GREMLIN Database
Q97UQ7 - Uncharacterized protein
UniProt: Q97UQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (207)
Sequences: 122 (118)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_R188_D3.7410.96
54_E59_K3.4110.94
200_E206_K2.8130.85
88_V91_L2.6610.81
98_V102_M2.4970.76
227_A230_K2.4890.76
46_Q49_E2.4480.75
78_V82_M2.3800.73
55_I59_K2.3480.72
35_R40_Q2.3040.70
97_E100_K2.1970.66
77_E80_K2.1920.66
30_Y33_L2.1460.64
81_T84_T2.1210.63
71_L75_I2.1130.63
56_E60_K2.0990.63
55_I58_V2.0650.61
166_Y177_L2.0570.61
59_K63_A2.0160.59
86_Q89_E2.0120.59
80_K84_T2.0010.59
52_D55_I1.9990.59
110_R200_E1.9930.58
94_E99_K1.9510.57
118_L215_P1.9160.55
119_G122_W1.8500.52
196_K210_V1.8340.52
86_Q90_R1.8260.52
90_R93_K1.7990.50
102_M105_K1.7970.50
53_K73_K1.7610.49
31_Q34_A1.7410.48
87_D92_D1.7020.46
75_I78_V1.6810.45
102_M106_E1.6580.45
151_Y177_L1.6260.43
54_E61_T1.6210.43
86_Q91_L1.6130.43
79_K82_M1.5790.41
136_E237_I1.5760.41
96_E100_K1.5400.40
57_E60_K1.5380.40
193_K197_E1.5290.39
28_I36_L1.5190.39
151_Y231_D1.5180.39
175_V207_V1.5150.39
51_L55_I1.4900.38
47_D52_D1.4880.38
29_V37_T1.4500.36
122_W182_S1.4480.36
33_L36_L1.4000.34
28_I40_Q1.3860.34
63_A76_E1.3760.33
48_V52_D1.3600.33
207_V210_V1.3550.33
79_K83_A1.3470.32
49_E76_E1.3410.32
91_L95_I1.3340.32
139_S235_E1.3270.32
60_K64_T1.3220.31
37_T47_D1.3170.31
36_L40_Q1.3170.31
29_V33_L1.3120.31
125_L135_S1.2950.31
130_F199_Y1.2900.30
134_I137_I1.2480.29
189_L212_V1.2460.29
74_E77_E1.2410.29
54_E57_E1.2390.29
33_L39_W1.2350.28
30_Y34_A1.2300.28
28_I35_R1.2260.28
93_K103_A1.2070.28
140_N144_K1.1940.27
88_V92_D1.1920.27
78_V96_E1.1920.27
66_Q86_Q1.1810.27
73_K77_E1.1630.26
73_K76_E1.1570.26
37_T44_T1.1470.26
196_K205_I1.1370.25
87_D91_L1.1150.25
132_Q135_S1.1150.25
31_Q35_R1.1110.24
34_A38_P1.1110.24
150_L202_V1.1100.24
40_Q46_Q1.1050.24
38_P41_S1.0980.24
151_Y161_P1.0880.24
196_K207_V1.0870.24
30_Y38_P1.0830.24
192_I225_I1.0820.24
33_L38_P1.0810.24
29_V39_W1.0740.23
154_D220_R1.0700.23
176_I196_K1.0600.23
28_I33_L1.0580.23
44_T47_D1.0580.23
87_D93_K1.0550.23
215_P237_I1.0450.22
94_E98_V1.0410.22
157_V194_K1.0370.22
51_L58_V1.0340.22
80_K213_I1.0320.22
118_L168_I1.0310.22
28_I38_P1.0290.22
95_I98_V1.0280.22
176_I211_Y1.0240.22
210_V227_A1.0200.22
160_E201_K1.0190.22
28_I39_W1.0180.22
99_K211_Y1.0140.22
150_L175_V1.0110.22
214_T217_I1.0100.21
208_N236_I1.0070.21
91_L94_E0.9990.21
52_D56_E0.9920.21
100_K104_T0.9790.21
80_K83_A0.9700.20
33_L49_E0.9690.20
131_R199_Y0.9640.20
217_I238_Y0.9590.20
61_T81_T0.9500.20
29_V48_V0.9500.20
93_K97_E0.9430.20
194_K199_Y0.9420.20
175_V203_K0.9290.19
175_V205_I0.9260.19
131_R161_P0.9260.19
53_K56_E0.9240.19
31_Q36_L0.9200.19
44_T48_V0.9130.19
184_I212_V0.9120.19
74_E79_K0.9110.19
130_F215_P0.9060.19
35_R38_P0.9040.19
58_V63_A0.9010.19
161_P199_Y0.8990.19
192_I195_K0.8990.19
180_I238_Y0.8900.18
128_D186_R0.8770.18
28_I31_Q0.8730.18
126_N131_R0.8700.18
52_D59_K0.8580.18
192_I212_V0.8560.17
177_L207_V0.8560.17
126_N194_K0.8560.17
68_V71_L0.8550.17
109_K139_S0.8530.17
147_R178_V0.8490.17
39_W44_T0.8490.17
121_R152_D0.8480.17
37_T41_S0.8480.17
170_V178_V0.8450.17
70_R140_N0.8350.17
181_T185_R0.8340.17
191_T195_K0.8310.17
39_W52_D0.8250.17
51_L56_E0.8220.17
75_I79_K0.8210.17
119_G215_P0.8210.17
36_L48_V0.8160.17
72_D75_I0.8110.16
113_T129_S0.8070.16
119_G232_M0.8050.16
106_E236_I0.7990.16
90_R94_E0.7990.16
33_L37_T0.7990.16
97_E108_L0.7950.16
32_V35_R0.7950.16
49_E52_D0.7930.16
130_F194_K0.7920.16
29_V47_D0.7920.16
226_K230_K0.7920.16
185_R191_T0.7860.16
130_F186_R0.7840.16
28_I37_T0.7760.16
93_K101_T0.7760.16
189_L218_H0.7760.16
196_K208_N0.7720.16
184_I188_D0.7680.15
115_I214_T0.7640.15
154_D172_D0.7620.15
133_G199_Y0.7570.15
201_K220_R0.7540.15
188_D191_T0.7450.15
36_L39_W0.7430.15
102_M108_L0.7410.15
63_A79_K0.7300.15
117_G161_P0.7280.15
130_F159_D0.7270.15
32_V38_P0.7240.15
30_Y39_W0.7200.14
141_S207_V0.7120.14
205_I208_N0.7120.14
174_S211_Y0.7110.14
129_S135_S0.7090.14
154_D201_K0.7080.14
86_Q230_K0.7040.14
132_Q198_F0.7010.14
54_E58_V0.6990.14
29_V36_L0.6980.14
64_T92_D0.6950.14
94_E102_M0.6920.14
158_Y161_P0.6910.14
144_K158_Y0.6890.14
148_E177_L0.6840.14
57_E64_T0.6790.14
120_A187_G0.6760.14
94_E97_E0.6740.14
192_I196_K0.6730.14
141_S186_R0.6680.13
132_Q180_I0.6680.13
37_T52_D0.6680.13
141_S178_V0.6670.13
23_T34_A0.6660.13
31_Q38_P0.6640.13
189_L228_M0.6630.13
90_R95_I0.6570.13
35_R39_W0.6560.13
148_E203_K0.6540.13
157_V199_Y0.6540.13
29_V52_D0.6480.13
71_L171_K0.6480.13
53_K86_Q0.6460.13
64_T80_K0.6430.13
55_I63_A0.6430.13
107_D219_D0.6420.13
70_R164_V0.6390.13
140_N164_V0.6370.13
147_R165_E0.6360.13
30_Y35_R0.6330.13
63_A67_D0.6320.13
77_E82_M0.6310.13
136_E192_I0.6270.13
67_D72_D0.6260.13
57_E90_R0.6250.13
96_E99_K0.6230.13
126_N199_Y0.6170.12
135_S208_N0.6170.12
150_L207_V0.6160.12
41_S201_K0.6150.12
196_K236_I0.6150.12
115_I147_R0.6130.12
196_K211_Y0.6110.12
150_L203_K0.6090.12
145_I166_Y0.6080.12
48_V75_I0.6060.12
49_E53_K0.6010.12
175_V196_K0.5960.12
48_V54_E0.5930.12
126_N205_I0.5880.12
198_F204_N0.5870.12
176_I215_P0.5870.12
98_V106_E0.5860.12
184_I228_M0.5850.12
29_V40_Q0.5830.12
92_D96_E0.5810.12
161_P194_K0.5810.12
131_R194_K0.5770.12
136_E225_I0.5760.12
116_T156_Y0.5750.12
34_A37_T0.5740.12
128_D178_V0.5730.12
172_D238_Y0.5720.12
134_I192_I0.5710.12
104_T219_D0.5710.12
72_D79_K0.5660.12
80_K102_M0.5650.12
133_G236_I0.5630.12
39_W43_A0.5620.12
132_Q196_K0.5620.12
63_A72_D0.5620.12
168_I217_I0.5620.12
130_F176_I0.5610.11
137_I169_V0.5590.11
135_S198_F0.5570.11
110_R172_D0.5570.11
132_Q227_A0.5540.11
131_R157_V0.5530.11
95_I226_K0.5510.11
197_E200_E0.5450.11
180_I226_K0.5450.11
209_L235_E0.5430.11
141_S225_I0.5410.11
130_F133_G0.5390.11
78_V91_L0.5380.11
174_S208_N0.5360.11
60_K73_K0.5350.11
38_P44_T0.5350.11
49_E58_V0.5340.11
168_I230_K0.5330.11
136_E235_E0.5320.11
195_K201_K0.5320.11
35_R41_S0.5300.11
118_L217_I0.5250.11
56_E63_A0.5210.11
119_G182_S0.5210.11
143_W146_S0.5200.11
126_N161_P0.5150.11
134_I169_V0.5120.11
61_T67_D0.5120.11
49_E56_E0.5110.11
23_T37_T0.5110.11
96_E201_K0.5060.11
182_S238_Y0.5050.11
129_S148_E0.5040.11
56_E89_E0.5030.11
153_R220_R0.5020.11
88_V95_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y88A 5 0.4357 95.7 0.917 Contact Map
1xmxA 2 0.9129 87.5 0.936 Contact Map
2wcwA 2 0.4066 81.9 0.94 Contact Map
2inbA 2 0.4108 71.9 0.945 Contact Map
2eo0A 2 0.3776 70.3 0.946 Contact Map
1gefA 2 0.4274 70.3 0.946 Contact Map
1ob8A 1 0.39 62 0.949 Contact Map
1hh1A 2 0.3568 54.3 0.951 Contact Map
1m0dA 2 0.4232 52.7 0.952 Contact Map
3fovA 2 0.3776 40.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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