GREMLIN Database
Q97UR1 - 2-hydroxyhepta-2 ,4-diene-1,7-dioate isomerase (HpcE-3)
UniProt: Q97UR1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (256)
Sequences: 7669 (5187)
Seq/√Len: 324.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_F243_S3.6051.00
207_N264_E3.6021.00
201_R213_D3.3311.00
123_S126_D2.9801.00
271_E277_R2.9101.00
269_V279_E2.8771.00
205_Y210_L2.8021.00
222_S225_E2.7671.00
124_R228_S2.7171.00
112_G137_F2.6781.00
119_M122_V2.6271.00
269_V277_R2.5881.00
124_R225_E2.5591.00
109_V204_S2.4631.00
128_K131_I2.4591.00
126_D129_K2.3861.00
203_R213_D2.3641.00
203_R271_E2.3531.00
97_P281_P2.3291.00
210_L213_D2.2881.00
119_M130_Y2.2811.00
201_R273_E2.2551.00
267_L279_E2.2131.00
205_Y269_V2.1491.00
184_I241_V2.1361.00
7_F16_G2.1041.00
118_K237_P2.0711.00
122_V130_Y2.0701.00
179_D235_T2.0381.00
124_R222_S1.9381.00
214_G218_E1.9031.00
109_V270_A1.8741.00
205_Y271_E1.8401.00
118_K238_P1.8381.00
5_V18_V1.8361.00
8_Y45_N1.8311.00
206_Y260_L1.7771.00
134_Y191_E1.7621.00
211_V258_F1.7451.00
97_P283_K1.7401.00
201_R215_Y1.7141.00
16_G23_V1.7091.00
89_T237_P1.7061.00
92_I96_Q1.7051.00
99_I180_T1.7021.00
107_P211_V1.6491.00
112_G135_T1.6481.00
22_Y38_S1.6211.00
194_I200_L1.6021.00
109_V202_M1.5931.00
128_K224_E1.5791.00
100_S105_I1.5741.00
87_L177_V1.5571.00
113_V223_I1.5361.00
93_A96_Q1.5221.00
137_F182_A1.5191.00
136_V272_V1.5051.00
112_G243_S1.4771.00
120_K179_D1.4721.00
14_K25_E1.4441.00
203_R210_L1.4431.00
132_L188_I1.4431.00
64_K248_G1.4391.00
58_T83_F1.4381.00
112_G241_V1.4361.00
206_Y211_V1.4321.00
83_F230_L1.4131.00
254_D258_F1.4041.00
209_E258_F1.4011.00
40_R43_E1.4001.00
45_N96_Q1.3931.00
53_S237_P1.3931.00
199_S215_Y1.3861.00
64_K218_E1.3631.00
115_T227_L1.3611.00
199_S217_S1.3601.00
111_I272_V1.3371.00
23_V44_I1.3301.00
262_P283_K1.3251.00
55_I182_A1.3171.00
135_T184_I1.3161.00
211_V254_D1.3051.00
99_I283_K1.2991.00
205_Y277_R1.2841.00
13_R47_D1.2631.00
58_T226_I1.2601.00
198_N224_E1.2561.00
182_A243_S1.2201.00
145_G178_R1.2141.00
85_I173_F1.2131.00
267_L281_P1.1971.00
103_D144_P1.1951.00
117_F129_K1.1901.00
104_A144_P1.1811.00
98_I268_M1.1641.00
19_E22_Y1.1631.00
98_I140_I1.1611.00
5_V23_V1.1611.00
196_D199_S1.1571.00
90_V182_A1.1511.00
113_V242_I1.1481.00
198_N222_S1.1391.00
48_I91_A1.1381.00
190_T193_E1.1321.00
114_I188_I1.1311.00
100_S262_P1.1261.00
95_R279_E1.1131.00
92_I180_T1.1041.00
5_V46_V1.0951.00
58_T230_L1.0831.00
198_N219_F1.0791.00
138_N280_N1.0711.00
195_G274_K1.0661.00
135_T275_I1.0641.00
105_I282_I1.0581.00
124_R224_E1.0581.00
63_P71_K1.0571.00
63_P78_V1.0561.00
106_R143_P1.0531.00
137_F184_I1.0431.00
140_I183_P1.0411.00
200_L272_V1.0351.00
117_F130_Y1.0311.00
5_V16_G1.0291.00
189_V275_I1.0291.00
173_F177_V1.0231.00
8_Y13_R1.0191.00
228_S232_K1.0191.00
136_V270_A1.0051.00
8_Y47_D1.0031.00
5_V187_Y0.9921.00
22_Y40_R0.9891.00
142_Y181_F0.9821.00
60_V75_K0.9761.00
221_F225_E0.9751.00
46_V94_H0.9731.00
111_I216_S0.9701.00
251_N256_S0.9671.00
252_V259_N0.9651.00
56_I234_V0.9561.00
90_V235_T0.9431.00
136_V275_I0.9421.00
18_V187_Y0.9401.00
204_S270_A0.9401.00
149_D169_R0.9351.00
118_K235_T0.9211.00
95_R278_L0.9091.00
123_S228_S0.9031.00
7_F44_I0.9021.00
116_R132_L0.8971.00
49_P135_T0.8951.00
56_I230_L0.8921.00
76_E79_K0.8901.00
254_D257_E0.8881.00
225_E228_S0.8851.00
28_E32_E0.8761.00
62_S244_T0.8721.00
208_G269_V0.8721.00
65_M143_P0.8671.00
129_K191_E0.8671.00
82_K172_H0.8661.00
118_K130_Y0.8641.00
100_S282_I0.8631.00
48_I94_H0.8621.00
77_M220_I0.8601.00
115_T236_I0.8601.00
18_V41_L0.8601.00
114_I135_T0.8571.00
9_V12_L0.8571.00
30_G33_E0.8481.00
206_Y268_M0.8471.00
102_P121_D0.8461.00
131_I223_I0.8411.00
120_K235_T0.8401.00
98_I282_I0.8371.00
203_R273_E0.8251.00
101_P181_F0.8251.00
118_K122_V0.8221.00
178_R233_I0.8211.00
187_Y275_I0.8211.00
28_E31_K0.8211.00
134_Y197_V0.8161.00
122_V228_S0.8161.00
94_H278_L0.8151.00
24_Y38_S0.8151.00
48_I93_A0.8141.00
29_I33_E0.8131.00
105_I181_F0.8121.00
39_Y44_I0.8041.00
9_V14_K0.8021.00
57_C243_S0.8021.00
133_G188_I0.8001.00
19_E24_Y0.7991.00
80_S148_E0.7961.00
63_P77_M0.7931.00
41_L46_V0.7881.00
81_P226_I0.7871.00
226_I244_T0.7871.00
121_D232_K0.7831.00
56_I85_I0.7831.00
60_V73_E0.7811.00
113_V227_L0.7801.00
128_K198_N0.7771.00
143_P146_L0.7771.00
25_E39_Y0.7741.00
78_V221_F0.7721.00
33_E37_N0.7711.00
112_G184_I0.7701.00
200_L216_S0.7671.00
201_R217_S0.7661.00
31_K34_E0.7610.99
204_S268_M0.7590.99
7_F25_E0.7550.99
113_V134_Y0.7540.99
6_S15_I0.7530.99
60_V66_V0.7460.99
208_G267_L0.7430.99
66_V77_M0.7430.99
54_A87_L0.7400.99
54_A179_D0.7320.99
31_K35_R0.7320.99
104_A259_N0.7260.99
173_F178_R0.7200.99
6_S47_D0.7160.99
236_I242_I0.7160.99
9_V39_Y0.7160.99
250_T253_S0.7140.99
141_T146_L0.7130.99
227_L242_I0.7120.99
138_N268_M0.7120.99
202_M214_G0.7090.99
228_S231_S0.7060.99
7_F23_V0.7050.99
140_I260_L0.7030.99
51_Q237_P0.7010.99
54_A85_I0.6990.99
98_I280_N0.6990.99
3_R187_Y0.6940.99
101_P178_R0.6930.99
50_I188_I0.6910.99
127_V131_I0.6900.99
52_P91_A0.6890.99
65_M146_L0.6860.99
54_A88_P0.6850.99
109_V136_V0.6850.99
219_F226_I0.6770.99
7_F14_K0.6750.99
98_I180_T0.6730.99
86_K182_A0.6720.99
75_K147_K0.6690.99
14_K27_S0.6680.99
29_I32_E0.6670.99
17_V26_I0.6660.99
65_M250_T0.6610.99
66_V220_I0.6600.99
71_K77_M0.6600.99
99_I120_K0.6580.99
98_I181_F0.6520.98
135_T185_G0.6510.98
100_S261_K0.6500.98
140_I282_I0.6500.98
95_R281_P0.6490.98
119_M227_L0.6490.98
224_E228_S0.6430.98
104_A147_K0.6390.98
32_E36_G0.6380.98
113_V131_I0.6380.98
142_Y145_G0.6370.98
174_R233_I0.6360.98
212_Q249_Y0.6360.98
191_E195_G0.6360.98
3_R193_E0.6350.98
91_A184_I0.6350.98
140_I180_T0.6310.98
169_R174_R0.6290.98
62_S216_S0.6280.98
89_T179_D0.6270.98
251_N258_F0.6260.98
30_G34_E0.6260.98
144_P148_E0.6230.98
83_F229_E0.6200.98
71_K74_A0.6190.98
226_I242_I0.6170.98
126_D130_Y0.6160.98
19_E38_S0.6160.98
117_F238_P0.6130.98
128_K134_Y0.6130.98
128_K223_I0.6130.98
6_S13_R0.6120.98
119_M123_S0.6120.98
104_A148_E0.6080.98
64_K214_G0.6030.97
34_E38_S0.6020.97
105_I180_T0.6000.97
3_R190_T0.6000.97
65_M106_R0.6000.97
4_Y190_T0.5970.97
3_R18_V0.5960.97
63_P218_E0.5950.97
184_I243_S0.5940.97
5_V9_V0.5940.97
114_I241_V0.5890.97
268_M282_I0.5890.97
60_V82_K0.5870.97
140_I280_N0.5860.97
111_I134_Y0.5850.97
60_V226_I0.5820.97
226_I230_L0.5810.97
29_I34_E0.5780.97
260_L282_I0.5780.97
191_E227_L0.5770.97
194_I197_V0.5760.97
49_P188_I0.5740.97
4_Y132_L0.5740.97
7_F39_Y0.5730.97
127_V227_L0.5730.97
55_I137_F0.5730.97
23_V41_L0.5730.97
198_N223_I0.5720.96
128_K191_E0.5720.96
131_I227_L0.5710.96
223_I244_T0.5690.96
197_V216_S0.5680.96
37_N40_R0.5670.96
202_M272_V0.5650.96
16_G46_V0.5640.96
214_G248_G0.5580.96
123_S127_V0.5550.96
131_I134_Y0.5540.96
197_V200_L0.5530.96
63_P220_I0.5520.96
136_V278_L0.5510.96
79_K221_F0.5480.96
176_K232_K0.5470.95
264_E267_L0.5440.95
189_V194_I0.5430.95
53_S89_T0.5430.95
218_E248_G0.5420.95
33_E36_G0.5420.95
205_Y213_D0.5400.95
125_S228_S0.5400.95
35_R38_S0.5370.95
74_A78_V0.5360.95
123_S130_Y0.5350.95
25_E38_S0.5350.95
35_R39_Y0.5340.95
92_I97_P0.5310.95
149_D233_I0.5310.95
111_I223_I0.5310.95
89_T235_T0.5300.95
50_I114_I0.5290.95
205_Y208_G0.5260.94
48_I184_I0.5260.94
54_A89_T0.5240.94
46_V187_Y0.5240.94
251_N259_N0.5230.94
37_N41_L0.5220.94
272_V275_I0.5220.94
66_V73_E0.5220.94
30_G35_R0.5210.94
55_I243_S0.5200.94
219_F224_E0.5200.94
178_R181_F0.5180.94
53_S88_P0.5170.94
81_P229_E0.5170.94
66_V75_K0.5140.94
80_S229_E0.5120.94
73_E147_K0.5110.94
170_G174_R0.5110.94
261_K264_E0.5110.94
230_L234_V0.5090.93
17_V24_Y0.5080.93
80_S149_D0.5080.93
18_V23_V0.5080.93
230_L242_I0.5080.93
80_S221_F0.5070.93
74_A77_M0.5070.93
40_R44_I0.5060.93
148_E229_E0.5050.93
60_V77_M0.5050.93
227_L231_S0.5040.93
225_E229_E0.5010.93
8_Y12_L0.5010.93
94_H279_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r6oA 2 0.8403 100 0.221 Contact Map
4dbfA 2 0.8368 100 0.235 Contact Map
3rr6A 1 0.8507 100 0.24 Contact Map
1wzoA 4 0.8264 100 0.26 Contact Map
2dfuA 2 0.8264 100 0.275 Contact Map
3lzkA 2 0.9271 100 0.281 Contact Map
2q18X 3 0.8333 100 0.312 Contact Map
4qkuA 2 0.9236 100 0.313 Contact Map
1gttA 1 0.8576 100 0.331 Contact Map
1hyoA 2 0.9201 100 0.346 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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