GREMLIN Database
Q97UT8 - Phytoene synthetase (CrtB)
UniProt: Q97UT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (260)
Sequences: 3885 (2676)
Seq/√Len: 165.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_F238_K4.7921.00
111_S114_E4.7731.00
179_F196_Y4.3691.00
59_R101_E4.3161.00
146_M207_E3.8551.00
178_K196_Y3.4911.00
175_D197_E2.7231.00
202_F235_L2.5751.00
91_S95_A2.5051.00
63_Q94_D2.4831.00
55_Y59_R2.4741.00
81_E85_R2.4401.00
30_D86_K2.3871.00
106_K114_E2.3521.00
110_Y114_E2.3141.00
154_L205_E2.2841.00
236_R255_K2.2421.00
56_Y101_E2.2371.00
182_D185_E2.1611.00
243_I246_S2.1351.00
111_S174_E2.0761.00
63_Q90_D2.0621.00
232_W255_K2.0081.00
59_R98_D1.9491.00
33_K82_L1.9251.00
191_I241_P1.9241.00
89_E132_K1.9101.00
99_A122_S1.8921.00
146_M204_F1.8911.00
30_D85_R1.8901.00
31_V130_M1.8851.00
179_F192_E1.8851.00
110_Y173_V1.8841.00
52_I105_Y1.8811.00
117_K121_G1.8651.00
110_Y177_E1.8341.00
56_Y60_K1.8051.00
120_Y145_R1.7801.00
161_Q165_Y1.6831.00
99_A121_G1.6491.00
112_I200_R1.6471.00
261_I265_A1.6131.00
175_D179_F1.6041.00
209_E231_K1.6001.00
57_N61_L1.5931.00
27_I133_I1.5881.00
90_D94_D1.5711.00
102_S117_K1.5701.00
198_I234_A1.5331.00
34_L133_I1.5261.00
113_E116_L1.5231.00
88_F129_F1.5121.00
122_S156_F1.5071.00
173_V177_E1.5021.00
61_L64_L1.4881.00
128_L145_R1.4831.00
116_L149_R1.4821.00
175_D196_Y1.4551.00
35_Y39_R1.4501.00
198_I238_K1.4401.00
149_R204_F1.4251.00
34_L129_F1.4221.00
64_L69_Y1.4071.00
258_I262_K1.3791.00
190_F194_I1.3671.00
123_A127_G1.3591.00
108_V183_K1.3581.00
10_K17_Y1.3411.00
152_Q155_N1.3151.00
54_E57_N1.3061.00
9_F32_T1.2961.00
37_F41_F1.2951.00
204_F207_E1.2951.00
74_I78_N1.2891.00
42_D46_D1.2851.00
236_R239_K1.2811.00
79_F93_I1.2801.00
59_R94_D1.2761.00
66_K90_D1.2691.00
195_R238_K1.2641.00
181_I193_F1.2551.00
60_K64_L1.2471.00
103_D170_Y1.2291.00
42_D159_D1.2211.00
140_S214_F1.2151.00
193_F197_E1.2141.00
197_E200_R1.2021.00
198_I242_C1.1991.00
185_E189_G1.1691.00
202_F231_K1.1641.00
46_D159_D1.1611.00
179_F193_F1.1601.00
120_Y128_L1.1591.00
37_F97_L1.1571.00
173_V183_K1.1481.00
175_D200_R1.1461.00
30_D82_L1.1421.00
195_R242_C1.1401.00
110_Y174_E1.1351.00
191_I243_I1.1331.00
188_E192_E1.1251.00
15_T229_M1.1221.00
120_Y125_V1.1181.00
42_D163_D1.1151.00
102_S121_G1.1041.00
126_V155_N1.1021.00
175_D193_F1.0951.00
59_R62_Y1.0901.00
232_W235_L1.0841.00
175_D178_K1.0831.00
41_F97_L1.0801.00
57_N60_K1.0791.00
63_Q67_S1.0771.00
215_I223_I1.0731.00
52_I56_Y1.0700.99
98_D117_K1.0660.99
150_A154_L1.0580.99
181_I189_G1.0440.99
155_N158_R1.0420.99
92_W132_K1.0400.99
55_Y62_Y1.0360.99
27_I218_R1.0220.99
174_E178_K1.0170.99
124_E148_G1.0140.99
88_F93_I1.0070.99
34_L93_I1.0060.99
80_V84_R1.0040.99
61_L73_N0.9900.99
209_E227_S0.9880.99
7_E11_K0.9810.99
255_K258_I0.9800.99
143_Y211_G0.9800.99
206_R231_K0.9790.99
92_W128_L0.9780.99
6_E32_T0.9780.99
48_V51_K0.9770.99
203_E207_E0.9770.99
205_E230_Y0.9750.99
162_E166_L0.9740.99
89_E92_W0.9700.99
240_S247_K0.9700.99
112_I197_E0.9700.99
24_P27_I0.9640.99
164_L186_C0.9580.99
112_I175_D0.9540.99
59_R63_Q0.9520.99
196_Y200_R0.9470.99
158_R230_Y0.9440.99
195_R199_S0.9370.99
39_R43_D0.9360.99
83_A93_I0.9360.99
23_F31_V0.9350.99
56_Y59_R0.9230.98
39_R127_G0.9210.98
12_G43_D0.9150.98
86_K133_I0.8990.98
53_E56_Y0.8970.98
27_I30_D0.8960.98
143_Y214_F0.8940.98
123_A152_Q0.8930.98
199_S203_E0.8930.98
58_L62_Y0.8910.98
62_Y66_K0.8900.98
202_F234_A0.8760.98
29_E78_N0.8680.98
132_K141_M0.8670.98
39_R159_D0.8580.98
106_K109_Y0.8560.98
73_N82_L0.8550.98
112_I196_Y0.8550.98
199_S238_K0.8530.97
238_K242_C0.8510.97
41_F100_M0.8450.97
42_D152_Q0.8440.97
103_D168_R0.8430.97
16_Y35_Y0.8390.97
39_R46_D0.8370.97
181_I187_N0.8360.97
157_I234_A0.8340.97
42_D155_N0.8280.97
77_Q81_E0.8240.97
96_F100_M0.8240.97
35_Y123_A0.8210.97
68_G71_T0.8190.97
78_N81_E0.8170.97
46_D155_N0.8170.97
115_L153_F0.8150.97
254_T258_I0.8080.97
53_E57_N0.8070.96
190_F244_V0.8060.96
39_R42_D0.8060.96
169_Q176_M0.8050.96
16_Y39_R0.8030.96
144_A148_G0.8010.96
232_W259_T0.8000.96
251_P256_I0.7990.96
95_A98_D0.7970.96
73_N77_Q0.7950.96
102_S109_Y0.7950.96
208_A227_S0.7940.96
123_A155_N0.7920.96
157_I237_I0.7910.96
169_Q183_K0.7910.96
62_Y93_I0.7890.96
35_Y127_G0.7890.96
75_V82_L0.7880.96
236_R240_S0.7860.96
130_M134_L0.7860.96
30_D33_K0.7840.96
253_R256_I0.7830.96
96_F125_V0.7800.96
40_V73_N0.7790.96
52_I101_E0.7770.96
65_E68_G0.7730.96
233_S248_K0.7720.95
35_Y155_N0.7670.95
78_N82_L0.7640.95
161_Q245_L0.7610.95
39_R155_N0.7610.95
163_D170_Y0.7580.95
212_F227_S0.7550.95
14_V18_N0.7530.95
82_L86_K0.7500.95
29_E33_K0.7460.95
108_V167_G0.7420.94
16_Y155_N0.7420.94
123_A126_V0.7410.94
16_Y126_V0.7390.94
235_L238_K0.7330.94
210_K213_K0.7310.94
25_K29_E0.7300.94
159_D163_D0.7280.94
16_Y123_A0.7260.94
57_N73_N0.7230.94
150_A205_E0.7200.93
212_F224_K0.7180.93
61_L76_L0.7170.93
124_E149_R0.7170.93
26_K85_R0.7160.93
41_F58_L0.7140.93
16_Y127_G0.7110.93
207_E210_K0.7090.93
142_Y207_E0.7080.93
181_I190_F0.7060.93
112_I116_L0.7060.93
152_Q159_D0.7040.93
112_I204_F0.7030.93
215_I220_L0.7010.93
54_E61_L0.7000.93
98_D101_E0.6990.92
192_E195_R0.6960.92
38_V126_V0.6900.92
124_E131_M0.6840.92
7_E10_K0.6830.92
254_T261_I0.6830.92
142_Y146_M0.6830.92
153_F200_R0.6820.92
219_Y222_P0.6800.91
76_L80_V0.6800.91
9_F19_S0.6800.91
98_D121_G0.6710.91
152_Q163_D0.6700.91
187_N246_S0.6700.91
44_L54_E0.6690.91
92_W120_Y0.6680.91
176_M193_F0.6660.91
146_M149_R0.6620.90
237_I244_V0.6590.90
127_G152_Q0.6560.90
96_F151_M0.6540.90
99_A156_F0.6540.90
103_D118_Y0.6500.89
27_I216_P0.6480.89
148_G158_R0.6460.89
42_D123_A0.6460.89
161_Q240_S0.6460.89
154_L201_Y0.6450.89
95_A121_G0.6450.89
79_F83_A0.6440.89
9_F13_S0.6420.89
39_R123_A0.6410.89
240_S243_I0.6400.89
130_M223_I0.6380.89
223_I226_A0.6370.89
127_G155_N0.6350.88
62_Y90_D0.6350.88
73_N80_V0.6350.88
38_V122_S0.6340.88
67_S90_D0.6320.88
101_E104_I0.6310.88
154_L233_S0.6310.88
198_I202_F0.6300.88
35_Y42_D0.6260.88
141_M145_R0.6250.88
181_I185_E0.6220.87
196_Y199_S0.6220.87
38_V129_F0.6200.87
232_W236_R0.6190.87
172_P197_E0.6190.87
245_L249_V0.6160.87
231_K235_L0.6050.86
123_A159_D0.6040.86
68_G72_G0.6020.86
39_R163_D0.6010.85
52_I104_I0.5990.85
43_D47_S0.5950.85
147_L227_S0.5940.85
125_V148_G0.5940.85
131_M211_G0.5940.85
108_V173_V0.5930.85
195_R198_I0.5930.85
211_G215_I0.5890.84
213_K224_K0.5860.84
56_Y62_Y0.5860.84
101_E105_Y0.5850.84
35_Y118_Y0.5800.83
39_R126_V0.5790.83
41_F130_M0.5780.83
56_Y105_Y0.5750.83
155_N159_D0.5740.83
15_T45_V0.5730.83
22_F225_T0.5730.83
157_I198_I0.5730.83
128_L132_K0.5720.83
39_R152_Q0.5720.83
155_N163_D0.5710.82
46_D152_Q0.5710.82
127_G151_M0.5700.82
251_P259_T0.5680.82
200_R203_E0.5660.82
234_A238_K0.5630.82
38_V43_D0.5600.81
233_S251_P0.5600.81
222_P226_A0.5590.81
200_R204_F0.5570.81
96_F129_F0.5560.81
123_A170_Y0.5560.81
216_P220_L0.5550.81
142_Y247_K0.5530.80
202_F206_R0.5520.80
205_E234_A0.5510.80
154_L234_A0.5500.80
252_R258_I0.5500.80
82_L85_R0.5500.80
153_F197_E0.5490.80
15_T158_R0.5480.80
248_K251_P0.5470.80
54_E58_L0.5470.80
203_E206_R0.5460.80
180_G183_K0.5460.80
35_Y46_D0.5440.79
124_E156_F0.5420.79
16_Y46_D0.5370.79
201_Y234_A0.5360.78
159_D168_R0.5360.78
95_A128_L0.5350.78
171_L197_E0.5340.78
46_D118_Y0.5340.78
131_M141_M0.5320.78
156_F163_D0.5320.78
38_V226_A0.5310.78
39_R151_M0.5300.78
193_F196_Y0.5290.77
6_E10_K0.5260.77
251_P255_K0.5240.77
134_L219_Y0.5240.77
153_F204_F0.5240.77
212_F215_I0.5240.77
41_F134_L0.5230.77
100_M122_S0.5210.76
75_V83_A0.5200.76
122_S126_V0.5180.76
66_K93_I0.5170.76
22_F28_R0.5160.76
224_K263_N0.5160.76
124_E128_L0.5150.76
192_E199_S0.5140.75
14_V20_S0.5130.75
181_I186_C0.5120.75
91_S132_K0.5120.75
127_G163_D0.5110.75
83_A86_K0.5100.75
151_M155_N0.5100.75
124_E146_M0.5080.75
122_S155_N0.5070.74
206_R209_E0.5060.74
226_A230_Y0.5050.74
145_R149_R0.5040.74
26_K29_E0.5030.74
123_A163_D0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hd1A 1 0.8809 100 0.118 Contact Map
3acxA 1 0.9567 100 0.121 Contact Map
3we9A 1 0.8231 100 0.15 Contact Map
3wcaA 1 0.9964 100 0.196 Contact Map
3vj8A 1 0.9928 100 0.22 Contact Map
1wy0A 2 0.8339 95.9 0.901 Contact Map
4dhdA 2 0.8267 95.5 0.904 Contact Map
3oyrA 2 0.8375 95.4 0.904 Contact Map
3ts7A 2 0.7726 95.4 0.904 Contact Map
4lfgA 2 0.769 95.4 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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