Q97UR6 - SULSO - GREMLIN Contacts

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Q97UR6 - N-methylhydantoinase A (HyuA-3)

UniProt:	Q97UR6	Sequences: MMNMECKVAIDIGGTFTDFIVLASDGEIKTIKILTNPKDPGQVIKDVISTLNCNVSEIAHATTLATNTLLGQENLTIPKTALLVTKGFRDIIEIGRQNRPRLYDLYFEKPRQLVLRSLRFEIDERINAEGNMIKEVDQDEIERVAKKLLDENVISIAVSYLHSYLNPKNELITENVLKKYFKYISISSKIAPEPREYERTSTAVVNAVLMPIVSAYLERLQVSLPTENFYIMSSSGGLVDIKEASEKPVQLIESGPAAGVIASASFLPNESLISFDMGGTTAKAGVIINGNFEMTTEYEVGGEVHYGRIVKGSGYPVRFPFVDLAEVSAGGGTIIWRDEANALKVGPISAGADPGPISYGKGGNRPTIADANLILGRLGTELIGGNLKLDKESAIRGMSKLGDPYEVSKNALGLVNLEMARAIRLVTVERGLDPSNFSLIAFGGAGPQHAVYLAEEVGIGKVIIPPHPGLFSALGLLLADWRFEVRKSYPKDLGSEFEQLEKELYEKLKGNVDYFLRLADVRYEGQGWELTIPVNNVNEIRKVFEEKHLATYGFVMKDREIEVVTIRVFAIKKRPLPKIKVAFGNYDKPREVRKVVIDDDWVNVDVYVREKLPKGFRIGGPAIIEEYSSTTVIKDGWNAIIDDSIVLVRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	650 (622)
Sequences:	2947 (2034)
Seq/√Len:	81.6

SULSO - Q97UR6 Q97WV4 Q97XP8 Q97XP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
160_Y	173_T	6.292	1.00
138_Q	172_I	5.034	1.00
142_E	179_K	4.684	1.00
127_N	131_N	4.468	1.00
174_E	186_I	4.368	1.00
124_E	132_M	4.343	1.00
391_K	395_I	4.097	1.00
86_K	123_D	3.977	1.00
123_D	140_E	3.882	1.00
594_K	603_N	3.848	1.00
141_I	173_T	3.497	1.00
146_K	150_D	3.244	1.00
89_R	121_E	3.208	1.00
501_E	517_R	3.078	1.00
159_S	200_T	3.058	1.00
174_E	178_K	3.051	1.00
172_I	175_N	3.032	1.00
142_E	180_Y	2.990	1.00
504_L	570_A	2.972	1.00
642_D	646_V	2.951	1.00
81_A	148_L	2.922	1.00
138_Q	176_V	2.905	1.00
85_T	124_E	2.861	1.00
592_V	603_N	2.843	1.00
146_K	180_Y	2.707	1.00
42_Q	46_D	2.678	1.00
118_L	151_E	2.657	1.00
336_W	348_I	2.652	1.00
497_F	517_R	2.642	1.00
81_A	120_F	2.569	1.00
82_L	200_T	2.562	1.00
438_S	461_K	2.559	1.00
101_R	104_D	2.542	1.00
127_N	133_I	2.502	1.00
79_K	117_S	2.496	1.00
399_S	403_D	2.495	1.00
74_N	208_V	2.480	1.00
398_M	411_A	2.477	1.00
145_A	177_L	2.473	1.00
174_E	189_K	2.466	1.00
541_R	545_E	2.460	1.00
142_E	176_V	2.453	1.00
514_Y	573_K	2.382	1.00
487_K	499_Q	2.370	1.00
137_D	140_E	2.346	1.00
455_E	637_W	2.344	1.00
335_I	411_A	2.336	1.00
35_T	64_L	2.307	1.00
43_V	47_V	2.252	1.00
158_V	186_I	2.231	1.00
149_L	180_Y	2.221	1.00
123_D	134_K	2.220	1.00
390_D	393_S	2.198	1.00
185_S	203_A	2.190	1.00
597_I	604_V	2.154	1.00
47_V	51_L	2.144	1.00
38_K	42_Q	2.085	1.00
595_V	604_V	2.073	1.00
608_V	611_K	2.066	1.00
357_I	393_S	2.057	1.00
118_L	153_V	2.027	1.00
547_K	550_A	2.014	1.00
596_V	601_W	2.012	1.00
360_G	390_D	2.010	1.00
501_E	505_Y	2.009	1.00
149_L	154_I	1.970	1.00
613_P	616_F	1.915	1.00
158_V	177_L	1.914	1.00
269_N	461_K	1.908	1.00
393_S	397_G	1.896	1.00
617_R	638_N	1.884	1.00
619_G	638_N	1.884	1.00
136_V	173_T	1.881	1.00
140_E	144_V	1.875	1.00
126_I	132_M	1.875	1.00
167_P	171_L	1.874	1.00
597_I	635_D	1.867	1.00
274_S	285_G	1.847	1.00
126_I	169_N	1.831	1.00
594_K	601_W	1.813	1.00
392_E	395_I	1.804	1.00
641_I	647_L	1.799	1.00
172_I	176_V	1.782	1.00
617_R	640_I	1.782	1.00
157_A	203_A	1.782	1.00
373_L	378_L	1.776	1.00
83_L	122_I	1.776	1.00
549_L	555_V	1.775	1.00
146_K	149_L	1.774	1.00
73_E	348_I	1.774	1.00
353_D	361_K	1.771	1.00
515_F	570_A	1.759	1.00
372_N	449_H	1.759	1.00
374_I	394_A	1.713	1.00
338_D	344_K	1.711	1.00
70_L	281_T	1.708	1.00
136_V	169_N	1.707	1.00
136_V	172_I	1.705	1.00
79_K	154_I	1.701	1.00
176_V	180_Y	1.696	1.00
158_V	173_T	1.688	1.00
401_L	407_V	1.688	1.00
451_V	634_K	1.686	1.00
374_I	398_M	1.681	1.00
156_I	177_L	1.677	1.00
123_D	137_D	1.669	1.00
438_S	463_I	1.658	1.00
487_K	496_E	1.651	1.00
81_A	144_V	1.649	1.00
93_E	119_R	1.642	1.00
171_L	189_K	1.637	1.00
539_E	543_V	1.634	1.00
609_R	626_E	1.633	1.00
536_N	539_E	1.628	1.00
19_F	47_V	1.627	1.00
72_Q	315_Y	1.624	1.00
171_L	175_N	1.623	1.00
334_I	367_T	1.620	1.00
92_I	204_V	1.616	1.00
96_R	198_E	1.604	1.00
158_V	174_E	1.591	1.00
581_V	643_D	1.590	1.00
545_E	555_V	1.583	1.00
631_T	647_L	1.579	1.00
416_N	449_H	1.579	1.00
258_A	476_L	1.572	1.00
72_Q	208_V	1.571	1.00
37_P	352_A	1.570	1.00
139_D	142_E	1.570	1.00
487_K	503_E	1.570	1.00
281_T	326_E	1.560	1.00
23_A	27_E	1.524	0.99
634_K	637_W	1.522	0.99
78_P	154_I	1.513	0.99
283_K	326_E	1.507	0.99
175_N	179_K	1.504	0.99
485_V	504_L	1.501	0.99
396_R	399_S	1.489	0.99
291_N	516_L	1.479	0.99
183_Y	210_M	1.474	0.99
253_E	281_T	1.467	0.99
618_I	639_A	1.466	0.99
126_I	166_N	1.464	0.99
138_Q	142_E	1.456	0.99
336_W	344_K	1.453	0.99
253_E	283_K	1.453	0.99
122_I	141_I	1.451	0.99
590_R	608_V	1.441	0.99
273_I	423_I	1.441	0.99
249_V	319_F	1.438	0.99
124_E	134_K	1.435	0.99
633_I	639_A	1.430	0.99
593_R	625_E	1.425	0.99
623_I	632_V	1.417	0.99
541_R	561_I	1.407	0.99
340_A	344_K	1.405	0.99
482_R	569_F	1.402	0.99
404_P	407_V	1.401	0.99
60_H	216_Y	1.399	0.99
624_I	639_A	1.393	0.99
393_S	396_R	1.393	0.99
519_A	566_I	1.391	0.99
519_A	540_I	1.391	0.99
377_R	412_L	1.389	0.99
43_V	51_L	1.388	0.99
409_K	599_D	1.388	0.99
373_L	389_L	1.370	0.99
163_S	188_S	1.369	0.99
275_F	282_A	1.352	0.99
171_L	188_S	1.351	0.99
441_A	447_P	1.349	0.99
401_L	404_P	1.342	0.99
214_S	245_S	1.342	0.99
195_R	529_E	1.336	0.99
516_L	571_I	1.336	0.99
498_E	502_K	1.329	0.99
506_E	510_G	1.326	0.98
523_Y	548_H	1.322	0.98
394_A	398_M	1.322	0.98
253_E	326_E	1.319	0.98
382_L	385_G	1.318	0.98
20_I	470_L	1.317	0.98
501_E	515_F	1.313	0.98
149_L	181_F	1.313	0.98
441_A	450_A	1.310	0.98
639_A	647_L	1.301	0.98
485_V	507_K	1.301	0.98
515_F	568_V	1.297	0.98
486_R	565_T	1.290	0.98
379_G	382_L	1.289	0.98
615_G	641_I	1.287	0.98
589_P	607_Y	1.282	0.98
86_K	140_E	1.280	0.98
520_D	565_T	1.277	0.98
400_K	404_P	1.271	0.98
451_V	637_W	1.270	0.98
604_V	635_D	1.269	0.98
86_K	121_E	1.268	0.98
368_I	415_V	1.263	0.98
498_E	501_E	1.250	0.98
523_Y	545_E	1.249	0.98
502_K	506_E	1.247	0.98
45_K	48_I	1.247	0.98
335_I	371_A	1.243	0.98
221_Q	242_K	1.241	0.98
496_E	499_Q	1.239	0.98
263_S	274_S	1.239	0.98
542_K	546_E	1.233	0.98
142_E	146_K	1.232	0.98
505_Y	513_D	1.230	0.98
83_L	144_V	1.227	0.97
518_L	531_T	1.225	0.97
80_T	155_S	1.221	0.97
176_V	179_K	1.220	0.97
85_T	132_M	1.214	0.97
168_K	171_L	1.213	0.97
39_D	42_Q	1.211	0.97
358_S	373_L	1.209	0.97
38_K	353_D	1.208	0.97
23_A	29_K	1.208	0.97
520_D	531_T	1.206	0.97
357_I	397_G	1.203	0.97
145_A	173_T	1.202	0.97
68_T	212_I	1.193	0.97
509_K	513_D	1.178	0.97
618_I	622_A	1.177	0.97
381_E	591_E	1.177	0.97
494_G	498_E	1.176	0.97
409_K	413_G	1.173	0.97
494_G	517_R	1.171	0.97
592_V	605_D	1.169	0.97
120_F	148_L	1.168	0.97
213_V	251_L	1.161	0.96
147_K	151_E	1.157	0.96
487_K	500_L	1.156	0.96
193_E	318_R	1.153	0.96
524_E	560_E	1.153	0.96
8_V	48_I	1.147	0.96
141_I	144_V	1.143	0.96
185_S	206_N	1.142	0.96
522_R	562_E	1.139	0.96
413_G	456_E	1.136	0.96
589_P	592_V	1.135	0.96
247_K	250_Q	1.134	0.96
8_V	55_V	1.125	0.96
588_K	611_K	1.125	0.96
132_M	135_E	1.124	0.96
379_G	625_E	1.123	0.96
260_V	285_G	1.123	0.96
65_A	209_L	1.117	0.96
139_D	143_R	1.116	0.96
68_T	73_E	1.114	0.96
379_G	593_R	1.110	0.95
392_E	396_R	1.110	0.95
609_R	631_T	1.109	0.95
120_F	144_V	1.103	0.95
519_A	563_V	1.101	0.95
372_N	416_N	1.101	0.95
91_I	196_E	1.099	0.95
161_L	196_E	1.093	0.95
114_V	204_V	1.091	0.95
585_N	588_K	1.090	0.95
143_R	146_K	1.090	0.95
587_D	611_K	1.085	0.95
191_A	318_R	1.084	0.95
45_K	49_S	1.071	0.94
120_F	147_K	1.071	0.94
84_V	91_I	1.069	0.94
187_S	203_A	1.067	0.94
350_A	367_T	1.066	0.94
136_V	141_I	1.062	0.94
597_I	632_V	1.050	0.94
499_Q	503_E	1.048	0.94
398_M	402_G	1.047	0.94
624_I	647_L	1.046	0.94
357_I	364_N	1.044	0.94
163_S	187_S	1.041	0.94
497_F	501_E	1.041	0.94
606_V	623_I	1.037	0.93
373_L	391_K	1.036	0.93
593_R	606_V	1.036	0.93
589_P	611_K	1.029	0.93
377_R	452_Y	1.028	0.93
156_I	181_F	1.026	0.93
235_S	484_E	1.026	0.93
610_E	627_Y	1.025	0.93
46_D	50_T	1.022	0.93
394_A	397_G	1.021	0.93
159_S	187_S	1.019	0.93
522_R	529_E	1.018	0.93
543_V	547_K	1.016	0.93
583_F	616_F	1.015	0.93
500_L	503_E	1.010	0.93
148_L	153_V	1.009	0.92
10_I	58_I	1.008	0.92
41_G	219_R	1.008	0.92
141_I	176_V	1.007	0.92
217_L	241_I	1.007	0.92
626_E	631_T	1.005	0.92
417_L	456_E	1.001	0.92
513_D	570_A	0.999	0.92
520_D	567_R	0.998	0.92
80_T	204_V	0.997	0.92
79_K	118_L	0.995	0.92
229_F	241_I	0.995	0.92
189_K	246_E	0.993	0.92
596_V	600_D	0.991	0.92
47_V	52_N	0.990	0.92
590_R	611_K	0.989	0.92
122_I	144_V	0.988	0.92
413_G	598_D	0.985	0.92
7_K	57_E	0.982	0.91
614_K	645_I	0.978	0.91
612_L	641_I	0.977	0.91
383_I	387_L	0.975	0.91
35_T	43_V	0.975	0.91
81_A	153_V	0.975	0.91
546_E	550_A	0.974	0.91
589_P	605_D	0.974	0.91
217_L	231_I	0.972	0.91
543_V	546_E	0.972	0.91
521_V	561_I	0.970	0.91
50_T	386_N	0.967	0.91
485_V	503_E	0.964	0.91
264_A	292_F	0.964	0.91
270_E	289_N	0.963	0.91
19_F	31_I	0.963	0.91
143_R	147_K	0.961	0.91
530_L	551_T	0.960	0.90
468_P	629_S	0.960	0.90
272_L	440_I	0.959	0.90
587_D	616_F	0.957	0.90
480_D	576_L	0.954	0.90
470_L	628_S	0.952	0.90
163_S	203_A	0.951	0.90
622_A	633_I	0.950	0.90
513_D	572_K	0.950	0.90
595_V	623_I	0.950	0.90
271_S	436_N	0.947	0.90
366_P	400_K	0.945	0.90
545_E	561_I	0.943	0.90
185_S	190_I	0.942	0.90
277_M	372_N	0.940	0.90
65_A	251_L	0.940	0.90
7_K	56_S	0.940	0.90
609_R	647_L	0.940	0.90
72_Q	111_R	0.937	0.89
416_N	452_Y	0.935	0.89
488_S	565_T	0.933	0.89
252_I	317_V	0.933	0.89
374_I	395_I	0.931	0.89
33_I	46_D	0.927	0.89
190_I	247_K	0.927	0.89
451_V	633_I	0.924	0.89
86_K	134_K	0.924	0.89
79_K	153_V	0.924	0.89
167_P	188_S	0.919	0.88
145_A	180_Y	0.918	0.88
402_G	407_V	0.917	0.88
548_H	554_F	0.916	0.88
9_A	477_L	0.916	0.88
269_N	438_S	0.914	0.88
372_N	377_R	0.911	0.88
206_N	210_M	0.910	0.88
84_V	196_E	0.910	0.88
380_T	391_K	0.908	0.88
582_A	585_N	0.907	0.88
145_A	181_F	0.907	0.88
441_A	464_I	0.906	0.88
7_K	22_L	0.906	0.88
175_N	178_K	0.904	0.88
194_P	488_S	0.900	0.87
624_I	633_I	0.892	0.87
482_R	571_I	0.891	0.87
423_I	426_V	0.889	0.87
168_K	172_I	0.887	0.87
271_S	289_N	0.886	0.87
357_I	366_P	0.885	0.87
409_K	596_V	0.884	0.86
585_N	616_F	0.882	0.86
343_L	407_V	0.877	0.86
469_G	629_S	0.876	0.86
607_Y	612_L	0.875	0.86
360_G	393_S	0.874	0.86
253_E	324_L	0.873	0.86
138_Q	175_N	0.873	0.86
338_D	341_N	0.873	0.86
70_L	326_E	0.872	0.86
135_E	172_I	0.871	0.86
418_E	421_R	0.870	0.86
604_V	623_I	0.869	0.86
341_N	344_K	0.864	0.85
162_H	165_L	0.862	0.85
480_D	571_I	0.862	0.85
122_I	136_V	0.861	0.85
177_L	181_F	0.861	0.85
468_P	628_S	0.860	0.85
505_Y	509_K	0.859	0.85
273_I	434_P	0.859	0.85
233_S	250_Q	0.855	0.85
202_T	249_V	0.852	0.84
91_I	200_T	0.851	0.84
237_G	482_R	0.848	0.84
210_M	248_P	0.847	0.84
83_L	177_L	0.847	0.84
503_E	506_E	0.846	0.84
497_F	566_I	0.846	0.84
159_S	203_A	0.846	0.84
483_F	507_K	0.844	0.84
415_V	419_M	0.842	0.84
468_P	609_R	0.842	0.84
124_E	169_N	0.839	0.83
233_S	239_V	0.839	0.83
495_S	499_Q	0.838	0.83
61_A	258_A	0.836	0.83
523_Y	556_M	0.836	0.83
44_I	220_L	0.834	0.83
8_V	21_V	0.832	0.83
83_L	160_Y	0.830	0.83
512_V	575_P	0.830	0.83
49_S	227_E	0.830	0.83
604_V	632_V	0.827	0.83
82_L	159_S	0.826	0.83
588_K	607_Y	0.824	0.82
223_S	226_T	0.823	0.82
141_I	145_A	0.821	0.82
39_D	219_R	0.821	0.82
6_C	21_V	0.821	0.82
274_S	281_T	0.820	0.82
396_R	400_K	0.820	0.82
397_G	400_K	0.820	0.82
542_K	555_V	0.817	0.82
21_V	29_K	0.814	0.82
147_K	150_D	0.811	0.81
69_L	205_V	0.810	0.81
274_S	442_F	0.810	0.81
454_A	462_V	0.810	0.81
395_I	399_S	0.809	0.81
283_K	298_Y	0.809	0.81
504_L	515_F	0.808	0.81
608_V	627_Y	0.807	0.81
232_M	476_L	0.806	0.81
12_I	40_P	0.806	0.81
277_M	449_H	0.805	0.81
266_F	471_F	0.805	0.81
485_V	568_V	0.804	0.81
489_Y	496_E	0.803	0.81
273_I	427_T	0.802	0.81
496_E	566_I	0.802	0.81
357_I	394_A	0.800	0.80
581_V	644_S	0.799	0.80
597_I	600_D	0.798	0.80
345_V	414_L	0.797	0.80
81_A	156_I	0.797	0.80
18_D	32_K	0.796	0.80
548_H	555_V	0.795	0.80
66_T	71_G	0.794	0.80
223_S	227_E	0.794	0.80
532_I	547_K	0.793	0.80
82_L	119_R	0.789	0.80
153_V	156_I	0.789	0.80
253_E	325_A	0.787	0.79
474_L	579_I	0.785	0.79
282_A	326_E	0.784	0.79
618_I	624_I	0.782	0.79
335_I	398_M	0.781	0.79
597_I	602_V	0.780	0.79
284_A	327_V	0.780	0.79
469_G	609_R	0.779	0.79
607_Y	618_I	0.778	0.79
277_M	415_V	0.777	0.78
148_L	156_I	0.777	0.78
584_G	588_K	0.776	0.78
321_F	326_E	0.775	0.78
454_A	459_I	0.774	0.78
607_Y	616_F	0.773	0.78
177_L	180_Y	0.771	0.78
44_I	47_V	0.771	0.78
95_G	99_R	0.771	0.78
145_A	176_V	0.769	0.78
432_L	437_F	0.767	0.78
495_S	498_E	0.767	0.78
337_R	401_L	0.766	0.78
34_L	352_A	0.763	0.77
69_L	252_I	0.762	0.77
31_I	47_V	0.761	0.77
154_I	180_Y	0.761	0.77
150_D	180_Y	0.761	0.77
391_K	394_A	0.761	0.77
171_L	174_E	0.761	0.77
595_V	632_V	0.758	0.77
590_R	625_E	0.757	0.77
122_I	140_E	0.757	0.77
516_L	533_P	0.755	0.76
193_E	486_R	0.754	0.76
40_P	64_L	0.753	0.76
148_L	151_E	0.753	0.76
590_R	607_Y	0.752	0.76
61_A	476_L	0.750	0.76
381_E	388_K	0.750	0.76
366_P	398_M	0.750	0.76
144_V	148_L	0.750	0.76
242_K	246_E	0.750	0.76
83_L	173_T	0.748	0.76
277_M	445_A	0.747	0.76
218_E	222_V	0.747	0.76
117_S	153_V	0.747	0.76
143_R	150_D	0.747	0.76
368_I	411_A	0.747	0.76
146_K	175_N	0.743	0.75
518_L	533_P	0.743	0.75
178_K	184_I	0.740	0.75
119_R	200_T	0.740	0.75
259_G	442_F	0.740	0.75
163_S	167_P	0.740	0.75
504_L	508_L	0.739	0.75
6_C	26_G	0.734	0.74
118_L	148_L	0.734	0.74
214_S	218_E	0.734	0.74
545_E	557_K	0.731	0.74
450_A	462_V	0.728	0.74
43_V	49_S	0.722	0.73
372_N	442_F	0.719	0.73
401_L	550_A	0.719	0.73
274_S	472_S	0.718	0.73
505_Y	515_F	0.718	0.73
284_A	326_E	0.716	0.73
277_M	326_E	0.716	0.73
274_S	283_K	0.711	0.72
70_L	213_V	0.707	0.72
157_A	207_A	0.706	0.72
585_N	613_P	0.706	0.72
221_Q	225_P	0.701	0.71
545_E	548_H	0.701	0.71
120_F	151_E	0.700	0.71
500_L	568_V	0.699	0.71
539_E	542_K	0.698	0.71
122_I	173_T	0.697	0.71
337_R	404_P	0.697	0.71
277_M	368_I	0.696	0.70
422_A	426_V	0.695	0.70
398_M	404_P	0.694	0.70
512_V	573_K	0.694	0.70
599_D	602_V	0.693	0.70
66_T	326_E	0.691	0.70
140_E	143_R	0.690	0.70
253_E	282_A	0.689	0.70
22_L	26_G	0.688	0.70
357_I	362_G	0.685	0.69
447_P	629_S	0.684	0.69
144_V	177_L	0.681	0.69
528_W	552_Y	0.679	0.69
206_N	249_V	0.678	0.68
592_V	608_V	0.678	0.68
325_A	425_L	0.677	0.68
284_A	422_A	0.676	0.68
377_R	597_I	0.675	0.68
447_P	468_P	0.675	0.68
73_E	641_I	0.675	0.68
584_G	608_V	0.674	0.68
498_E	546_E	0.673	0.68
585_N	589_P	0.672	0.68
83_L	156_I	0.672	0.68
382_L	387_L	0.672	0.68
48_I	58_I	0.672	0.68
584_G	613_P	0.671	0.68
588_K	591_E	0.671	0.68
113_L	208_V	0.671	0.68
220_L	224_L	0.671	0.68
286_V	432_L	0.670	0.68
313_S	324_L	0.668	0.67
144_V	147_K	0.667	0.67
144_V	152_N	0.666	0.67
352_A	355_G	0.665	0.67
357_I	402_G	0.665	0.67
244_A	258_A	0.665	0.67
138_Q	141_I	0.664	0.67
497_F	515_F	0.662	0.67
36_N	43_V	0.662	0.67
398_M	401_L	0.662	0.67
154_I	182_K	0.662	0.67
218_E	245_S	0.661	0.67
177_L	184_I	0.659	0.66
390_D	395_I	0.659	0.66
38_K	361_K	0.658	0.66
178_K	189_K	0.658	0.66
80_T	157_A	0.658	0.66
58_I	229_F	0.657	0.66
114_V	118_L	0.657	0.66
36_N	39_D	0.655	0.66
285_G	427_T	0.654	0.66
592_V	617_R	0.653	0.66
66_T	257_A	0.652	0.65
615_G	640_I	0.650	0.65
127_N	166_N	0.650	0.65
129_E	133_I	0.649	0.65
70_L	253_E	0.649	0.65
357_I	360_G	0.648	0.65
149_L	182_K	0.648	0.65
265_S	478_L	0.647	0.65
267_L	471_F	0.647	0.65
222_V	492_D	0.647	0.65
232_M	258_A	0.646	0.65
529_E	548_H	0.645	0.65
352_A	356_P	0.644	0.65
377_R	595_V	0.644	0.65
263_S	272_L	0.644	0.65
606_V	625_E	0.643	0.64
262_A	471_F	0.642	0.64
31_I	50_T	0.641	0.64
498_E	517_R	0.641	0.64
81_A	122_I	0.640	0.64
157_A	187_S	0.638	0.64
516_L	569_F	0.637	0.64
78_P	211_P	0.637	0.64
286_V	427_T	0.637	0.64
275_F	372_N	0.637	0.64
85_T	88_F	0.637	0.64
41_G	223_S	0.636	0.64
253_E	298_Y	0.635	0.63
288_I	432_L	0.635	0.63
284_A	471_F	0.632	0.63
337_R	405_Y	0.632	0.63
442_F	472_S	0.632	0.63
454_A	637_W	0.632	0.63
40_P	43_V	0.631	0.63
586_Y	594_K	0.629	0.63
383_I	386_N	0.629	0.63
526_Q	548_H	0.628	0.63
84_V	159_S	0.627	0.62
190_I	203_A	0.627	0.62
186_I	189_K	0.626	0.62
70_L	340_A	0.626	0.62
232_M	472_S	0.625	0.62
480_D	573_K	0.624	0.62
146_K	154_I	0.624	0.62
479_A	574_R	0.622	0.62
622_A	639_A	0.622	0.62
614_K	643_D	0.619	0.61
440_I	463_I	0.618	0.61
368_I	449_H	0.618	0.61
624_I	641_I	0.617	0.61
65_A	71_G	0.617	0.61
126_I	136_V	0.617	0.61
423_I	453_L	0.617	0.61
46_D	49_S	0.616	0.61
337_R	407_V	0.616	0.61
504_L	572_K	0.616	0.61
19_F	51_L	0.616	0.61
200_T	204_V	0.614	0.61
612_L	616_F	0.613	0.61
267_L	463_I	0.613	0.61
613_P	617_R	0.611	0.60
66_T	282_A	0.610	0.60
489_Y	566_I	0.610	0.60
377_R	632_V	0.609	0.60
576_L	579_I	0.608	0.60
201_S	316_P	0.607	0.60
464_I	631_T	0.607	0.60
452_Y	634_K	0.606	0.60
78_P	215_A	0.605	0.60
493_L	566_I	0.605	0.60
42_Q	45_K	0.605	0.60
419_M	449_H	0.604	0.60
271_S	437_F	0.604	0.60
484_E	567_R	0.604	0.60
593_R	623_I	0.603	0.59
136_V	160_Y	0.603	0.59
274_S	326_E	0.603	0.59
113_L	204_V	0.602	0.59
633_I	637_W	0.601	0.59
85_T	134_K	0.601	0.59
367_T	612_L	0.601	0.59
469_G	626_E	0.600	0.59
328_S	333_T	0.600	0.59
480_D	572_K	0.600	0.59
104_D	417_L	0.599	0.59
395_I	542_K	0.599	0.59
93_E	109_K	0.598	0.59
400_K	537_V	0.596	0.59
298_Y	326_E	0.595	0.58
468_P	626_E	0.595	0.58
485_V	511_N	0.594	0.58
409_K	600_D	0.594	0.58
401_L	411_A	0.594	0.58
53_C	607_Y	0.594	0.58
508_L	513_D	0.593	0.58
364_N	397_G	0.593	0.58
36_N	231_I	0.593	0.58
221_Q	245_S	0.592	0.58
535_N	539_E	0.591	0.58
91_I	105_L	0.589	0.58
372_N	448_Q	0.588	0.58
69_L	314_G	0.588	0.58
582_A	613_P	0.587	0.57
91_I	548_H	0.586	0.57
192_P	203_A	0.586	0.57
591_E	606_V	0.585	0.57
579_I	644_S	0.584	0.57
506_E	509_K	0.584	0.57
335_I	368_I	0.583	0.57
135_E	169_N	0.583	0.57
132_M	168_K	0.583	0.57
209_L	212_I	0.582	0.57
99_R	103_Y	0.582	0.57
244_A	251_L	0.581	0.57
205_V	327_V	0.581	0.57
239_V	476_L	0.581	0.57
547_K	551_T	0.580	0.57
14_G	18_D	0.579	0.56
68_T	209_L	0.579	0.56
83_L	214_S	0.579	0.56
186_I	190_I	0.578	0.56
157_A	185_S	0.576	0.56
495_S	502_K	0.576	0.56
239_V	244_A	0.576	0.56
626_E	629_S	0.575	0.56
584_G	589_P	0.575	0.56
356_P	359_Y	0.575	0.56
95_G	119_R	0.575	0.56
46_D	52_N	0.575	0.56
511_N	572_K	0.574	0.56
354_P	359_Y	0.574	0.56
580_K	643_D	0.574	0.56
155_S	210_M	0.573	0.56
96_R	446_G	0.573	0.56
225_P	242_K	0.573	0.56
49_S	52_N	0.573	0.56
283_K	313_S	0.572	0.56
84_V	160_Y	0.572	0.56
366_P	411_A	0.571	0.55
483_F	511_N	0.570	0.55
13_G	18_D	0.570	0.55
11_D	18_D	0.570	0.55
455_E	636_G	0.570	0.55
84_V	119_R	0.570	0.55
132_M	169_N	0.569	0.55
37_P	40_P	0.569	0.55
398_M	407_V	0.568	0.55
548_H	556_M	0.568	0.55
33_I	47_V	0.568	0.55
148_L	152_N	0.568	0.55
69_L	209_L	0.566	0.55
378_L	447_P	0.566	0.55
402_G	405_Y	0.566	0.55
557_K	560_E	0.566	0.55
61_A	324_L	0.565	0.55
72_Q	313_S	0.565	0.55
37_P	353_D	0.565	0.55
216_Y	257_A	0.564	0.54
194_P	529_E	0.564	0.54
610_E	614_K	0.564	0.54
14_G	17_T	0.563	0.54
257_A	322_V	0.563	0.54
531_T	567_R	0.563	0.54
372_N	412_L	0.562	0.54
281_T	298_Y	0.561	0.54
42_Q	223_S	0.561	0.54
42_Q	49_S	0.560	0.54
30_T	467_H	0.560	0.54
609_R	624_I	0.559	0.54
327_V	422_A	0.558	0.54
253_E	274_S	0.558	0.54
102_L	105_L	0.558	0.54
354_P	357_I	0.556	0.53
283_K	324_L	0.556	0.53
417_L	421_R	0.554	0.53
174_E	184_I	0.553	0.53
512_V	572_K	0.553	0.53
239_V	243_E	0.553	0.53
535_N	543_V	0.553	0.53
396_R	581_V	0.553	0.53
139_D	175_N	0.552	0.53
99_R	377_R	0.552	0.53
586_Y	616_F	0.551	0.53
66_T	448_Q	0.550	0.53
283_K	321_F	0.550	0.53
39_D	223_S	0.549	0.53
374_I	393_S	0.549	0.53
416_N	424_R	0.549	0.53
71_G	472_S	0.549	0.53
588_K	608_V	0.549	0.53
589_P	616_F	0.549	0.53
395_I	506_E	0.549	0.53
591_E	607_Y	0.549	0.53
267_L	646_V	0.549	0.53
596_V	602_V	0.548	0.52
416_N	437_F	0.548	0.52
581_V	615_G	0.548	0.52
326_E	329_A	0.548	0.52
83_L	204_V	0.548	0.52
450_A	464_I	0.547	0.52
579_I	645_I	0.547	0.52
118_L	147_K	0.546	0.52
96_R	434_P	0.546	0.52
504_L	568_V	0.545	0.52
414_L	417_L	0.545	0.52
476_L	527_G	0.544	0.52
277_M	416_N	0.544	0.52
231_I	251_L	0.544	0.52
97_Q	527_G	0.544	0.52
332_G	368_I	0.543	0.52
583_F	586_Y	0.542	0.52
589_P	613_P	0.542	0.52
103_Y	119_R	0.541	0.51
608_V	625_E	0.541	0.51
45_K	51_L	0.540	0.51
66_T	232_M	0.540	0.51
83_L	181_F	0.540	0.51
95_G	100_P	0.539	0.51
371_A	408_S	0.539	0.51
282_A	453_L	0.539	0.51
16_F	234_S	0.539	0.51
188_S	203_A	0.539	0.51
366_P	374_I	0.538	0.51
97_Q	476_L	0.538	0.51
164_Y	442_F	0.538	0.51
355_G	359_Y	0.538	0.51
253_E	257_A	0.538	0.51
11_D	14_G	0.537	0.51
439_L	459_I	0.537	0.51
392_E	579_I	0.537	0.51
143_R	172_I	0.537	0.51
232_M	457_V	0.536	0.51
243_E	507_K	0.536	0.51
65_A	213_V	0.536	0.51
372_N	415_V	0.536	0.51
415_V	418_E	0.536	0.51
215_A	219_R	0.535	0.51
587_D	605_D	0.535	0.51
584_G	618_I	0.534	0.51
546_E	549_L	0.534	0.51
499_Q	502_K	0.534	0.51
578_K	594_K	0.534	0.51
576_L	644_S	0.534	0.51
414_L	421_R	0.533	0.50
7_K	24_S	0.532	0.50
68_T	71_G	0.532	0.50
173_T	176_V	0.531	0.50
354_P	363_G	0.531	0.50
15_T	18_D	0.531	0.50
260_V	274_S	0.531	0.50
406_E	599_D	0.530	0.50
275_F	453_L	0.529	0.50
434_P	437_F	0.529	0.50
537_V	541_R	0.529	0.50
608_V	624_I	0.528	0.50
8_V	24_S	0.528	0.50
70_L	328_S	0.528	0.50
534_V	571_I	0.527	0.50
390_D	396_R	0.527	0.50
284_A	325_A	0.527	0.50
394_A	401_L	0.527	0.50
582_A	614_K	0.527	0.50
594_K	602_V	0.526	0.50
370_D	473_A	0.526	0.50
427_T	432_L	0.526	0.50
218_E	221_Q	0.525	0.49
476_L	529_E	0.525	0.49
95_G	109_K	0.525	0.49
234_S	253_E	0.525	0.49
89_R	119_R	0.525	0.49
512_V	592_V	0.524	0.49
45_K	227_E	0.524	0.49
406_E	409_K	0.524	0.49
54_N	57_E	0.523	0.49
586_Y	589_P	0.523	0.49
31_I	46_D	0.522	0.49
494_G	501_E	0.522	0.49
400_K	403_D	0.522	0.49
352_A	383_I	0.522	0.49
83_L	148_L	0.521	0.49
419_M	453_L	0.520	0.49
377_R	448_Q	0.519	0.49
194_P	471_F	0.519	0.49
543_V	594_K	0.518	0.48
59_A	238_L	0.518	0.48
277_M	419_M	0.518	0.48
42_Q	48_I	0.518	0.48
584_G	611_K	0.517	0.48
521_V	566_I	0.517	0.48
414_L	418_E	0.516	0.48
533_P	543_V	0.516	0.48
325_A	426_V	0.515	0.48
586_Y	611_K	0.515	0.48
486_R	520_D	0.515	0.48
97_Q	102_L	0.515	0.48
61_A	283_K	0.514	0.48
238_L	429_E	0.513	0.48
612_L	617_R	0.513	0.48
563_V	571_I	0.513	0.48
205_V	251_L	0.513	0.48
99_R	422_A	0.513	0.48
222_V	403_D	0.513	0.48
137_D	141_I	0.512	0.48
574_R	603_N	0.512	0.48
201_S	313_S	0.512	0.48
37_P	64_L	0.511	0.48
144_V	173_T	0.511	0.48
571_I	617_R	0.511	0.48
542_K	557_K	0.511	0.48
71_G	333_T	0.511	0.48
139_D	150_D	0.511	0.48
206_N	244_A	0.510	0.47
474_L	628_S	0.510	0.47
155_S	183_Y	0.510	0.47
493_L	563_V	0.510	0.47
476_L	623_I	0.510	0.47
538_N	586_Y	0.510	0.47
21_V	47_V	0.509	0.47
351_G	362_G	0.509	0.47
63_T	67_N	0.509	0.47
139_D	539_E	0.508	0.47
135_E	140_E	0.507	0.47
83_L	271_S	0.507	0.47
334_I	348_I	0.506	0.47
587_D	603_N	0.506	0.47
576_L	580_K	0.505	0.47
59_A	476_L	0.505	0.47
492_D	587_D	0.504	0.47
419_M	422_A	0.504	0.47
524_E	530_L	0.503	0.46
587_D	614_K	0.503	0.46
24_S	56_S	0.503	0.46
517_R	568_V	0.503	0.46
66_T	97_Q	0.503	0.46
240_D	511_N	0.502	0.46
28_I	458_G	0.502	0.46
578_K	581_V	0.501	0.46
493_L	497_F	0.500	0.46
234_S	324_L	0.500	0.46
446_G	468_P	0.500	0.46
327_V	421_R	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cetA	2	0.4677	100	0.772	Contact Map
3hz6A	1	0.6846	100	0.881	Contact Map
3ifrA	2	0.6754	100	0.881	Contact Map
4a2aA	1	0.5246	99.3	0.939	Contact Map
2itmA	2	0.6708	99.2	0.941	Contact Map
2zf5O	3	0.6877	99.1	0.945	Contact Map
3qdkA	2	0.74	98.8	0.95	Contact Map
3wqtA	2	0.5354	98.8	0.951	Contact Map
3ll3A	2	0.6938	98.8	0.951	Contact Map
3h1qA	1	0.3785	98.8	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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