GREMLIN Database
Q97UQ8 - Second ORF in transposon ISC1904
UniProt: Q97UQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (344)
Sequences: 4389 (2821)
Seq/√Len: 152.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.3051.00
288_N291_S4.5101.00
340_P367_N4.2151.00
320_A327_V3.7321.00
284_V316_L3.0181.00
313_H329_E3.0121.00
206_L312_I3.0091.00
19_F322_L3.0051.00
347_R350_G2.9481.00
311_S315_V2.8271.00
271_N275_D2.7501.00
311_S314_R2.4951.00
334_F337_R2.4571.00
338_S345_V2.4421.00
173_P182_L2.4321.00
337_R346_S2.4281.00
317_K329_E2.3791.00
330_V372_I2.3691.00
312_I316_L2.3451.00
274_L320_A2.3051.00
226_K302_R2.2851.00
293_F305_S2.1891.00
282_F320_A2.1321.00
171_G187_K2.1261.00
232_K247_G2.0951.00
225_L261_R2.0911.00
284_V327_V2.0771.00
267_H315_V2.0501.00
354_E361_K2.0381.00
54_K120_K2.0231.00
335_T372_I2.0231.00
342_C358_C1.9961.00
267_H318_Y1.9891.00
36_R180_V1.9781.00
49_L97_I1.9761.00
263_L311_S1.9211.00
298_D301_S1.9181.00
28_R31_S1.9151.00
270_V315_V1.8871.00
206_L265_F1.8831.00
51_N55_I1.8671.00
37_E87_H1.8611.00
278_P325_S1.8531.00
317_K321_P1.8411.00
247_G251_M1.8401.00
266_V315_V1.8211.00
50_W100_A1.8091.00
341_R360_F1.8061.00
342_C355_C1.7901.00
351_K364_R1.7881.00
242_K245_K1.7721.00
339_C342_C1.7721.00
339_C358_C1.7581.00
353_F362_L1.7481.00
160_W165_V1.7221.00
284_V329_E1.7201.00
355_C358_C1.7161.00
267_H319_K1.6931.00
266_V311_S1.6691.00
346_S350_G1.6651.00
232_K235_K1.6641.00
245_K248_R1.6591.00
267_H270_V1.6301.00
44_K84_K1.6031.00
33_E37_E1.5721.00
286_K329_E1.5711.00
68_L72_R1.5621.00
35_I180_V1.5431.00
339_C355_C1.5381.00
199_I207_D1.5371.00
208_A366_L1.5341.00
284_V313_H1.5131.00
20_T183_P1.5101.00
344_F356_E1.5001.00
352_T361_K1.4951.00
101_F105_K1.4911.00
32_K36_R1.4861.00
196_F373_Y1.4811.00
49_L100_A1.4491.00
353_F360_F1.4401.00
375_K380_P1.4291.00
111_A118_I1.4291.00
142_V145_T1.4241.00
205_T208_A1.4231.00
370_L374_L1.4191.00
209_Y213_K1.4001.00
106_S118_I1.3981.00
110_R118_I1.3941.00
317_K327_V1.3841.00
285_E332_P1.3821.00
39_T180_V1.3821.00
236_V248_R1.3761.00
270_V318_Y1.3751.00
295_D301_S1.3661.00
270_V319_K1.3581.00
197_L209_Y1.3311.00
256_H260_N1.3141.00
348_K351_K1.3021.00
304_I309_W1.2781.00
91_H131_K1.2651.00
197_L277_Y1.2611.00
177_E256_H1.2421.00
233_R237_Q1.2391.00
69_P72_R1.2321.00
270_V312_I1.2261.00
105_K109_K1.2201.00
99_D129_R1.2191.00
229_M251_M1.2181.00
179_K256_H1.2171.00
274_L323_Y1.2101.00
229_M255_S1.2021.00
196_F281_F1.2011.00
102_S106_S1.1941.00
366_L370_L1.1901.00
225_L258_E1.1851.00
104_L120_K1.1791.00
54_K58_R1.1791.00
340_P370_L1.1731.00
29_E32_K1.1731.00
95_K98_N1.1691.00
142_V146_V1.1651.00
232_K254_Y1.1601.00
198_A373_Y1.1571.00
288_N332_P1.1541.00
79_R93_V1.1501.00
42_L96_A1.1491.00
91_H133_T1.1371.00
347_R351_K1.1341.00
335_T375_K1.1341.00
139_G142_V1.1331.00
338_S375_K1.1301.00
214_F363_D1.1281.00
201_S309_W1.1211.00
330_V375_K1.1180.99
272_T276_L1.1180.99
145_T151_Y1.1140.99
55_I59_K1.1090.99
340_P362_L1.1080.99
62_G65_K1.1060.99
110_R119_E1.1060.99
270_V316_L1.1040.99
203_L307_T1.1040.99
65_K70_K1.0950.99
228_S232_K1.0910.99
263_L315_V1.0830.99
348_K364_R1.0800.99
201_S313_H1.0790.99
128_V132_T1.0780.99
315_V318_Y1.0740.99
46_I96_A1.0730.99
259_R263_L1.0690.99
193_P278_P1.0630.99
266_V312_I1.0610.99
347_R364_R1.0550.99
66_I70_K1.0550.99
27_K31_S1.0550.99
362_L370_L1.0510.99
236_V251_M1.0510.99
21_Y186_Y1.0380.99
319_K322_L1.0380.99
314_R317_K1.0370.99
106_S111_A1.0350.99
199_I209_Y1.0350.99
205_T216_T1.0270.99
271_N323_Y1.0250.99
274_L325_S1.0230.99
275_D323_Y1.0200.99
143_R151_Y1.0150.99
89_A92_Y1.0130.99
24_K179_K1.0070.99
138_V141_S1.0060.99
54_K104_L1.0000.99
286_K332_P0.9970.99
266_V270_V0.9950.99
289_K310_G0.9900.99
71_K98_N0.9900.99
283_A372_I0.9890.99
281_F326_F0.9890.99
240_A244_T0.9890.99
207_D269_F0.9810.99
233_R251_M0.9790.99
32_K180_V0.9770.99
362_L366_L0.9760.99
156_W159_S0.9740.99
244_T248_R0.9720.99
337_R345_V0.9720.99
213_K272_T0.9720.99
197_L210_D0.9710.99
351_K363_D0.9690.99
274_L282_F0.9670.99
295_D299_S0.9640.98
75_Y78_L0.9640.98
208_A214_F0.9540.98
107_W120_K0.9530.98
106_S109_K0.9490.98
27_K35_I0.9410.98
232_K251_M0.9380.98
70_K73_E0.9370.98
229_M258_E0.9360.98
136_K139_G0.9340.98
129_R172_E0.9310.98
295_D298_D0.9260.98
95_K129_R0.9260.98
340_P360_F0.9190.98
341_R370_L0.9160.98
50_W104_L0.9140.98
94_D98_N0.9100.98
344_F357_R0.9070.98
44_K48_Y0.9050.98
346_S353_F0.9040.98
352_T362_L0.9030.98
74_V97_I0.9030.98
46_I100_A0.9020.98
250_L253_K0.9010.98
340_P374_L0.9000.98
45_A96_A0.8960.98
366_L369_S0.8950.98
334_F375_K0.8940.98
106_S110_R0.8920.97
368_A371_N0.8920.97
40_T43_Q0.8910.97
230_E233_R0.8890.97
67_T98_N0.8860.97
128_V131_K0.8860.97
18_Y187_K0.8840.97
196_F283_A0.8830.97
18_Y185_R0.8830.97
66_I69_P0.8820.97
232_K250_L0.8790.97
281_F328_K0.8780.97
273_L282_F0.8760.97
91_H95_K0.8710.97
53_T101_F0.8700.97
332_P335_T0.8690.97
218_S307_T0.8690.97
46_I103_I0.8650.97
76_K80_E0.8640.97
95_K99_D0.8600.97
346_S364_R0.8590.97
254_Y258_E0.8570.97
320_A325_S0.8530.97
350_G364_R0.8510.97
195_D211_G0.8510.97
229_M237_Q0.8500.97
266_V308_V0.8500.97
175_I182_L0.8500.97
257_R261_R0.8490.97
73_E76_K0.8490.97
176_K179_K0.8470.97
107_W121_P0.8460.97
48_Y52_L0.8450.97
230_E234_A0.8420.96
353_F364_R0.8410.96
154_F157_S0.8410.96
203_L303_K0.8390.96
221_Q225_L0.8330.96
236_V247_G0.8310.96
65_K74_V0.8290.96
367_N371_N0.8260.96
91_H132_T0.8230.96
99_D174_I0.8200.96
174_I183_P0.8150.96
370_L373_Y0.8130.96
289_K309_W0.8130.96
57_V104_L0.8090.96
205_T214_F0.8010.95
149_H152_I0.8010.95
271_N319_K0.8000.95
67_T71_K0.7990.95
221_Q261_R0.7980.95
169_E187_K0.7920.95
41_L84_K0.7910.95
344_F353_F0.7900.95
41_L88_L0.7890.95
24_K181_Y0.7840.95
201_S207_D0.7830.95
85_I93_V0.7830.95
79_R85_I0.7800.95
269_F272_T0.7800.95
293_F301_S0.7780.94
136_K145_T0.7760.94
340_P368_A0.7750.94
134_L147_R0.7740.94
63_N66_I0.7720.94
23_I158_K0.7690.94
23_I182_L0.7690.94
265_F269_F0.7690.94
248_R252_R0.7660.94
338_S371_N0.7660.94
70_K75_Y0.7650.94
144_I182_L0.7640.94
214_F366_L0.7630.94
197_L282_F0.7630.94
218_S221_Q0.7620.94
53_T104_L0.7590.94
26_D155_S0.7550.94
77_P81_E0.7530.93
233_R255_S0.7530.93
34_L38_Y0.7520.93
300_L304_I0.7510.93
273_L277_Y0.7480.93
192_T195_D0.7440.93
287_L332_P0.7440.93
283_A373_Y0.7430.93
229_M233_R0.7410.93
291_S332_P0.7410.93
25_N182_L0.7410.93
231_V235_K0.7400.93
103_I121_P0.7400.93
291_S304_I0.7340.93
95_K131_K0.7310.92
225_L257_R0.7220.92
97_I101_F0.7210.92
286_K313_H0.7210.92
91_H94_D0.7200.92
51_N123_V0.7200.92
44_K82_L0.7170.92
235_K247_G0.7160.92
283_A375_K0.7130.91
133_T136_K0.7110.91
230_E237_Q0.7090.91
200_D365_Q0.7080.91
104_L107_W0.7070.91
283_A379_F0.7070.91
40_T44_K0.7060.91
241_S244_T0.7040.91
72_R76_K0.7020.91
282_F316_L0.7020.91
258_E306_R0.6980.91
206_L307_T0.6950.90
172_E185_R0.6930.90
52_L56_Q0.6930.90
204_Y208_A0.6920.90
29_E33_E0.6910.90
75_Y94_D0.6900.90
207_D312_I0.6890.90
100_A104_L0.6880.90
37_E41_L0.6880.90
69_P73_E0.6850.90
88_L91_H0.6850.90
310_G314_R0.6850.90
334_F338_S0.6840.90
131_K134_L0.6810.90
190_W193_P0.6770.89
215_V265_F0.6760.89
263_L267_H0.6750.89
356_E364_R0.6750.89
41_L44_K0.6720.89
283_A328_K0.6710.89
30_K33_E0.6700.89
76_K79_R0.6660.88
129_R174_I0.6660.88
202_N208_A0.6660.88
104_L108_R0.6650.88
262_V306_R0.6630.88
334_F345_V0.6620.88
69_P75_Y0.6610.88
190_W325_S0.6600.88
52_L74_V0.6600.88
237_Q251_M0.6600.88
38_Y42_L0.6580.88
206_L270_V0.6570.88
23_I165_V0.6540.88
179_K260_N0.6510.87
316_L327_V0.6500.87
91_H134_L0.6500.87
295_D304_I0.6470.87
225_L229_M0.6450.87
313_H317_K0.6450.87
96_A100_A0.6440.87
17_V187_K0.6440.87
346_S351_K0.6430.87
235_K250_L0.6410.87
298_D305_S0.6400.86
35_I39_T0.6380.86
338_S343_G0.6370.86
138_V143_R0.6340.86
97_I100_A0.6330.86
25_N154_F0.6310.86
131_K135_R0.6290.86
277_Y282_F0.6290.86
71_K74_V0.6270.85
20_T185_R0.6250.85
195_D277_Y0.6240.85
49_L74_V0.6230.85
225_L254_Y0.6220.85
350_G353_F0.6210.85
243_H246_R0.6190.85
65_K71_K0.6160.84
144_I147_R0.6150.84
68_L71_K0.6130.84
255_S262_V0.6120.84
154_F158_K0.6110.84
92_Y128_V0.6080.84
22_S183_P0.6080.84
107_W110_R0.6060.83
146_V175_I0.6060.83
52_L78_L0.6050.83
235_K238_S0.6050.83
134_L137_V0.6050.83
38_Y89_A0.6040.83
206_L266_V0.6040.83
203_L294_K0.6040.83
348_K363_D0.6040.83
48_Y78_L0.6020.83
93_V96_A0.6020.83
236_V244_T0.6010.83
71_K75_Y0.6010.83
142_V147_R0.6010.83
52_L55_I0.6010.83
362_L367_N0.6000.83
21_Y158_K0.5980.83
341_R362_L0.5970.82
215_V272_T0.5950.82
255_S259_R0.5930.82
52_L73_E0.5900.82
245_K249_E0.5900.82
209_Y215_V0.5880.81
244_T251_M0.5870.81
372_I375_K0.5870.81
67_T70_K0.5860.81
109_K118_I0.5790.80
338_S353_F0.5770.80
34_L37_E0.5720.80
232_K236_V0.5720.80
55_I58_R0.5720.80
318_Y322_L0.5710.80
289_K292_M0.5690.79
128_V134_L0.5690.79
233_R238_S0.5690.79
210_D366_L0.5680.79
90_S133_T0.5670.79
275_D281_F0.5670.79
334_F353_F0.5650.79
66_I71_K0.5640.79
350_G356_E0.5630.79
222_L225_L0.5620.79
51_N54_K0.5610.78
223_Y226_K0.5590.78
75_Y79_R0.5590.78
215_V269_F0.5570.78
320_A323_Y0.5570.78
70_K74_V0.5560.78
223_Y302_R0.5550.78
76_K97_I0.5540.78
234_A238_S0.5540.78
260_N263_L0.5510.77
203_L293_F0.5510.77
244_T247_G0.5510.77
269_F312_I0.5500.77
333_R337_R0.5490.77
127_Y130_I0.5490.77
331_N334_F0.5480.77
27_K152_I0.5450.76
315_V319_K0.5450.76
230_E298_D0.5450.76
42_L128_V0.5440.76
45_A93_V0.5440.76
223_Y303_K0.5430.76
248_R251_M0.5410.76
200_D336_S0.5400.76
283_A378_G0.5390.76
181_Y260_N0.5390.76
38_Y88_L0.5390.76
291_S294_K0.5390.76
266_V269_F0.5390.76
154_F159_S0.5380.75
127_Y131_K0.5380.75
92_Y130_I0.5360.75
74_V94_D0.5350.75
136_K143_R0.5330.75
204_Y351_K0.5320.75
310_G313_H0.5320.75
27_K32_K0.5300.74
129_R132_T0.5290.74
300_L303_K0.5280.74
18_Y171_G0.5270.74
48_Y84_K0.5270.74
73_E77_P0.5270.74
348_K352_T0.5270.74
271_N274_L0.5270.74
289_K304_I0.5220.73
39_T128_V0.5200.73
181_Y256_H0.5200.73
37_E88_L0.5190.73
201_S312_I0.5190.73
68_L74_V0.5180.73
293_F298_D0.5180.73
146_V149_H0.5180.73
66_I75_Y0.5170.73
130_I135_R0.5160.72
223_Y227_Y0.5160.72
108_R111_A0.5140.72
336_S346_S0.5140.72
230_E238_S0.5130.72
88_L93_V0.5130.72
66_I72_R0.5130.72
37_E40_T0.5130.72
74_V78_L0.5120.72
219_L307_T0.5110.72
41_L85_I0.5110.72
71_K97_I0.5110.72
57_V108_R0.5100.72
354_E360_F0.5090.71
268_K271_N0.5090.71
143_R153_T0.5080.71
22_S263_L0.5080.71
76_K83_E0.5070.71
58_R62_G0.5060.71
38_Y130_I0.5050.71
38_Y41_L0.5040.71
196_F379_F0.5030.71
342_C345_V0.5010.70
176_K256_H0.5010.70
127_Y132_T0.5000.70
53_T71_K0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3066 94.8 0.935 Contact Map
1vhxA 2 0.3231 94.3 0.936 Contact Map
1iv0A 1 0.2288 91.4 0.942 Contact Map
2k4xA 1 0.125 86.1 0.948 Contact Map
3j20Y 1 0.1132 85.4 0.948 Contact Map
1qypA 1 0.1014 84.3 0.949 Contact Map
4aybP 1 0.0943 81.7 0.95 Contact Map
1vd4A 1 0.125 75.6 0.953 Contact Map
1ffkW 1 0.1651 73.2 0.954 Contact Map
3j3w0 1 0.1297 72.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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