Q97UQ7 - SULSO - GREMLIN Contacts

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Q97UQ7 - Uncharacterized protein

UniProt:	Q97UQ7	Sequences: MSLEEEIKKVLLNNPSILVDVLTAKPEIVYQVLARLTPWQSLATKQDVERLDKEIEEVKKTMATKQDVERLDKEIEEVKKTMATKQDVERLDKEIEEVKKTMATKEDLKRLETIITGLGARWGILNEDSFRQGISEILSNSGWKISREVLYDRDGYVYDEPSDVEYDIVVKDSSVILVEITSSIRRGDLPTIKKKKEFYEKVKNIKVNLVYVITPFIHDRYPERIKAMAKDMGIEIIYPSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	241 (207)
Sequences:	122 (118)
Seq/√Len:	8.2

SULSO - Q97UQ7 Q97YH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
185_R	188_D	3.741	0.96
54_E	59_K	3.411	0.94
200_E	206_K	2.813	0.85
88_V	91_L	2.661	0.81
98_V	102_M	2.497	0.76
227_A	230_K	2.489	0.76
46_Q	49_E	2.448	0.75
78_V	82_M	2.380	0.73
55_I	59_K	2.348	0.72
35_R	40_Q	2.304	0.70
97_E	100_K	2.197	0.66
77_E	80_K	2.192	0.66
30_Y	33_L	2.146	0.64
81_T	84_T	2.121	0.63
71_L	75_I	2.113	0.63
56_E	60_K	2.099	0.63
55_I	58_V	2.065	0.61
166_Y	177_L	2.057	0.61
59_K	63_A	2.016	0.59
86_Q	89_E	2.012	0.59
80_K	84_T	2.001	0.59
52_D	55_I	1.999	0.59
110_R	200_E	1.993	0.58
94_E	99_K	1.951	0.57
118_L	215_P	1.916	0.55
119_G	122_W	1.850	0.52
196_K	210_V	1.834	0.52
86_Q	90_R	1.826	0.52
90_R	93_K	1.799	0.50
102_M	105_K	1.797	0.50
53_K	73_K	1.761	0.49
31_Q	34_A	1.741	0.48
87_D	92_D	1.702	0.46
75_I	78_V	1.681	0.45
102_M	106_E	1.658	0.45
151_Y	177_L	1.626	0.43
54_E	61_T	1.621	0.43
86_Q	91_L	1.613	0.43
79_K	82_M	1.579	0.41
136_E	237_I	1.576	0.41
96_E	100_K	1.540	0.40
57_E	60_K	1.538	0.40
193_K	197_E	1.529	0.39
28_I	36_L	1.519	0.39
151_Y	231_D	1.518	0.39
175_V	207_V	1.515	0.39
51_L	55_I	1.490	0.38
47_D	52_D	1.488	0.38
29_V	37_T	1.450	0.36
122_W	182_S	1.448	0.36
33_L	36_L	1.400	0.34
28_I	40_Q	1.386	0.34
63_A	76_E	1.376	0.33
48_V	52_D	1.360	0.33
207_V	210_V	1.355	0.33
79_K	83_A	1.347	0.32
49_E	76_E	1.341	0.32
91_L	95_I	1.334	0.32
139_S	235_E	1.327	0.32
60_K	64_T	1.322	0.31
37_T	47_D	1.317	0.31
36_L	40_Q	1.317	0.31
29_V	33_L	1.312	0.31
125_L	135_S	1.295	0.31
130_F	199_Y	1.290	0.30
134_I	137_I	1.248	0.29
189_L	212_V	1.246	0.29
74_E	77_E	1.241	0.29
54_E	57_E	1.239	0.29
33_L	39_W	1.235	0.28
30_Y	34_A	1.230	0.28
28_I	35_R	1.226	0.28
93_K	103_A	1.207	0.28
140_N	144_K	1.194	0.27
88_V	92_D	1.192	0.27
78_V	96_E	1.192	0.27
66_Q	86_Q	1.181	0.27
73_K	77_E	1.163	0.26
73_K	76_E	1.157	0.26
37_T	44_T	1.147	0.26
196_K	205_I	1.137	0.25
87_D	91_L	1.115	0.25
132_Q	135_S	1.115	0.25
31_Q	35_R	1.111	0.24
34_A	38_P	1.111	0.24
150_L	202_V	1.110	0.24
40_Q	46_Q	1.105	0.24
38_P	41_S	1.098	0.24
151_Y	161_P	1.088	0.24
196_K	207_V	1.087	0.24
30_Y	38_P	1.083	0.24
192_I	225_I	1.082	0.24
33_L	38_P	1.081	0.24
29_V	39_W	1.074	0.23
154_D	220_R	1.070	0.23
176_I	196_K	1.060	0.23
28_I	33_L	1.058	0.23
44_T	47_D	1.058	0.23
87_D	93_K	1.055	0.23
215_P	237_I	1.045	0.22
94_E	98_V	1.041	0.22
157_V	194_K	1.037	0.22
51_L	58_V	1.034	0.22
80_K	213_I	1.032	0.22
118_L	168_I	1.031	0.22
28_I	38_P	1.029	0.22
95_I	98_V	1.028	0.22
176_I	211_Y	1.024	0.22
210_V	227_A	1.020	0.22
160_E	201_K	1.019	0.22
28_I	39_W	1.018	0.22
99_K	211_Y	1.014	0.22
150_L	175_V	1.011	0.22
214_T	217_I	1.010	0.21
208_N	236_I	1.007	0.21
91_L	94_E	0.999	0.21
52_D	56_E	0.992	0.21
100_K	104_T	0.979	0.21
80_K	83_A	0.970	0.20
33_L	49_E	0.969	0.20
131_R	199_Y	0.964	0.20
217_I	238_Y	0.959	0.20
61_T	81_T	0.950	0.20
29_V	48_V	0.950	0.20
93_K	97_E	0.943	0.20
194_K	199_Y	0.942	0.20
175_V	203_K	0.929	0.19
175_V	205_I	0.926	0.19
131_R	161_P	0.926	0.19
53_K	56_E	0.924	0.19
31_Q	36_L	0.920	0.19
44_T	48_V	0.913	0.19
184_I	212_V	0.912	0.19
74_E	79_K	0.911	0.19
130_F	215_P	0.906	0.19
35_R	38_P	0.904	0.19
58_V	63_A	0.901	0.19
161_P	199_Y	0.899	0.19
192_I	195_K	0.899	0.19
180_I	238_Y	0.890	0.18
128_D	186_R	0.877	0.18
28_I	31_Q	0.873	0.18
126_N	131_R	0.870	0.18
52_D	59_K	0.858	0.18
192_I	212_V	0.856	0.17
177_L	207_V	0.856	0.17
126_N	194_K	0.856	0.17
68_V	71_L	0.855	0.17
109_K	139_S	0.853	0.17
147_R	178_V	0.849	0.17
39_W	44_T	0.849	0.17
121_R	152_D	0.848	0.17
37_T	41_S	0.848	0.17
170_V	178_V	0.845	0.17
70_R	140_N	0.835	0.17
181_T	185_R	0.834	0.17
191_T	195_K	0.831	0.17
39_W	52_D	0.825	0.17
51_L	56_E	0.822	0.17
75_I	79_K	0.821	0.17
119_G	215_P	0.821	0.17
36_L	48_V	0.816	0.17
72_D	75_I	0.811	0.16
113_T	129_S	0.807	0.16
119_G	232_M	0.805	0.16
106_E	236_I	0.799	0.16
90_R	94_E	0.799	0.16
33_L	37_T	0.799	0.16
97_E	108_L	0.795	0.16
32_V	35_R	0.795	0.16
49_E	52_D	0.793	0.16
130_F	194_K	0.792	0.16
29_V	47_D	0.792	0.16
226_K	230_K	0.792	0.16
185_R	191_T	0.786	0.16
130_F	186_R	0.784	0.16
28_I	37_T	0.776	0.16
93_K	101_T	0.776	0.16
189_L	218_H	0.776	0.16
196_K	208_N	0.772	0.16
184_I	188_D	0.768	0.15
115_I	214_T	0.764	0.15
154_D	172_D	0.762	0.15
133_G	199_Y	0.757	0.15
201_K	220_R	0.754	0.15
188_D	191_T	0.745	0.15
36_L	39_W	0.743	0.15
102_M	108_L	0.741	0.15
63_A	79_K	0.730	0.15
117_G	161_P	0.728	0.15
130_F	159_D	0.727	0.15
32_V	38_P	0.724	0.15
30_Y	39_W	0.720	0.14
141_S	207_V	0.712	0.14
205_I	208_N	0.712	0.14
174_S	211_Y	0.711	0.14
129_S	135_S	0.709	0.14
154_D	201_K	0.708	0.14
86_Q	230_K	0.704	0.14
132_Q	198_F	0.701	0.14
54_E	58_V	0.699	0.14
29_V	36_L	0.698	0.14
64_T	92_D	0.695	0.14
94_E	102_M	0.692	0.14
158_Y	161_P	0.691	0.14
144_K	158_Y	0.689	0.14
148_E	177_L	0.684	0.14
57_E	64_T	0.679	0.14
120_A	187_G	0.676	0.14
94_E	97_E	0.674	0.14
192_I	196_K	0.673	0.14
141_S	186_R	0.668	0.13
132_Q	180_I	0.668	0.13
37_T	52_D	0.668	0.13
141_S	178_V	0.667	0.13
23_T	34_A	0.666	0.13
31_Q	38_P	0.664	0.13
189_L	228_M	0.663	0.13
90_R	95_I	0.657	0.13
35_R	39_W	0.656	0.13
148_E	203_K	0.654	0.13
157_V	199_Y	0.654	0.13
29_V	52_D	0.648	0.13
71_L	171_K	0.648	0.13
53_K	86_Q	0.646	0.13
64_T	80_K	0.643	0.13
55_I	63_A	0.643	0.13
107_D	219_D	0.642	0.13
70_R	164_V	0.639	0.13
140_N	164_V	0.637	0.13
147_R	165_E	0.636	0.13
30_Y	35_R	0.633	0.13
63_A	67_D	0.632	0.13
77_E	82_M	0.631	0.13
136_E	192_I	0.627	0.13
67_D	72_D	0.626	0.13
57_E	90_R	0.625	0.13
96_E	99_K	0.623	0.13
126_N	199_Y	0.617	0.12
135_S	208_N	0.617	0.12
150_L	207_V	0.616	0.12
41_S	201_K	0.615	0.12
196_K	236_I	0.615	0.12
115_I	147_R	0.613	0.12
196_K	211_Y	0.611	0.12
150_L	203_K	0.609	0.12
145_I	166_Y	0.608	0.12
48_V	75_I	0.606	0.12
49_E	53_K	0.601	0.12
175_V	196_K	0.596	0.12
48_V	54_E	0.593	0.12
126_N	205_I	0.588	0.12
198_F	204_N	0.587	0.12
176_I	215_P	0.587	0.12
98_V	106_E	0.586	0.12
184_I	228_M	0.585	0.12
29_V	40_Q	0.583	0.12
92_D	96_E	0.581	0.12
161_P	194_K	0.581	0.12
131_R	194_K	0.577	0.12
136_E	225_I	0.576	0.12
116_T	156_Y	0.575	0.12
34_A	37_T	0.574	0.12
128_D	178_V	0.573	0.12
172_D	238_Y	0.572	0.12
134_I	192_I	0.571	0.12
104_T	219_D	0.571	0.12
72_D	79_K	0.566	0.12
80_K	102_M	0.565	0.12
133_G	236_I	0.563	0.12
39_W	43_A	0.562	0.12
132_Q	196_K	0.562	0.12
63_A	72_D	0.562	0.12
168_I	217_I	0.562	0.12
130_F	176_I	0.561	0.11
137_I	169_V	0.559	0.11
135_S	198_F	0.557	0.11
110_R	172_D	0.557	0.11
132_Q	227_A	0.554	0.11
131_R	157_V	0.553	0.11
95_I	226_K	0.551	0.11
197_E	200_E	0.545	0.11
180_I	226_K	0.545	0.11
209_L	235_E	0.543	0.11
141_S	225_I	0.541	0.11
130_F	133_G	0.539	0.11
78_V	91_L	0.538	0.11
174_S	208_N	0.536	0.11
60_K	73_K	0.535	0.11
38_P	44_T	0.535	0.11
49_E	58_V	0.534	0.11
168_I	230_K	0.533	0.11
136_E	235_E	0.532	0.11
195_K	201_K	0.532	0.11
35_R	41_S	0.530	0.11
118_L	217_I	0.525	0.11
56_E	63_A	0.521	0.11
119_G	182_S	0.521	0.11
143_W	146_S	0.520	0.11
126_N	161_P	0.515	0.11
134_I	169_V	0.512	0.11
61_T	67_D	0.512	0.11
49_E	56_E	0.511	0.11
23_T	37_T	0.511	0.11
96_E	201_K	0.506	0.11
182_S	238_Y	0.505	0.11
129_S	148_E	0.504	0.11
56_E	89_E	0.503	0.11
153_R	220_R	0.502	0.11
88_V	95_I	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y88A	5	0.4357	95.7	0.917	Contact Map
1xmxA	2	0.9129	87.5	0.936	Contact Map
2wcwA	2	0.4066	81.9	0.94	Contact Map
2inbA	2	0.4108	71.9	0.945	Contact Map
2eo0A	2	0.3776	70.3	0.946	Contact Map
1gefA	2	0.4274	70.3	0.946	Contact Map
1ob8A	1	0.39	62	0.949	Contact Map
1hh1A	2	0.3568	54.3	0.951	Contact Map
1m0dA	2	0.4232	52.7	0.952	Contact Map
3fovA	2	0.3776	40.1	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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