GREMLIN Database
Q97UT2 - Sulfate adenylyltransferase (Sat)
UniProt: Q97UT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (360)
Sequences: 1073 (569)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E67_P4.9321.00
54_Y58_D4.3021.00
109_I143_L4.0631.00
92_I104_M3.9731.00
239_L381_K3.8431.00
108_E144_A3.8411.00
62_E116_K3.7171.00
26_R95_T3.5771.00
301_S304_E3.5311.00
119_E125_K3.4271.00
304_E307_E3.3801.00
162_F242_D3.3741.00
59_G63_N3.2561.00
14_R18_I3.1751.00
53_N108_E3.0521.00
133_K137_S2.9151.00
20_D91_T2.9141.00
65_R316_D2.7711.00
172_V176_K2.7691.00
54_Y108_E2.7421.00
358_S362_D2.7171.00
332_R347_E2.6841.00
107_K146_D2.6461.00
25_H90_D2.6351.00
82_Q140_D2.6261.00
86_V106_V2.6221.00
183_A284_C2.5821.00
123_K304_E2.5691.00
172_V175_K2.5560.99
333_C342_C2.5170.99
91_T105_K2.5080.99
73_P273_L2.4940.99
105_K148_W2.4910.99
49_K146_D2.3520.99
13_E148_W2.3430.99
359_I366_P2.3150.99
333_C344_H2.3020.99
93_G100_P2.3010.99
111_K141_A2.2000.98
53_N56_E2.1910.98
250_I253_K2.1890.98
114_K140_D2.1630.98
330_C333_C2.1550.98
52_M60_V2.1440.98
86_V143_L2.1100.98
219_L258_S2.0910.98
30_K33_L2.0420.97
33_L79_D2.0290.97
53_N107_K2.0270.97
371_M376_Y1.9460.97
365_K377_D1.9320.96
169_H173_F1.9280.96
260_T274_L1.8910.96
152_E165_T1.8780.96
126_D299_Y1.8630.96
189_V237_I1.8620.95
171_T175_K1.8420.95
280_S318_L1.8390.95
82_Q111_K1.8270.95
71_L312_I1.8190.95
127_I136_L1.8190.95
195_E372_R1.7960.95
164_L258_S1.7900.94
46_S170_R1.7820.94
366_P380_M1.7660.94
115_L125_K1.7500.94
377_D381_K1.7210.93
27_I104_M1.7070.93
62_E120_K1.6570.92
102_A150_V1.6540.92
310_D323_F1.6360.91
239_L378_V1.6320.91
57_V117_I1.6220.91
330_C342_C1.5970.90
99_K151_R1.5600.89
185_Q264_M1.5490.89
112_Y142_F1.5390.88
172_V256_L1.5370.88
352_S357_R1.5200.88
116_K120_K1.4870.87
106_V143_L1.4570.85
34_A101_L1.4470.85
37_I147_V1.4250.84
183_A197_L1.4100.83
37_I101_L1.3990.83
161_E242_D1.3980.83
243_A378_V1.3920.83
232_Y237_I1.3850.82
222_V241_H1.3810.82
124_T132_V1.3560.81
21_F93_G1.3510.81
327_N338_N1.3500.81
88_E109_I1.3350.80
260_T278_I1.3140.79
188_N291_R1.3140.79
326_E350_E1.3060.78
373_P377_D1.3030.78
28_E98_G1.2780.77
378_V381_K1.2680.76
28_E95_T1.2670.76
240_T378_V1.2590.76
53_N144_A1.2430.75
330_C344_H1.2330.74
232_Y383_A1.2320.74
37_I102_A1.2170.73
169_H219_L1.2140.73
64_M308_I1.2050.72
104_M143_L1.2030.72
227_K237_I1.1860.71
185_Q188_N1.1800.71
77_V142_F1.1760.71
233_I236_A1.1730.70
164_L169_H1.1660.70
28_E96_Y1.1640.70
38_V149_L1.1630.70
39_S44_F1.1600.70
304_E308_I1.1550.69
303_Y306_H1.1540.69
356_I366_P1.1520.69
27_I92_I1.1520.69
246_K251_S1.1520.69
291_R352_S1.1430.68
180_R285_T1.1370.68
53_N146_D1.1350.68
150_V298_N1.1310.68
40_I46_S1.1300.67
187_R225_G1.1140.66
17_T20_D1.1110.66
19_S22_K1.1070.66
21_F24_L1.1020.65
291_R354_S1.0910.65
55_E67_P1.0870.64
86_V109_I1.0870.64
16_K19_S1.0790.64
271_E275_H1.0780.64
29_V33_L1.0750.64
188_N357_R1.0740.63
39_S102_A1.0700.63
231_D264_M1.0700.63
366_P376_Y1.0650.63
355_L359_I1.0540.62
81_S139_A1.0510.62
307_E310_D1.0470.61
188_N352_S1.0470.61
19_S23_E1.0460.61
354_S357_R1.0430.61
124_T284_C1.0420.61
261_L282_L1.0300.60
353_G357_R1.0240.60
164_L172_V1.0200.59
292_D295_G1.0170.59
70_V277_I1.0060.58
111_K140_D0.9930.57
189_V232_Y0.9860.57
163_W238_L0.9850.57
337_E341_L0.9840.57
144_A366_P0.9790.56
173_F219_L0.9790.56
193_G351_F0.9710.56
219_L284_C0.9680.55
32_Q134_R0.9680.55
55_E108_E0.9620.55
225_G279_R0.9550.54
36_E263_D0.9530.54
106_V109_I0.9530.54
14_R151_R0.9530.54
61_V120_K0.9500.54
39_S42_Y0.9480.54
264_M275_H0.9440.53
96_Y99_K0.9430.53
36_E265_R0.9430.53
120_K123_K0.9370.53
351_F356_I0.9320.53
184_F271_E0.9260.52
359_I364_V0.9230.52
187_R264_M0.9220.52
214_P322_I0.9210.52
58_D116_K0.9170.51
123_K311_S0.9140.51
171_T174_E0.9140.51
355_L358_S0.9140.51
187_R231_D0.9140.51
242_D246_K0.9120.51
291_R353_G0.9110.51
188_N290_G0.9090.51
29_V37_I0.9080.51
225_G231_D0.9070.51
187_R357_R0.9060.50
325_R351_F0.9010.50
118_A135_T0.9010.50
183_A287_H0.8990.50
109_I126_D0.8980.50
96_Y101_L0.8930.49
15_I18_I0.8930.49
14_R17_T0.8900.49
24_L91_T0.8900.49
323_F338_N0.8900.49
17_T93_G0.8850.49
291_R357_R0.8830.49
81_S84_E0.8830.49
123_K307_E0.8830.49
17_T103_I0.8790.48
188_N353_G0.8730.48
188_N194_H0.8710.48
188_N354_S0.8690.48
189_V227_K0.8690.48
117_I142_F0.8680.47
54_Y111_K0.8670.47
365_K380_M0.8660.47
55_E92_I0.8660.47
122_Y135_T0.8630.47
43_G170_R0.8620.47
334_G368_K0.8610.47
190_P237_I0.8600.47
308_I312_I0.8590.47
186_T249_Y0.8510.46
183_A198_M0.8460.46
109_I141_A0.8440.46
175_K346_D0.8400.45
91_T148_W0.8390.45
190_P220_V0.8360.45
365_K373_P0.8360.45
115_L127_I0.8360.45
71_L92_I0.8350.45
27_I321_P0.8340.45
15_I19_S0.8290.44
114_K142_F0.8290.44
275_H353_G0.8150.43
50_G72_W0.8150.43
185_Q231_D0.8110.43
42_Y277_I0.8100.43
139_A143_L0.8100.43
221_N279_R0.8060.43
330_C337_E0.8060.43
218_I317_L0.8050.42
93_G102_A0.8030.42
279_R352_S0.7960.42
225_G357_R0.7930.42
143_L246_K0.7930.42
334_G364_V0.7930.42
291_R294_A0.7920.41
115_L136_L0.7900.41
105_K146_D0.7900.41
264_M279_R0.7890.41
168_M171_T0.7890.41
27_I143_L0.7850.41
80_Y143_L0.7810.41
301_S307_E0.7760.40
13_E16_K0.7730.40
187_R353_G0.7670.40
227_K232_Y0.7620.39
336_I340_I0.7620.39
196_Y328_Y0.7620.39
16_K20_D0.7610.39
57_V142_F0.7540.39
25_H162_F0.7510.38
116_K119_E0.7510.38
279_R291_R0.7500.38
313_N316_D0.7500.38
295_G354_S0.7500.38
63_N101_L0.7490.38
184_F222_V0.7480.38
290_G295_G0.7470.38
139_A321_P0.7420.38
225_G264_M0.7420.38
73_P274_L0.7360.37
275_H291_R0.7340.37
173_F256_L0.7310.37
22_K25_H0.7310.37
326_E351_F0.7290.37
185_Q294_A0.7290.37
165_T168_M0.7280.37
122_Y257_L0.7260.37
224_I259_F0.7260.37
303_Y325_R0.7230.36
146_D242_D0.7230.36
188_N228_R0.7220.36
271_E294_A0.7190.36
90_D219_L0.7180.36
291_R295_G0.7170.36
194_H290_G0.7160.36
220_V238_L0.7150.36
275_H294_A0.7120.35
194_H295_G0.7110.35
28_E97_L0.7100.35
15_I90_D0.7090.35
52_M277_I0.7090.35
328_Y348_K0.7090.35
86_V381_K0.7090.35
342_C348_K0.7080.35
365_K368_K0.7040.35
194_H352_S0.7020.35
218_I318_L0.7020.35
290_G353_G0.7020.35
147_V150_V0.7010.35
82_Q109_I0.6980.34
308_I313_N0.6970.34
45_L108_E0.6960.34
331_P347_E0.6960.34
61_V116_K0.6960.34
111_K301_S0.6950.34
188_N231_D0.6950.34
231_D357_R0.6930.34
192_T237_I0.6930.34
58_D61_V0.6920.34
31_R96_Y0.6910.34
29_V102_A0.6900.34
80_Y109_I0.6900.34
20_D24_L0.6890.34
122_Y126_D0.6890.34
349_Q355_L0.6880.34
184_F275_H0.6870.34
41_A147_V0.6840.33
237_I261_L0.6840.33
359_I367_T0.6810.33
169_H321_P0.6800.33
195_E217_G0.6780.33
43_G47_P0.6780.33
98_G151_R0.6770.33
187_R275_H0.6770.33
54_Y116_K0.6760.33
264_M294_A0.6760.33
29_V258_S0.6730.33
110_F240_T0.6700.32
95_T100_P0.6680.32
185_Q279_R0.6670.32
76_L104_M0.6670.32
187_R290_G0.6670.32
229_V235_E0.6660.32
102_A144_A0.6650.32
123_K269_P0.6650.32
264_M291_R0.6640.32
92_I143_L0.6640.32
85_K102_A0.6630.32
36_E45_L0.6630.32
371_M375_V0.6620.32
117_I261_L0.6620.32
156_N163_W0.6610.32
194_H292_D0.6610.32
58_D62_E0.6610.32
75_P191_H0.6600.32
217_G372_R0.6600.32
276_A289_F0.6590.32
113_D116_K0.6580.32
112_Y141_A0.6570.32
331_P349_Q0.6550.31
18_I40_I0.6540.31
139_A181_V0.6530.31
228_R353_G0.6480.31
131_G271_E0.6470.31
90_D127_I0.6460.31
190_P198_M0.6460.31
101_L382_A0.6440.31
64_M270_R0.6410.30
157_K163_W0.6410.30
187_R291_R0.6390.30
176_K256_L0.6370.30
163_W261_L0.6360.30
40_I243_A0.6360.30
109_I144_A0.6350.30
225_G269_P0.6340.30
198_M249_Y0.6320.30
40_I224_I0.6320.30
64_M267_A0.6300.30
98_G136_L0.6290.30
230_G361_L0.6280.30
102_A165_T0.6260.29
330_C335_S0.6220.29
77_V197_L0.6200.29
234_D237_I0.6190.29
227_K261_L0.6190.29
285_T318_L0.6180.29
13_E19_S0.6180.29
250_I254_V0.6180.29
88_E108_E0.6170.29
99_K242_D0.6160.29
235_E239_L0.6150.29
44_F278_I0.6150.29
114_K136_L0.6120.29
240_T382_A0.6100.28
277_I317_L0.6100.28
290_G357_R0.6080.28
133_K161_E0.6060.28
279_R292_D0.6060.28
312_I316_D0.6050.28
23_E103_I0.6050.28
53_N256_L0.6030.28
84_E140_D0.6030.28
192_T196_Y0.6020.28
199_K372_R0.6010.28
228_R231_D0.6010.28
230_G262_W0.5980.28
52_M383_A0.5980.28
31_R226_E0.5950.27
81_S146_D0.5950.27
228_R354_S0.5930.27
187_R279_R0.5920.27
264_M353_G0.5920.27
27_I84_E0.5920.27
292_D300_Y0.5910.27
15_I171_T0.5900.27
195_E199_K0.5890.27
187_R292_D0.5890.27
227_K262_W0.5880.27
194_H353_G0.5880.27
81_S86_V0.5870.27
184_F241_H0.5870.27
194_H357_R0.5870.27
230_G233_I0.5870.27
185_Q291_R0.5850.27
241_H263_D0.5830.27
195_E333_C0.5830.27
29_V93_G0.5810.27
180_R320_K0.5810.27
327_N350_E0.5810.27
20_D105_K0.5790.26
18_I151_R0.5790.26
156_N244_L0.5780.26
30_K138_Y0.5770.26
275_H293_H0.5770.26
183_A201_A0.5760.26
195_E356_I0.5760.26
223_V262_W0.5750.26
22_K26_R0.5740.26
112_Y117_I0.5740.26
329_Y334_G0.5730.26
33_L144_A0.5730.26
293_H297_G0.5730.26
222_V287_H0.5720.26
27_I31_R0.5720.26
228_R264_M0.5710.26
187_R354_S0.5700.26
43_G50_G0.5690.26
193_G371_M0.5690.26
228_R291_R0.5690.26
57_V257_L0.5670.26
16_K22_K0.5670.26
48_L76_L0.5640.26
108_E365_K0.5630.26
271_E353_G0.5620.25
271_E279_R0.5620.25
158_P163_W0.5610.25
228_R324_L0.5600.25
309_F323_F0.5590.25
193_G326_E0.5580.25
87_K161_E0.5580.25
188_N264_M0.5580.25
32_Q138_Y0.5570.25
292_D354_S0.5560.25
88_E146_D0.5550.25
275_H357_R0.5550.25
35_H45_L0.5540.25
271_E293_H0.5530.25
356_I371_M0.5510.25
185_Q352_S0.5510.25
194_H291_R0.5510.25
199_K321_P0.5500.25
26_R81_S0.5490.25
332_R346_D0.5490.25
177_G215_R0.5490.25
356_I370_V0.5480.25
358_S368_K0.5470.25
227_K324_L0.5470.25
292_D352_S0.5470.25
121_V186_T0.5450.24
14_R23_E0.5450.24
183_A280_S0.5430.24
271_E352_S0.5430.24
95_T122_Y0.5430.24
104_M146_D0.5400.24
119_E128_K0.5400.24
163_W260_T0.5380.24
192_T301_S0.5380.24
91_T143_L0.5380.24
78_F329_Y0.5370.24
188_N271_E0.5360.24
252_P346_D0.5350.24
327_N336_I0.5350.24
97_L110_F0.5350.24
26_R150_V0.5340.24
186_T293_H0.5340.24
233_I237_I0.5340.24
225_G291_R0.5340.24
36_E117_I0.5320.24
182_V288_V0.5320.24
73_P262_W0.5310.24
50_G144_A0.5310.24
333_C337_E0.5300.24
140_D381_K0.5300.24
32_Q45_L0.5280.23
90_D143_L0.5280.23
247_Y374_E0.5280.23
131_G286_H0.5270.23
40_I149_L0.5260.23
107_K144_A0.5260.23
330_C348_K0.5250.23
91_T106_V0.5250.23
53_N310_D0.5240.23
20_D148_W0.5230.23
338_N342_C0.5230.23
91_T103_I0.5230.23
63_N247_Y0.5230.23
81_S377_D0.5220.23
59_G120_K0.5220.23
195_E330_C0.5200.23
87_K106_V0.5200.23
243_A246_K0.5200.23
185_Q225_G0.5200.23
24_L133_K0.5200.23
157_K160_S0.5190.23
95_T98_G0.5190.23
222_V227_K0.5180.23
331_P346_D0.5170.23
121_V265_R0.5170.23
68_N242_D0.5170.23
184_F353_G0.5170.23
31_R86_V0.5130.23
32_Q117_I0.5120.23
62_E136_L0.5120.23
196_Y203_F0.5110.23
87_K315_E0.5110.23
225_G353_G0.5100.22
67_P70_V0.5100.22
45_L262_W0.5100.22
294_A305_A0.5100.22
107_K373_P0.5100.22
190_P219_L0.5100.22
41_A149_L0.5090.22
290_G352_S0.5090.22
344_H372_R0.5080.22
129_H271_E0.5070.22
112_Y138_Y0.5070.22
243_A247_Y0.5020.22
228_R352_S0.5020.22
57_V112_Y0.5020.22
244_L338_N0.5020.22
17_T377_D0.5010.22
116_K315_E0.5010.22
231_D279_R0.5010.22
47_P268_G0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x6vB 2 0.9409 100 0.138 Contact Map
1r6xA 1 0.899 100 0.146 Contact Map
4mafA 2 0.9409 100 0.154 Contact Map
1m8pA 5 0.9655 100 0.176 Contact Map
1g8fA 5 0.9581 100 0.185 Contact Map
2gksA 2 0.8892 100 0.192 Contact Map
3cr8A 4 0.8744 100 0.263 Contact Map
1v47A 2 0.8473 100 0.314 Contact Map
4dnxA 2 0.931 100 0.36 Contact Map
4f3rA 5 0.3645 99.2 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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