GREMLIN Database
Q97UQ9 - First ORF in transposon ISC1904
UniProt: Q97UQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (185)
Sequences: 480 (334)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.3121.00
60_A78_L4.2471.00
117_R144_E3.6061.00
82_V119_I3.5841.00
103_F126_L2.7560.99
7_A11_L2.7520.99
110_I138_C2.6790.99
58_L148_L2.5800.99
17_T21_Y2.5120.99
13_I21_Y2.4910.99
135_E139_K2.4110.98
91_D102_G2.4050.98
5_K9_Q2.3790.98
106_L115_V2.3240.98
16_A19_R2.2440.97
111_L141_H2.2200.97
58_L78_L2.1450.96
18_L39_F2.1270.96
75_V88_V2.1210.96
85_Y146_V2.0440.95
22_V37_W2.0230.95
98_M132_E1.9330.94
3_R34_S1.8700.92
119_I132_E1.8590.92
96_L129_F1.8200.91
77_Y121_A1.7350.89
75_V90_T1.7300.89
55_K109_M1.7130.89
131_F145_I1.6880.88
110_I118_V1.6830.88
127_V131_F1.6780.87
89_I102_G1.6570.87
110_I115_V1.6310.86
58_L88_V1.6230.86
110_I120_T1.6120.85
138_C143_C1.5670.84
22_V29_P1.5660.84
40_R43_D1.5510.83
26_Y33_Q1.5060.81
16_A24_K1.5010.81
98_M169_S1.4720.79
4_P19_R1.4520.78
12_G142_N1.4220.77
168_V179_S1.4130.77
138_C174_L1.3820.75
157_E161_E1.3670.74
96_L130_G1.3640.74
109_M114_E1.3610.74
17_T20_E1.3520.73
31_I37_W1.3500.73
27_I30_V1.3400.73
72_A76_K1.3250.72
7_A44_I1.3080.71
169_S172_G1.3040.70
119_I146_V1.2560.68
76_K79_E1.2520.67
56_V144_E1.2490.67
7_A27_I1.2440.67
4_P18_L1.2180.65
70_D73_N1.2160.65
121_A180_Q1.2140.65
57_I75_V1.2070.64
122_Y161_E1.2040.64
107_L111_L1.2010.64
175_H178_R1.1990.64
8_C13_I1.1800.63
62_V67_Q1.1790.62
14_S20_E1.1770.62
15_Y19_R1.1760.62
168_V172_G1.1730.62
131_F147_V1.1710.62
22_V39_F1.1710.62
8_C15_Y1.1500.61
172_G177_M1.1430.60
166_I176_G1.1390.60
122_Y153_K1.1350.59
20_E23_K1.1260.59
75_V107_L1.1100.58
89_I118_V1.1090.58
22_V27_I1.1080.58
78_L148_L1.1070.58
91_D169_S1.1010.57
56_V119_I1.0850.56
67_Q70_D1.0780.55
95_G126_L1.0670.55
3_R38_R1.0630.54
89_I106_L1.0580.54
57_I89_I1.0450.53
62_V71_L1.0380.53
58_L82_V1.0300.52
117_R146_V1.0250.52
28_K43_D1.0180.51
27_I134_L1.0090.51
43_D46_R1.0080.50
161_E172_G0.9990.50
8_C18_L0.9920.49
127_V134_L0.9870.49
82_V85_Y0.9840.49
39_F43_D0.9750.48
14_S174_L0.9710.48
56_V93_G0.9560.47
110_I143_C0.9440.46
91_D121_A0.9440.46
5_K34_S0.9400.46
131_F134_L0.9390.46
19_R39_F0.9290.45
72_A75_V0.9290.45
138_C171_S0.9220.44
54_R142_N0.9170.44
4_P15_Y0.9170.44
158_E170_F0.9090.43
81_Q146_V0.9060.43
64_S67_Q0.9040.43
13_I20_E0.9000.43
73_N164_A0.8860.42
129_F162_D0.8860.42
153_K173_K0.8850.42
7_A18_L0.8720.41
95_G103_F0.8600.40
7_A38_R0.8530.39
4_P29_P0.8520.39
118_V145_I0.8430.39
98_M127_V0.8430.39
19_R22_V0.8400.39
163_L167_L0.8390.39
79_E88_V0.8360.38
26_Y34_S0.8330.38
148_L156_E0.8230.37
11_L18_L0.8160.37
172_G179_S0.8150.37
70_D121_A0.8140.37
22_V31_I0.8110.37
63_S67_Q0.8100.37
42_E73_N0.8050.36
4_P7_A0.8040.36
119_I134_L0.8020.36
67_Q73_N0.8010.36
91_D185_V0.8010.36
72_A186_K0.7970.36
107_L146_V0.7960.36
77_Y149_N0.7920.35
64_S73_N0.7910.35
159_L168_V0.7830.35
18_L22_V0.7750.34
19_R31_I0.7730.34
78_L151_E0.7710.34
160_V163_L0.7680.34
108_R140_A0.7650.34
81_Q149_N0.7630.34
44_I118_V0.7620.33
8_C173_K0.7510.33
9_Q68_K0.7510.33
3_R33_Q0.7500.33
157_E160_V0.7460.32
168_V180_Q0.7440.32
134_L138_C0.7410.32
121_A168_V0.7370.32
34_S113_N0.7330.32
48_M51_I0.7320.32
84_E119_I0.7300.31
76_K80_E0.7300.31
81_Q85_Y0.7270.31
173_K177_M0.7260.31
163_L176_G0.7260.31
27_I43_D0.7180.31
120_T145_I0.7170.31
78_L143_C0.7160.31
23_K31_I0.7140.30
153_K161_E0.7090.30
93_G165_T0.7020.30
57_I115_V0.7010.30
100_R127_V0.7000.30
111_L137_V0.6980.29
6_E43_D0.6950.29
97_N141_H0.6940.29
99_K173_K0.6930.29
51_I116_S0.6900.29
19_R36_K0.6870.29
57_I106_L0.6830.29
73_N76_K0.6760.28
68_K181_K0.6710.28
6_E146_V0.6680.28
54_R143_C0.6660.28
147_V167_L0.6630.27
19_R37_W0.6620.27
120_T162_D0.6570.27
13_I38_R0.6540.27
183_E186_K0.6510.27
87_L100_R0.6500.27
162_D176_G0.6500.27
63_S128_R0.6440.26
180_Q186_K0.6400.26
30_V38_R0.6390.26
93_G154_T0.6370.26
184_K187_K0.6360.26
159_L162_D0.6330.26
3_R36_K0.6330.26
119_I136_E0.6250.25
30_V43_D0.6210.25
14_S22_V0.6190.25
8_C103_F0.6190.25
4_P8_C0.6130.25
6_E159_L0.6120.25
103_F116_S0.6040.24
13_I16_A0.6030.24
119_I183_E0.6030.24
103_F169_S0.6020.24
33_Q113_N0.6010.24
129_F166_I0.5990.24
130_G171_S0.5970.24
15_Y37_W0.5970.24
155_P177_M0.5960.24
146_V152_D0.5930.24
134_L155_P0.5850.23
163_L166_I0.5840.23
77_Y165_T0.5780.23
171_S177_M0.5770.23
123_P167_L0.5760.23
35_G106_L0.5730.23
57_I150_Q0.5670.22
97_N128_R0.5660.22
103_F127_V0.5650.22
93_G144_E0.5640.22
152_D167_L0.5640.22
26_Y167_L0.5630.22
120_T147_V0.5610.22
66_T121_A0.5590.22
13_I31_I0.5590.22
129_F176_G0.5570.22
101_K156_E0.5560.22
96_L133_I0.5550.22
22_V32_L0.5540.22
128_R175_H0.5530.22
159_L170_F0.5530.22
23_K101_K0.5530.22
145_I148_L0.5470.21
56_V116_S0.5460.21
54_R112_N0.5430.21
44_I48_M0.5410.21
12_G129_F0.5410.21
55_K116_S0.5400.21
85_Y96_L0.5390.21
16_A36_K0.5380.21
162_D166_I0.5380.21
5_K8_C0.5380.21
137_V140_A0.5370.21
55_K91_D0.5370.21
77_Y180_Q0.5350.21
167_L171_S0.5330.21
16_A20_E0.5330.21
20_E29_P0.5330.21
127_V165_T0.5320.21
6_E10_R0.5320.21
29_P43_D0.5320.21
123_P181_K0.5310.21
106_L138_C0.5300.21
149_N152_D0.5250.20
58_L149_N0.5230.20
177_M184_K0.5220.20
118_V147_V0.5200.20
9_Q76_K0.5190.20
118_V126_L0.5170.20
180_Q184_K0.5160.20
126_L133_I0.5150.20
86_D119_I0.5140.20
8_C12_G0.5130.20
13_I18_L0.5120.20
112_N152_D0.5120.20
154_T180_Q0.5110.20
115_V143_C0.5090.20
100_R155_P0.5070.19
30_V36_K0.5070.19
63_S129_F0.5050.19
97_N106_L0.5050.19
92_I100_R0.5040.19
118_V152_D0.5030.19
9_Q51_I0.5010.19
110_I145_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7216 100 0.64 Contact Map
3lhkA 2 0.732 100 0.648 Contact Map
3g13A 2 0.7165 99.8 0.735 Contact Map
3bvpA 4 0.6289 99.8 0.74 Contact Map
3guvA 2 0.6959 99.8 0.743 Contact Map
4bqqA 2 0.7113 99.8 0.749 Contact Map
2mhcA 1 0.5567 99.8 0.75 Contact Map
2gm5A 4 0.6186 99.8 0.755 Contact Map
3pkzA 4 0.5722 99.7 0.76 Contact Map
1gdtA 2 0.6856 99.7 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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