GREMLIN Database
Q97UT3 - 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) (CysH)
UniProt: Q97UT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (204)
Sequences: 4642 (2726)
Seq/√Len: 190.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_Y195_D3.9111.00
33_K136_E3.8911.00
49_D53_K3.3211.00
70_Q74_D2.7871.00
23_L139_I2.5241.00
49_D182_Y2.3701.00
121_E126_R2.3611.00
59_R88_R2.3251.00
119_C206_C2.2891.00
78_E82_K2.2491.00
30_F137_A2.1811.00
107_N110_Y2.1691.00
74_D78_E2.0551.00
53_K186_N2.0341.00
118_A121_E1.9591.00
48_L60_V1.9381.00
119_C203_C1.9241.00
181_E185_K1.9191.00
145_E176_W1.9171.00
64_D89_I1.8761.00
90_Y131_A1.8121.00
178_Q181_E1.7571.00
78_E189_P1.7541.00
42_A183_I1.7391.00
203_C206_C1.7351.00
53_K182_Y1.7311.00
98_E102_N1.7211.00
22_V155_K1.6931.00
175_T178_Q1.6901.00
25_W29_K1.6901.00
47_I139_I1.6801.00
126_R130_R1.6671.00
64_D73_Y1.6631.00
62_I68_L1.6371.00
120_C203_C1.6241.00
57_K86_D1.6091.00
70_Q204_V1.5891.00
120_C206_C1.5791.00
49_D186_N1.5791.00
174_W182_Y1.5781.00
214_E218_A1.5541.00
99_D103_K1.5221.00
49_D52_S1.5181.00
190_Y194_Y1.4791.00
137_A168_L1.4781.00
26_G34_I1.4731.00
177_E181_E1.4691.00
72_S191_N1.4581.00
215_H218_A1.4511.00
22_V173_D1.4491.00
19_P50_M1.4461.00
140_T169_N1.4001.00
24_K54_V1.3951.00
26_G168_L1.3841.00
208_R222_W1.3831.00
129_K163_G1.3691.00
42_A201_I1.3611.00
199_K210_V1.3541.00
144_R172_A1.3541.00
180_W190_Y1.3301.00
71_E196_K1.3011.00
21_E24_K1.2961.00
194_Y199_K1.2941.00
20_L24_K1.2901.00
36_L47_I1.2831.00
30_F166_I1.2821.00
36_L51_L1.2781.00
77_E81_K1.2641.00
40_L76_I1.2611.00
23_L50_M1.2601.00
47_I171_L1.2541.00
153_I172_A1.2241.00
182_Y186_N1.1851.00
153_I157_E1.1751.00
196_K209_P1.1741.00
35_A61_F1.1701.00
48_L79_I1.1651.00
176_W180_W1.1611.00
23_L51_L1.1601.00
145_E175_T1.1571.00
20_L53_K1.1531.00
211_K214_E1.1451.00
46_V183_I1.1431.00
18_E21_E1.1411.00
100_L104_Y1.1391.00
50_M182_Y1.1381.00
61_F131_A1.1351.00
180_W184_N1.1351.00
46_V179_V1.1281.00
131_A134_G1.1161.00
34_I137_A1.1151.00
34_I139_I1.1051.00
41_Q44_D1.1021.00
50_M54_V1.0851.00
59_R86_D1.0851.00
82_K187_N1.0701.00
46_V182_Y1.0641.00
56_E85_I1.0501.00
24_K28_E1.0501.00
67_R205_P1.0481.00
93_D130_R1.0421.00
42_A194_Y1.0421.00
142_L172_A1.0421.00
142_L169_N1.0421.00
159_D163_G1.0301.00
142_L153_I1.0301.00
37_A61_F1.0251.00
39_S44_D1.0231.00
52_S83_Y1.0221.00
180_W194_Y1.0181.00
156_I168_L1.0151.00
80_V87_L1.0121.00
65_T124_K0.9930.99
100_L108_L0.9870.99
88_R135_M0.9840.99
42_A180_W0.9810.99
20_L50_M0.9790.99
27_I30_F0.9790.99
45_L79_I0.9790.99
20_L54_V0.9750.99
193_L201_I0.9710.99
176_W216_P0.9670.99
49_D83_Y0.9660.99
104_Y118_A0.9510.99
46_V49_D0.9440.99
96_E126_R0.9430.99
154_R172_A0.9410.99
15_E18_E0.9400.99
77_E80_V0.9390.99
183_I188_V0.9360.99
35_A138_W0.9320.99
148_F151_G0.9280.99
154_R157_E0.9250.99
16_D20_L0.9210.99
80_V86_D0.9100.99
21_E25_W0.9090.99
144_R173_D0.9060.99
126_R129_K0.9040.99
59_R135_M0.9000.99
73_Y76_I0.8960.99
19_P174_W0.8910.99
19_P26_G0.8900.99
118_A122_V0.8860.99
158_I166_I0.8850.99
101_V106_I0.8820.99
192_K196_K0.8800.99
120_C124_K0.8790.99
200_S207_T0.8780.99
14_F17_K0.8760.99
79_I83_Y0.8740.99
90_Y130_R0.8730.99
63_I90_Y0.8700.99
183_I190_Y0.8680.99
74_D77_E0.8620.99
67_R97_V0.8570.98
71_E74_D0.8510.98
132_L138_W0.8400.98
17_K21_E0.8390.98
119_C124_K0.8320.98
51_L58_P0.8250.98
208_R218_A0.8240.98
98_E101_V0.8070.98
119_C123_R0.8040.98
45_L75_L0.7990.98
76_I80_V0.7910.97
200_S219_G0.7850.97
19_P22_V0.7810.97
129_K133_D0.7800.97
157_E169_N0.7740.97
43_E146_Q0.7730.97
90_Y134_G0.7720.97
82_K189_P0.7700.97
124_K203_C0.7690.97
208_R214_E0.7690.97
69_H198_Y0.7660.97
62_I76_I0.7650.97
22_V168_L0.7580.97
46_V174_W0.7480.96
155_K173_D0.7440.96
155_K172_A0.7430.96
181_E184_N0.7310.96
14_F18_E0.7300.96
78_E192_K0.7290.96
78_E81_K0.7250.96
176_W199_K0.7230.96
77_E89_I0.7220.96
66_G91_F0.7200.96
43_E194_Y0.7160.95
158_I164_G0.7150.95
52_S85_I0.7120.95
52_S56_E0.7110.95
49_D188_V0.7080.95
48_L85_I0.7070.95
97_V100_L0.7030.95
38_C79_I0.7030.95
60_V85_I0.7010.95
88_R131_A0.7000.95
193_L197_G0.6990.95
71_E192_K0.6970.95
22_V26_G0.6960.95
55_T58_P0.6960.95
93_D126_R0.6950.95
42_A146_Q0.6920.94
14_F156_I0.6900.94
106_I109_F0.6900.94
74_D192_K0.6890.94
46_V171_L0.6880.94
67_R204_V0.6880.94
210_V214_E0.6880.94
184_N195_D0.6860.94
96_E99_D0.6860.94
75_L192_K0.6820.94
128_L132_L0.6760.94
86_D135_M0.6740.94
37_A199_K0.6740.94
215_H221_W0.6740.94
51_L56_E0.6710.94
65_T202_G0.6710.94
38_C45_L0.6680.93
93_D96_E0.6660.93
217_R221_W0.6650.93
106_I110_Y0.6640.93
76_I89_I0.6640.93
149_T153_I0.6580.93
72_S201_I0.6560.93
206_C222_W0.6550.93
68_L124_K0.6540.93
25_W156_I0.6520.93
69_H193_L0.6460.92
138_W167_K0.6440.92
45_L188_V0.6430.92
212_P215_H0.6430.92
138_W165_I0.6400.92
83_Y188_V0.6380.92
190_Y197_G0.6350.92
32_P59_R0.6340.91
217_R220_R0.6250.91
27_I58_P0.6240.91
124_K150_R0.6210.91
119_C127_P0.6150.90
88_R134_G0.6140.90
68_L200_S0.6120.90
198_Y209_P0.6090.90
26_G137_A0.6040.89
39_S147_N0.6010.89
61_F128_L0.5970.89
18_E155_K0.5950.89
151_G172_A0.5920.88
132_L135_M0.5910.88
174_W178_Q0.5900.88
39_S203_C0.5880.88
16_D185_K0.5850.88
211_K216_P0.5840.88
180_W183_I0.5820.88
39_S141_G0.5790.87
62_I73_Y0.5770.87
43_E180_W0.5760.87
130_R134_G0.5750.87
104_Y108_L0.5710.87
40_L146_Q0.5700.87
158_I165_I0.5700.87
147_N150_R0.5690.86
90_Y135_M0.5680.86
29_K32_P0.5680.86
101_V107_N0.5660.86
25_W28_E0.5660.86
67_R109_F0.5660.86
97_V101_V0.5640.86
103_K106_I0.5640.86
23_L27_I0.5640.86
80_V85_I0.5610.86
122_V126_R0.5570.85
61_F90_Y0.5570.85
41_Q146_Q0.5560.85
75_L190_Y0.5550.85
214_E222_W0.5550.85
51_L139_I0.5540.85
217_R222_W0.5480.84
18_E173_D0.5480.84
63_I200_S0.5470.84
36_L44_D0.5420.84
48_L83_Y0.5410.84
64_D91_F0.5400.84
214_E217_R0.5380.83
63_I128_L0.5370.83
145_E151_G0.5370.83
143_R180_W0.5330.83
184_N190_Y0.5310.82
49_D82_K0.5300.82
41_Q179_V0.5290.82
46_V186_N0.5290.82
106_I111_K0.5290.82
93_D103_K0.5250.82
45_L183_I0.5250.82
53_K177_E0.5240.82
37_A138_W0.5180.81
107_N111_K0.5170.81
50_M171_L0.5170.81
63_I140_T0.5170.81
128_L138_W0.5130.80
70_Q107_N0.5100.80
66_G92_P0.5090.80
67_R203_C0.5080.80
102_N105_G0.5030.79
96_E100_L0.5020.79
105_G108_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oq2A 2 0.9707 100 0.282 Contact Map
4bwvA 2 0.8828 100 0.289 Contact Map
2goyA 3 0.9121 100 0.303 Contact Map
2o8vA 2 0.8954 100 0.332 Contact Map
1zunA 1 0.7197 100 0.394 Contact Map
3fwkA 1 0.887 100 0.429 Contact Map
2wsiA 1 0.8787 100 0.45 Contact Map
1surA 2 0.8368 100 0.505 Contact Map
2pg3A 2 0.8243 99.8 0.696 Contact Map
3bl5A 3 0.728 99.8 0.706 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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