GREMLIN Database
Q97UU6 - Uncharacterized protein
UniProt: Q97UU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (102)
Sequences: 9459 (5631)
Seq/√Len: 557.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L54_P2.8391.00
71_K85_S2.8371.00
55_K59_D2.7661.00
92_K106_E2.7481.00
77_S81_R2.6311.00
73_V85_S2.6051.00
34_I70_V2.3171.00
71_K87_T2.2461.00
33_T48_S2.1781.00
75_V83_E1.9611.00
89_E107_H1.8141.00
75_V81_R1.8021.00
30_V60_V1.8001.00
99_P102_K1.7711.00
34_I45_I1.7451.00
36_N94_R1.7161.00
96_A99_P1.7101.00
95_K99_P1.6981.00
86_L90_G1.6441.00
39_K85_S1.6201.00
40_L48_S1.6011.00
39_K83_E1.5851.00
18_T100_L1.5451.00
62_K65_E1.5321.00
91_K94_R1.4411.00
27_L63_T1.4251.00
56_A59_D1.4231.00
72_K82_V1.4001.00
88_Y91_K1.3811.00
69_L90_G1.3001.00
54_P58_S1.2851.00
27_L60_V1.2531.00
101_F105_A1.2371.00
92_K103_W1.2361.00
24_R63_T1.2221.00
18_T104_A1.2181.00
21_V67_M1.1941.00
43_N47_N1.1941.00
89_E92_K1.1851.00
17_D108_T1.1481.00
34_I40_L1.1461.00
74_I82_V1.1291.00
40_L44_S1.1291.00
73_V83_E1.1261.00
31_L86_L1.1181.00
75_V79_P1.1161.00
41_G83_E1.1091.00
24_R60_V1.1051.00
89_E110_H1.1001.00
69_L93_L1.0921.00
74_I79_P1.0761.00
42_F58_S1.0711.00
21_V69_L1.0611.00
92_K107_H1.0521.00
65_E70_V1.0321.00
24_R27_L1.0301.00
76_K79_P1.0281.00
58_S62_K1.0231.00
28_L97_V1.0021.00
75_V80_P0.9851.00
30_V49_I0.9641.00
74_I80_P0.9601.00
27_L64_M0.9581.00
85_S91_K0.9551.00
52_I57_L0.9551.00
75_V78_S0.9461.00
94_R98_I0.9181.00
95_K102_K0.9121.00
93_L103_W0.8941.00
14_P105_A0.8861.00
44_S47_N0.8791.00
43_N46_L0.8591.00
56_A60_V0.8581.00
32_N101_F0.8451.00
32_N36_N0.8421.00
42_F54_P0.8411.00
53_S56_A0.8241.00
68_G89_E0.8171.00
37_E40_L0.8131.00
96_A100_L0.8051.00
27_L67_M0.8041.00
33_T45_I0.7971.00
102_K106_E0.7871.00
40_L45_I0.7871.00
74_I78_S0.7731.00
16_I20_N0.7721.00
49_I52_I0.7571.00
63_T67_M0.7461.00
26_W52_I0.7371.00
30_V52_I0.7361.00
17_D107_H0.7361.00
98_I102_K0.7201.00
11_Q16_I0.7011.00
104_A108_T0.6981.00
74_I77_S0.6941.00
17_D111_Y0.6861.00
19_I100_L0.6811.00
107_H110_H0.6631.00
59_D63_T0.6631.00
33_T37_E0.6621.00
78_S82_V0.6541.00
52_I82_V0.6531.00
98_I101_F0.6471.00
41_G75_V0.6391.00
36_N98_I0.6381.00
77_S83_E0.6241.00
65_E72_K0.6141.00
29_L49_I0.6141.00
105_A108_T0.6111.00
11_Q20_N0.6111.00
102_K105_A0.6101.00
93_L96_A0.6071.00
31_L93_L0.6071.00
65_E74_I0.6061.00
19_I28_L0.5981.00
44_S48_S0.5971.00
77_S82_V0.5811.00
64_M69_L0.5770.99
34_I65_E0.5740.99
106_E109_G0.5710.99
11_Q17_D0.5710.99
29_L33_T0.5700.99
34_I39_K0.5660.99
77_S80_P0.5640.99
9_K15_L0.5600.99
36_N86_L0.5600.99
89_E111_Y0.5550.99
38_G91_K0.5550.99
95_K98_I0.5540.99
88_Y92_K0.5540.99
15_L108_T0.5450.99
103_W107_H0.5450.99
89_E108_T0.5430.99
73_V76_K0.5420.99
96_A104_A0.5410.99
54_P60_V0.5390.99
79_P82_V0.5370.99
86_L91_K0.5300.99
15_L32_N0.5260.99
10_Q50_D0.5260.99
32_N42_F0.5250.99
31_L69_L0.5250.99
78_S81_R0.5200.99
18_T22_I0.5200.99
33_T40_L0.5170.99
43_N54_P0.5150.99
26_W57_L0.5130.99
16_I29_L0.5130.99
36_N40_L0.5110.99
92_K95_K0.5090.99
19_I93_L0.5020.99
14_P101_F0.5000.99
79_P83_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.8898 99.9 0.437 Contact Map
4a5nA 2 0.8268 99.7 0.512 Contact Map
1yyvA 2 0.8583 99.7 0.518 Contact Map
2hztA 2 0.748 99.7 0.524 Contact Map
1z7uA 2 0.874 99.7 0.538 Contact Map
2f2eA 4 0.937 99.7 0.543 Contact Map
2fswA 2 0.811 99.6 0.547 Contact Map
4hw0A 2 0.7717 99.6 0.569 Contact Map
3df8A 2 0.8031 99.5 0.586 Contact Map
4hqeA 2 0.8425 99.4 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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