GREMLIN Database
Q97US4 - Uncharacterized protein
UniProt: Q97US4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (160)
Sequences: 277 (171)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_P91_A3.1120.98
52_V76_V2.7800.95
5_T8_Q2.7510.95
36_V160_W2.6000.93
27_I130_F2.5410.92
22_F26_E2.5220.92
99_R114_W2.3850.90
137_F156_L2.3500.89
69_K88_K2.3420.89
22_F71_Y2.3090.88
94_K97_L2.1780.85
41_V141_V2.1640.84
6_G10_I2.1450.84
72_D114_W2.0930.82
26_E48_S2.0820.82
12_A17_T2.0600.81
129_L132_A2.0370.80
41_V153_S2.0110.80
38_N81_V2.0040.79
3_N21_K1.9950.79
34_F129_L1.9440.77
86_P149_R1.9100.76
19_D23_L1.8820.75
28_V32_N1.8100.72
4_V21_K1.7980.71
152_S161_L1.7010.67
148_L155_G1.6730.65
156_L159_G1.6140.62
21_K44_N1.5660.60
34_F132_A1.5440.59
2_D5_T1.5410.59
2_D8_Q1.5240.58
72_D99_R1.4980.57
23_L132_A1.4860.56
132_A160_W1.4740.55
141_V153_S1.4710.55
77_Y86_P1.4710.55
83_V102_A1.4680.55
64_K146_L1.4530.54
121_G124_W1.4500.54
65_F83_V1.4440.54
48_S161_L1.4140.52
118_K121_G1.3880.51
41_V150_L1.3880.51
90_N112_D1.3720.50
146_L150_L1.3700.50
51_T54_D1.3280.48
30_D70_A1.3170.47
91_A103_V1.3070.46
56_Q81_V1.3070.46
76_V94_K1.3060.46
45_E106_F1.2930.46
67_G78_K1.2760.45
54_D89_K1.2720.45
66_Y84_V1.2530.44
9_Y26_E1.2500.43
14_W22_F1.2450.43
58_K144_V1.2190.42
56_Q119_G1.2050.41
3_N15_G1.1950.41
38_N56_Q1.1910.40
144_V152_S1.1820.40
52_V121_G1.1560.39
55_L71_Y1.1560.39
30_D84_V1.1350.38
133_V141_V1.1330.37
29_M125_R1.1300.37
132_A141_V1.0910.35
129_L143_Q1.0910.35
28_V118_K1.0870.35
49_V89_K1.0650.34
93_T103_V1.0640.34
110_G114_W1.0600.34
10_I17_T1.0570.34
4_V18_R1.0490.33
11_V17_T1.0430.33
10_I125_R1.0420.33
83_V98_A1.0420.33
73_A76_V1.0360.33
47_E50_K1.0360.33
12_A18_R1.0290.32
105_E109_L1.0220.32
158_R162_T1.0200.32
107_R116_E1.0140.32
38_N111_Y1.0140.32
43_S46_V1.0110.32
44_N74_N1.0110.32
7_G88_K1.0070.31
22_F161_L1.0030.31
128_S131_S0.9970.31
125_R129_L0.9920.31
145_L148_L0.9850.30
91_A100_R0.9750.30
3_N10_I0.9740.30
69_K72_D0.9710.30
81_V125_R0.9630.29
113_R121_G0.9630.29
113_R117_E0.9510.29
150_L159_G0.9510.29
94_K121_G0.9490.29
8_Q11_V0.9360.28
143_Q151_S0.9340.28
133_V157_T0.9270.28
113_R137_F0.9240.28
148_L158_R0.9230.28
26_E161_L0.9170.27
22_F48_S0.9140.27
34_F106_F0.8830.26
47_E124_W0.8750.26
14_W24_K0.8690.25
104_R107_R0.8580.25
115_R133_V0.8570.25
10_I66_Y0.8540.25
83_V139_E0.8520.25
5_T36_V0.8520.25
63_K78_K0.8510.25
90_N100_R0.8460.24
155_G160_W0.8440.24
30_D72_D0.8370.24
63_K96_H0.8340.24
13_K103_V0.8320.24
5_T9_Y0.8320.24
80_G105_E0.8260.24
51_T65_F0.8260.24
48_S67_G0.8170.23
38_N62_V0.8120.23
87_P141_V0.8010.23
53_K65_F0.7970.23
38_N140_S0.7870.22
32_N133_V0.7840.22
24_K48_S0.7810.22
42_T143_Q0.7810.22
147_E162_T0.7750.22
142_R157_T0.7740.22
14_W26_E0.7710.22
20_S144_V0.7640.21
95_R126_V0.7600.21
65_F81_V0.7540.21
6_G11_V0.7420.21
44_N58_K0.7380.20
58_K138_G0.7370.20
50_K115_R0.7300.20
143_Q146_L0.7250.20
49_V82_E0.7220.20
148_L157_T0.7200.20
94_K130_F0.7200.20
89_K92_S0.7150.20
30_D88_K0.7110.20
68_D123_R0.7030.19
25_I87_P0.7010.19
115_R121_G0.6980.19
146_L151_S0.6970.19
9_Y28_V0.6930.19
65_F76_V0.6920.19
33_E83_V0.6870.19
89_K147_E0.6860.19
101_K104_R0.6850.19
107_R117_E0.6710.18
38_N126_V0.6630.18
100_R124_W0.6590.18
14_W23_L0.6570.18
112_D115_R0.6570.18
41_V87_P0.6510.18
78_K84_V0.6430.17
62_V88_K0.6390.17
62_V93_T0.6380.17
3_N126_V0.6370.17
51_T89_K0.6360.17
7_G18_R0.6340.17
87_P99_R0.6340.17
127_E152_S0.6330.17
75_E104_R0.6330.17
49_V140_S0.6320.17
132_A139_E0.6290.17
88_K94_K0.6240.17
24_K42_T0.6240.17
151_S154_S0.6230.17
5_T149_R0.6220.17
41_V133_V0.6170.17
33_E121_G0.6160.17
87_P102_A0.6140.17
6_G121_G0.6110.16
36_V128_S0.6090.16
42_T111_Y0.6060.16
144_V149_R0.6030.16
67_G118_K0.6010.16
61_K81_V0.6000.16
6_G122_V0.5990.16
61_K97_L0.5980.16
50_K102_A0.5980.16
137_F142_R0.5900.16
79_T110_G0.5900.16
134_K143_Q0.5900.16
14_W130_F0.5900.16
25_I29_M0.5890.16
143_Q159_G0.5850.16
154_S162_T0.5840.16
9_Y24_K0.5830.16
66_Y126_V0.5830.16
105_E108_K0.5830.16
44_N104_R0.5820.16
104_R110_G0.5790.16
29_M34_F0.5770.15
82_E96_H0.5750.15
15_G23_L0.5740.15
63_K67_G0.5710.15
4_V11_V0.5710.15
51_T103_V0.5710.15
5_T14_W0.5700.15
47_E90_N0.5680.15
10_I115_R0.5620.15
75_E140_S0.5600.15
31_N70_A0.5590.15
46_V133_V0.5500.15
26_E42_T0.5500.15
149_R161_L0.5480.15
107_R162_T0.5460.15
30_D114_W0.5460.15
49_V155_G0.5400.14
52_V77_Y0.5370.14
45_E89_K0.5360.14
50_K98_A0.5290.14
12_A16_K0.5240.14
12_A115_R0.5220.14
46_V118_K0.5210.14
25_I98_A0.5200.14
136_T142_R0.5200.14
128_S146_L0.5190.14
67_G157_T0.5180.14
98_A102_A0.5160.14
86_P134_K0.5160.14
35_N47_E0.5100.14
66_Y97_L0.5090.14
47_E56_Q0.5060.14
8_Q132_A0.5050.14
67_G71_Y0.5050.14
109_L113_R0.5040.14
39_A154_S0.5020.13
143_Q155_G0.5010.13
73_A145_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.988 91 0.918 Contact Map
4fw1A 2 0.7771 20.2 0.954 Contact Map
3l3uA 2 0.7711 18.2 0.955 Contact Map
1c6vA 4 0.7349 13.4 0.957 Contact Map
4cf8A 2 0.7651 12.2 0.958 Contact Map
1cxqA 2 0.8012 10.9 0.959 Contact Map
1k6yA 4 0.6928 10.4 0.96 Contact Map
2x78A 2 0.7952 8.7 0.961 Contact Map
3f9kA 5 0.7289 7.8 0.962 Contact Map
4fw2A 2 0.7892 7.7 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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