GREMLIN Database
Q97UQ2 - Deoxycytidine triphosphate deaminase (DcD-2)
UniProt: Q97UQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (156)
Sequences: 1948 (914)
Seq/√Len: 73.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_N119_K5.3051.00
39_R83_C3.7441.00
17_K21_K3.6001.00
114_I122_I3.3371.00
38_L141_H3.3081.00
91_N147_E2.9071.00
83_C137_G2.4761.00
23_I36_Y2.3351.00
107_F132_S2.2891.00
94_V145_F2.2501.00
100_S104_R2.1971.00
16_K153_E2.1941.00
14_S149_D2.0801.00
81_E121_K2.0311.00
30_N39_R2.0041.00
34_N116_A1.9031.00
85_E119_K1.9011.00
95_L146_L1.8841.00
26_Y36_Y1.8191.00
11_S14_S1.7701.00
41_C81_E1.7691.00
16_K28_E1.7691.00
56_A59_A1.7481.00
14_S150_Q1.7251.00
38_L143_L1.7131.00
14_S17_K1.6721.00
119_K162_G1.6311.00
118_Y163_G1.6000.99
18_L92_L1.5940.99
73_S76_K1.5740.99
88_M94_V1.5530.99
88_M92_L1.5160.99
31_V36_Y1.5120.99
19_L26_Y1.4900.99
26_Y31_V1.4710.99
114_I143_L1.4550.99
59_A62_R1.4500.99
100_S142_H1.4200.99
10_L14_S1.4090.99
9_I146_L1.3620.98
43_D63_E1.3570.98
104_R142_H1.3520.98
41_C137_G1.3480.98
13_Q153_E1.3310.98
90_E155_I1.3160.98
69_V133_S1.3050.98
83_C136_K1.2530.97
99_K139_S1.2470.97
48_V62_R1.2320.97
125_A163_G1.2070.96
14_S18_L1.1940.96
38_L86_F1.1920.96
15_I36_Y1.1720.95
18_L89_P1.1710.95
32_R142_H1.1670.95
152_T155_I1.1660.95
102_M138_I1.1580.95
73_S131_N1.1560.95
98_L103_A1.1520.95
18_L91_N1.1510.95
115_D118_Y1.1510.95
57_I62_R1.1340.94
47_V79_L1.1200.94
98_L110_P1.1190.94
71_D133_S1.1010.94
109_A141_H1.0940.93
30_N139_S1.0920.93
115_D160_Y1.0900.93
69_V135_A1.0900.93
82_S124_L1.0760.93
27_V30_N1.0690.93
112_T115_D1.0690.93
95_L113_V1.0500.92
108_L127_T1.0480.92
11_S150_Q1.0440.92
80_F98_L1.0330.91
91_N151_R1.0240.91
148_L152_T1.0200.91
57_I60_K1.0120.90
94_V114_I0.9980.90
37_D99_K0.9980.90
31_V34_N0.9910.89
38_L82_S0.9790.89
9_I93_A0.9750.89
65_P69_V0.9680.88
40_I80_F0.9680.88
99_K142_H0.9660.88
46_Y106_G0.9610.88
10_L147_E0.9580.88
46_Y50_E0.9580.88
9_I144_I0.9420.87
101_T142_H0.9400.87
56_A60_K0.9380.87
89_P92_L0.9320.86
48_V60_K0.9120.85
94_V143_L0.9100.85
55_P59_A0.9070.85
103_A125_A0.9020.84
66_F69_V0.8980.84
126_I134_L0.8980.84
80_F126_I0.8730.82
55_P60_K0.8730.82
97_T110_P0.8680.82
58_K61_I0.8670.82
144_I148_L0.8630.82
89_P120_G0.8620.82
79_L123_Y0.8590.81
16_K20_G0.8540.81
27_V39_R0.8520.81
32_R37_D0.8490.81
103_A112_T0.8470.81
74_P107_F0.8430.80
99_K104_R0.8390.80
90_E117_G0.8380.80
74_P131_N0.8290.79
72_L126_I0.8280.79
35_G144_I0.8120.78
22_V87_N0.8110.78
56_A62_R0.8060.77
115_D120_G0.7870.75
40_I134_L0.7860.75
33_E142_H0.7770.74
37_D144_I0.7770.74
98_L163_G0.7760.74
95_L144_I0.7650.73
21_K63_E0.7630.73
76_K139_S0.7610.73
20_G26_Y0.7610.73
24_I27_V0.7500.72
68_E71_D0.7460.71
16_K31_V0.7460.71
58_K64_I0.7420.71
90_E151_R0.7400.71
113_V118_Y0.7260.69
107_F126_I0.7180.69
44_K70_A0.7170.68
16_K21_K0.7150.68
17_K22_V0.7120.68
55_P64_I0.7070.67
79_L98_L0.7050.67
60_K64_I0.7010.67
35_G158_G0.7000.67
17_K20_G0.6910.66
35_G113_V0.6870.65
56_A64_I0.6810.64
118_Y122_I0.6780.64
48_V51_G0.6750.64
12_H154_R0.6740.64
97_T118_Y0.6730.64
24_I85_E0.6670.63
82_S98_L0.6560.62
12_H15_I0.6540.61
15_I23_I0.6480.61
107_F128_S0.6470.60
79_L124_L0.6420.60
77_T127_T0.6420.60
106_G141_H0.6380.59
80_F140_T0.6380.59
15_I26_Y0.6350.59
128_S132_S0.6330.59
72_L141_H0.6310.59
93_A113_V0.6300.58
43_D81_E0.6290.58
133_S136_K0.6280.58
86_F143_L0.6280.58
82_S103_A0.6190.57
19_L36_Y0.6190.57
29_E59_A0.6100.56
20_G28_E0.6100.56
103_A110_P0.6100.56
106_G128_S0.6080.56
32_R100_S0.6060.56
24_I87_N0.6030.55
100_S103_A0.6000.55
50_E53_Q0.5970.54
55_P61_I0.5950.54
82_S123_Y0.5930.54
15_I33_E0.5920.54
94_V118_Y0.5880.53
71_D76_K0.5870.53
97_T103_A0.5860.53
34_N135_A0.5860.53
67_K154_R0.5820.53
85_E121_K0.5800.52
70_A96_I0.5790.52
124_L140_T0.5740.52
126_I140_T0.5710.51
96_I114_I0.5700.51
82_S140_T0.5690.51
62_R65_P0.5690.51
70_A73_S0.5680.51
58_K62_R0.5630.50
27_V124_L0.5620.50
24_I28_E0.5610.50
107_F113_V0.5560.49
47_V50_E0.5490.48
134_L148_L0.5490.48
95_L111_P0.5480.48
26_Y30_N0.5470.48
75_L129_V0.5470.48
13_Q17_K0.5460.48
99_K159_K0.5460.48
31_V157_S0.5430.48
104_R120_G0.5430.48
55_P58_K0.5400.47
150_Q153_E0.5390.47
15_I145_F0.5360.47
95_L112_T0.5340.47
38_L94_V0.5310.46
90_E145_F0.5290.46
93_A115_D0.5290.46
46_Y76_K0.5290.46
91_N119_K0.5270.46
14_S152_T0.5260.46
89_P145_F0.5240.45
90_E154_R0.5240.45
79_L125_A0.5230.45
59_A68_E0.5210.45
38_L140_T0.5210.45
81_E122_I0.5190.45
42_G147_E0.5180.45
40_I140_T0.5180.45
25_N84_E0.5170.45
73_S78_Y0.5150.44
45_Y81_E0.5130.44
49_E130_Y0.5120.44
13_Q150_Q0.5120.44
46_Y49_E0.5110.44
78_Y122_I0.5070.43
11_S148_L0.5040.43
68_E136_K0.5020.43
57_I64_I0.5010.43
82_S99_K0.5010.43
93_A144_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzjA 3 0.9518 100 0.203 Contact Map
1xs1A 5 0.9578 100 0.25 Contact Map
4xjcA 3 0.9458 100 0.253 Contact Map
2qxxA 3 0.9578 100 0.26 Contact Map
1pkhA 5 0.8916 100 0.262 Contact Map
4dhkA 5 0.8855 100 0.263 Contact Map
3km3A 4 0.8675 100 0.272 Contact Map
2r9qA 4 0.9337 100 0.348 Contact Map
3lqwA 3 0.7048 99.9 0.566 Contact Map
1dunA 3 0.7108 99.9 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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