GREMLIN Database
Q97UU2 - Uncharacterized protein
UniProt: Q97UU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (165)
Sequences: 4468 (3120)
Seq/√Len: 242.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V125_I2.9181.00
86_F99_A2.8501.00
9_R37_K2.7421.00
26_G156_I2.7401.00
33_E162_S2.6601.00
71_R74_K2.6351.00
33_E159_Y2.5821.00
31_F36_Y2.4051.00
30_I34_K2.3881.00
12_I28_I2.3081.00
39_S82_K2.2951.00
124_N127_K2.2711.00
30_I159_Y2.2371.00
75_I169_Q2.2121.00
13_V129_V2.1701.00
10_V31_F2.1441.00
45_D66_R2.0761.00
29_Q162_S1.8951.00
112_S129_V1.7941.00
41_I103_F1.7741.00
110_V133_Y1.7701.00
67_Q71_R1.7451.00
165_R168_N1.7261.00
11_L41_I1.7261.00
11_L104_L1.6991.00
37_K79_D1.6391.00
71_R169_Q1.6351.00
9_R108_D1.6251.00
42_I69_A1.6211.00
31_F111_F1.6051.00
75_I165_R1.5611.00
97_E131_K1.5561.00
82_K103_F1.5441.00
28_I32_K1.5401.00
96_A128_A1.5081.00
32_K38_I1.5071.00
21_T72_A1.5041.00
66_R70_L1.4691.00
13_V41_I1.4481.00
9_R39_S1.4371.00
12_I20_E1.4261.00
99_A102_E1.4261.00
164_L168_N1.4221.00
12_I111_F1.4081.00
39_S80_E1.3861.00
66_R85_N1.3801.00
15_P113_P1.3801.00
101_A135_N1.3621.00
28_I38_I1.3481.00
75_I162_S1.3301.00
24_C111_F1.3061.00
123_A127_K1.3031.00
101_A105_R1.2941.00
45_D85_N1.2911.00
29_Q33_E1.2621.00
105_R136_A1.2191.00
139_Y143_G1.2141.00
33_E158_K1.2021.00
139_Y142_W1.2001.00
71_R171_I1.1991.00
29_Q76_L1.1971.00
110_V129_V1.1941.00
137_Y147_V1.1941.00
162_S165_R1.1841.00
57_G60_E1.1831.00
29_Q166_A1.1661.00
30_I158_K1.1571.00
32_K79_D1.1421.00
84_L99_A1.1391.00
95_D99_A1.1361.00
30_I154_F1.1201.00
66_R83_F1.1151.00
27_T31_F1.1031.00
26_G163_K1.0831.00
67_Q70_L1.0811.00
94_E98_N1.0731.00
70_L74_K1.0661.00
104_L110_V1.0581.00
161_E165_R1.0541.00
76_L166_A1.0471.00
14_A20_E1.0471.00
42_I81_V1.0451.00
28_I76_L1.0431.00
93_E97_E1.0401.00
44_T91_V1.0331.00
140_L143_G1.0331.00
69_A83_F1.0311.00
160_K164_L1.0291.00
14_A113_P1.0161.00
25_G76_L1.0111.00
71_R75_I1.0051.00
29_Q159_Y1.0021.00
125_I129_V0.9971.00
159_Y162_S0.9911.00
155_D159_Y0.9831.00
8_R108_D0.9801.00
72_A166_A0.9731.00
41_I100_L0.9671.00
68_E173_Q0.9651.00
60_E63_E0.9611.00
124_N128_A0.9411.00
100_L128_A0.9391.00
17_P46_G0.9261.00
97_E135_N0.9241.00
48_Y87_E0.9221.00
26_G155_D0.9201.00
20_E40_V0.9141.00
56_K60_E0.9101.00
93_E127_K0.9011.00
126_G130_E0.8941.00
25_G166_A0.8891.00
138_F141_I0.8831.00
171_I175_G0.8820.99
70_L81_V0.8760.99
11_L107_N0.8740.99
32_K77_G0.8740.99
13_V43_V0.8700.99
138_F142_W0.8690.99
42_I83_F0.8610.99
29_Q32_K0.8560.99
40_V73_T0.8560.99
114_I117_D0.8550.99
73_T81_V0.8550.99
36_Y108_D0.8520.99
50_S61_L0.8420.99
87_E90_K0.8360.99
8_R39_S0.8330.99
70_L83_F0.8300.99
43_V84_L0.8280.99
46_G88_D0.8280.99
43_V91_V0.8230.99
91_V124_N0.8040.99
27_T154_F0.7930.99
10_V36_Y0.7890.99
13_V100_L0.7860.99
138_F143_G0.7860.99
10_V111_F0.7860.99
73_T78_I0.7840.99
97_E132_L0.7780.99
28_I40_V0.7750.99
49_G88_D0.7730.99
10_V109_V0.7660.99
113_P117_D0.7590.98
156_I159_Y0.7580.98
98_N135_N0.7580.98
8_R36_Y0.7500.98
93_E96_A0.7500.98
39_S79_D0.7480.98
69_A170_Y0.7450.98
68_E172_S0.7430.98
64_I172_S0.7390.98
86_F91_V0.7300.98
37_K80_E0.7190.98
47_R87_E0.7180.98
27_T111_F0.7130.98
86_F96_A0.7060.98
88_D121_D0.7030.98
63_E67_Q0.6990.97
131_K134_P0.6980.97
48_Y90_K0.6960.97
148_N151_E0.6940.97
21_T170_Y0.6930.97
112_S126_G0.6910.97
40_V78_I0.6890.97
36_Y111_F0.6870.97
101_A132_L0.6850.97
11_L103_F0.6780.97
98_N102_E0.6730.97
45_D83_F0.6730.97
49_G173_Q0.6700.97
156_I160_K0.6700.97
97_E101_A0.6660.97
101_A136_A0.6580.96
41_I84_L0.6560.96
21_T69_A0.6520.96
18_D119_H0.6510.96
72_A169_Q0.6460.96
46_G65_R0.6380.96
59_S63_E0.6340.95
91_V96_A0.6340.95
43_V100_L0.6330.95
99_A103_F0.6280.95
48_Y89_S0.6250.95
47_R62_I0.6230.95
39_S103_F0.6210.95
26_G159_Y0.6210.95
93_E124_N0.6160.95
9_R36_Y0.6120.95
13_V125_I0.6080.94
14_A117_D0.6060.94
51_P56_K0.6050.94
49_G89_S0.6010.94
132_L136_A0.5960.94
94_E135_N0.5930.94
45_D62_I0.5910.93
69_A73_T0.5890.93
115_P126_G0.5890.93
94_E131_K0.5800.93
84_L103_F0.5790.93
18_D122_H0.5790.93
14_A24_C0.5790.93
112_S130_E0.5760.93
95_D98_N0.5750.92
93_E131_K0.5740.92
161_E164_L0.5720.92
94_E97_E0.5690.92
19_D122_H0.5630.92
22_L147_V0.5620.92
143_G147_V0.5600.92
120_P124_N0.5600.92
52_D56_K0.5600.92
51_P57_G0.5570.91
65_R88_D0.5560.91
65_R173_Q0.5540.91
115_P138_F0.5530.91
61_L173_Q0.5510.91
45_D87_E0.5430.90
28_I78_I0.5420.90
21_T25_G0.5420.90
52_D57_G0.5400.90
127_K131_K0.5360.90
24_C27_T0.5330.89
91_V125_I0.5320.89
115_P127_K0.5320.89
113_P123_A0.5300.89
28_I73_T0.5280.89
155_D158_K0.5270.89
104_L132_L0.5260.89
14_A112_S0.5250.89
75_I166_A0.5250.89
17_P170_Y0.5240.89
137_Y141_I0.5230.89
46_G89_S0.5230.89
15_P43_V0.5210.88
35_G38_I0.5200.88
142_W147_V0.5200.88
156_I163_K0.5170.88
104_L133_Y0.5150.88
43_V129_V0.5150.88
168_N171_I0.5120.87
20_E69_A0.5090.87
12_I24_C0.5080.87
87_E94_E0.5040.87
11_L39_S0.5030.87
90_K94_E0.5020.86
25_G32_K0.5010.86
137_Y140_L0.5010.86
60_E64_I0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixdA 5 0.9171 100 0.278 Contact Map
4xlzA 5 0.9948 100 0.281 Contact Map
1uanA 5 0.8964 100 0.288 Contact Map
5bmoA 3 0.9845 100 0.29 Contact Map
3dffA 1 0.9585 100 0.296 Contact Map
3dfiA 1 0.9326 100 0.301 Contact Map
1q74A 1 0.9741 100 0.315 Contact Map
2r60A 1 0.8756 86.3 0.91 Contact Map
2x0dA 2 0.8394 79.4 0.917 Contact Map
3s28A 4 0.9482 76.2 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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