GREMLIN Database
Y2899 - Uncharacterized protein SSO2899
UniProt: Q97UU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (159)
Sequences: 3926 (2837)
Seq/√Len: 225.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_L156_I2.9861.00
11_Y153_K2.9641.00
54_E76_G2.5811.00
96_E134_I2.4801.00
20_I155_M2.4421.00
116_S152_R2.3681.00
54_E74_S2.3361.00
160_T163_A2.2271.00
72_V109_K2.1301.00
47_G51_I2.1121.00
101_S105_K2.0621.00
69_E105_K2.0221.00
164_Y168_K2.0111.00
72_V113_L1.9941.00
50_I77_K1.9931.00
67_V98_K1.9291.00
104_F142_V1.8651.00
105_K108_L1.8651.00
19_E46_K1.8311.00
132_F163_A1.8231.00
14_K161_K1.7811.00
91_Y95_G1.7641.00
14_K164_Y1.7611.00
111_D146_Y1.7031.00
35_H40_A1.6781.00
82_Y115_L1.6751.00
52_Q56_D1.6621.00
142_V145_G1.6291.00
132_F166_V1.6161.00
130_Y134_I1.5891.00
107_L146_Y1.5621.00
130_Y138_I1.5571.00
86_A106_S1.5441.00
109_K112_E1.5331.00
100_E142_V1.5171.00
24_A115_L1.5161.00
47_G76_G1.4221.00
13_I20_I1.4131.00
22_A119_A1.4041.00
161_K165_D1.3611.00
143_L154_V1.3541.00
111_D149_K1.3471.00
122_A125_T1.3221.00
70_V84_I1.3111.00
12_L164_Y1.3101.00
122_A167_F1.3021.00
62_F71_A1.2941.00
158_L164_Y1.2911.00
132_F162_D1.2791.00
20_I157_C1.2701.00
25_I43_I1.2631.00
108_L146_Y1.2591.00
50_I76_G1.2521.00
86_A102_A1.2331.00
75_A80_A1.2331.00
66_P71_A1.2311.00
166_V170_I1.2291.00
100_E141_N1.2231.00
96_E130_Y1.2221.00
133_E169_S1.1931.00
23_D81_K1.1821.00
106_S120_M1.1691.00
73_T85_H1.1571.00
82_Y113_L1.1541.00
122_A163_A1.1531.00
111_D151_L1.1491.00
158_L167_F1.1461.00
23_D115_L1.1421.00
65_V71_A1.1401.00
51_I76_G1.1361.00
136_A166_V1.1111.00
109_K113_L1.1061.00
110_A118_I1.1001.00
125_T163_A1.0871.00
103_I139_M1.0861.00
88_G124_S1.0781.00
84_I106_S1.0731.00
70_V105_K1.0531.00
72_V115_L1.0501.00
12_L171_F1.0431.00
165_D169_S1.0331.00
40_A44_V1.0311.00
141_N145_G1.0301.00
24_A84_I1.0281.00
100_E104_F1.0261.00
163_A167_F1.0241.00
108_L112_E1.0221.00
122_A132_F1.0091.00
15_G157_C1.0071.00
137_R170_I1.0041.00
132_F160_T0.9871.00
66_P69_E0.9841.00
50_I74_S0.9781.00
15_G20_I0.9781.00
100_E145_G0.9771.00
34_Q52_Q0.9721.00
34_Q56_D0.9721.00
15_G19_E0.9701.00
41_Y45_R0.9671.00
122_A136_A0.9651.00
91_Y134_I0.9361.00
106_S118_I0.9211.00
67_V90_R0.9201.00
31_S87_V0.9150.99
22_A155_M0.9120.99
134_I137_R0.9090.99
125_T135_C0.9060.99
50_I53_K0.9030.99
132_F136_A0.8980.99
31_S66_P0.8870.99
51_I83_V0.8740.99
12_L158_L0.8710.99
104_F108_L0.8700.99
74_S82_Y0.8630.99
100_E138_I0.8620.99
94_E97_D0.8590.99
111_D150_T0.8580.99
70_V109_K0.8570.99
97_D101_S0.8560.99
69_E101_S0.8540.99
21_E79_K0.8540.99
140_A171_F0.8540.99
42_A46_K0.8490.99
91_Y131_P0.8240.99
138_I142_V0.8240.99
140_A170_I0.8170.99
147_K150_T0.8120.99
104_F145_G0.8000.99
165_D168_K0.7940.99
12_L140_A0.7900.98
148_P151_L0.7890.98
40_A52_Q0.7890.98
31_S67_V0.7870.98
133_E166_V0.7870.98
125_T136_A0.7860.98
91_Y130_Y0.7830.98
16_D19_E0.7760.98
163_A166_V0.7710.98
111_D152_R0.7630.98
28_A39_V0.7550.98
78_L83_V0.7540.98
95_G98_K0.7520.98
136_A170_I0.7490.98
96_E138_I0.7470.98
94_E98_K0.7430.98
117_S153_K0.7390.98
136_A167_F0.7370.98
54_E73_T0.7360.98
110_A115_L0.7310.98
96_E100_E0.7270.97
103_I135_C0.7270.97
36_G41_Y0.7230.97
111_D148_P0.7220.97
35_H55_S0.7200.97
122_A158_L0.7190.97
146_Y149_K0.7160.97
14_K160_T0.7060.97
151_L154_V0.7040.97
125_T167_F0.6980.97
49_Y53_K0.6950.97
88_G123_I0.6940.97
31_S64_P0.6920.97
35_H44_V0.6790.96
53_K56_D0.6760.96
89_P99_L0.6750.96
107_L143_L0.6730.96
24_A118_I0.6710.96
137_R141_N0.6670.96
35_H52_Q0.6660.96
167_F170_I0.6640.96
25_I79_K0.6620.96
119_A157_C0.6570.95
114_S150_T0.6560.95
51_I74_S0.6560.95
25_I78_L0.6540.95
161_K164_Y0.6460.95
38_G41_Y0.6460.95
29_A36_G0.6430.95
139_M156_I0.6390.95
92_G95_G0.6380.95
11_Y155_M0.6360.94
70_V86_A0.6350.94
22_A117_S0.6330.94
20_I119_A0.6330.94
133_E137_R0.6320.94
86_A123_I0.6310.94
17_I39_V0.6300.94
107_L154_V0.6300.94
63_G71_A0.6280.94
32_Y64_P0.6220.94
44_V55_S0.6210.94
111_D147_K0.6150.93
122_A166_V0.6110.93
81_K117_S0.6100.93
120_M139_M0.6030.93
124_S128_Y0.6020.93
130_Y135_C0.6010.93
135_C139_M0.5960.92
125_T132_F0.5950.92
115_L118_I0.5950.92
149_K152_R0.5930.92
142_V146_Y0.5920.92
122_A160_T0.5920.92
18_T43_I0.5870.92
146_Y154_V0.5850.92
122_A156_I0.5840.92
27_N43_I0.5820.91
156_I167_F0.5760.91
27_N85_H0.5750.91
13_I155_M0.5740.91
12_L168_K0.5700.91
108_L111_D0.5640.90
146_Y151_L0.5590.90
62_F65_V0.5580.90
61_K76_G0.5470.89
40_A128_Y0.5460.89
68_G86_A0.5420.88
52_Q128_Y0.5410.88
29_A55_S0.5390.88
33_L71_A0.5380.88
122_A170_I0.5370.88
44_V52_Q0.5370.88
61_K64_P0.5360.88
33_L55_S0.5350.88
26_V120_M0.5290.87
106_S110_A0.5270.87
23_D116_S0.5260.87
88_G128_Y0.5220.86
29_A38_G0.5190.86
29_A128_Y0.5190.86
9_E152_R0.5180.86
36_G128_Y0.5150.86
44_V51_I0.5110.85
136_A158_L0.5060.85
109_K115_L0.5050.85
87_V102_A0.5040.84
47_G74_S0.5010.84
162_D165_D0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q6zA 1 0.9887 100 0.148 Contact Map
4d86A 1 0.9887 100 0.16 Contact Map
1yd9A 1 1 100 0.168 Contact Map
2xd7A 1 0.9831 100 0.169 Contact Map
3q71A 1 0.9887 100 0.173 Contact Map
1vhuA 1 0.9887 100 0.174 Contact Map
4umlA 1 0.9718 100 0.178 Contact Map
1spvA 1 0.9435 100 0.185 Contact Map
2x47A 1 0.9774 100 0.185 Contact Map
4iqyA 1 0.9718 100 0.189 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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