GREMLIN Database
Q97UR6 - N-methylhydantoinase A (HyuA-3)
UniProt: Q97UR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 650 (622)
Sequences: 2947 (2034)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_Y173_T6.2921.00
138_Q172_I5.0341.00
142_E179_K4.6841.00
127_N131_N4.4681.00
174_E186_I4.3681.00
124_E132_M4.3431.00
391_K395_I4.0971.00
86_K123_D3.9771.00
123_D140_E3.8821.00
594_K603_N3.8481.00
141_I173_T3.4971.00
146_K150_D3.2441.00
89_R121_E3.2081.00
501_E517_R3.0781.00
159_S200_T3.0581.00
174_E178_K3.0511.00
172_I175_N3.0321.00
142_E180_Y2.9901.00
504_L570_A2.9721.00
642_D646_V2.9511.00
81_A148_L2.9221.00
138_Q176_V2.9051.00
85_T124_E2.8611.00
592_V603_N2.8431.00
146_K180_Y2.7071.00
42_Q46_D2.6781.00
118_L151_E2.6571.00
336_W348_I2.6521.00
497_F517_R2.6421.00
81_A120_F2.5691.00
82_L200_T2.5621.00
438_S461_K2.5591.00
101_R104_D2.5421.00
127_N133_I2.5021.00
79_K117_S2.4961.00
399_S403_D2.4951.00
74_N208_V2.4801.00
398_M411_A2.4771.00
145_A177_L2.4731.00
174_E189_K2.4661.00
541_R545_E2.4601.00
142_E176_V2.4531.00
514_Y573_K2.3821.00
487_K499_Q2.3701.00
137_D140_E2.3461.00
455_E637_W2.3441.00
335_I411_A2.3361.00
35_T64_L2.3071.00
43_V47_V2.2521.00
158_V186_I2.2311.00
149_L180_Y2.2211.00
123_D134_K2.2201.00
390_D393_S2.1981.00
185_S203_A2.1901.00
597_I604_V2.1541.00
47_V51_L2.1441.00
38_K42_Q2.0851.00
595_V604_V2.0731.00
608_V611_K2.0661.00
357_I393_S2.0571.00
118_L153_V2.0271.00
547_K550_A2.0141.00
596_V601_W2.0121.00
360_G390_D2.0101.00
501_E505_Y2.0091.00
149_L154_I1.9701.00
613_P616_F1.9151.00
158_V177_L1.9141.00
269_N461_K1.9081.00
393_S397_G1.8961.00
617_R638_N1.8841.00
619_G638_N1.8841.00
136_V173_T1.8811.00
140_E144_V1.8751.00
126_I132_M1.8751.00
167_P171_L1.8741.00
597_I635_D1.8671.00
274_S285_G1.8471.00
126_I169_N1.8311.00
594_K601_W1.8131.00
392_E395_I1.8041.00
641_I647_L1.7991.00
172_I176_V1.7821.00
617_R640_I1.7821.00
157_A203_A1.7821.00
373_L378_L1.7761.00
83_L122_I1.7761.00
549_L555_V1.7751.00
146_K149_L1.7741.00
73_E348_I1.7741.00
353_D361_K1.7711.00
515_F570_A1.7591.00
372_N449_H1.7591.00
374_I394_A1.7131.00
338_D344_K1.7111.00
70_L281_T1.7081.00
136_V169_N1.7071.00
136_V172_I1.7051.00
79_K154_I1.7011.00
176_V180_Y1.6961.00
158_V173_T1.6881.00
401_L407_V1.6881.00
451_V634_K1.6861.00
374_I398_M1.6811.00
156_I177_L1.6771.00
123_D137_D1.6691.00
438_S463_I1.6581.00
487_K496_E1.6511.00
81_A144_V1.6491.00
93_E119_R1.6421.00
171_L189_K1.6371.00
539_E543_V1.6341.00
609_R626_E1.6331.00
536_N539_E1.6281.00
19_F47_V1.6271.00
72_Q315_Y1.6241.00
171_L175_N1.6231.00
334_I367_T1.6201.00
92_I204_V1.6161.00
96_R198_E1.6041.00
158_V174_E1.5911.00
581_V643_D1.5901.00
545_E555_V1.5831.00
631_T647_L1.5791.00
416_N449_H1.5791.00
258_A476_L1.5721.00
72_Q208_V1.5711.00
37_P352_A1.5701.00
139_D142_E1.5701.00
487_K503_E1.5701.00
281_T326_E1.5601.00
23_A27_E1.5240.99
634_K637_W1.5220.99
78_P154_I1.5130.99
283_K326_E1.5070.99
175_N179_K1.5040.99
485_V504_L1.5010.99
396_R399_S1.4890.99
291_N516_L1.4790.99
183_Y210_M1.4740.99
253_E281_T1.4670.99
618_I639_A1.4660.99
126_I166_N1.4640.99
138_Q142_E1.4560.99
336_W344_K1.4530.99
253_E283_K1.4530.99
122_I141_I1.4510.99
590_R608_V1.4410.99
273_I423_I1.4410.99
249_V319_F1.4380.99
124_E134_K1.4350.99
633_I639_A1.4300.99
593_R625_E1.4250.99
623_I632_V1.4170.99
541_R561_I1.4070.99
340_A344_K1.4050.99
482_R569_F1.4020.99
404_P407_V1.4010.99
60_H216_Y1.3990.99
624_I639_A1.3930.99
393_S396_R1.3930.99
519_A566_I1.3910.99
519_A540_I1.3910.99
377_R412_L1.3890.99
43_V51_L1.3880.99
409_K599_D1.3880.99
373_L389_L1.3700.99
163_S188_S1.3690.99
275_F282_A1.3520.99
171_L188_S1.3510.99
441_A447_P1.3490.99
401_L404_P1.3420.99
214_S245_S1.3420.99
195_R529_E1.3360.99
516_L571_I1.3360.99
498_E502_K1.3290.99
506_E510_G1.3260.98
523_Y548_H1.3220.98
394_A398_M1.3220.98
253_E326_E1.3190.98
382_L385_G1.3180.98
20_I470_L1.3170.98
501_E515_F1.3130.98
149_L181_F1.3130.98
441_A450_A1.3100.98
639_A647_L1.3010.98
485_V507_K1.3010.98
515_F568_V1.2970.98
486_R565_T1.2900.98
379_G382_L1.2890.98
615_G641_I1.2870.98
589_P607_Y1.2820.98
86_K140_E1.2800.98
520_D565_T1.2770.98
400_K404_P1.2710.98
451_V637_W1.2700.98
604_V635_D1.2690.98
86_K121_E1.2680.98
368_I415_V1.2630.98
498_E501_E1.2500.98
523_Y545_E1.2490.98
502_K506_E1.2470.98
45_K48_I1.2470.98
335_I371_A1.2430.98
221_Q242_K1.2410.98
496_E499_Q1.2390.98
263_S274_S1.2390.98
542_K546_E1.2330.98
142_E146_K1.2320.98
505_Y513_D1.2300.98
83_L144_V1.2270.97
518_L531_T1.2250.97
80_T155_S1.2210.97
176_V179_K1.2200.97
85_T132_M1.2140.97
168_K171_L1.2130.97
39_D42_Q1.2110.97
358_S373_L1.2090.97
38_K353_D1.2080.97
23_A29_K1.2080.97
520_D531_T1.2060.97
357_I397_G1.2030.97
145_A173_T1.2020.97
68_T212_I1.1930.97
509_K513_D1.1780.97
618_I622_A1.1770.97
381_E591_E1.1770.97
494_G498_E1.1760.97
409_K413_G1.1730.97
494_G517_R1.1710.97
592_V605_D1.1690.97
120_F148_L1.1680.97
213_V251_L1.1610.96
147_K151_E1.1570.96
487_K500_L1.1560.96
193_E318_R1.1530.96
524_E560_E1.1530.96
8_V48_I1.1470.96
141_I144_V1.1430.96
185_S206_N1.1420.96
522_R562_E1.1390.96
413_G456_E1.1360.96
589_P592_V1.1350.96
247_K250_Q1.1340.96
8_V55_V1.1250.96
588_K611_K1.1250.96
132_M135_E1.1240.96
379_G625_E1.1230.96
260_V285_G1.1230.96
65_A209_L1.1170.96
139_D143_R1.1160.96
68_T73_E1.1140.96
379_G593_R1.1100.95
392_E396_R1.1100.95
609_R631_T1.1090.95
120_F144_V1.1030.95
519_A563_V1.1010.95
372_N416_N1.1010.95
91_I196_E1.0990.95
161_L196_E1.0930.95
114_V204_V1.0910.95
585_N588_K1.0900.95
143_R146_K1.0900.95
587_D611_K1.0850.95
191_A318_R1.0840.95
45_K49_S1.0710.94
120_F147_K1.0710.94
84_V91_I1.0690.94
187_S203_A1.0670.94
350_A367_T1.0660.94
136_V141_I1.0620.94
597_I632_V1.0500.94
499_Q503_E1.0480.94
398_M402_G1.0470.94
624_I647_L1.0460.94
357_I364_N1.0440.94
163_S187_S1.0410.94
497_F501_E1.0410.94
606_V623_I1.0370.93
373_L391_K1.0360.93
593_R606_V1.0360.93
589_P611_K1.0290.93
377_R452_Y1.0280.93
156_I181_F1.0260.93
235_S484_E1.0260.93
610_E627_Y1.0250.93
46_D50_T1.0220.93
394_A397_G1.0210.93
159_S187_S1.0190.93
522_R529_E1.0180.93
543_V547_K1.0160.93
583_F616_F1.0150.93
500_L503_E1.0100.93
148_L153_V1.0090.92
10_I58_I1.0080.92
41_G219_R1.0080.92
141_I176_V1.0070.92
217_L241_I1.0070.92
626_E631_T1.0050.92
417_L456_E1.0010.92
513_D570_A0.9990.92
520_D567_R0.9980.92
80_T204_V0.9970.92
79_K118_L0.9950.92
229_F241_I0.9950.92
189_K246_E0.9930.92
596_V600_D0.9910.92
47_V52_N0.9900.92
590_R611_K0.9890.92
122_I144_V0.9880.92
413_G598_D0.9850.92
7_K57_E0.9820.91
614_K645_I0.9780.91
612_L641_I0.9770.91
383_I387_L0.9750.91
35_T43_V0.9750.91
81_A153_V0.9750.91
546_E550_A0.9740.91
589_P605_D0.9740.91
217_L231_I0.9720.91
543_V546_E0.9720.91
521_V561_I0.9700.91
50_T386_N0.9670.91
485_V503_E0.9640.91
264_A292_F0.9640.91
270_E289_N0.9630.91
19_F31_I0.9630.91
143_R147_K0.9610.91
530_L551_T0.9600.90
468_P629_S0.9600.90
272_L440_I0.9590.90
587_D616_F0.9570.90
480_D576_L0.9540.90
470_L628_S0.9520.90
163_S203_A0.9510.90
622_A633_I0.9500.90
513_D572_K0.9500.90
595_V623_I0.9500.90
271_S436_N0.9470.90
366_P400_K0.9450.90
545_E561_I0.9430.90
185_S190_I0.9420.90
277_M372_N0.9400.90
65_A251_L0.9400.90
7_K56_S0.9400.90
609_R647_L0.9400.90
72_Q111_R0.9370.89
416_N452_Y0.9350.89
488_S565_T0.9330.89
252_I317_V0.9330.89
374_I395_I0.9310.89
33_I46_D0.9270.89
190_I247_K0.9270.89
451_V633_I0.9240.89
86_K134_K0.9240.89
79_K153_V0.9240.89
167_P188_S0.9190.88
145_A180_Y0.9180.88
402_G407_V0.9170.88
548_H554_F0.9160.88
9_A477_L0.9160.88
269_N438_S0.9140.88
372_N377_R0.9110.88
206_N210_M0.9100.88
84_V196_E0.9100.88
380_T391_K0.9080.88
582_A585_N0.9070.88
145_A181_F0.9070.88
441_A464_I0.9060.88
7_K22_L0.9060.88
175_N178_K0.9040.88
194_P488_S0.9000.87
624_I633_I0.8920.87
482_R571_I0.8910.87
423_I426_V0.8890.87
168_K172_I0.8870.87
271_S289_N0.8860.87
357_I366_P0.8850.87
409_K596_V0.8840.86
585_N616_F0.8820.86
343_L407_V0.8770.86
469_G629_S0.8760.86
607_Y612_L0.8750.86
360_G393_S0.8740.86
253_E324_L0.8730.86
138_Q175_N0.8730.86
338_D341_N0.8730.86
70_L326_E0.8720.86
135_E172_I0.8710.86
418_E421_R0.8700.86
604_V623_I0.8690.86
341_N344_K0.8640.85
162_H165_L0.8620.85
480_D571_I0.8620.85
122_I136_V0.8610.85
177_L181_F0.8610.85
468_P628_S0.8600.85
505_Y509_K0.8590.85
273_I434_P0.8590.85
233_S250_Q0.8550.85
202_T249_V0.8520.84
91_I200_T0.8510.84
237_G482_R0.8480.84
210_M248_P0.8470.84
83_L177_L0.8470.84
503_E506_E0.8460.84
497_F566_I0.8460.84
159_S203_A0.8460.84
483_F507_K0.8440.84
415_V419_M0.8420.84
468_P609_R0.8420.84
124_E169_N0.8390.83
233_S239_V0.8390.83
495_S499_Q0.8380.83
61_A258_A0.8360.83
523_Y556_M0.8360.83
44_I220_L0.8340.83
8_V21_V0.8320.83
83_L160_Y0.8300.83
512_V575_P0.8300.83
49_S227_E0.8300.83
604_V632_V0.8270.83
82_L159_S0.8260.83
588_K607_Y0.8240.82
223_S226_T0.8230.82
141_I145_A0.8210.82
39_D219_R0.8210.82
6_C21_V0.8210.82
274_S281_T0.8200.82
396_R400_K0.8200.82
397_G400_K0.8200.82
542_K555_V0.8170.82
21_V29_K0.8140.82
147_K150_D0.8110.81
69_L205_V0.8100.81
274_S442_F0.8100.81
454_A462_V0.8100.81
395_I399_S0.8090.81
283_K298_Y0.8090.81
504_L515_F0.8080.81
608_V627_Y0.8070.81
232_M476_L0.8060.81
12_I40_P0.8060.81
277_M449_H0.8050.81
266_F471_F0.8050.81
485_V568_V0.8040.81
489_Y496_E0.8030.81
273_I427_T0.8020.81
496_E566_I0.8020.81
357_I394_A0.8000.80
581_V644_S0.7990.80
597_I600_D0.7980.80
345_V414_L0.7970.80
81_A156_I0.7970.80
18_D32_K0.7960.80
548_H555_V0.7950.80
66_T71_G0.7940.80
223_S227_E0.7940.80
532_I547_K0.7930.80
82_L119_R0.7890.80
153_V156_I0.7890.80
253_E325_A0.7870.79
474_L579_I0.7850.79
282_A326_E0.7840.79
618_I624_I0.7820.79
335_I398_M0.7810.79
597_I602_V0.7800.79
284_A327_V0.7800.79
469_G609_R0.7790.79
607_Y618_I0.7780.79
277_M415_V0.7770.78
148_L156_I0.7770.78
584_G588_K0.7760.78
321_F326_E0.7750.78
454_A459_I0.7740.78
607_Y616_F0.7730.78
177_L180_Y0.7710.78
44_I47_V0.7710.78
95_G99_R0.7710.78
145_A176_V0.7690.78
432_L437_F0.7670.78
495_S498_E0.7670.78
337_R401_L0.7660.78
34_L352_A0.7630.77
69_L252_I0.7620.77
31_I47_V0.7610.77
154_I180_Y0.7610.77
150_D180_Y0.7610.77
391_K394_A0.7610.77
171_L174_E0.7610.77
595_V632_V0.7580.77
590_R625_E0.7570.77
122_I140_E0.7570.77
516_L533_P0.7550.76
193_E486_R0.7540.76
40_P64_L0.7530.76
148_L151_E0.7530.76
590_R607_Y0.7520.76
61_A476_L0.7500.76
381_E388_K0.7500.76
366_P398_M0.7500.76
144_V148_L0.7500.76
242_K246_E0.7500.76
83_L173_T0.7480.76
277_M445_A0.7470.76
218_E222_V0.7470.76
117_S153_V0.7470.76
143_R150_D0.7470.76
368_I411_A0.7470.76
146_K175_N0.7430.75
518_L533_P0.7430.75
178_K184_I0.7400.75
119_R200_T0.7400.75
259_G442_F0.7400.75
163_S167_P0.7400.75
504_L508_L0.7390.75
6_C26_G0.7340.74
118_L148_L0.7340.74
214_S218_E0.7340.74
545_E557_K0.7310.74
450_A462_V0.7280.74
43_V49_S0.7220.73
372_N442_F0.7190.73
401_L550_A0.7190.73
274_S472_S0.7180.73
505_Y515_F0.7180.73
284_A326_E0.7160.73
277_M326_E0.7160.73
274_S283_K0.7110.72
70_L213_V0.7070.72
157_A207_A0.7060.72
585_N613_P0.7060.72
221_Q225_P0.7010.71
545_E548_H0.7010.71
120_F151_E0.7000.71
500_L568_V0.6990.71
539_E542_K0.6980.71
122_I173_T0.6970.71
337_R404_P0.6970.71
277_M368_I0.6960.70
422_A426_V0.6950.70
398_M404_P0.6940.70
512_V573_K0.6940.70
599_D602_V0.6930.70
66_T326_E0.6910.70
140_E143_R0.6900.70
253_E282_A0.6890.70
22_L26_G0.6880.70
357_I362_G0.6850.69
447_P629_S0.6840.69
144_V177_L0.6810.69
528_W552_Y0.6790.69
206_N249_V0.6780.68
592_V608_V0.6780.68
325_A425_L0.6770.68
284_A422_A0.6760.68
377_R597_I0.6750.68
447_P468_P0.6750.68
73_E641_I0.6750.68
584_G608_V0.6740.68
498_E546_E0.6730.68
585_N589_P0.6720.68
83_L156_I0.6720.68
382_L387_L0.6720.68
48_I58_I0.6720.68
584_G613_P0.6710.68
588_K591_E0.6710.68
113_L208_V0.6710.68
220_L224_L0.6710.68
286_V432_L0.6700.68
313_S324_L0.6680.67
144_V147_K0.6670.67
144_V152_N0.6660.67
352_A355_G0.6650.67
357_I402_G0.6650.67
244_A258_A0.6650.67
138_Q141_I0.6640.67
497_F515_F0.6620.67
36_N43_V0.6620.67
398_M401_L0.6620.67
154_I182_K0.6620.67
218_E245_S0.6610.67
177_L184_I0.6590.66
390_D395_I0.6590.66
38_K361_K0.6580.66
178_K189_K0.6580.66
80_T157_A0.6580.66
58_I229_F0.6570.66
114_V118_L0.6570.66
36_N39_D0.6550.66
285_G427_T0.6540.66
592_V617_R0.6530.66
66_T257_A0.6520.65
615_G640_I0.6500.65
127_N166_N0.6500.65
129_E133_I0.6490.65
70_L253_E0.6490.65
357_I360_G0.6480.65
149_L182_K0.6480.65
265_S478_L0.6470.65
267_L471_F0.6470.65
222_V492_D0.6470.65
232_M258_A0.6460.65
529_E548_H0.6450.65
352_A356_P0.6440.65
377_R595_V0.6440.65
263_S272_L0.6440.65
606_V625_E0.6430.64
262_A471_F0.6420.64
31_I50_T0.6410.64
498_E517_R0.6410.64
81_A122_I0.6400.64
157_A187_S0.6380.64
516_L569_F0.6370.64
78_P211_P0.6370.64
286_V427_T0.6370.64
275_F372_N0.6370.64
85_T88_F0.6370.64
41_G223_S0.6360.64
253_E298_Y0.6350.63
288_I432_L0.6350.63
284_A471_F0.6320.63
337_R405_Y0.6320.63
442_F472_S0.6320.63
454_A637_W0.6320.63
40_P43_V0.6310.63
586_Y594_K0.6290.63
383_I386_N0.6290.63
526_Q548_H0.6280.63
84_V159_S0.6270.62
190_I203_A0.6270.62
186_I189_K0.6260.62
70_L340_A0.6260.62
232_M472_S0.6250.62
480_D573_K0.6240.62
146_K154_I0.6240.62
479_A574_R0.6220.62
622_A639_A0.6220.62
614_K643_D0.6190.61
440_I463_I0.6180.61
368_I449_H0.6180.61
624_I641_I0.6170.61
65_A71_G0.6170.61
126_I136_V0.6170.61
423_I453_L0.6170.61
46_D49_S0.6160.61
337_R407_V0.6160.61
504_L572_K0.6160.61
19_F51_L0.6160.61
200_T204_V0.6140.61
612_L616_F0.6130.61
267_L463_I0.6130.61
613_P617_R0.6110.60
66_T282_A0.6100.60
489_Y566_I0.6100.60
377_R632_V0.6090.60
576_L579_I0.6080.60
201_S316_P0.6070.60
464_I631_T0.6070.60
452_Y634_K0.6060.60
78_P215_A0.6050.60
493_L566_I0.6050.60
42_Q45_K0.6050.60
419_M449_H0.6040.60
271_S437_F0.6040.60
484_E567_R0.6040.60
593_R623_I0.6030.59
136_V160_Y0.6030.59
274_S326_E0.6030.59
113_L204_V0.6020.59
633_I637_W0.6010.59
85_T134_K0.6010.59
367_T612_L0.6010.59
469_G626_E0.6000.59
328_S333_T0.6000.59
480_D572_K0.6000.59
104_D417_L0.5990.59
395_I542_K0.5990.59
93_E109_K0.5980.59
400_K537_V0.5960.59
298_Y326_E0.5950.58
468_P626_E0.5950.58
485_V511_N0.5940.58
409_K600_D0.5940.58
401_L411_A0.5940.58
53_C607_Y0.5940.58
508_L513_D0.5930.58
364_N397_G0.5930.58
36_N231_I0.5930.58
221_Q245_S0.5920.58
535_N539_E0.5910.58
91_I105_L0.5890.58
372_N448_Q0.5880.58
69_L314_G0.5880.58
582_A613_P0.5870.57
91_I548_H0.5860.57
192_P203_A0.5860.57
591_E606_V0.5850.57
579_I644_S0.5840.57
506_E509_K0.5840.57
335_I368_I0.5830.57
135_E169_N0.5830.57
132_M168_K0.5830.57
209_L212_I0.5820.57
99_R103_Y0.5820.57
244_A251_L0.5810.57
205_V327_V0.5810.57
239_V476_L0.5810.57
547_K551_T0.5800.57
14_G18_D0.5790.56
68_T209_L0.5790.56
83_L214_S0.5790.56
186_I190_I0.5780.56
157_A185_S0.5760.56
495_S502_K0.5760.56
239_V244_A0.5760.56
626_E629_S0.5750.56
584_G589_P0.5750.56
356_P359_Y0.5750.56
95_G119_R0.5750.56
46_D52_N0.5750.56
511_N572_K0.5740.56
354_P359_Y0.5740.56
580_K643_D0.5740.56
155_S210_M0.5730.56
96_R446_G0.5730.56
225_P242_K0.5730.56
49_S52_N0.5730.56
283_K313_S0.5720.56
84_V160_Y0.5720.56
366_P411_A0.5710.55
483_F511_N0.5700.55
13_G18_D0.5700.55
11_D18_D0.5700.55
455_E636_G0.5700.55
84_V119_R0.5700.55
132_M169_N0.5690.55
37_P40_P0.5690.55
398_M407_V0.5680.55
548_H556_M0.5680.55
33_I47_V0.5680.55
148_L152_N0.5680.55
69_L209_L0.5660.55
378_L447_P0.5660.55
402_G405_Y0.5660.55
557_K560_E0.5660.55
61_A324_L0.5650.55
72_Q313_S0.5650.55
37_P353_D0.5650.55
216_Y257_A0.5640.54
194_P529_E0.5640.54
610_E614_K0.5640.54
14_G17_T0.5630.54
257_A322_V0.5630.54
531_T567_R0.5630.54
372_N412_L0.5620.54
281_T298_Y0.5610.54
42_Q223_S0.5610.54
42_Q49_S0.5600.54
30_T467_H0.5600.54
609_R624_I0.5590.54
327_V422_A0.5580.54
253_E274_S0.5580.54
102_L105_L0.5580.54
354_P357_I0.5560.53
283_K324_L0.5560.53
417_L421_R0.5540.53
174_E184_I0.5530.53
512_V572_K0.5530.53
239_V243_E0.5530.53
535_N543_V0.5530.53
396_R581_V0.5530.53
139_D175_N0.5520.53
99_R377_R0.5520.53
586_Y616_F0.5510.53
66_T448_Q0.5500.53
283_K321_F0.5500.53
39_D223_S0.5490.53
374_I393_S0.5490.53
416_N424_R0.5490.53
71_G472_S0.5490.53
588_K608_V0.5490.53
589_P616_F0.5490.53
395_I506_E0.5490.53
591_E607_Y0.5490.53
267_L646_V0.5490.53
596_V602_V0.5480.52
416_N437_F0.5480.52
581_V615_G0.5480.52
326_E329_A0.5480.52
83_L204_V0.5480.52
450_A464_I0.5470.52
579_I645_I0.5470.52
118_L147_K0.5460.52
96_R434_P0.5460.52
504_L568_V0.5450.52
414_L417_L0.5450.52
476_L527_G0.5440.52
277_M416_N0.5440.52
231_I251_L0.5440.52
97_Q527_G0.5440.52
332_G368_I0.5430.52
583_F586_Y0.5420.52
589_P613_P0.5420.52
103_Y119_R0.5410.51
608_V625_E0.5410.51
45_K51_L0.5400.51
66_T232_M0.5400.51
83_L181_F0.5400.51
95_G100_P0.5390.51
371_A408_S0.5390.51
282_A453_L0.5390.51
16_F234_S0.5390.51
188_S203_A0.5390.51
366_P374_I0.5380.51
97_Q476_L0.5380.51
164_Y442_F0.5380.51
355_G359_Y0.5380.51
253_E257_A0.5380.51
11_D14_G0.5370.51
439_L459_I0.5370.51
392_E579_I0.5370.51
143_R172_I0.5370.51
232_M457_V0.5360.51
243_E507_K0.5360.51
65_A213_V0.5360.51
372_N415_V0.5360.51
415_V418_E0.5360.51
215_A219_R0.5350.51
587_D605_D0.5350.51
584_G618_I0.5340.51
546_E549_L0.5340.51
499_Q502_K0.5340.51
578_K594_K0.5340.51
576_L644_S0.5340.51
414_L421_R0.5330.50
7_K24_S0.5320.50
68_T71_G0.5320.50
173_T176_V0.5310.50
354_P363_G0.5310.50
15_T18_D0.5310.50
260_V274_S0.5310.50
406_E599_D0.5300.50
275_F453_L0.5290.50
434_P437_F0.5290.50
537_V541_R0.5290.50
608_V624_I0.5280.50
8_V24_S0.5280.50
70_L328_S0.5280.50
534_V571_I0.5270.50
390_D396_R0.5270.50
284_A325_A0.5270.50
394_A401_L0.5270.50
582_A614_K0.5270.50
594_K602_V0.5260.50
370_D473_A0.5260.50
427_T432_L0.5260.50
218_E221_Q0.5250.49
476_L529_E0.5250.49
95_G109_K0.5250.49
234_S253_E0.5250.49
89_R119_R0.5250.49
512_V592_V0.5240.49
45_K227_E0.5240.49
406_E409_K0.5240.49
54_N57_E0.5230.49
586_Y589_P0.5230.49
31_I46_D0.5220.49
494_G501_E0.5220.49
400_K403_D0.5220.49
352_A383_I0.5220.49
83_L148_L0.5210.49
419_M453_L0.5200.49
377_R448_Q0.5190.49
194_P471_F0.5190.49
543_V594_K0.5180.48
59_A238_L0.5180.48
277_M419_M0.5180.48
42_Q48_I0.5180.48
584_G611_K0.5170.48
521_V566_I0.5170.48
414_L418_E0.5160.48
533_P543_V0.5160.48
325_A426_V0.5150.48
586_Y611_K0.5150.48
486_R520_D0.5150.48
97_Q102_L0.5150.48
61_A283_K0.5140.48
238_L429_E0.5130.48
612_L617_R0.5130.48
563_V571_I0.5130.48
205_V251_L0.5130.48
99_R422_A0.5130.48
222_V403_D0.5130.48
137_D141_I0.5120.48
574_R603_N0.5120.48
201_S313_S0.5120.48
37_P64_L0.5110.48
144_V173_T0.5110.48
571_I617_R0.5110.48
542_K557_K0.5110.48
71_G333_T0.5110.48
139_D150_D0.5110.48
206_N244_A0.5100.47
474_L628_S0.5100.47
155_S183_Y0.5100.47
493_L563_V0.5100.47
476_L623_I0.5100.47
538_N586_Y0.5100.47
21_V47_V0.5090.47
351_G362_G0.5090.47
63_T67_N0.5090.47
139_D539_E0.5080.47
135_E140_E0.5070.47
83_L271_S0.5070.47
334_I348_I0.5060.47
587_D603_N0.5060.47
576_L580_K0.5050.47
59_A476_L0.5050.47
492_D587_D0.5040.47
419_M422_A0.5040.47
524_E530_L0.5030.46
587_D614_K0.5030.46
24_S56_S0.5030.46
517_R568_V0.5030.46
66_T97_Q0.5030.46
240_D511_N0.5020.46
28_I458_G0.5020.46
578_K581_V0.5010.46
493_L497_F0.5000.46
234_S324_L0.5000.46
446_G468_P0.5000.46
327_V421_R0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cetA 2 0.4677 100 0.772 Contact Map
3hz6A 1 0.6846 100 0.881 Contact Map
3ifrA 2 0.6754 100 0.881 Contact Map
4a2aA 1 0.5246 99.3 0.939 Contact Map
2itmA 2 0.6708 99.2 0.941 Contact Map
2zf5O 3 0.6877 99.1 0.945 Contact Map
3qdkA 2 0.74 98.8 0.95 Contact Map
3wqtA 2 0.5354 98.8 0.951 Contact Map
3ll3A 2 0.6938 98.8 0.951 Contact Map
3h1qA 1 0.3785 98.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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