GREMLIN Database
Q97UR2 - Uncharacterized protein
UniProt: Q97UR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (176)
Sequences: 12541 (9123)
Seq/√Len: 687.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_L141_G4.8291.00
32_K62_D4.2311.00
66_L77_S3.4891.00
63_G86_Y2.9511.00
128_K145_K2.8721.00
65_I142_V2.6861.00
34_L63_G2.5881.00
127_L144_Y2.5201.00
28_D33_Y2.4651.00
36_Y67_S2.4101.00
129_F140_L2.3651.00
171_D174_E2.3321.00
63_G84_K2.1691.00
129_F142_V2.1521.00
88_T140_L2.0011.00
147_T190_V1.9241.00
183_L205_K1.9191.00
25_V190_V1.9091.00
33_Y56_L1.8791.00
128_K143_M1.8351.00
91_E138_G1.7881.00
180_R208_I1.7831.00
139_S151_G1.7661.00
84_K116_V1.7351.00
89_R119_K1.6961.00
25_V149_F1.6951.00
141_G148_I1.6521.00
120_N181_K1.6371.00
32_K63_G1.6211.00
36_Y149_F1.5991.00
143_M148_I1.5581.00
122_E128_K1.5371.00
50_A53_D1.5281.00
92_V96_K1.5131.00
183_L208_I1.5071.00
130_I143_M1.4961.00
86_Y116_V1.4721.00
28_D56_L1.4681.00
205_K208_I1.4321.00
33_Y61_I1.4261.00
50_A54_S1.4171.00
115_I118_V1.4051.00
34_L65_I1.3981.00
134_G178_S1.3741.00
181_K184_K1.3721.00
204_N208_I1.3571.00
87_T91_E1.3471.00
164_E169_Y1.3431.00
38_P64_V1.3401.00
136_T139_S1.3311.00
199_I202_D1.3211.00
88_T131_L1.3061.00
61_I83_A1.3021.00
174_E177_K1.3001.00
67_S151_G1.2811.00
51_L61_I1.2711.00
132_L178_S1.2671.00
132_L139_S1.2471.00
150_V189_V1.2401.00
143_M187_N1.2361.00
141_G182_V1.2181.00
33_Y62_D1.2091.00
177_K180_R1.1971.00
48_L52_K1.1961.00
49_K52_K1.1791.00
77_S85_V1.1781.00
49_K53_D1.1711.00
45_E49_K1.1581.00
36_Y142_V1.1401.00
38_P77_S1.1241.00
130_I141_G1.1221.00
46_V50_A1.1191.00
133_P178_S1.1031.00
89_R93_E1.0901.00
180_R184_K1.0871.00
93_E97_N1.0811.00
35_I61_I1.0761.00
153_A182_V1.0761.00
67_S142_V1.0761.00
173_T177_K1.0681.00
203_S206_I1.0471.00
81_P115_I1.0381.00
188_K196_P1.0321.00
130_I181_K1.0291.00
118_V121_N1.0271.00
78_L81_P1.0131.00
167_F170_Y1.0061.00
90_E93_E0.9931.00
32_K57_S0.9931.00
29_I32_K0.9881.00
91_E136_T0.9771.00
203_S207_E0.9721.00
110_L113_E0.9721.00
27_M36_Y0.9691.00
117_L121_N0.9691.00
26_L50_A0.9671.00
78_L82_N0.9571.00
86_Y118_V0.9431.00
118_V140_L0.9381.00
23_N194_D0.9291.00
143_M185_L0.9281.00
141_G153_A0.9161.00
166_S169_Y0.9121.00
147_T188_K0.9071.00
180_R183_L0.9051.00
26_L35_I0.9011.00
175_A179_I0.9001.00
35_I38_P0.8851.00
128_K185_L0.8801.00
88_T91_E0.8721.00
95_T98_T0.8651.00
89_R92_V0.8601.00
201_R205_K0.8591.00
176_N180_R0.8581.00
172_I175_A0.8531.00
120_N131_L0.8491.00
34_L127_L0.8461.00
91_E94_Y0.8441.00
114_R118_V0.8431.00
92_V117_L0.8411.00
35_I47_L0.8371.00
188_K198_T0.8351.00
69_M91_E0.8171.00
36_Y65_I0.8141.00
165_T168_A0.8101.00
93_E96_K0.8041.00
90_E131_L0.8011.00
64_V83_A0.7981.00
149_F190_V0.7961.00
25_V192_G0.7941.00
122_E125_D0.7891.00
115_I121_N0.7881.00
91_E95_T0.7881.00
24_I47_L0.7871.00
165_T170_Y0.7821.00
164_E170_Y0.7811.00
177_K181_K0.7801.00
29_I125_D0.7771.00
172_I176_N0.7721.00
191_P194_D0.7701.00
87_T92_V0.7681.00
148_I189_V0.7681.00
148_I185_L0.7641.00
179_I183_L0.7621.00
153_A178_S0.7531.00
23_N192_G0.7511.00
150_V154_I0.7501.00
164_E167_F0.7491.00
77_S81_P0.7451.00
26_L33_Y0.7411.00
47_L50_A0.7331.00
52_K57_S0.7331.00
64_V85_V0.7331.00
153_A175_A0.7311.00
164_E168_A0.7281.00
114_R117_L0.7241.00
64_V77_S0.7241.00
71_Y75_L0.7241.00
117_L120_N0.7201.00
121_N128_K0.7171.00
166_S170_Y0.7141.00
167_F172_I0.7131.00
65_I127_L0.7131.00
24_I39_G0.7131.00
92_V95_T0.7111.00
95_T99_P0.7091.00
46_V49_K0.7081.00
181_K185_L0.7071.00
62_D84_K0.7001.00
64_V80_F0.6981.00
40_H44_R0.6981.00
51_L56_L0.6981.00
38_P76_N0.6961.00
76_N79_L0.6951.00
116_V119_K0.6941.00
202_D206_I0.6941.00
94_Y99_P0.6881.00
94_Y97_N0.6871.00
27_M144_Y0.6871.00
44_R76_N0.6871.00
144_Y147_T0.6851.00
33_Y51_L0.6801.00
44_R79_L0.6781.00
176_N208_I0.6781.00
66_L85_V0.6761.00
66_L74_S0.6681.00
155_K160_A0.6651.00
65_I140_L0.6601.00
94_Y137_G0.6601.00
69_M74_S0.6591.00
40_H43_N0.6571.00
23_N204_N0.6551.00
68_H152_D0.6541.00
89_R117_L0.6531.00
189_V197_F0.6491.00
81_P85_V0.6481.00
132_L153_A0.6481.00
87_T95_T0.6451.00
24_I38_P0.6441.00
83_A87_T0.6431.00
88_T92_V0.6361.00
119_K131_L0.6311.00
183_L201_R0.6301.00
28_D54_S0.6281.00
165_T169_Y0.6281.00
156_Y195_A0.6271.00
130_I185_L0.6211.00
35_I51_L0.6131.00
141_G178_S0.6121.00
191_P197_F0.6061.00
78_L110_L0.6031.00
139_S153_A0.6021.00
69_M136_T0.6011.00
45_E48_L0.6001.00
127_L142_V0.6001.00
41_F44_R0.6001.00
34_L125_D0.5941.00
189_V200_V0.5921.00
79_L82_N0.5891.00
84_K115_I0.5871.00
186_A189_V0.5851.00
186_A201_R0.5831.00
131_L181_K0.5821.00
39_G66_L0.5811.00
38_P66_L0.5791.00
169_Y175_A0.5781.00
134_G139_S0.5771.00
27_M34_L0.5711.00
74_S77_S0.5701.00
155_K159_D0.5681.00
25_V28_D0.5661.00
84_K87_T0.5661.00
150_V192_G0.5651.00
190_V196_P0.5631.00
144_Y149_F0.5631.00
34_L62_D0.5621.00
48_L79_L0.5611.00
63_G66_L0.5601.00
131_L140_L0.5601.00
100_D109_D0.5581.00
28_D50_A0.5581.00
133_P174_E0.5541.00
47_L76_N0.5461.00
178_S181_K0.5441.00
174_E178_S0.5411.00
157_I200_V0.5361.00
37_D68_H0.5351.00
137_G174_E0.5341.00
81_P114_R0.5321.00
83_A88_T0.5311.00
26_L61_I0.5311.00
148_I187_N0.5271.00
64_V81_P0.5231.00
150_V191_P0.5221.00
94_Y98_T0.5201.00
37_D192_G0.5170.99
27_M127_L0.5140.99
52_K55_G0.5110.99
22_C39_G0.5090.99
160_A163_G0.5080.99
26_L51_L0.5050.99
41_F76_N0.5030.99
39_G47_L0.5010.99
163_G170_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.983 100 0.381 Contact Map
3aj3A 2 0.9149 100 0.423 Contact Map
3dhaA 1 0.8596 100 0.425 Contact Map
2r2dA 5 0.8851 100 0.426 Contact Map
2yheA 3 0.9872 100 0.429 Contact Map
2cfuA 2 0.9702 100 0.434 Contact Map
3eshA 5 0.9319 100 0.437 Contact Map
4pdxA 2 0.9702 100 0.438 Contact Map
4le6A 4 0.8255 100 0.439 Contact Map
4zo2A 2 0.9191 100 0.444 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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