GREMLIN Database
Q97UQ6 - Transposase ISC1229
UniProt: Q97UQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (312)
Sequences: 4173 (3153)
Seq/√Len: 178.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_V131_V5.0231.00
237_V353_P3.0281.00
205_R227_M2.9101.00
268_F341_A2.9061.00
323_H326_K2.8681.00
256_V268_F2.7241.00
108_L127_L2.5331.00
152_M156_Q2.4561.00
272_C298_L2.4221.00
317_L321_E2.4041.00
240_T353_P2.3971.00
209_V220_E2.3861.00
290_I334_T2.3651.00
77_I98_V2.3621.00
78_V127_L2.3461.00
252_I344_V2.3131.00
119_T278_V2.2411.00
263_P267_S2.2341.00
48_H58_K2.1551.00
212_R220_E2.1051.00
237_V347_V2.0941.00
272_C341_A2.0281.00
274_L337_A2.0161.00
244_I249_A1.9871.00
157_T161_N1.9741.00
338_G342_R1.9571.00
238_L344_V1.9491.00
241_I344_V1.9181.00
216_Q220_E1.9151.00
150_L255_I1.9041.00
163_L214_L1.8891.00
352_K355_E1.8691.00
42_I49_L1.8651.00
264_R267_S1.8591.00
280_R285_E1.8521.00
241_I347_V1.8241.00
153_K300_S1.8221.00
110_K113_D1.8061.00
237_V240_T1.8011.00
328_K331_K1.7991.00
92_Y96_R1.7861.00
251_I301_L1.7811.00
62_N65_G1.7731.00
232_V239_L1.7701.00
76_I101_L1.7701.00
346_S350_N1.7631.00
227_M230_G1.7541.00
248_A301_L1.7421.00
156_Q221_L1.7411.00
152_M225_R1.7361.00
213_T216_Q1.7161.00
310_Y320_Y1.7091.00
129_N133_K1.6981.00
347_V353_P1.6981.00
262_F271_Y1.6891.00
316_L343_I1.6561.00
42_I89_P1.6511.00
324_K330_R1.6411.00
304_F307_E1.6351.00
91_Q143_K1.6291.00
79_I100_V1.6101.00
92_Y95_E1.6081.00
320_Y336_L1.6011.00
47_E283_R1.5991.00
163_L207_I1.5781.00
155_V221_L1.5741.00
222_K225_R1.5561.00
306_A340_L1.5401.00
212_R219_E1.5271.00
327_L331_K1.5261.00
322_T326_K1.5131.00
306_A337_A1.4921.00
214_L218_R1.4751.00
212_R216_Q1.4611.00
300_S304_F1.4551.00
239_L246_K1.4531.00
211_A215_L1.4491.00
209_V223_E1.4471.00
316_L336_L1.4361.00
255_I295_N1.4351.00
345_W349_Y1.4231.00
213_T220_E1.4191.00
320_Y332_L1.4031.00
59_F72_M1.4011.00
244_I248_A1.3911.00
321_E325_D1.3731.00
77_I93_F1.3621.00
152_M247_L1.3611.00
153_K297_Y1.3591.00
184_F189_F1.3371.00
78_V103_V1.3351.00
269_V338_G1.3251.00
76_I99_K1.3161.00
45_S48_H1.3121.00
65_G68_E1.3091.00
343_I347_V1.3061.00
241_I340_L1.2991.00
290_I299_R1.2921.00
181_L188_D1.2921.00
238_L249_A1.2831.00
238_L348_W1.2721.00
189_F192_V1.2681.00
303_Y337_A1.2671.00
149_Y297_Y1.2571.00
186_K190_S1.2561.00
225_R229_E1.2541.00
158_K161_N1.2531.00
225_R228_I1.2501.00
324_K329_G1.2481.00
319_F339_K1.2411.00
41_G128_E1.2331.00
323_H332_L1.2321.00
180_R183_K1.2281.00
269_V275_D1.2241.00
181_L189_F1.2231.00
117_K278_V1.2221.00
185_S189_F1.2181.00
79_I90_C1.2141.00
305_L340_L1.2121.00
39_V131_V1.2111.00
185_S188_D1.2061.00
160_E178_E1.2051.00
151_F155_V1.1991.00
159_Q162_R1.1961.00
181_L184_F1.1951.00
51_T124_A1.1901.00
314_P318_K1.1851.00
346_S349_Y1.1851.00
159_Q163_L1.1801.00
248_A305_L1.1801.00
103_V108_L1.1771.00
154_D162_R1.1761.00
244_I344_V1.1731.00
306_A336_L1.1721.00
259_I348_W1.1681.00
303_Y334_T1.1681.00
152_M221_L1.1591.00
40_I77_I1.1561.00
319_F335_A1.1411.00
306_A333_Y1.1341.00
233_P351_N1.1291.00
347_V352_K1.1281.00
319_F336_L1.1271.00
218_R222_K1.1271.00
292_K299_R1.1171.00
148_L224_V1.1091.00
319_F323_H1.1011.00
90_C100_V1.0941.00
81_P105_P1.0931.00
281_S285_E1.0801.00
61_N69_I1.0701.00
178_E182_E1.0691.00
303_Y307_E1.0681.00
144_E200_T1.0601.00
229_E246_K1.0601.00
244_I340_L1.0481.00
70_L93_F1.0401.00
39_V132_N1.0391.00
256_V259_I1.0351.00
70_L96_R1.0341.00
106_T110_K1.0300.99
184_F188_D1.0260.99
125_E129_N1.0140.99
176_L180_R1.0130.99
302_F341_A1.0130.99
204_L208_Q1.0110.99
139_N142_L1.0090.99
307_E310_Y1.0040.99
184_F187_G0.9970.99
60_T65_G0.9960.99
264_R345_W0.9960.99
316_L340_L0.9940.99
86_S102_L0.9850.99
118_K123_D0.9820.99
160_E214_L0.9810.99
323_H327_L0.9790.99
56_V125_E0.9790.99
183_K187_G0.9760.99
227_M231_N0.9710.99
323_H328_K0.9660.99
44_V49_L0.9650.99
219_E223_E0.9630.99
149_Y228_I0.9610.99
149_Y250_G0.9610.99
67_E92_Y0.9590.99
216_Q219_E0.9560.99
171_S174_E0.9550.99
146_V255_I0.9520.99
64_K68_E0.9460.99
101_L131_V0.9350.99
324_K332_L0.9340.99
89_P93_F0.9240.99
307_E330_R0.9200.99
232_V235_D0.9100.99
186_K189_F0.9050.99
310_Y324_K0.9030.99
223_E227_M0.8960.99
63_E67_E0.8950.99
188_D191_D0.8950.99
209_V227_M0.8930.99
66_Y88_R0.8880.98
116_G293_R0.8860.98
42_I69_I0.8850.98
149_Y254_G0.8830.98
44_V79_I0.8810.98
255_I297_Y0.8790.98
127_L130_M0.8770.98
315_T354_Y0.8740.98
252_I298_L0.8710.98
314_P317_L0.8710.98
220_E223_E0.8680.98
104_S107_L0.8670.98
41_G124_A0.8640.98
168_F172_D0.8590.98
201_G227_M0.8510.98
66_Y93_F0.8490.98
45_S282_G0.8480.98
215_L219_E0.8430.98
51_T55_R0.8420.98
105_P255_I0.8400.98
159_Q214_L0.8380.98
181_L187_G0.8310.98
307_E337_A0.8280.98
90_C137_Y0.8270.98
179_E183_K0.8250.98
66_Y92_Y0.8240.98
344_V347_V0.8220.97
330_R333_Y0.8190.97
274_L338_G0.8180.97
275_D278_V0.8070.97
275_D291_S0.8060.97
271_Y295_N0.8060.97
237_V351_N0.8010.97
70_L98_V0.8010.97
149_Y251_I0.7980.97
307_E333_Y0.7980.97
120_D281_S0.7940.97
209_V213_T0.7940.97
258_D261_R0.7940.97
82_T85_Y0.7920.97
278_V285_E0.7910.97
210_L213_T0.7910.97
61_N66_Y0.7890.97
176_L179_E0.7890.97
76_I131_V0.7850.97
183_K186_K0.7820.97
174_E184_F0.7800.97
81_P102_L0.7780.97
155_V224_V0.7760.96
267_S270_A0.7720.96
90_C102_L0.7720.96
42_I66_Y0.7700.96
175_K187_G0.7690.96
322_T325_D0.7690.96
265_P345_W0.7670.96
218_R221_L0.7670.96
68_E71_T0.7660.96
327_L330_R0.7650.96
241_I244_I0.7640.96
277_V291_S0.7630.96
162_R165_R0.7610.96
334_T337_A0.7590.96
266_E338_G0.7570.96
318_K322_T0.7570.96
103_V113_D0.7560.96
275_D292_K0.7540.96
49_L59_F0.7490.96
230_G234_Q0.7490.96
202_T205_R0.7460.96
79_I127_L0.7450.96
79_I102_L0.7440.96
151_F206_E0.7420.95
49_L61_N0.7420.95
168_F173_E0.7410.95
119_T280_R0.7360.95
275_D299_R0.7350.95
290_I294_G0.7350.95
41_G93_F0.7350.95
234_Q351_N0.7340.95
217_T221_L0.7340.95
180_R184_F0.7320.95
244_I252_I0.7310.95
331_K335_A0.7270.95
177_S181_L0.7260.95
49_L69_I0.7240.95
310_Y336_L0.7230.95
75_N99_K0.7230.95
134_A138_V0.7220.95
45_S49_L0.7180.95
65_G69_I0.7170.95
116_G270_A0.7140.94
221_L224_V0.7130.94
319_F322_T0.7130.94
184_F190_S0.7100.94
205_R209_V0.7090.94
184_F191_D0.7090.94
71_T96_R0.7080.94
342_R345_W0.7070.94
205_R208_Q0.7060.94
67_E96_R0.7040.94
159_Q213_T0.7040.94
65_G72_M0.7030.94
202_T227_M0.7010.94
251_I297_Y0.7000.94
59_F65_G0.6950.94
160_E164_R0.6930.93
181_L186_K0.6910.93
313_N354_Y0.6900.93
177_S180_R0.6840.93
141_P144_E0.6810.93
225_R247_L0.6790.93
313_N317_L0.6780.93
140_N144_E0.6770.93
290_I335_A0.6750.93
294_G299_R0.6740.93
304_F308_T0.6740.93
159_Q210_L0.6730.92
150_L297_Y0.6730.92
151_F154_D0.6720.92
310_Y333_Y0.6720.92
181_L185_S0.6720.92
180_R191_D0.6710.92
213_T217_T0.6700.92
112_K126_K0.6680.92
208_Q212_R0.6670.92
215_L218_R0.6650.92
203_V206_E0.6650.92
183_K188_D0.6650.92
70_L92_Y0.6650.92
328_K332_L0.6620.92
308_T312_R0.6590.92
175_K178_E0.6590.92
225_R246_K0.6570.92
269_V342_R0.6550.91
187_G192_V0.6550.91
323_H335_A0.6540.91
206_E209_V0.6540.91
40_I69_I0.6520.91
209_V212_R0.6490.91
116_G277_V0.6440.91
40_I93_F0.6410.91
101_L134_A0.6410.91
161_N165_R0.6400.90
106_T293_R0.6400.90
37_V52_S0.6400.90
302_F337_A0.6390.90
239_L249_A0.6380.90
155_V217_T0.6370.90
103_V130_M0.6370.90
45_S89_P0.6360.90
244_I305_L0.6330.90
143_K147_S0.6330.90
139_N143_K0.6310.90
265_P342_R0.6280.90
205_R216_Q0.6260.89
320_Y324_K0.6260.89
93_F340_L0.6200.89
151_F224_V0.6180.89
157_T351_N0.6170.89
159_Q217_T0.6160.89
178_E183_K0.6120.88
265_P270_A0.6120.88
269_V278_V0.6120.88
259_I345_W0.6090.88
44_V85_Y0.6080.88
180_R187_G0.6070.88
180_R189_F0.6060.88
186_K192_V0.6020.88
175_K184_F0.6000.87
252_I268_F0.6000.87
157_T160_E0.5960.87
147_S166_A0.5920.87
251_I255_I0.5910.87
232_V250_G0.5900.87
278_V287_R0.5890.86
240_T347_V0.5890.86
275_D293_R0.5880.86
153_K251_I0.5870.86
129_N132_N0.5870.86
176_L182_E0.5860.86
309_Q316_L0.5830.86
174_E178_E0.5830.86
171_S177_S0.5820.86
307_E311_S0.5810.86
182_E186_K0.5810.86
270_A275_D0.5780.85
151_F209_V0.5770.85
202_T206_E0.5770.85
160_E163_L0.5770.85
67_E71_T0.5770.85
260_K349_Y0.5760.85
136_E261_R0.5750.85
163_L210_L0.5740.85
108_L112_K0.5730.85
108_L130_M0.5700.85
155_V220_E0.5670.84
111_E114_V0.5670.84
45_S86_S0.5660.84
175_K186_K0.5660.84
217_T220_E0.5640.84
111_E130_M0.5640.84
221_L225_R0.5630.84
158_K165_R0.5620.84
309_Q313_N0.5620.84
147_S206_E0.5620.84
117_K291_S0.5610.84
117_K275_D0.5580.83
301_L305_L0.5570.83
66_Y70_L0.5560.83
185_S191_D0.5560.83
156_Q225_R0.5540.83
52_S55_R0.5520.83
150_L295_N0.5520.83
174_E180_R0.5520.83
291_S294_G0.5500.83
173_E176_L0.5500.83
313_N318_K0.5500.83
339_K342_R0.5490.82
309_Q312_R0.5490.82
154_D158_K0.5490.82
273_G299_R0.5480.82
168_F171_S0.5470.82
182_E188_D0.5470.82
235_D239_L0.5460.82
250_G297_Y0.5450.82
106_T116_G0.5440.82
134_A137_Y0.5430.82
221_L252_I0.5430.82
176_L181_L0.5430.82
138_V143_K0.5430.82
175_K179_E0.5420.82
277_V288_K0.5420.82
161_N164_R0.5410.81
140_N198_E0.5380.81
172_D176_L0.5370.81
178_E181_L0.5350.81
349_Y352_K0.5340.81
182_E215_L0.5320.80
62_N70_L0.5320.80
69_I72_M0.5310.80
205_R223_E0.5300.80
187_G191_D0.5260.80
214_L217_T0.5250.80
226_K229_E0.5250.80
302_F344_V0.5240.79
182_E190_S0.5240.79
52_S57_R0.5220.79
40_I50_V0.5210.79
70_L77_I0.5190.79
145_L231_N0.5190.79
228_I232_V0.5170.79
117_K122_Y0.5160.78
184_F192_V0.5150.78
122_Y126_K0.5140.78
268_F344_V0.5130.78
257_G261_R0.5130.78
299_R334_T0.5130.78
300_S303_Y0.5110.78
49_L89_P0.5100.78
305_L337_A0.5080.77
175_K180_R0.5080.77
269_V274_L0.5070.77
305_L309_Q0.5060.77
277_V334_T0.5040.77
145_L228_I0.5020.76
182_E187_G0.5010.76
185_S211_A0.5000.76
334_T347_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.2885 93.3 0.938 Contact Map
4ep4A 2 0.3501 88.3 0.945 Contact Map
3fhfA 1 0.5686 84.9 0.948 Contact Map
1pu6A 1 0.5602 79.6 0.951 Contact Map
2a1jB 2 0.2157 79.3 0.951 Contact Map
1z00B 1 0.2185 78 0.952 Contact Map
2a1jA 1 0.1653 77 0.952 Contact Map
2duyA 1 0.1821 76 0.953 Contact Map
1z00A 1 0.2297 75.8 0.953 Contact Map
1kftA 1 0.1513 75.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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