GREMLIN Database
Q97UT5 - Uroporphyrin-III C-methyltransferase (Siroheme synthase) (CysG)
UniProt: Q97UT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (214)
Sequences: 13401 (8738)
Seq/√Len: 597.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E23_K3.8081.00
22_I26_Q3.3551.00
5_V24_Y2.5851.00
177_P200_E2.5601.00
117_Y192_Q2.5461.00
28_A75_I2.5211.00
3_K103_E2.5001.00
197_N201_K2.4721.00
67_Y72_K2.4361.00
3_K101_E2.3941.00
185_E193_K2.3901.00
53_F56_N2.2031.00
7_V75_I2.1701.00
23_K27_M2.1621.00
19_L22_I2.1051.00
69_L98_D2.0971.00
186_R191_D2.0601.00
114_V187_G2.0501.00
110_S158_L2.0461.00
5_V73_L2.0431.00
38_S77_L2.0341.00
184_I187_G2.0291.00
180_D218_G1.9931.00
198_K201_K1.9881.00
94_E98_D1.8951.00
7_V21_G1.8761.00
29_D73_L1.8661.00
67_Y70_E1.8291.00
29_D72_K1.8101.00
197_N205_V1.7581.00
23_K26_Q1.7321.00
50_F67_Y1.7231.00
8_G105_I1.6721.00
65_R98_D1.6701.00
30_V67_Y1.6641.00
15_E20_K1.6541.00
181_V202_L1.6471.00
145_N148_K1.6201.00
66_K70_E1.6131.00
184_I194_V1.6001.00
94_E97_K1.5661.00
24_Y105_I1.5551.00
5_V103_E1.5431.00
3_K73_L1.5341.00
170_W173_A1.4821.00
39_R43_N1.4781.00
109_S112_N1.4711.00
69_L100_I1.4511.00
111_V158_L1.4331.00
117_Y194_V1.4301.00
27_M73_L1.4201.00
197_N202_L1.4041.00
118_A182_A1.4001.00
168_S172_M1.3671.00
13_D20_K1.3661.00
178_S200_E1.3621.00
63_L66_K1.3611.00
186_R189_Y1.3581.00
175_R179_E1.3531.00
20_K103_E1.3531.00
63_L67_Y1.3461.00
109_S158_L1.3231.00
114_V184_I1.2991.00
168_S203_A1.2911.00
201_K205_V1.2901.00
65_R69_L1.2871.00
17_I22_I1.2811.00
62_D66_K1.2791.00
171_L199_L1.2471.00
157_V217_L1.2411.00
83_Y88_G1.2371.00
8_G81_D1.2221.00
68_A100_I1.2131.00
32_V74_V1.2011.00
147_Q173_A1.1921.00
24_Y75_I1.1831.00
4_V95_L1.1801.00
4_V68_A1.1761.00
165_E169_K1.1731.00
59_I62_D1.1621.00
163_R166_E1.1601.00
22_I44_Y1.1591.00
104_V116_A1.1521.00
195_H205_V1.1511.00
143_L170_W1.1491.00
31_I45_A1.1481.00
18_T108_V1.1441.00
147_Q151_D1.1381.00
182_A196_V1.1211.00
61_V94_E1.1191.00
169_K173_A1.1171.00
171_L217_L1.1131.00
6_L88_G1.1121.00
172_M177_P1.1021.00
156_V216_V1.0981.00
127_V153_G1.0961.00
60_E63_L1.0891.00
172_M200_E1.0861.00
183_V213_S1.0831.00
32_V64_L1.0711.00
81_D116_A1.0581.00
181_V199_L1.0571.00
17_I21_G1.0551.00
148_K151_D1.0501.00
40_E43_N1.0501.00
37_V40_E1.0491.00
50_F72_K1.0321.00
33_Y51_V1.0291.00
49_S52_I1.0191.00
95_L100_I1.0151.00
65_R94_E1.0131.00
5_V105_I1.0091.00
16_L20_K1.0081.00
129_D153_G1.0061.00
185_E210_A0.9961.00
182_A194_V0.9901.00
30_V72_K0.9851.00
30_V74_V0.9781.00
92_C102_C0.9721.00
172_M203_A0.9671.00
57_D61_V0.9631.00
165_E203_A0.9631.00
28_A73_L0.9621.00
171_L175_R0.9581.00
96_I196_V0.9571.00
164_L215_L0.9501.00
45_A49_S0.9501.00
8_G82_P0.9481.00
164_L202_L0.9481.00
89_G124_F0.9481.00
96_I119_G0.9481.00
193_K207_N0.9471.00
166_E169_K0.9441.00
19_L23_K0.9391.00
169_K203_A0.9281.00
57_D90_K0.9241.00
15_E19_L0.9231.00
209_L213_S0.9131.00
157_V160_G0.9121.00
76_R91_I0.9031.00
166_E170_W0.8991.00
156_V214_L0.8981.00
93_Q97_K0.8971.00
147_Q170_W0.8961.00
32_V63_L0.8941.00
120_I182_A0.8851.00
172_M199_L0.8801.00
113_S188_T0.8801.00
136_A140_G0.8761.00
176_D179_E0.8661.00
104_V194_V0.8641.00
21_G105_I0.8601.00
130_M153_G0.8581.00
114_V216_V0.8561.00
185_E213_S0.8551.00
135_S140_G0.8541.00
32_V67_Y0.8491.00
178_S198_K0.8481.00
144_F147_Q0.8471.00
7_V105_I0.8421.00
5_V28_A0.8411.00
179_E219_N0.8401.00
41_L44_Y0.8391.00
83_Y104_V0.8321.00
24_Y27_M0.8321.00
62_D94_E0.8281.00
11_P16_L0.8241.00
125_N129_D0.8191.00
180_D198_K0.8141.00
96_I102_C0.8101.00
89_G93_Q0.8091.00
168_S199_L0.8081.00
84_I131_V0.8011.00
88_G92_C0.7971.00
137_V140_G0.7881.00
135_S145_N0.7881.00
147_Q150_P0.7881.00
20_K23_K0.7811.00
104_V117_Y0.7801.00
17_I41_L0.7791.00
84_I112_N0.7781.00
58_D94_E0.7771.00
24_Y103_E0.7721.00
159_M163_R0.7631.00
113_S187_G0.7611.00
195_H202_L0.7611.00
121_P124_F0.7571.00
7_V24_Y0.7561.00
134_V145_N0.7461.00
82_P86_G0.7451.00
161_G209_L0.7421.00
45_A51_V0.7411.00
46_K49_S0.7411.00
24_Y73_L0.7401.00
61_V65_R0.7401.00
59_I63_L0.7381.00
52_I67_Y0.7371.00
66_K69_L0.7351.00
165_E204_E0.7281.00
182_A216_V0.7251.00
158_L214_L0.7211.00
38_S42_I0.7181.00
68_A74_V0.7141.00
148_K152_Y0.7141.00
5_V75_I0.7121.00
14_P40_E0.7101.00
135_S139_Q0.7101.00
147_Q174_K0.7071.00
183_V202_L0.7011.00
117_Y188_T0.7011.00
129_D145_N0.6981.00
20_K105_I0.6971.00
155_L171_L0.6971.00
135_S138_S0.6901.00
8_G113_S0.6891.00
81_D104_V0.6881.00
78_K86_G0.6801.00
146_F167_V0.6791.00
62_D98_D0.6781.00
134_V146_F0.6781.00
52_I63_L0.6771.00
38_S45_A0.6751.00
83_Y116_A0.6731.00
85_F128_S0.6711.00
58_D62_D0.6701.00
89_G121_P0.6681.00
138_S143_L0.6671.00
92_C96_I0.6661.00
24_Y28_A0.6631.00
29_D46_K0.6621.00
32_V52_I0.6621.00
115_P216_V0.6601.00
20_K24_Y0.6551.00
114_V214_L0.6541.00
139_Q144_F0.6491.00
6_L92_C0.6481.00
195_H209_L0.6471.00
167_V215_L0.6431.00
143_L147_Q0.6401.00
41_L45_A0.6391.00
13_D16_L0.6381.00
13_D188_T0.6371.00
25_L31_I0.6361.00
161_G213_S0.6351.00
65_R95_L0.6341.00
143_L173_A0.6311.00
28_A31_I0.6301.00
155_L217_L0.6281.00
145_N151_D0.6271.00
171_L174_K0.6261.00
143_L166_E0.6251.00
31_I49_S0.6231.00
164_L213_S0.6211.00
40_E44_Y0.6211.00
47_P50_F0.6211.00
42_I45_A0.6191.00
26_Q44_Y0.6181.00
134_V139_Q0.6161.00
25_L75_I0.6151.00
127_V219_N0.6131.00
58_D90_K0.6091.00
168_S202_L0.6081.00
8_G108_V0.6061.00
44_Y47_P0.6051.00
111_V156_V0.5981.00
57_D60_E0.5961.00
130_M149_I0.5931.00
195_H207_N0.5921.00
201_K204_E0.5871.00
196_V221_V0.5861.00
39_R42_I0.5841.00
160_G167_V0.5831.00
21_G75_I0.5791.00
19_L26_Q0.5751.00
155_L175_R0.5741.00
131_V156_V0.5741.00
157_V167_V0.5721.00
43_N48_S0.5681.00
184_I216_V0.5681.00
146_F150_P0.5671.00
205_V208_N0.5641.00
145_N149_I0.5621.00
129_D149_I0.5601.00
93_Q124_F0.5591.00
134_V157_V0.5570.99
22_I45_A0.5520.99
167_V170_W0.5500.99
64_L68_A0.5480.99
61_V64_L0.5460.99
14_P44_Y0.5450.99
89_G123_T0.5440.99
113_S117_Y0.5420.99
25_L45_A0.5420.99
58_D61_V0.5410.99
4_V76_R0.5340.99
186_R212_P0.5330.99
52_I60_E0.5320.99
47_P52_I0.5310.99
61_V90_K0.5290.99
83_Y92_C0.5280.99
138_S170_W0.5250.99
37_V41_L0.5250.99
17_I45_A0.5240.99
123_T154_T0.5220.99
145_N150_P0.5220.99
19_L44_Y0.5210.99
48_S51_V0.5210.99
187_G194_V0.5210.99
127_V155_L0.5200.99
205_V209_L0.5190.99
164_L168_S0.5180.99
6_L102_C0.5170.99
181_V203_A0.5170.99
8_G117_Y0.5160.99
95_L102_C0.5160.99
151_D174_K0.5130.99
78_K87_R0.5120.99
42_I51_V0.5100.99
146_F149_I0.5080.99
46_K50_F0.5020.99
93_Q96_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 1 100 0.163 Contact Map
1s4dA 4 1 100 0.182 Contact Map
2yboA 2 1 100 0.192 Contact Map
1ve2A 2 0.9654 100 0.196 Contact Map
3kwpA 2 0.9524 100 0.225 Contact Map
4e16A 2 0.9524 100 0.226 Contact Map
1cbfA 2 0.9654 100 0.236 Contact Map
3ndcA 2 0.9827 100 0.243 Contact Map
1va0A 2 0.9437 100 0.249 Contact Map
2zvbA 2 0.9394 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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