GREMLIN Database
Q97UN4 - Quinol oxidase-2, subunit II (SoxH)
UniProt: Q97UN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (135)
Sequences: 5650 (2595)
Seq/√Len: 223.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_I105_A3.6271.00
55_M60_E2.9461.00
50_I73_L2.8691.00
77_A120_P2.6031.00
117_V144_V2.5631.00
77_A144_V2.5581.00
75_L117_V2.4171.00
83_L115_I2.3751.00
51_K62_I2.3331.00
72_Q143_V2.2241.00
53_V86_T2.1591.00
47_A79_Q2.0191.00
55_M88_K2.0091.00
127_C131_C1.9861.00
49_P82_L1.9751.00
102_K129_E1.9561.00
95_Y128_A1.9111.00
53_V62_I1.7931.00
80_T116_V1.7891.00
122_V141_T1.7771.00
125_I140_G1.7661.00
74_V143_V1.7461.00
54_A105_A1.7291.00
85_I103_F1.7081.00
55_M58_A1.7021.00
81_Y117_V1.6811.00
122_V143_V1.6571.00
51_K84_E1.6521.00
93_A128_A1.6251.00
82_L112_D1.6171.00
75_L142_L1.5991.00
52_V83_L1.5151.00
28_I32_S1.4951.00
120_P144_V1.4801.00
131_C135_H1.4761.00
99_L117_V1.4591.00
103_F113_F1.4371.00
93_A129_E1.4341.00
76_K81_Y1.4291.00
49_P84_E1.4151.00
104_E129_E1.4041.00
93_A102_K1.3991.00
84_E110_V1.3971.00
92_H131_C1.3871.00
92_H127_C1.3781.00
6_I10_S1.3781.00
24_V28_I1.3291.00
61_F140_G1.3221.00
99_L142_L1.2981.00
72_Q141_T1.2901.00
127_C135_H1.2801.00
47_A80_T1.2631.00
50_I83_L1.2421.00
51_K86_T1.2371.00
61_F73_L1.2281.00
67_T70_T1.1851.00
100_G115_I1.1071.00
96_I142_L1.0811.00
102_K128_A1.0791.00
13_V17_V1.0751.00
135_H138_M1.0551.00
5_R9_L1.0551.00
126_W139_K1.0541.00
72_Q122_V1.0351.00
124_D141_T1.0311.00
124_D139_K1.0111.00
127_C138_M1.0081.00
131_C138_M0.9951.00
103_F111_Y0.9891.00
134_G137_L0.9751.00
44_R47_A0.9741.00
52_V61_F0.9561.00
117_V120_P0.9261.00
61_F94_F0.9261.00
83_L113_F0.9241.00
50_I63_Y0.9210.99
56_Q89_D0.9190.99
84_E112_D0.9160.99
52_V85_I0.9160.99
34_N103_F0.9020.99
31_N34_N0.8980.99
75_L115_I0.8950.99
30_L34_N0.8860.99
44_R114_Y0.8790.99
50_I75_L0.8760.99
36_G114_Y0.8710.99
49_P65_N0.8620.99
27_D31_N0.8620.99
18_I21_V0.8610.99
89_D92_H0.8570.99
44_R80_T0.8510.99
96_I99_L0.8510.99
19_L25_F0.8320.99
48_I81_Y0.8270.99
75_L81_Y0.8270.99
17_V21_V0.8260.99
101_F113_F0.8210.99
123_Y144_V0.8180.99
19_L23_G0.8050.99
24_V32_S0.8020.99
61_F125_I0.7980.99
94_F142_L0.7940.99
66_G69_T0.7810.98
36_G112_D0.7800.98
48_I76_K0.7720.98
86_T110_V0.7720.98
56_Q90_V0.7650.98
91_I106_I0.7640.98
106_I109_Y0.7610.98
66_G70_T0.7560.98
78_N118_N0.7550.98
57_Y90_V0.7330.97
73_L83_L0.7320.97
78_N116_V0.7320.97
9_L13_V0.7320.97
23_G26_S0.7270.97
48_I79_Q0.7210.97
95_Y101_F0.7200.97
11_T15_A0.7180.97
82_L114_Y0.7030.97
120_P123_Y0.6940.97
80_T114_Y0.6880.96
92_H135_H0.6860.96
83_L94_F0.6780.96
58_A134_G0.6740.96
15_A25_F0.6710.96
85_I113_F0.6670.96
7_F11_T0.6600.95
90_V129_E0.6600.95
77_A119_K0.6530.95
95_Y126_W0.6500.95
104_E128_A0.6450.95
87_S91_I0.6420.95
56_Q130_F0.6390.95
20_T24_V0.6380.94
26_S30_L0.6360.94
100_G125_I0.6340.94
29_Y32_S0.6300.94
16_I19_L0.6250.94
15_A26_S0.6230.94
46_D79_Q0.6230.94
77_A117_V0.6220.94
99_L144_V0.6210.94
7_F10_S0.6180.93
6_I9_L0.6100.93
30_L33_I0.6100.93
29_Y33_I0.6100.93
53_V60_E0.6030.93
10_S15_A0.5930.92
52_V94_F0.5920.92
93_A104_E0.5900.92
75_L144_V0.5870.92
112_D119_K0.5870.92
125_I142_L0.5860.92
15_A23_G0.5790.91
81_Y115_I0.5780.91
14_F17_V0.5770.91
23_G27_D0.5680.90
66_G80_T0.5680.90
77_A118_N0.5670.90
73_L142_L0.5660.90
59_W105_A0.5660.90
24_V29_Y0.5660.90
95_Y102_K0.5650.90
51_K64_P0.5650.90
46_D49_P0.5650.90
54_A92_H0.5640.90
117_V142_L0.5640.90
47_A116_V0.5620.90
45_Q78_N0.5570.89
57_Y133_P0.5550.89
62_I68_T0.5540.89
54_A87_S0.5530.89
10_S14_F0.5530.89
28_I31_N0.5490.89
98_Q119_K0.5490.89
96_I123_Y0.5480.89
96_I121_G0.5480.89
63_Y76_K0.5470.89
95_Y136_Y0.5460.88
46_D82_L0.5460.88
14_F114_Y0.5440.88
71_D74_V0.5430.88
45_Q79_Q0.5420.88
60_E88_K0.5410.88
90_V131_C0.5360.88
26_S31_N0.5340.87
89_D127_C0.5340.87
91_I107_P0.5290.87
21_V27_D0.5250.87
4_A16_I0.5220.86
87_S105_A0.5210.86
57_Y130_F0.5160.86
94_F101_F0.5140.85
130_F133_P0.5120.85
53_V88_K0.5120.85
8_E12_I0.5090.85
26_S29_Y0.5040.84
80_T118_N0.5040.84
63_Y73_L0.5030.84
101_F115_I0.5020.84
5_R80_T0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hb3B 1 0.9589 100 0.084 Contact Map
1v54B 1 0.9521 100 0.085 Contact Map
1fftB 1 0.9863 100 0.091 Contact Map
2gsmB 1 0.9521 100 0.095 Contact Map
2yevB 1 0.9521 100 0.138 Contact Map
4txvB 1 0.7466 100 0.244 Contact Map
1cyxA 1 0.6918 100 0.265 Contact Map
3s8fB 1 0.9521 100 0.308 Contact Map
2cuaA 1 0.8082 100 0.496 Contact Map
3sbqA 2 0.9658 99.9 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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