GREMLIN Database
Q97UR3 - Maleate cis-trans isomerase, probable (MaiA)
UniProt: Q97UR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (230)
Sequences: 1271 (828)
Seq/√Len: 54.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V206_E6.3131.00
112_N221_E5.3181.00
119_I186_G4.4491.00
212_I217_A4.0981.00
120_K185_D3.9101.00
173_A189_I3.4321.00
73_S222_T3.3591.00
119_I185_D3.3071.00
201_S205_K3.1051.00
73_S218_T3.0331.00
71_I222_T2.7931.00
177_L209_K2.6791.00
170_Y206_E2.6621.00
183_D209_K2.6331.00
113_A220_W2.4381.00
121_R146_E2.2551.00
104_T221_E2.2521.00
173_A187_V2.2481.00
173_A203_L2.2411.00
93_Q97_K2.1641.00
155_I164_V2.1441.00
170_Y202_R2.0901.00
171_N175_N2.0501.00
123_V148_V1.9491.00
117_L212_I1.9191.00
123_V184_Y1.8470.99
58_E94_R1.8370.99
201_S234_E1.8350.99
148_V184_Y1.7960.99
114_L119_I1.7670.99
233_R240_E1.7480.99
119_I122_L1.7450.99
114_L145_F1.7300.99
190_S214_S1.7270.99
6_V222_T1.6980.99
138_E141_S1.6910.99
11_P14_N1.6890.99
207_T211_V1.6600.99
56_E59_R1.6600.99
123_V177_L1.6310.98
110_V217_A1.5930.98
115_R145_F1.5930.98
221_E225_K1.5890.98
187_V207_T1.5890.98
125_L176_V1.5830.98
201_S240_E1.5670.98
170_Y203_L1.5650.98
202_R205_K1.5320.98
62_S98_I1.5230.98
111_I143_N1.5160.98
124_L150_S1.4920.97
104_T225_K1.4910.97
110_V140_F1.4780.97
200_L213_S1.4520.97
182_G209_K1.4510.97
24_V197_F1.4230.96
166_P198_E1.4180.96
8_V75_A1.4170.96
165_T168_E1.4100.96
169_V194_L1.3900.96
9_I40_I1.3840.96
50_L53_M1.3810.96
141_S146_E1.3390.95
134_K138_E1.3330.95
203_L206_E1.3280.95
96_E99_A1.2840.94
15_T193_N1.2830.94
130_E134_K1.2740.93
50_L76_C1.2670.93
71_I226_I1.2670.93
72_I95_I1.2550.93
81_L107_S1.2460.93
221_E224_Y1.2420.93
39_R127_P1.2400.92
200_L216_S1.2390.92
213_S216_S1.2220.92
59_R63_E1.2150.92
151_A175_N1.1970.91
90_E93_Q1.1890.91
110_V188_F1.1820.91
133_N150_S1.1580.90
127_P191_C1.1470.89
24_V232_V1.1390.89
122_L140_F1.1230.88
14_N158_N1.1220.88
24_V235_L1.1080.87
181_K209_K1.0990.87
113_A238_L1.0960.87
24_V219_L1.0940.87
169_V196_T1.0930.87
76_C128_Y1.0910.87
10_I14_N1.0710.86
110_V212_I1.0490.84
125_L172_F1.0370.84
110_V122_L1.0350.84
20_E80_S1.0250.83
149_K176_V1.0250.83
89_E143_N1.0240.83
77_T106_T1.0240.83
153_M164_V1.0160.82
13_S158_N1.0160.82
17_V193_N1.0130.82
137_I150_S1.0090.82
170_Y199_I1.0070.82
79_G191_C1.0040.82
76_C191_C1.0040.82
177_L181_K0.9940.81
11_P158_N0.9820.80
153_M172_F0.9810.80
181_K184_Y0.9790.80
148_V182_G0.9700.79
116_R220_W0.9690.79
23_N198_E0.9680.79
203_L207_T0.9660.79
166_P199_I0.9630.79
75_A79_G0.9630.79
204_E236_G0.9480.78
109_S221_E0.9440.78
11_P65_S0.9350.77
111_I140_F0.9320.77
124_L212_I0.9150.75
121_R185_D0.9140.75
151_A176_V0.9110.75
115_R143_N0.9070.75
107_S139_F0.9040.74
220_W238_L0.8960.74
133_N152_G0.8940.74
169_V203_L0.8940.74
148_V181_K0.8920.73
25_F219_L0.8920.73
87_H90_E0.8880.73
25_F35_P0.8820.73
125_L151_A0.8820.73
4_I226_I0.8810.72
184_Y209_K0.8760.72
189_I211_V0.8730.72
220_W224_Y0.8680.71
36_H39_R0.8540.70
38_S63_E0.8540.70
177_L182_G0.8530.70
192_T215_N0.8520.70
130_E133_N0.8460.69
74_Y191_C0.8460.69
17_V75_A0.8330.68
17_V194_L0.8330.68
33_I228_L0.8310.68
113_A117_L0.8250.67
38_S60_A0.8170.67
199_I203_L0.8160.67
12_S158_N0.8150.66
7_G90_E0.8140.66
142_K229_N0.8140.66
114_L212_I0.8130.66
11_P106_T0.8090.66
20_E215_N0.8050.66
168_E171_N0.8040.65
14_N106_T0.8020.65
177_L184_Y0.7900.64
111_I145_F0.7860.64
164_V168_E0.7850.64
161_I193_N0.7850.64
81_L136_E0.7790.63
15_T162_G0.7780.63
165_T169_V0.7780.63
236_G239_F0.7710.62
186_G210_P0.7700.62
18_E50_L0.7620.61
32_R230_I0.7540.60
106_T192_T0.7460.60
128_Y191_C0.7410.59
7_G64_L0.7400.59
76_C190_S0.7390.59
130_E154_G0.7380.59
33_I223_L0.7320.58
113_A204_E0.7250.57
81_L140_F0.7250.57
54_E91_I0.7230.57
106_T188_F0.7210.57
4_I32_R0.7150.56
53_M190_S0.7130.56
16_T194_L0.7110.56
14_N18_E0.7100.56
106_T136_E0.7050.55
80_S190_S0.7030.55
224_Y230_I0.7030.55
205_K239_F0.6990.55
164_V194_L0.6990.55
45_V193_N0.6980.55
153_M218_T0.6970.54
110_V114_L0.6960.54
76_C215_N0.6960.54
73_S104_T0.6940.54
116_R224_Y0.6930.54
65_S97_K0.6920.54
121_R148_V0.6870.53
53_M78_T0.6860.53
165_T195_R0.6840.53
122_L182_G0.6830.53
53_M161_I0.6820.53
72_I101_V0.6810.53
132_V169_V0.6800.53
166_P195_R0.6750.52
134_K137_I0.6720.52
4_I33_I0.6710.52
8_V25_F0.6690.51
126_T191_C0.6680.51
14_N192_T0.6670.51
10_I15_T0.6670.51
107_S136_E0.6640.51
88_H106_T0.6640.51
11_P188_F0.6620.51
98_I103_A0.6610.51
61_A72_I0.6600.51
111_I114_L0.6570.50
14_N42_L0.6550.50
130_E152_G0.6520.50
181_K187_V0.6500.49
174_V203_L0.6500.49
71_I102_P0.6500.49
18_E22_S0.6500.49
80_S136_E0.6490.49
113_A116_R0.6490.49
107_S169_V0.6490.49
111_I115_R0.6480.49
9_I49_D0.6480.49
106_T153_M0.6470.49
6_V226_I0.6460.49
11_P88_H0.6450.49
200_L204_E0.6450.49
65_S101_V0.6420.49
199_I202_R0.6410.48
72_I93_Q0.6410.48
14_N36_H0.6380.48
59_R62_S0.6340.48
95_I103_A0.6320.48
115_R171_N0.6310.47
74_Y190_S0.6300.47
53_M74_Y0.6280.47
12_S110_V0.6270.47
117_L239_F0.6270.47
14_N136_E0.6240.47
18_E158_N0.6220.46
8_V21_F0.6220.46
187_V203_L0.6200.46
182_G185_D0.6190.46
11_P95_I0.6180.46
86_K90_E0.6160.46
115_R119_I0.6150.46
207_T210_P0.6150.46
121_R240_E0.6140.46
74_Y188_F0.6120.45
77_T191_C0.6110.45
77_T192_T0.6100.45
157_E160_K0.6090.45
48_E202_R0.6090.45
185_D210_P0.6040.45
74_Y108_G0.6040.45
20_E213_S0.6020.44
81_L191_C0.6000.44
20_E75_A0.5980.44
118_D121_R0.5970.44
58_E98_I0.5960.44
5_K124_L0.5960.44
120_K146_E0.5950.44
19_Y22_S0.5930.43
14_N78_T0.5920.43
209_K224_Y0.5890.43
128_Y192_T0.5880.43
224_Y227_N0.5850.43
20_E195_R0.5840.42
171_N206_E0.5830.42
198_E201_S0.5810.42
51_A135_K0.5810.42
151_A172_F0.5800.42
79_G157_E0.5790.42
103_A148_V0.5770.42
64_L77_T0.5760.42
187_V211_V0.5760.42
167_E199_I0.5720.41
69_P95_I0.5690.41
119_I145_F0.5640.40
115_R120_K0.5630.40
106_T218_T0.5620.40
16_T20_E0.5610.40
109_S112_N0.5610.40
119_I212_I0.5600.40
116_R186_G0.5580.40
31_Y34_T0.5570.40
232_V235_L0.5560.40
46_T53_M0.5550.39
13_S17_V0.5550.39
77_T215_N0.5540.39
153_M168_E0.5530.39
187_V209_K0.5520.39
125_L173_A0.5520.39
148_V183_D0.5510.39
204_E238_L0.5510.39
108_G112_N0.5510.39
167_E171_N0.5500.39
182_G231_K0.5480.39
58_E72_I0.5460.38
171_N231_K0.5450.38
9_I61_A0.5420.38
137_I151_A0.5420.38
61_A145_F0.5390.38
47_I51_A0.5380.38
96_E100_K0.5370.38
65_S69_P0.5360.37
112_N116_R0.5340.37
14_N216_S0.5310.37
116_R200_L0.5300.37
25_F187_V0.5300.37
113_A216_S0.5290.37
21_F25_F0.5290.37
171_N183_D0.5290.37
124_L147_I0.5280.37
8_V73_S0.5270.37
104_T108_G0.5270.37
15_T36_H0.5270.37
235_L239_F0.5260.36
167_E202_R0.5250.36
211_V216_S0.5250.36
62_S174_V0.5250.36
117_L145_F0.5250.36
79_G192_T0.5230.36
175_N202_R0.5230.36
114_L122_L0.5220.36
141_S150_S0.5200.36
71_I225_K0.5190.36
93_Q231_K0.5170.36
201_S227_N0.5150.35
16_T163_Q0.5140.35
13_S42_L0.5140.35
170_Y174_V0.5130.35
174_V237_H0.5130.35
106_T214_S0.5130.35
155_I161_I0.5130.35
62_S95_I0.5120.35
53_M81_L0.5090.35
83_K88_H0.5080.35
5_K196_T0.5080.35
141_S147_I0.5070.35
81_L139_F0.5060.35
88_H95_I0.5040.34
81_L218_T0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fq5B 4 0.9835 100 0.419 Contact Map
2xedA 1 0.9711 100 0.432 Contact Map
4ix1A 2 0.9339 100 0.435 Contact Map
3ixlA 1 0.9545 100 0.442 Contact Map
2dgdA 4 0.9091 100 0.506 Contact Map
2eq5A 2 0.8719 99.9 0.637 Contact Map
3qvlA 3 0.9174 99.9 0.653 Contact Map
3istA 2 0.9132 99.9 0.683 Contact Map
1b73A 2 0.8884 99.9 0.687 Contact Map
2vvtA 2 0.9132 99.9 0.702 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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