Q97UT5 - SULSO - GREMLIN Contacts

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Q97UT5 - Uroporphyrin-III C-methyltransferase (Siroheme synthase) (CysG)

UniProt:	Q97UT5	Sequences: MGKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIEVDLLRKYALEDKLVIRLKNGDPYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGIPLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMGGRRLEEVSKWLMAKRDPSEDVAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (214)
Sequences:	13401 (8738)
Seq/√Len:	597.3

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPN2 Q9HPM9 Q9HMY4 Q9HPN0 Q9HPM0 Q9HPN3
SULSO - Q97UT5 Q97W12 Q97WC9 Q97WC5 Q97WD1 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
15_E	23_K	3.808	1.00
22_I	26_Q	3.355	1.00
5_V	24_Y	2.585	1.00
177_P	200_E	2.560	1.00
117_Y	192_Q	2.546	1.00
28_A	75_I	2.521	1.00
3_K	103_E	2.500	1.00
197_N	201_K	2.472	1.00
67_Y	72_K	2.436	1.00
3_K	101_E	2.394	1.00
185_E	193_K	2.390	1.00
53_F	56_N	2.203	1.00
7_V	75_I	2.170	1.00
23_K	27_M	2.162	1.00
19_L	22_I	2.105	1.00
69_L	98_D	2.097	1.00
186_R	191_D	2.060	1.00
114_V	187_G	2.050	1.00
110_S	158_L	2.046	1.00
5_V	73_L	2.043	1.00
38_S	77_L	2.034	1.00
184_I	187_G	2.029	1.00
180_D	218_G	1.993	1.00
198_K	201_K	1.988	1.00
94_E	98_D	1.895	1.00
7_V	21_G	1.876	1.00
29_D	73_L	1.866	1.00
67_Y	70_E	1.829	1.00
29_D	72_K	1.810	1.00
197_N	205_V	1.758	1.00
23_K	26_Q	1.732	1.00
50_F	67_Y	1.723	1.00
8_G	105_I	1.672	1.00
65_R	98_D	1.670	1.00
30_V	67_Y	1.664	1.00
15_E	20_K	1.654	1.00
181_V	202_L	1.647	1.00
145_N	148_K	1.620	1.00
66_K	70_E	1.613	1.00
184_I	194_V	1.600	1.00
94_E	97_K	1.566	1.00
24_Y	105_I	1.555	1.00
5_V	103_E	1.543	1.00
3_K	73_L	1.534	1.00
170_W	173_A	1.482	1.00
39_R	43_N	1.478	1.00
109_S	112_N	1.471	1.00
69_L	100_I	1.451	1.00
111_V	158_L	1.433	1.00
117_Y	194_V	1.430	1.00
27_M	73_L	1.420	1.00
197_N	202_L	1.404	1.00
118_A	182_A	1.400	1.00
168_S	172_M	1.367	1.00
13_D	20_K	1.366	1.00
178_S	200_E	1.362	1.00
63_L	66_K	1.361	1.00
186_R	189_Y	1.358	1.00
175_R	179_E	1.353	1.00
20_K	103_E	1.353	1.00
63_L	67_Y	1.346	1.00
109_S	158_L	1.323	1.00
114_V	184_I	1.299	1.00
168_S	203_A	1.291	1.00
201_K	205_V	1.290	1.00
65_R	69_L	1.287	1.00
17_I	22_I	1.281	1.00
62_D	66_K	1.279	1.00
171_L	199_L	1.247	1.00
157_V	217_L	1.241	1.00
83_Y	88_G	1.237	1.00
8_G	81_D	1.222	1.00
68_A	100_I	1.213	1.00
32_V	74_V	1.201	1.00
147_Q	173_A	1.192	1.00
24_Y	75_I	1.183	1.00
4_V	95_L	1.180	1.00
4_V	68_A	1.176	1.00
165_E	169_K	1.173	1.00
59_I	62_D	1.162	1.00
163_R	166_E	1.160	1.00
22_I	44_Y	1.159	1.00
104_V	116_A	1.152	1.00
195_H	205_V	1.151	1.00
143_L	170_W	1.149	1.00
31_I	45_A	1.148	1.00
18_T	108_V	1.144	1.00
147_Q	151_D	1.138	1.00
182_A	196_V	1.121	1.00
61_V	94_E	1.119	1.00
169_K	173_A	1.117	1.00
171_L	217_L	1.113	1.00
6_L	88_G	1.112	1.00
172_M	177_P	1.102	1.00
156_V	216_V	1.098	1.00
127_V	153_G	1.096	1.00
60_E	63_L	1.089	1.00
172_M	200_E	1.086	1.00
183_V	213_S	1.083	1.00
32_V	64_L	1.071	1.00
81_D	116_A	1.058	1.00
181_V	199_L	1.057	1.00
17_I	21_G	1.055	1.00
148_K	151_D	1.050	1.00
40_E	43_N	1.050	1.00
37_V	40_E	1.049	1.00
50_F	72_K	1.032	1.00
33_Y	51_V	1.029	1.00
49_S	52_I	1.019	1.00
95_L	100_I	1.015	1.00
65_R	94_E	1.013	1.00
5_V	105_I	1.009	1.00
16_L	20_K	1.008	1.00
129_D	153_G	1.006	1.00
185_E	210_A	0.996	1.00
182_A	194_V	0.990	1.00
30_V	72_K	0.985	1.00
30_V	74_V	0.978	1.00
92_C	102_C	0.972	1.00
172_M	203_A	0.967	1.00
57_D	61_V	0.963	1.00
165_E	203_A	0.963	1.00
28_A	73_L	0.962	1.00
171_L	175_R	0.958	1.00
96_I	196_V	0.957	1.00
164_L	215_L	0.950	1.00
45_A	49_S	0.950	1.00
8_G	82_P	0.948	1.00
164_L	202_L	0.948	1.00
89_G	124_F	0.948	1.00
96_I	119_G	0.948	1.00
193_K	207_N	0.947	1.00
166_E	169_K	0.944	1.00
19_L	23_K	0.939	1.00
169_K	203_A	0.928	1.00
57_D	90_K	0.924	1.00
15_E	19_L	0.923	1.00
209_L	213_S	0.913	1.00
157_V	160_G	0.912	1.00
76_R	91_I	0.903	1.00
166_E	170_W	0.899	1.00
156_V	214_L	0.898	1.00
93_Q	97_K	0.897	1.00
147_Q	170_W	0.896	1.00
32_V	63_L	0.894	1.00
120_I	182_A	0.885	1.00
172_M	199_L	0.880	1.00
113_S	188_T	0.880	1.00
136_A	140_G	0.876	1.00
176_D	179_E	0.866	1.00
104_V	194_V	0.864	1.00
21_G	105_I	0.860	1.00
130_M	153_G	0.858	1.00
114_V	216_V	0.856	1.00
185_E	213_S	0.855	1.00
135_S	140_G	0.854	1.00
32_V	67_Y	0.849	1.00
178_S	198_K	0.848	1.00
144_F	147_Q	0.847	1.00
7_V	105_I	0.842	1.00
5_V	28_A	0.841	1.00
179_E	219_N	0.840	1.00
41_L	44_Y	0.839	1.00
83_Y	104_V	0.832	1.00
24_Y	27_M	0.832	1.00
62_D	94_E	0.828	1.00
11_P	16_L	0.824	1.00
125_N	129_D	0.819	1.00
180_D	198_K	0.814	1.00
96_I	102_C	0.810	1.00
89_G	93_Q	0.809	1.00
168_S	199_L	0.808	1.00
84_I	131_V	0.801	1.00
88_G	92_C	0.797	1.00
137_V	140_G	0.788	1.00
135_S	145_N	0.788	1.00
147_Q	150_P	0.788	1.00
20_K	23_K	0.781	1.00
104_V	117_Y	0.780	1.00
17_I	41_L	0.779	1.00
84_I	112_N	0.778	1.00
58_D	94_E	0.777	1.00
24_Y	103_E	0.772	1.00
159_M	163_R	0.763	1.00
113_S	187_G	0.761	1.00
195_H	202_L	0.761	1.00
121_P	124_F	0.757	1.00
7_V	24_Y	0.756	1.00
134_V	145_N	0.746	1.00
82_P	86_G	0.745	1.00
161_G	209_L	0.742	1.00
45_A	51_V	0.741	1.00
46_K	49_S	0.741	1.00
24_Y	73_L	0.740	1.00
61_V	65_R	0.740	1.00
59_I	63_L	0.738	1.00
52_I	67_Y	0.737	1.00
66_K	69_L	0.735	1.00
165_E	204_E	0.728	1.00
182_A	216_V	0.725	1.00
158_L	214_L	0.721	1.00
38_S	42_I	0.718	1.00
68_A	74_V	0.714	1.00
148_K	152_Y	0.714	1.00
5_V	75_I	0.712	1.00
14_P	40_E	0.710	1.00
135_S	139_Q	0.710	1.00
147_Q	174_K	0.707	1.00
183_V	202_L	0.701	1.00
117_Y	188_T	0.701	1.00
129_D	145_N	0.698	1.00
20_K	105_I	0.697	1.00
155_L	171_L	0.697	1.00
135_S	138_S	0.690	1.00
8_G	113_S	0.689	1.00
81_D	104_V	0.688	1.00
78_K	86_G	0.680	1.00
146_F	167_V	0.679	1.00
62_D	98_D	0.678	1.00
134_V	146_F	0.678	1.00
52_I	63_L	0.677	1.00
38_S	45_A	0.675	1.00
83_Y	116_A	0.673	1.00
85_F	128_S	0.671	1.00
58_D	62_D	0.670	1.00
89_G	121_P	0.668	1.00
138_S	143_L	0.667	1.00
92_C	96_I	0.666	1.00
24_Y	28_A	0.663	1.00
29_D	46_K	0.662	1.00
32_V	52_I	0.662	1.00
115_P	216_V	0.660	1.00
20_K	24_Y	0.655	1.00
114_V	214_L	0.654	1.00
139_Q	144_F	0.649	1.00
6_L	92_C	0.648	1.00
195_H	209_L	0.647	1.00
167_V	215_L	0.643	1.00
143_L	147_Q	0.640	1.00
41_L	45_A	0.639	1.00
13_D	16_L	0.638	1.00
13_D	188_T	0.637	1.00
25_L	31_I	0.636	1.00
161_G	213_S	0.635	1.00
65_R	95_L	0.634	1.00
143_L	173_A	0.631	1.00
28_A	31_I	0.630	1.00
155_L	217_L	0.628	1.00
145_N	151_D	0.627	1.00
171_L	174_K	0.626	1.00
143_L	166_E	0.625	1.00
31_I	49_S	0.623	1.00
164_L	213_S	0.621	1.00
40_E	44_Y	0.621	1.00
47_P	50_F	0.621	1.00
42_I	45_A	0.619	1.00
26_Q	44_Y	0.618	1.00
134_V	139_Q	0.616	1.00
25_L	75_I	0.615	1.00
127_V	219_N	0.613	1.00
58_D	90_K	0.609	1.00
168_S	202_L	0.608	1.00
8_G	108_V	0.606	1.00
44_Y	47_P	0.605	1.00
111_V	156_V	0.598	1.00
57_D	60_E	0.596	1.00
130_M	149_I	0.593	1.00
195_H	207_N	0.592	1.00
201_K	204_E	0.587	1.00
196_V	221_V	0.586	1.00
39_R	42_I	0.584	1.00
160_G	167_V	0.583	1.00
21_G	75_I	0.579	1.00
19_L	26_Q	0.575	1.00
155_L	175_R	0.574	1.00
131_V	156_V	0.574	1.00
157_V	167_V	0.572	1.00
43_N	48_S	0.568	1.00
184_I	216_V	0.568	1.00
146_F	150_P	0.567	1.00
205_V	208_N	0.564	1.00
145_N	149_I	0.562	1.00
129_D	149_I	0.560	1.00
93_Q	124_F	0.559	1.00
134_V	157_V	0.557	0.99
22_I	45_A	0.552	0.99
167_V	170_W	0.550	0.99
64_L	68_A	0.548	0.99
61_V	64_L	0.546	0.99
14_P	44_Y	0.545	0.99
89_G	123_T	0.544	0.99
113_S	117_Y	0.542	0.99
25_L	45_A	0.542	0.99
58_D	61_V	0.541	0.99
4_V	76_R	0.534	0.99
186_R	212_P	0.533	0.99
52_I	60_E	0.532	0.99
47_P	52_I	0.531	0.99
61_V	90_K	0.529	0.99
83_Y	92_C	0.528	0.99
138_S	170_W	0.525	0.99
37_V	41_L	0.525	0.99
17_I	45_A	0.524	0.99
123_T	154_T	0.522	0.99
145_N	150_P	0.522	0.99
19_L	44_Y	0.521	0.99
48_S	51_V	0.521	0.99
187_G	194_V	0.521	0.99
127_V	155_L	0.520	0.99
205_V	209_L	0.519	0.99
164_L	168_S	0.518	0.99
6_L	102_C	0.517	0.99
181_V	203_A	0.517	0.99
8_G	117_Y	0.516	0.99
95_L	102_C	0.516	0.99
151_D	174_K	0.513	0.99
78_K	87_R	0.512	0.99
42_I	51_V	0.510	0.99
146_F	149_I	0.508	0.99
46_K	50_F	0.502	0.99
93_Q	96_I	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pjqA	2	1	100	0.163	Contact Map
1s4dA	4	1	100	0.182	Contact Map
2yboA	2	1	100	0.192	Contact Map
1ve2A	2	0.9654	100	0.196	Contact Map
3kwpA	2	0.9524	100	0.225	Contact Map
4e16A	2	0.9524	100	0.226	Contact Map
1cbfA	2	0.9654	100	0.236	Contact Map
3ndcA	2	0.9827	100	0.243	Contact Map
1va0A	2	0.9437	100	0.249	Contact Map
2zvbA	2	0.9394	100	0.255	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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