Q97UQ6 - SULSO - GREMLIN Contacts

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Q97UQ6 - Transposase ISC1229

UniProt:	Q97UQ6	Sequences: MVEMGIEAKSSGEGVTSPYSRTEHCENIHEYRCDTRVGVIGIDVSKEHLVTSKGRVRKFTNNEKGYEEILTMKPNIIVIEPTGVYSTRPCQYFKERGVKVLLVSPTLLWKEKDVRGKKTDFYDAEKLENMVNKAREYVNNPLKELVSLYLFMKDVQTKQENRLRRALFLVSDEEKLSEERLEKFSKGDFSDVKLYQLEYTGTVLREIQVLARTLLQTREELKEVRKMIEGNVPQDHVLLTIPGIGKLAAGIIIGIVGDIKRFPRPESFVAYCGLDPVVERSGRIEVRKGISKRGNKYLRSLFYFLAETQYSRNPTLLKFYETHKDKLKGRKLYTALAGKLARIVWSVWYNNKPYEVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (312)
Sequences:	4173 (3153)
Seq/√Len:	178.5

SULSO - Q97UQ6 Q97X29 Q97X12 Q97UF7 Q97WZ5 Q97X07 Q97Y59 Q97XK2 Q97ZN4 Q97VS0 Q97WC0 Q97X26 Q97YE1 Q97Y06 Q97VB2 Q97XM7 Q97Z62 Q97UU8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
78_V	131_V	5.023	1.00
237_V	353_P	3.028	1.00
205_R	227_M	2.910	1.00
268_F	341_A	2.906	1.00
323_H	326_K	2.868	1.00
256_V	268_F	2.724	1.00
108_L	127_L	2.533	1.00
152_M	156_Q	2.456	1.00
272_C	298_L	2.422	1.00
317_L	321_E	2.404	1.00
240_T	353_P	2.397	1.00
209_V	220_E	2.386	1.00
290_I	334_T	2.365	1.00
77_I	98_V	2.362	1.00
78_V	127_L	2.346	1.00
252_I	344_V	2.313	1.00
119_T	278_V	2.241	1.00
263_P	267_S	2.234	1.00
48_H	58_K	2.155	1.00
212_R	220_E	2.105	1.00
237_V	347_V	2.094	1.00
272_C	341_A	2.028	1.00
274_L	337_A	2.016	1.00
244_I	249_A	1.987	1.00
157_T	161_N	1.974	1.00
338_G	342_R	1.957	1.00
238_L	344_V	1.949	1.00
241_I	344_V	1.918	1.00
216_Q	220_E	1.915	1.00
150_L	255_I	1.904	1.00
163_L	214_L	1.889	1.00
352_K	355_E	1.869	1.00
42_I	49_L	1.865	1.00
264_R	267_S	1.859	1.00
280_R	285_E	1.852	1.00
241_I	347_V	1.824	1.00
153_K	300_S	1.822	1.00
110_K	113_D	1.806	1.00
237_V	240_T	1.801	1.00
328_K	331_K	1.799	1.00
92_Y	96_R	1.786	1.00
251_I	301_L	1.781	1.00
62_N	65_G	1.773	1.00
232_V	239_L	1.770	1.00
76_I	101_L	1.770	1.00
346_S	350_N	1.763	1.00
227_M	230_G	1.754	1.00
248_A	301_L	1.742	1.00
156_Q	221_L	1.741	1.00
152_M	225_R	1.736	1.00
213_T	216_Q	1.716	1.00
310_Y	320_Y	1.709	1.00
129_N	133_K	1.698	1.00
347_V	353_P	1.698	1.00
262_F	271_Y	1.689	1.00
316_L	343_I	1.656	1.00
42_I	89_P	1.651	1.00
324_K	330_R	1.641	1.00
304_F	307_E	1.635	1.00
91_Q	143_K	1.629	1.00
79_I	100_V	1.610	1.00
92_Y	95_E	1.608	1.00
320_Y	336_L	1.601	1.00
47_E	283_R	1.599	1.00
163_L	207_I	1.578	1.00
155_V	221_L	1.574	1.00
222_K	225_R	1.556	1.00
306_A	340_L	1.540	1.00
212_R	219_E	1.527	1.00
327_L	331_K	1.526	1.00
322_T	326_K	1.513	1.00
306_A	337_A	1.492	1.00
214_L	218_R	1.475	1.00
212_R	216_Q	1.461	1.00
300_S	304_F	1.455	1.00
239_L	246_K	1.453	1.00
211_A	215_L	1.449	1.00
209_V	223_E	1.447	1.00
316_L	336_L	1.436	1.00
255_I	295_N	1.435	1.00
345_W	349_Y	1.423	1.00
213_T	220_E	1.419	1.00
320_Y	332_L	1.403	1.00
59_F	72_M	1.401	1.00
244_I	248_A	1.391	1.00
321_E	325_D	1.373	1.00
77_I	93_F	1.362	1.00
152_M	247_L	1.361	1.00
153_K	297_Y	1.359	1.00
184_F	189_F	1.337	1.00
78_V	103_V	1.335	1.00
269_V	338_G	1.325	1.00
76_I	99_K	1.316	1.00
45_S	48_H	1.312	1.00
65_G	68_E	1.309	1.00
343_I	347_V	1.306	1.00
241_I	340_L	1.299	1.00
290_I	299_R	1.292	1.00
181_L	188_D	1.292	1.00
238_L	249_A	1.283	1.00
238_L	348_W	1.272	1.00
189_F	192_V	1.268	1.00
303_Y	337_A	1.267	1.00
149_Y	297_Y	1.257	1.00
186_K	190_S	1.256	1.00
225_R	229_E	1.254	1.00
158_K	161_N	1.253	1.00
225_R	228_I	1.250	1.00
324_K	329_G	1.248	1.00
319_F	339_K	1.241	1.00
41_G	128_E	1.233	1.00
323_H	332_L	1.232	1.00
180_R	183_K	1.228	1.00
269_V	275_D	1.224	1.00
181_L	189_F	1.223	1.00
117_K	278_V	1.222	1.00
185_S	189_F	1.218	1.00
79_I	90_C	1.214	1.00
305_L	340_L	1.212	1.00
39_V	131_V	1.211	1.00
185_S	188_D	1.206	1.00
160_E	178_E	1.205	1.00
151_F	155_V	1.199	1.00
159_Q	162_R	1.196	1.00
181_L	184_F	1.195	1.00
51_T	124_A	1.190	1.00
314_P	318_K	1.185	1.00
346_S	349_Y	1.185	1.00
159_Q	163_L	1.180	1.00
248_A	305_L	1.180	1.00
103_V	108_L	1.177	1.00
154_D	162_R	1.176	1.00
244_I	344_V	1.173	1.00
306_A	336_L	1.172	1.00
259_I	348_W	1.168	1.00
303_Y	334_T	1.168	1.00
152_M	221_L	1.159	1.00
40_I	77_I	1.156	1.00
319_F	335_A	1.141	1.00
306_A	333_Y	1.134	1.00
233_P	351_N	1.129	1.00
347_V	352_K	1.128	1.00
319_F	336_L	1.127	1.00
218_R	222_K	1.127	1.00
292_K	299_R	1.117	1.00
148_L	224_V	1.109	1.00
319_F	323_H	1.101	1.00
90_C	100_V	1.094	1.00
81_P	105_P	1.093	1.00
281_S	285_E	1.080	1.00
61_N	69_I	1.070	1.00
178_E	182_E	1.069	1.00
303_Y	307_E	1.068	1.00
144_E	200_T	1.060	1.00
229_E	246_K	1.060	1.00
244_I	340_L	1.048	1.00
70_L	93_F	1.040	1.00
39_V	132_N	1.039	1.00
256_V	259_I	1.035	1.00
70_L	96_R	1.034	1.00
106_T	110_K	1.030	0.99
184_F	188_D	1.026	0.99
125_E	129_N	1.014	0.99
176_L	180_R	1.013	0.99
302_F	341_A	1.013	0.99
204_L	208_Q	1.011	0.99
139_N	142_L	1.009	0.99
307_E	310_Y	1.004	0.99
184_F	187_G	0.997	0.99
60_T	65_G	0.996	0.99
264_R	345_W	0.996	0.99
316_L	340_L	0.994	0.99
86_S	102_L	0.985	0.99
118_K	123_D	0.982	0.99
160_E	214_L	0.981	0.99
323_H	327_L	0.979	0.99
56_V	125_E	0.979	0.99
183_K	187_G	0.976	0.99
227_M	231_N	0.971	0.99
323_H	328_K	0.966	0.99
44_V	49_L	0.965	0.99
219_E	223_E	0.963	0.99
149_Y	228_I	0.961	0.99
149_Y	250_G	0.961	0.99
67_E	92_Y	0.959	0.99
216_Q	219_E	0.956	0.99
171_S	174_E	0.955	0.99
146_V	255_I	0.952	0.99
64_K	68_E	0.946	0.99
101_L	131_V	0.935	0.99
324_K	332_L	0.934	0.99
89_P	93_F	0.924	0.99
307_E	330_R	0.920	0.99
232_V	235_D	0.910	0.99
186_K	189_F	0.905	0.99
310_Y	324_K	0.903	0.99
223_E	227_M	0.896	0.99
63_E	67_E	0.895	0.99
188_D	191_D	0.895	0.99
209_V	227_M	0.893	0.99
66_Y	88_R	0.888	0.98
116_G	293_R	0.886	0.98
42_I	69_I	0.885	0.98
149_Y	254_G	0.883	0.98
44_V	79_I	0.881	0.98
255_I	297_Y	0.879	0.98
127_L	130_M	0.877	0.98
315_T	354_Y	0.874	0.98
252_I	298_L	0.871	0.98
314_P	317_L	0.871	0.98
220_E	223_E	0.868	0.98
104_S	107_L	0.867	0.98
41_G	124_A	0.864	0.98
168_F	172_D	0.859	0.98
201_G	227_M	0.851	0.98
66_Y	93_F	0.849	0.98
45_S	282_G	0.848	0.98
215_L	219_E	0.843	0.98
51_T	55_R	0.842	0.98
105_P	255_I	0.840	0.98
159_Q	214_L	0.838	0.98
181_L	187_G	0.831	0.98
307_E	337_A	0.828	0.98
90_C	137_Y	0.827	0.98
179_E	183_K	0.825	0.98
66_Y	92_Y	0.824	0.98
344_V	347_V	0.822	0.97
330_R	333_Y	0.819	0.97
274_L	338_G	0.818	0.97
275_D	278_V	0.807	0.97
275_D	291_S	0.806	0.97
271_Y	295_N	0.806	0.97
237_V	351_N	0.801	0.97
70_L	98_V	0.801	0.97
149_Y	251_I	0.798	0.97
307_E	333_Y	0.798	0.97
120_D	281_S	0.794	0.97
209_V	213_T	0.794	0.97
258_D	261_R	0.794	0.97
82_T	85_Y	0.792	0.97
278_V	285_E	0.791	0.97
210_L	213_T	0.791	0.97
61_N	66_Y	0.789	0.97
176_L	179_E	0.789	0.97
76_I	131_V	0.785	0.97
183_K	186_K	0.782	0.97
174_E	184_F	0.780	0.97
81_P	102_L	0.778	0.97
155_V	224_V	0.776	0.96
267_S	270_A	0.772	0.96
90_C	102_L	0.772	0.96
42_I	66_Y	0.770	0.96
175_K	187_G	0.769	0.96
322_T	325_D	0.769	0.96
265_P	345_W	0.767	0.96
218_R	221_L	0.767	0.96
68_E	71_T	0.766	0.96
327_L	330_R	0.765	0.96
241_I	244_I	0.764	0.96
277_V	291_S	0.763	0.96
162_R	165_R	0.761	0.96
334_T	337_A	0.759	0.96
266_E	338_G	0.757	0.96
318_K	322_T	0.757	0.96
103_V	113_D	0.756	0.96
275_D	292_K	0.754	0.96
49_L	59_F	0.749	0.96
230_G	234_Q	0.749	0.96
202_T	205_R	0.746	0.96
79_I	127_L	0.745	0.96
79_I	102_L	0.744	0.96
151_F	206_E	0.742	0.95
49_L	61_N	0.742	0.95
168_F	173_E	0.741	0.95
119_T	280_R	0.736	0.95
275_D	299_R	0.735	0.95
290_I	294_G	0.735	0.95
41_G	93_F	0.735	0.95
234_Q	351_N	0.734	0.95
217_T	221_L	0.734	0.95
180_R	184_F	0.732	0.95
244_I	252_I	0.731	0.95
331_K	335_A	0.727	0.95
177_S	181_L	0.726	0.95
49_L	69_I	0.724	0.95
310_Y	336_L	0.723	0.95
75_N	99_K	0.723	0.95
134_A	138_V	0.722	0.95
45_S	49_L	0.718	0.95
65_G	69_I	0.717	0.95
116_G	270_A	0.714	0.94
221_L	224_V	0.713	0.94
319_F	322_T	0.713	0.94
184_F	190_S	0.710	0.94
205_R	209_V	0.709	0.94
184_F	191_D	0.709	0.94
71_T	96_R	0.708	0.94
342_R	345_W	0.707	0.94
205_R	208_Q	0.706	0.94
67_E	96_R	0.704	0.94
159_Q	213_T	0.704	0.94
65_G	72_M	0.703	0.94
202_T	227_M	0.701	0.94
251_I	297_Y	0.700	0.94
59_F	65_G	0.695	0.94
160_E	164_R	0.693	0.93
181_L	186_K	0.691	0.93
313_N	354_Y	0.690	0.93
177_S	180_R	0.684	0.93
141_P	144_E	0.681	0.93
225_R	247_L	0.679	0.93
313_N	317_L	0.678	0.93
140_N	144_E	0.677	0.93
290_I	335_A	0.675	0.93
294_G	299_R	0.674	0.93
304_F	308_T	0.674	0.93
159_Q	210_L	0.673	0.92
150_L	297_Y	0.673	0.92
151_F	154_D	0.672	0.92
310_Y	333_Y	0.672	0.92
181_L	185_S	0.672	0.92
180_R	191_D	0.671	0.92
213_T	217_T	0.670	0.92
112_K	126_K	0.668	0.92
208_Q	212_R	0.667	0.92
215_L	218_R	0.665	0.92
203_V	206_E	0.665	0.92
183_K	188_D	0.665	0.92
70_L	92_Y	0.665	0.92
328_K	332_L	0.662	0.92
308_T	312_R	0.659	0.92
175_K	178_E	0.659	0.92
225_R	246_K	0.657	0.92
269_V	342_R	0.655	0.91
187_G	192_V	0.655	0.91
323_H	335_A	0.654	0.91
206_E	209_V	0.654	0.91
40_I	69_I	0.652	0.91
209_V	212_R	0.649	0.91
116_G	277_V	0.644	0.91
40_I	93_F	0.641	0.91
101_L	134_A	0.641	0.91
161_N	165_R	0.640	0.90
106_T	293_R	0.640	0.90
37_V	52_S	0.640	0.90
302_F	337_A	0.639	0.90
239_L	249_A	0.638	0.90
155_V	217_T	0.637	0.90
103_V	130_M	0.637	0.90
45_S	89_P	0.636	0.90
244_I	305_L	0.633	0.90
143_K	147_S	0.633	0.90
139_N	143_K	0.631	0.90
265_P	342_R	0.628	0.90
205_R	216_Q	0.626	0.89
320_Y	324_K	0.626	0.89
93_F	340_L	0.620	0.89
151_F	224_V	0.618	0.89
157_T	351_N	0.617	0.89
159_Q	217_T	0.616	0.89
178_E	183_K	0.612	0.88
265_P	270_A	0.612	0.88
269_V	278_V	0.612	0.88
259_I	345_W	0.609	0.88
44_V	85_Y	0.608	0.88
180_R	187_G	0.607	0.88
180_R	189_F	0.606	0.88
186_K	192_V	0.602	0.88
175_K	184_F	0.600	0.87
252_I	268_F	0.600	0.87
157_T	160_E	0.596	0.87
147_S	166_A	0.592	0.87
251_I	255_I	0.591	0.87
232_V	250_G	0.590	0.87
278_V	287_R	0.589	0.86
240_T	347_V	0.589	0.86
275_D	293_R	0.588	0.86
153_K	251_I	0.587	0.86
129_N	132_N	0.587	0.86
176_L	182_E	0.586	0.86
309_Q	316_L	0.583	0.86
174_E	178_E	0.583	0.86
171_S	177_S	0.582	0.86
307_E	311_S	0.581	0.86
182_E	186_K	0.581	0.86
270_A	275_D	0.578	0.85
151_F	209_V	0.577	0.85
202_T	206_E	0.577	0.85
160_E	163_L	0.577	0.85
67_E	71_T	0.577	0.85
260_K	349_Y	0.576	0.85
136_E	261_R	0.575	0.85
163_L	210_L	0.574	0.85
108_L	112_K	0.573	0.85
108_L	130_M	0.570	0.85
155_V	220_E	0.567	0.84
111_E	114_V	0.567	0.84
45_S	86_S	0.566	0.84
175_K	186_K	0.566	0.84
217_T	220_E	0.564	0.84
111_E	130_M	0.564	0.84
221_L	225_R	0.563	0.84
158_K	165_R	0.562	0.84
309_Q	313_N	0.562	0.84
147_S	206_E	0.562	0.84
117_K	291_S	0.561	0.84
117_K	275_D	0.558	0.83
301_L	305_L	0.557	0.83
66_Y	70_L	0.556	0.83
185_S	191_D	0.556	0.83
156_Q	225_R	0.554	0.83
52_S	55_R	0.552	0.83
150_L	295_N	0.552	0.83
174_E	180_R	0.552	0.83
291_S	294_G	0.550	0.83
173_E	176_L	0.550	0.83
313_N	318_K	0.550	0.83
339_K	342_R	0.549	0.82
309_Q	312_R	0.549	0.82
154_D	158_K	0.549	0.82
273_G	299_R	0.548	0.82
168_F	171_S	0.547	0.82
182_E	188_D	0.547	0.82
235_D	239_L	0.546	0.82
250_G	297_Y	0.545	0.82
106_T	116_G	0.544	0.82
134_A	137_Y	0.543	0.82
221_L	252_I	0.543	0.82
176_L	181_L	0.543	0.82
138_V	143_K	0.543	0.82
175_K	179_E	0.542	0.82
277_V	288_K	0.542	0.82
161_N	164_R	0.541	0.81
140_N	198_E	0.538	0.81
172_D	176_L	0.537	0.81
178_E	181_L	0.535	0.81
349_Y	352_K	0.534	0.81
182_E	215_L	0.532	0.80
62_N	70_L	0.532	0.80
69_I	72_M	0.531	0.80
205_R	223_E	0.530	0.80
187_G	191_D	0.526	0.80
214_L	217_T	0.525	0.80
226_K	229_E	0.525	0.80
302_F	344_V	0.524	0.79
182_E	190_S	0.524	0.79
52_S	57_R	0.522	0.79
40_I	50_V	0.521	0.79
70_L	77_I	0.519	0.79
145_L	231_N	0.519	0.79
228_I	232_V	0.517	0.79
117_K	122_Y	0.516	0.78
184_F	192_V	0.515	0.78
122_Y	126_K	0.514	0.78
268_F	344_V	0.513	0.78
257_G	261_R	0.513	0.78
299_R	334_T	0.513	0.78
300_S	303_Y	0.511	0.78
49_L	89_P	0.510	0.78
305_L	337_A	0.508	0.77
175_K	180_R	0.508	0.77
269_V	274_L	0.507	0.77
305_L	309_Q	0.506	0.77
277_V	334_T	0.504	0.77
145_L	228_I	0.502	0.76
182_E	187_G	0.501	0.76
185_S	211_A	0.500	0.76
334_T	347_V	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.2885	93.3	0.938	Contact Map
4ep4A	2	0.3501	88.3	0.945	Contact Map
3fhfA	1	0.5686	84.9	0.948	Contact Map
1pu6A	1	0.5602	79.6	0.951	Contact Map
2a1jB	2	0.2157	79.3	0.951	Contact Map
1z00B	1	0.2185	78	0.952	Contact Map
2a1jA	1	0.1653	77	0.952	Contact Map
2duyA	1	0.1821	76	0.953	Contact Map
1z00A	1	0.2297	75.8	0.953	Contact Map
1kftA	1	0.1513	75.3	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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