GREMLIN Database
Q97UT7 - Beta carotene hydroxylase (CrtZ)
UniProt: Q97UT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (137)
Sequences: 363 (187)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_S84_S4.5811.00
66_F80_A3.7591.00
33_L54_F3.6591.00
24_M28_V3.6521.00
84_S88_I3.2210.99
57_V61_V2.7050.97
36_I57_V2.6200.96
22_R27_Y2.6110.96
14_F89_A2.4710.94
38_E42_K2.2370.91
13_T79_I2.2250.90
10_A85_S2.1790.89
6_Y10_A2.1130.88
6_Y78_S2.0280.86
96_M104_H1.9840.84
63_V67_F1.9660.84
22_R26_K1.9010.82
79_I91_F1.8080.78
38_E50_K1.7730.77
77_L81_I1.7300.75
12_L16_G1.6580.72
8_G16_G1.5860.68
59_A63_V1.5660.67
19_F23_L1.5610.67
63_V81_I1.5320.65
80_A105_L1.5290.65
10_A78_S1.5150.64
8_G12_L1.5010.64
132_N139_I1.4960.63
64_Y68_L1.4920.63
36_I53_L1.4780.62
93_I118_L1.4590.61
20_V24_M1.4230.59
112_H115_F1.4200.59
55_G98_I1.3520.55
42_K120_L1.2860.52
97_V115_F1.2650.50
74_Y78_S1.2650.50
97_V120_L1.2420.49
39_D105_L1.2400.49
75_V79_I1.2390.49
13_T26_K1.2370.49
39_D50_K1.2300.48
18_E25_H1.2270.48
35_F54_F1.2150.48
38_E48_L1.2020.47
16_G19_F1.1920.46
96_M103_L1.1850.46
117_D143_D1.1730.45
117_D138_V1.1730.45
13_T62_S1.1250.42
119_I132_N1.1230.42
53_L135_F1.1200.42
103_L141_G1.0970.41
98_I117_D1.0920.40
96_M118_L1.0920.40
33_L110_L1.0880.40
48_L135_F1.0690.39
58_F86_Y1.0680.39
58_F76_A1.0650.39
77_L80_A1.0630.39
67_F71_Q1.0330.37
131_G141_G1.0320.37
23_L28_V1.0250.37
39_D123_D1.0150.36
88_I92_F1.0110.36
39_D84_S1.0020.36
138_V143_D0.9810.34
19_F28_V0.9620.33
55_G135_F0.9600.33
39_D115_F0.9520.33
20_V23_L0.9270.32
28_V32_L0.9270.32
98_I143_D0.9250.32
76_A137_F0.9250.32
33_L36_I0.9240.32
97_V119_I0.9150.31
17_M25_H0.9130.31
74_Y80_A0.9080.31
21_A106_R0.9080.31
5_Y64_Y0.9020.30
119_I123_D0.9000.30
36_I135_F0.8860.30
36_I55_G0.8820.30
23_L27_Y0.8810.29
10_A81_I0.8660.29
46_A97_V0.8660.29
61_V83_M0.8600.28
98_I142_L0.8560.28
15_V23_L0.8540.28
43_E104_H0.8530.28
42_K140_K0.8490.28
24_M79_I0.8440.28
22_R83_M0.8320.27
81_I84_S0.8250.27
105_L123_D0.8210.27
58_F91_F0.8190.27
55_G117_D0.8080.26
5_Y11_V0.7990.26
14_F85_S0.7950.25
63_V66_F0.7910.25
120_L131_G0.7870.25
93_I100_D0.7770.25
55_G143_D0.7730.25
77_L136_L0.7710.24
111_K135_F0.7630.24
117_D124_I0.7600.24
86_Y91_F0.7550.24
50_K80_A0.7540.24
48_L102_H0.7490.24
89_A93_I0.7450.23
6_Y74_Y0.7410.23
118_L137_F0.7380.23
97_V117_D0.7370.23
57_V76_A0.7330.23
28_V48_L0.7320.23
97_V132_N0.7310.23
31_G86_Y0.7260.23
10_A14_F0.7250.23
5_Y88_I0.7200.22
119_I140_K0.7180.22
110_L131_G0.7170.22
35_F61_V0.7150.22
9_M124_I0.7130.22
20_V58_F0.7010.22
56_L110_L0.7010.22
24_M81_I0.6980.21
6_Y9_M0.6910.21
12_L15_V0.6890.21
139_I143_D0.6840.21
56_L76_A0.6830.21
11_V15_V0.6820.21
91_F101_R0.6760.21
47_E118_L0.6760.21
16_G20_V0.6760.21
96_M102_H0.6750.21
110_L124_I0.6730.20
47_E56_L0.6730.20
66_F70_I0.6710.20
58_F101_R0.6650.20
96_M131_G0.6650.20
22_R133_W0.6600.20
111_K116_K0.6560.20
8_G88_I0.6550.20
110_L132_N0.6540.20
28_V128_E0.6510.20
13_T65_L0.6470.20
103_L117_D0.6460.19
7_V62_S0.6400.19
127_K133_W0.6370.19
13_T137_F0.6330.19
23_L68_L0.6330.19
105_L135_F0.6320.19
103_L127_K0.6300.19
93_I130_K0.6300.19
66_F93_I0.6300.19
6_Y75_V0.6240.19
11_V38_E0.6170.18
9_M75_V0.6150.18
123_D136_L0.6070.18
29_M58_F0.6030.18
124_I131_G0.6000.18
60_S89_A0.5920.18
29_M132_N0.5890.18
69_G78_S0.5860.17
28_V44_K0.5810.17
92_F105_L0.5810.17
21_A55_G0.5800.17
26_K133_W0.5790.17
13_T123_D0.5770.17
7_V48_L0.5740.17
14_F138_V0.5680.17
92_F141_G0.5670.17
36_I130_K0.5670.17
15_V112_H0.5650.17
123_D135_F0.5610.17
56_L81_I0.5600.17
39_D127_K0.5560.16
60_S63_V0.5540.16
89_A98_I0.5520.16
50_K70_I0.5520.16
8_G11_V0.5500.16
68_L83_M0.5480.16
93_I112_H0.5460.16
33_L116_K0.5430.16
12_L59_A0.5370.16
110_L113_R0.5290.16
124_I141_G0.5290.16
102_H130_K0.5260.16
100_D123_D0.5240.15
123_D130_K0.5220.15
100_D132_N0.5220.15
16_G73_S0.5220.15
13_T81_I0.5210.15
8_G48_L0.5180.15
11_V88_I0.5150.15
8_G128_E0.5150.15
16_G85_S0.5110.15
97_V111_K0.5100.15
140_K143_D0.5050.15
92_F96_M0.5040.15
21_A24_M0.5030.15
7_V83_M0.5020.15
31_G118_L0.5010.15
120_L132_N0.5000.15
26_K93_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zr0A 1 0.8808 99.1 0.808 Contact Map
4zr1A 1 0.8808 98.8 0.831 Contact Map
4ymkA 1 0.6623 7.1 0.963 Contact Map
1mhsA 2 0.4172 5.8 0.965 Contact Map
4qtnA 3 0.6159 4.6 0.967 Contact Map
3j1zP 8 0.9205 4.1 0.967 Contact Map
3h90A 3 0.9205 3.9 0.968 Contact Map
4mf5A 2 0.4702 2.7 0.97 Contact Map
2ls2A 1 0.1656 2.4 0.971 Contact Map
4krwA 2 0.1325 1.9 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.