4217	82.1	0.927	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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