GREMLIN Database
Q97UT9 - Uncharacterized protein
UniProt: Q97UT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (216)
Sequences: 123 (109)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_T182_I4.5110.98
214_F218_G4.4230.98
9_L12_D3.7250.95
185_S188_I3.2780.90
133_D204_S3.1290.88
28_R97_K2.9070.83
12_D82_V2.6790.78
42_P77_V2.6100.76
137_L205_F2.5470.74
91_F205_F2.5420.74
121_L169_L2.3650.68
82_V90_I2.3600.68
25_L28_R2.2970.65
193_F201_F2.2940.65
22_L25_L2.2310.63
18_P83_T2.2180.63
157_F216_I2.1970.62
70_I118_L2.1790.61
77_V137_L2.1580.60
90_I204_S2.1310.59
143_V198_I2.0680.57
157_F167_P1.9960.54
137_L202_I1.9290.52
41_S46_F1.9050.51
138_I198_I1.8440.48
25_L97_K1.7920.46
130_T189_V1.7330.44
15_I171_F1.7220.43
40_V210_F1.6960.42
94_V163_L1.6300.40
15_I83_T1.6230.40
22_L97_K1.6170.39
153_A205_F1.5850.38
89_L172_D1.5600.37
18_P90_I1.5420.37
78_M121_L1.5250.36
178_D194_I1.5200.36
117_L137_L1.5010.35
61_P68_Y1.4990.35
86_A163_L1.4880.35
123_F191_I1.4770.34
86_A109_V1.4510.33
212_T216_I1.4460.33
122_P214_F1.4420.33
36_S64_V1.4400.33
28_R31_V1.4390.33
37_I167_P1.4380.33
25_L93_F1.4370.33
30_Y78_M1.4070.32
166_I207_M1.3920.31
70_I74_I1.3870.31
33_L37_I1.3860.31
85_F112_V1.3780.31
25_L96_G1.3710.31
175_L181_V1.3630.30
45_L49_F1.3560.30
18_P30_Y1.3400.30
104_K146_L1.3210.29
176_T200_D1.3180.29
70_I198_I1.3050.28
9_L64_V1.2930.28
159_I215_Y1.2900.28
70_I208_I1.2880.28
18_P22_L1.2810.28
9_L27_K1.2620.27
83_T92_D1.2600.27
70_I86_A1.2520.27
124_V189_V1.2390.26
169_L220_S1.2290.26
144_S213_V1.2080.25
48_D57_W1.2030.25
104_K108_K1.2020.25
7_D11_I1.1890.25
22_L28_R1.1890.25
121_L138_I1.1830.25
30_Y33_L1.1750.24
51_A184_G1.1710.24
112_V115_P1.1700.24
36_S45_L1.1640.24
191_I198_I1.1380.23
11_I37_I1.1360.23
16_F211_Y1.1360.23
57_W80_F1.1320.23
53_W71_D1.1320.23
48_D80_F1.1300.23
25_L29_N1.1220.23
17_F127_Y1.1210.23
133_D206_S1.1190.23
74_I78_M1.1170.23
79_F176_T1.1060.22
124_V127_Y1.0980.22
176_T192_R1.0960.22
115_P119_L1.0850.22
46_F128_S1.0810.22
65_A206_S1.0690.21
165_Y170_V1.0640.21
30_Y90_I1.0600.21
117_L121_L1.0590.21
13_S17_F1.0580.21
119_L145_L1.0580.21
87_T172_D1.0560.21
91_F145_L1.0560.21
154_S209_T1.0530.21
181_V200_D1.0520.21
86_A123_F1.0510.21
99_R180_V1.0490.21
38_G67_I1.0470.21
94_V134_L1.0440.21
7_D13_S1.0390.21
90_I164_S1.0390.21
20_L41_S1.0380.21
128_S180_V1.0370.21
112_V202_I1.0300.20
152_L204_S1.0180.20
174_F193_F1.0000.20
21_I150_N0.9820.19
39_I180_V0.9810.19
81_L106_V0.9780.19
7_D33_L0.9760.19
57_W176_T0.9730.19
116_L180_V0.9640.19
48_D183_Y0.9600.19
166_I170_V0.9570.19
90_I182_I0.9540.19
103_V159_I0.9450.18
88_L104_K0.9440.18
130_T180_V0.9430.18
34_L112_V0.9380.18
125_Y131_F0.9340.18
48_D176_T0.9310.18
34_L126_N0.9270.18
7_D17_F0.9270.18
90_I160_F0.9260.18
66_G75_E0.9230.18
83_T90_I0.9150.18
35_K157_F0.9120.18
39_I191_I0.9070.17
28_R75_E0.9050.17
20_L50_L0.8940.17
42_P69_V0.8870.17
164_S204_S0.8850.17
107_P110_V0.8850.17
141_L185_S0.8830.17
79_F200_D0.8760.17
74_I194_I0.8760.17
67_I118_L0.8750.17
114_I142_I0.8750.17
47_W57_W0.8660.17
80_F176_T0.8640.17
22_L157_F0.8620.16
172_D200_D0.8610.16
64_V207_M0.8590.16
59_F197_P0.8540.16
192_R200_D0.8490.16
45_L133_D0.8490.16
67_I146_L0.8490.16
81_L139_M0.8430.16
78_M169_L0.8370.16
22_L160_F0.8260.16
182_I196_I0.8230.16
57_W175_L0.8220.16
22_L90_I0.8200.16
26_I38_G0.8150.15
12_D94_V0.8120.15
15_I87_T0.8120.15
18_P82_V0.8090.15
87_T184_G0.8020.15
89_L184_G0.7990.15
75_E201_F0.7960.15
19_T113_A0.7930.15
89_L173_Y0.7910.15
79_F195_T0.7900.15
43_I128_S0.7870.15
23_S176_T0.7850.15
48_D175_L0.7840.15
79_F192_R0.7840.15
123_F210_F0.7820.15
47_W80_F0.7800.15
167_P180_V0.7740.15
169_L193_F0.7720.15
120_T180_V0.7700.15
57_W183_Y0.7650.14
57_W200_D0.7640.14
35_K40_V0.7610.14
84_P203_Y0.7570.14
175_L192_R0.7550.14
23_S192_R0.7500.14
116_L121_L0.7430.14
143_V201_F0.7430.14
172_D176_T0.7420.14
22_L26_I0.7410.14
49_F69_V0.7350.14
210_F215_Y0.7250.14
65_A75_E0.7240.14
43_I215_Y0.7230.14
16_F158_W0.7230.14
48_D200_D0.7220.14
90_I179_P0.7200.14
160_F164_S0.7190.14
80_F175_L0.7190.14
71_D113_A0.7140.14
137_L178_D0.7060.13
36_S138_I0.7050.13
93_F194_I0.7050.13
36_S46_F0.7020.13
178_D182_I0.7000.13
103_V220_S0.6950.13
54_R121_L0.6940.13
69_V120_T0.6930.13
17_F61_P0.6860.13
41_S81_L0.6840.13
110_V158_W0.6810.13
19_T172_D0.6790.13
40_V153_A0.6780.13
14_M36_S0.6780.13
69_V221_L0.6720.13
19_T182_I0.6710.13
50_L54_R0.6690.13
94_V154_S0.6680.13
8_Y11_I0.6670.13
15_I18_P0.6640.13
94_V133_D0.6620.13
185_S205_F0.6610.13
181_V192_R0.6610.13
8_Y24_F0.6590.13
149_R164_S0.6590.13
109_V219_N0.6570.12
56_S128_S0.6560.12
82_V204_S0.6550.12
124_V146_L0.6530.12
132_I136_Y0.6530.12
98_V159_I0.6530.12
80_F200_D0.6530.12
27_K138_I0.6520.12
56_S136_Y0.6520.12
36_S65_A0.6520.12
43_I71_D0.6520.12
59_F76_E0.6510.12
76_E197_P0.6510.12
28_R93_F0.6510.12
22_L83_T0.6470.12
80_F183_Y0.6460.12
71_D118_L0.6440.12
24_F30_Y0.6440.12
79_F183_Y0.6430.12
85_F215_Y0.6430.12
42_P136_Y0.6400.12
29_N32_K0.6400.12
105_W110_V0.6330.12
157_F212_T0.6220.12
44_Y103_V0.6190.12
144_S155_R0.6190.12
46_F68_Y0.6180.12
78_M163_L0.6170.12
11_I77_V0.6120.12
5_K170_V0.6110.12
21_I38_G0.6080.12
21_I34_L0.6060.12
98_V218_G0.6010.12
28_R83_T0.5980.12
112_V138_I0.5960.11
89_L200_D0.5940.11
43_I143_V0.5920.11
102_E154_S0.5920.11
189_V219_N0.5850.11
170_V218_G0.5840.11
47_W176_T0.5840.11
136_Y210_F0.5830.11
101_K155_R0.5820.11
127_Y193_F0.5790.11
11_I178_D0.5790.11
41_S117_L0.5740.11
45_L121_L0.5720.11
109_V123_F0.5700.11
121_L131_F0.5690.11
14_M115_P0.5690.11
119_L122_P0.5660.11
49_F186_H0.5660.11
34_L53_W0.5640.11
41_S217_R0.5620.11
112_V219_N0.5610.11
62_K121_L0.5610.11
33_L131_F0.5590.11
10_M38_G0.5590.11
16_F82_V0.5580.11
88_L211_Y0.5510.11
19_T188_I0.5470.11
40_V67_I0.5460.11
57_W192_R0.5450.11
114_I143_V0.5430.11
85_F214_F0.5420.11
143_V220_S0.5400.11
142_I214_F0.5380.11
65_A180_V0.5370.11
23_S200_D0.5370.11
36_S214_F0.5360.11
104_K109_V0.5350.11
198_I202_I0.5340.11
15_I19_T0.5330.11
77_V189_V0.5290.10
100_D155_R0.5280.10
176_T183_Y0.5270.10
187_S207_M0.5250.10
22_L92_D0.5250.10
12_D26_I0.5230.10
18_P204_S0.5230.10
179_P209_T0.5230.10
85_F202_I0.5210.10
125_Y135_V0.5210.10
87_T154_S0.5200.10
44_Y158_W0.5170.10
158_W206_S0.5160.10
169_L201_F0.5150.10
79_F85_F0.5150.10
51_A175_L0.5130.10
133_D152_L0.5110.10
64_V85_F0.5110.10
87_T173_Y0.5080.10
140_S206_S0.5080.10
97_K141_L0.5040.10
77_V151_L0.5030.10
68_Y217_R0.5020.10
67_I74_I0.5000.10
51_A172_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dveB 1 0.1018 3.5 0.977 Contact Map
3bxlB 1 0.0752 3.4 0.977 Contact Map
2m20A 2 0.146 2.7 0.978 Contact Map
2f3yB 1 0.0796 2.6 0.978 Contact Map
3dvkB 1 0.1018 2.3 0.979 Contact Map
3v4yB 1 0.1018 2.3 0.979 Contact Map
3rceA 1 0.8053 2.2 0.979 Contact Map
2l2tA 2 0.1814 1.9 0.98 Contact Map
2w39A 1 0.2478 1.3 0.982 Contact Map
2jf1T 1 0 1.2 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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