GREMLIN Database
Q97UT6 - Phytoene dehydrogenase (Desaturase) (CrtI)
UniProt: Q97UT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (418)
Sequences: 15309 (12414)
Seq/√Len: 607.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K26_E4.3681.00
5_V248_G4.1131.00
28_V221_K3.8251.00
213_A218_V3.7941.00
3_K249_D3.6081.00
32_K225_P3.6031.00
36_P222_F3.5311.00
228_K240_S3.3941.00
16_T252_V3.2721.00
30_L246_E3.2311.00
253_F260_A3.0701.00
5_V30_L3.0031.00
36_P210_Y2.9771.00
442_S446_S2.7531.00
5_V246_E2.7311.00
230_K240_S2.7191.00
34_T223_D2.6991.00
203_E207_K2.6221.00
9_A36_P2.6051.00
26_E219_E2.6041.00
240_S245_R2.5561.00
5_V239_V2.4641.00
7_V253_F2.4511.00
204_G207_K2.4371.00
146_D154_R2.3901.00
210_Y214_R2.3101.00
4_A25_D2.2201.00
30_L221_K2.2151.00
254_N425_V2.1931.00
19_L443_M2.1931.00
221_K224_F2.1741.00
210_Y220_F2.1131.00
3_K28_V2.1021.00
250_V423_Y2.0911.00
44_S49_R2.0751.00
366_E372_K2.0631.00
7_V255_M2.0441.00
11_L435_V2.0191.00
12_G254_N1.9861.00
35_T41_R1.9661.00
149_D153_A1.9571.00
221_K244_K1.9541.00
237_V247_M1.9041.00
359_D363_R1.8861.00
23_F450_S1.8841.00
42_Y49_R1.8781.00
30_L248_G1.8761.00
19_L22_K1.8701.00
252_V449_I1.8691.00
208_R211_E1.8391.00
221_K246_E1.8371.00
15_S439_T1.8151.00
18_I212_I1.8041.00
147_T150_N1.8041.00
232_D237_V1.7781.00
227_N240_S1.7431.00
241_S244_K1.7271.00
149_D177_F1.7031.00
19_L447_K1.6981.00
224_F242_N1.6941.00
225_P241_S1.6771.00
290_E374_K1.6761.00
227_N241_S1.6631.00
153_A162_R1.6321.00
25_D450_S1.6281.00
4_A250_V1.6281.00
236_V251_F1.6221.00
255_M260_A1.6171.00
100_T103_N1.6121.00
17_A29_V1.6061.00
229_V236_V1.5811.00
230_K237_V1.5781.00
358_I378_I1.5701.00
28_V219_E1.5581.00
214_R219_E1.5551.00
236_V421_N1.5521.00
425_V445_V1.5501.00
224_F244_K1.5441.00
230_K245_R1.5431.00
48_F288_G1.5431.00
291_D374_K1.5411.00
355_K359_D1.5381.00
237_V245_R1.5371.00
22_K69_E1.5321.00
68_S73_N1.5181.00
366_E370_G1.5051.00
28_V248_G1.4891.00
36_P206_V1.4851.00
30_L226_V1.4851.00
290_E376_S1.4741.00
4_A20_L1.4621.00
3_K25_D1.4501.00
335_N338_T1.4411.00
226_V239_V1.4301.00
392_A395_G1.4251.00
73_N199_Y1.4211.00
385_D388_R1.4111.00
5_V28_V1.4001.00
75_H199_Y1.3991.00
250_V449_I1.3991.00
350_G354_S1.3921.00
39_R427_Q1.3861.00
65_E69_E1.3821.00
207_K211_E1.3821.00
214_R218_V1.3811.00
289_L362_I1.3811.00
6_V17_A1.3791.00
423_Y445_V1.3751.00
18_I22_K1.3721.00
344_L347_V1.3621.00
40_A206_V1.3581.00
213_A220_F1.3541.00
21_K218_V1.3521.00
62_I443_M1.3481.00
211_E214_R1.3441.00
28_V246_E1.3371.00
29_V220_F1.3301.00
326_Y329_S1.3261.00
45_V379_R1.3171.00
65_E443_M1.3151.00
44_S47_E1.2881.00
36_P220_F1.2861.00
231_I236_V1.2801.00
202_F435_V1.2761.00
400_L403_T1.2731.00
358_I380_I1.2731.00
255_M263_L1.2691.00
13_G254_N1.2641.00
146_D150_N1.2621.00
64_E68_S1.2571.00
299_T302_I1.2571.00
330_Y333_A1.2561.00
300_V303_N1.2401.00
395_G398_F1.2311.00
140_N143_A1.2211.00
18_I209_L1.2211.00
9_A29_V1.2161.00
444_I448_K1.2141.00
445_V448_K1.2131.00
327_Y331_R1.2101.00
228_K265_P1.2061.00
248_G251_F1.2051.00
353_I356_E1.2031.00
93_K106_D1.1921.00
265_P269_K1.1901.00
30_L224_F1.1891.00
12_G441_S1.1871.00
224_F246_E1.1801.00
95_E98_E1.1751.00
256_D259_Y1.1711.00
84_V87_M1.1651.00
349_T352_E1.1641.00
88_E91_F1.1551.00
111_K114_L1.1521.00
359_D372_K1.1511.00
12_G425_V1.1501.00
257_Y428_Y1.1441.00
21_K213_A1.1431.00
21_K27_V1.1421.00
235_K247_M1.1401.00
340_D344_L1.1401.00
67_F70_A1.1361.00
6_V27_V1.1301.00
259_Y262_S1.1261.00
175_S178_R1.1241.00
19_L442_S1.1171.00
358_I362_I1.1161.00
131_D135_K1.1101.00
95_E100_T1.1091.00
423_Y449_I1.1091.00
121_K125_K1.1061.00
114_L118_F1.0951.00
229_V251_F1.0931.00
158_D162_R1.0891.00
232_D247_M1.0891.00
92_L95_E1.0861.00
94_K97_R1.0801.00
326_Y331_R1.0791.00
44_S203_E1.0761.00
360_G363_R1.0741.00
92_L96_Y1.0721.00
116_Y119_S1.0711.00
419_L422_L1.0671.00
429_T444_I1.0651.00
395_G400_L1.0651.00
79_R82_P1.0591.00
198_P205_Y1.0581.00
364_D367_V1.0571.00
82_P85_K1.0541.00
365_L369_I1.0531.00
227_N242_N1.0511.00
210_Y222_F1.0481.00
232_D235_K1.0451.00
207_K210_Y1.0431.00
204_G208_R1.0411.00
341_L344_L1.0381.00
399_G402_H1.0371.00
108_Y111_K1.0361.00
78_I199_Y1.0351.00
67_F72_E1.0341.00
356_E359_D1.0331.00
385_D389_D1.0291.00
19_L69_E1.0261.00
91_F94_K1.0231.00
429_T441_S1.0221.00
96_Y100_T1.0221.00
273_G276_Y1.0211.00
426_G441_S1.0171.00
349_T354_S1.0161.00
363_R372_K1.0151.00
375_A378_I1.0121.00
43_F52_M1.0101.00
18_I213_A1.0101.00
356_E360_G1.0081.00
130_S134_D1.0081.00
80_V83_P1.0071.00
11_L40_A1.0041.00
327_Y335_N1.0011.00
128_V131_D1.0001.00
374_K377_Y0.9981.00
362_I366_E0.9961.00
370_G373_I0.9931.00
121_K124_K0.9921.00
324_T327_Y0.9891.00
299_T303_N0.9881.00
302_I305_D0.9871.00
250_V421_N0.9871.00
423_Y448_K0.9861.00
20_L446_S0.9841.00
62_I65_E0.9821.00
113_R117_D0.9791.00
287_I362_I0.9761.00
443_M447_K0.9751.00
120_K124_K0.9671.00
151_F155_Y0.9651.00
65_E68_S0.9571.00
324_T329_S0.9531.00
63_F439_T0.9521.00
339_R343_I0.9511.00
363_R367_V0.9511.00
96_Y101_G0.9501.00
19_L23_F0.9491.00
285_A380_I0.9471.00
253_F422_L0.9461.00
28_V249_D0.9451.00
108_Y112_T0.9391.00
230_K266_E0.9381.00
42_Y203_E0.9371.00
128_V134_D0.9321.00
227_N243_I0.9271.00
78_I83_P0.9241.00
25_D28_V0.9211.00
9_A222_F0.9191.00
3_K246_E0.9181.00
200_K204_G0.9171.00
399_G403_T0.9171.00
107_R111_K0.9151.00
231_I421_N0.9121.00
325_S330_Y0.9121.00
68_S71_G0.9111.00
229_V253_F0.9111.00
326_Y330_Y0.9111.00
289_L375_A0.9101.00
3_K247_M0.9081.00
91_F95_E0.9081.00
339_R342_V0.9081.00
228_K266_E0.9021.00
363_R366_E0.9011.00
18_I69_E0.9001.00
130_S135_K0.9001.00
342_V347_V0.8981.00
114_L117_D0.8931.00
66_F70_A0.8921.00
212_I215_K0.8891.00
24_F27_V0.8881.00
341_L346_P0.8861.00
22_K212_I0.8861.00
110_N114_L0.8831.00
96_Y99_F0.8811.00
332_G335_N0.8701.00
206_V210_Y0.8691.00
349_T353_I0.8641.00
128_V132_F0.8631.00
364_D368_K0.8621.00
192_G195_V0.8601.00
33_N388_R0.8581.00
330_Y335_N0.8571.00
16_T442_S0.8561.00
395_G399_G0.8521.00
445_V449_I0.8501.00
33_N41_R0.8501.00
106_D110_N0.8461.00
62_I440_L0.8461.00
146_D151_F0.8451.00
12_G438_V0.8451.00
342_V346_P0.8411.00
166_G176_P0.8401.00
324_T331_R0.8371.00
395_G402_H0.8351.00
352_E356_E0.8341.00
131_D134_D0.8321.00
416_N448_K0.8281.00
339_R344_L0.8281.00
342_V345_I0.8211.00
111_K119_S0.8161.00
95_E103_N0.8151.00
229_V239_V0.8101.00
153_A158_D0.8081.00
265_P268_Y0.8041.00
231_I419_L0.8041.00
358_I361_V0.8041.00
26_E249_D0.8031.00
398_F402_H0.8031.00
340_D343_I0.8021.00
350_G353_I0.7991.00
395_G401_A0.7931.00
17_A213_A0.7911.00
159_S163_K0.7901.00
341_L347_V0.7891.00
139_V143_A0.7861.00
289_L293_L0.7841.00
327_Y330_Y0.7841.00
97_R102_D0.7821.00
324_T335_N0.7781.00
211_E215_K0.7781.00
438_V442_S0.7761.00
339_R346_P0.7761.00
94_K98_E0.7751.00
334_T337_E0.7741.00
446_S449_I0.7721.00
64_E74_P0.7701.00
101_G104_V0.7691.00
330_Y334_T0.7661.00
440_L444_I0.7661.00
48_F376_S0.7651.00
79_R83_P0.7651.00
6_V13_G0.7651.00
109_L112_T0.7631.00
82_P87_M0.7631.00
237_V240_S0.7591.00
108_Y116_Y0.7591.00
382_G385_D0.7591.00
11_L438_V0.7571.00
14_I213_A0.7531.00
198_P204_G0.7531.00
383_P388_R0.7511.00
329_S332_G0.7511.00
17_A218_V0.7471.00
183_Y187_N0.7461.00
70_A74_P0.7431.00
93_K97_R0.7431.00
67_F198_P0.7421.00
139_V142_S0.7401.00
3_K248_G0.7391.00
78_I81_N0.7371.00
409_P412_L0.7371.00
21_K219_E0.7361.00
124_K127_M0.7351.00
80_V84_V0.7341.00
72_E215_K0.7341.00
79_R85_K0.7331.00
83_P86_V0.7321.00
114_L119_S0.7311.00
39_R53_G0.7281.00
15_S19_L0.7271.00
327_Y333_A0.7231.00
121_K126_E0.7201.00
162_R166_G0.7201.00
11_L206_V0.7181.00
227_N230_K0.7181.00
425_V442_S0.7171.00
158_D161_M0.7161.00
157_R161_M0.7141.00
295_L301_I0.7141.00
174_G180_P0.7141.00
40_A54_P0.7141.00
15_S442_S0.7141.00
252_V423_Y0.7131.00
156_F165_M0.7111.00
141_I144_L0.7091.00
330_Y338_T0.7081.00
365_L371_C0.7081.00
324_T332_G0.7041.00
78_I82_P0.7041.00
15_S209_L0.7041.00
327_Y332_G0.7031.00
225_P262_S0.7011.00
355_K358_I0.7001.00
107_R110_N0.7001.00
29_V213_A0.6991.00
108_Y114_L0.6991.00
408_G411_R0.6981.00
210_Y218_V0.6981.00
112_T116_Y0.6961.00
208_R212_I0.6931.00
40_A435_V0.6921.00
264_L268_Y0.6921.00
185_M189_A0.6911.00
91_F100_T0.6911.00
264_L267_E0.6901.00
251_F421_N0.6891.00
51_D202_F0.6871.00
393_Y396_T0.6851.00
7_V226_V0.6851.00
327_Y334_T0.6841.00
325_S328_V0.6821.00
362_I375_A0.6801.00
174_G178_R0.6801.00
341_L345_I0.6791.00
62_I439_T0.6781.00
340_D345_I0.6761.00
334_T338_T0.6751.00
115_F119_S0.6751.00
100_T104_V0.6751.00
303_N306_W0.6741.00
11_L15_S0.6731.00
348_G351_T0.6731.00
115_F118_F0.6721.00
235_K420_K0.6721.00
172_I179_V0.6721.00
183_Y188_Y0.6721.00
31_E222_F0.6721.00
325_S329_S0.6711.00
274_R277_K0.6711.00
14_I29_V0.6691.00
106_D109_L0.6671.00
191_Y194_G0.6661.00
357_L382_G0.6661.00
329_S334_T0.6641.00
54_P202_F0.6641.00
129_F133_L0.6641.00
328_V331_R0.6621.00
70_A209_L0.6611.00
25_D250_V0.6611.00
120_K125_K0.6611.00
97_R104_V0.6591.00
397_A400_L0.6591.00
46_G377_Y0.6571.00
137_V140_N0.6541.00
182_V187_N0.6541.00
23_F447_K0.6521.00
51_D56_W0.6491.00
6_V252_V0.6491.00
300_V306_W0.6481.00
11_L439_T0.6481.00
288_G376_S0.6461.00
329_S333_A0.6461.00
138_L141_I0.6431.00
96_Y102_D0.6431.00
324_T330_Y0.6431.00
239_V251_F0.6431.00
25_D249_D0.6421.00
30_L239_V0.6401.00
331_R335_N0.6391.00
110_N113_R0.6391.00
343_I347_V0.6381.00
107_R114_L0.6361.00
331_R334_T0.6351.00
139_V144_L0.6351.00
91_F96_Y0.6341.00
78_I84_V0.6321.00
16_T445_V0.6301.00
407_T410_F0.6301.00
112_T118_F0.6301.00
252_V445_V0.6301.00
298_H303_N0.6291.00
163_K167_F0.6261.00
152_N166_G0.6251.00
272_S275_R0.6251.00
298_H301_I0.6241.00
191_Y195_V0.6231.00
407_T411_R0.6201.00
340_D346_P0.6201.00
177_F180_P0.6181.00
298_H302_I0.6161.00
88_E92_L0.6161.00
235_K421_N0.6161.00
128_V135_K0.6151.00
138_L142_S0.6141.00
182_V186_I0.6131.00
301_I304_G0.6131.00
192_G196_F0.6101.00
120_K123_I0.6101.00
228_K264_L0.6101.00
151_F181_A0.6101.00
174_G179_V0.6101.00
339_R347_V0.6091.00
343_I346_P0.6091.00
99_F103_N0.6081.00
340_D347_V0.6081.00
80_V87_M0.6061.00
54_P58_L0.6061.00
302_I306_W0.6051.00
93_K96_Y0.6051.00
384_D387_K0.6041.00
5_V251_F0.6031.00
66_F439_T0.6031.00
81_N85_K0.6021.00
122_F125_K0.6021.00
153_A177_F0.6011.00
354_S382_G0.5981.00
370_G374_K0.5971.00
132_F135_K0.5961.00
122_F126_E0.5961.00
326_Y334_T0.5961.00
224_F241_S0.5951.00
111_K115_F0.5941.00
150_N153_A0.5931.00
29_V36_P0.5931.00
326_Y333_A0.5931.00
35_T203_E0.5911.00
184_A187_N0.5891.00
179_V184_A0.5881.00
43_F379_R0.5881.00
109_L113_R0.5871.00
54_P435_V0.5871.00
82_P86_V0.5851.00
81_N84_V0.5851.00
64_E67_F0.5851.00
40_A202_F0.5851.00
117_D120_K0.5851.00
446_S450_S0.5841.00
88_E95_E0.5791.00
80_V85_K0.5781.00
99_F104_V0.5781.00
165_M168_S0.5781.00
109_L115_F0.5781.00
184_A188_Y0.5771.00
99_F102_D0.5771.00
159_S162_R0.5771.00
65_E70_A0.5751.00
256_D393_Y0.5731.00
168_S171_F0.5721.00
176_P179_V0.5701.00
377_Y381_Y0.5701.00
11_L209_L0.5691.00
255_M259_Y0.5681.00
324_T328_V0.5681.00
362_I378_I0.5661.00
283_I380_I0.5651.00
359_D378_I0.5641.00
123_I126_E0.5631.00
435_V439_T0.5621.00
397_A401_A0.5621.00
258_F261_D0.5621.00
288_G377_Y0.5601.00
325_S332_G0.5591.00
42_Y51_D0.5591.00
4_A449_I0.5591.00
324_T334_T0.5591.00
171_F176_P0.5581.00
149_D166_G0.5581.00
235_K249_D0.5581.00
21_K214_R0.5561.00
109_L116_Y0.5541.00
113_R116_Y0.5530.99
298_H304_G0.5520.99
18_I70_A0.5520.99
347_V350_G0.5520.99
27_V218_V0.5510.99
328_V334_T0.5510.99
323_N335_N0.5490.99
431_P434_G0.5480.99
171_F179_V0.5480.99
170_V173_G0.5480.99
256_D428_Y0.5470.99
381_Y389_D0.5460.99
62_I436_P0.5460.99
170_V174_G0.5460.99
392_A398_F0.5450.99
300_V305_D0.5450.99
95_E99_F0.5440.99
260_A263_L0.5440.99
301_I306_W0.5430.99
323_N327_Y0.5430.99
63_F67_F0.5420.99
253_F424_Y0.5410.99
97_R100_T0.5410.99
201_G204_G0.5410.99
61_E436_P0.5390.99
236_V422_L0.5370.99
297_H302_I0.5370.99
360_G364_D0.5360.99
6_V29_V0.5330.99
215_K218_V0.5330.99
92_L100_T0.5320.99
417_T420_K0.5310.99
45_V377_Y0.5280.99
392_A396_T0.5280.99
193_Q196_F0.5270.99
20_L449_I0.5250.99
224_F243_I0.5210.99
9_A210_Y0.5210.99
173_G180_P0.5170.99
112_T119_S0.5170.99
287_I343_I0.5170.99
401_A406_Q0.5170.99
66_F69_E0.5160.99
283_I357_L0.5150.99
359_D362_I0.5140.99
430_Q444_I0.5140.99
393_Y397_A0.5130.99
80_V86_V0.5110.99
79_R84_V0.5110.99
351_T354_S0.5110.99
417_T424_Y0.5110.99
126_E130_S0.5100.99
231_I422_L0.5100.99
51_D203_E0.5080.99
299_T304_G0.5080.99
425_V441_S0.5070.99
345_I361_V0.5070.99
63_F435_V0.5060.99
34_T222_F0.5060.99
118_F121_K0.5060.99
323_N328_V0.5060.99
140_N144_L0.5050.99
348_G353_I0.5050.99
325_S331_R0.5050.99
9_A31_E0.5050.99
326_Y335_N0.5040.99
128_V133_L0.5040.99
300_V304_G0.5030.99
113_R118_F0.5020.99
328_V335_N0.5010.99
91_F101_G0.5000.99
343_I365_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dgkA 1 0.804 100 0.347 Contact Map
4repA 1 0.9868 100 0.371 Contact Map
4i59A 1 0.9163 100 0.378 Contact Map
2yg5A 2 0.9185 100 0.389 Contact Map
3i6dA 1 0.8789 100 0.408 Contact Map
2vvmA 2 0.9295 100 0.411 Contact Map
1s3eA 2 0.9207 100 0.414 Contact Map
3ka7A 1 0.8943 100 0.419 Contact Map
2ivdA 1 0.9009 100 0.424 Contact Map
3nksA 2 0.9075 100 0.425 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.