GREMLIN Database
Q97UN3 - Quinol oxidase-2, cytochrome b (SoxG)
UniProt: Q97UN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 549 (417)
Sequences: 417 (170)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
411_V452_R5.6361.00
235_V238_W4.9651.00
140_L171_T4.3350.99
411_V448_W4.1840.98
145_T410_I3.6130.96
407_T452_R3.5910.95
137_V171_T3.4430.94
412_S444_F3.3910.94
155_Q386_E3.3390.93
443_C448_W3.3120.93
442_V447_I3.3090.93
483_L487_L3.1020.90
110_T114_Y3.0570.89
54_K58_D2.7940.85
356_Y420_A2.7920.84
313_L317_A2.5960.80
209_I213_T2.5720.79
353_L417_S2.5240.78
193_T197_L2.4610.76
483_L489_L2.4250.75
140_L168_A2.3950.74
162_I383_F2.3310.72
61_G258_H2.3190.71
147_N152_A2.2930.70
208_L212_F2.2750.70
58_D155_Q2.2590.69
285_D291_Q2.2400.68
252_L255_F2.2310.68
301_I304_F2.2050.67
373_G376_V2.1920.67
173_T372_L2.1380.65
128_L311_I2.1330.64
408_G450_L2.1130.64
105_P231_Q2.0990.63
422_L437_G2.0970.63
86_L248_I2.0600.62
340_E343_Q2.0530.61
177_L233_F1.9930.59
97_A100_A1.9830.58
119_V409_F1.9680.58
436_D440_F1.9670.58
174_E177_L1.9600.58
147_N250_L1.9560.57
197_L375_V1.9540.57
144_M311_I1.9170.56
124_F316_G1.9030.55
61_G212_F1.9000.55
355_I372_L1.8980.55
310_A315_A1.8910.55
197_L359_Y1.8870.55
466_S469_T1.8480.53
438_V442_V1.8100.51
439_I443_C1.7980.51
358_F416_N1.7950.51
92_E132_G1.7900.50
174_E185_L1.7700.50
138_F322_I1.7690.50
92_E248_I1.7510.49
94_I145_T1.7440.49
305_L336_F1.7230.48
165_A379_V1.7060.47
95_T425_G1.7050.47
185_L353_L1.7030.47
119_V323_V1.7000.47
287_K292_P1.6970.47
361_S415_V1.6820.46
162_I356_Y1.6660.45
62_I354_F1.6490.45
135_A209_I1.6410.44
398_L472_G1.6350.44
112_T323_V1.6340.44
264_V393_A1.6120.43
109_Y243_L1.5940.42
350_W411_V1.5890.42
58_D93_V1.5770.42
419_W440_F1.5760.42
95_T233_F1.5710.41
198_F374_W1.5700.41
198_F213_T1.5620.41
448_W452_R1.5620.41
197_L372_L1.5550.41
109_Y314_I1.5480.40
376_V379_V1.5350.40
153_Y468_L1.5340.40
55_W60_L1.5310.40
104_T231_Q1.5300.40
102_Y345_P1.5240.40
119_V438_V1.5120.39
145_T409_F1.5100.39
95_T125_L1.4970.38
453_Y462_K1.4950.38
162_I166_G1.4950.38
91_L315_A1.4860.38
80_W147_N1.4790.38
189_V421_A1.4760.38
438_V441_L1.4710.37
447_I469_T1.4590.37
101_L312_F1.4580.37
170_L243_L1.4350.36
144_M318_I1.4350.36
189_V343_Q1.4320.36
344_T356_Y1.4320.36
392_K477_Y1.4210.35
244_I352_F1.4210.35
286_P394_P1.4180.35
266_Q278_Y1.4140.35
48_L240_V1.4130.35
373_G378_T1.4100.35
196_N214_V1.4080.35
440_F453_Y1.4050.35
58_D244_I1.4040.35
316_G398_L1.3940.34
311_I315_A1.3830.34
240_V375_V1.3740.34
172_L362_V1.3700.34
252_L311_I1.3520.33
353_L387_Y1.3490.33
172_L227_D1.3450.33
264_V392_K1.3400.32
93_V239_I1.3360.32
291_Q436_D1.3310.32
197_L358_F1.3200.32
111_S115_L1.3070.31
89_F248_I1.2960.31
93_V97_A1.2830.30
70_A307_T1.2770.30
444_F450_L1.2680.30
159_I431_I1.2630.30
194_G372_L1.2550.29
90_I384_I1.2460.29
119_V242_G1.2440.29
401_A457_P1.2410.29
61_G471_G1.2350.29
318_I345_P1.2330.29
213_T236_F1.2320.29
418_V436_D1.2260.28
243_L323_V1.2190.28
174_E189_V1.2180.28
47_G279_Q1.2130.28
233_F239_I1.2120.28
286_P442_V1.1970.27
115_L455_A1.1960.27
162_I379_V1.1940.27
193_T428_I1.1930.27
54_K168_A1.1900.27
253_Y466_S1.1890.27
137_V142_V1.1880.27
194_G236_F1.1870.27
43_E253_Y1.1740.27
485_G489_L1.1630.26
433_T453_Y1.1470.26
201_M372_L1.1460.26
137_V140_L1.1450.26
285_D290_L1.1440.26
173_T193_T1.1430.26
386_E488_V1.1420.26
249_G335_A1.1380.26
69_P256_E1.1350.25
128_L235_V1.1290.25
238_W246_A1.1290.25
301_I308_F1.1270.25
51_R411_V1.1260.25
153_Y381_F1.1210.25
85_V139_L1.1120.25
55_W159_I1.1080.25
413_F416_N1.1050.24
293_L300_V1.1010.24
51_R209_I1.1000.24
140_L370_I1.0970.24
205_L213_T1.0950.24
47_G51_R1.0860.24
173_T236_F1.0820.24
234_F255_F1.0800.24
97_A135_A1.0750.24
361_S419_W1.0650.23
359_Y368_S1.0620.23
291_Q472_G1.0620.23
466_S470_D1.0590.23
227_D243_L1.0580.23
288_W307_T1.0560.23
387_Y408_G1.0530.23
70_A420_A1.0530.23
236_F246_A1.0490.23
358_F371_F1.0470.23
212_F286_P1.0450.23
362_V367_A1.0420.23
414_I452_R1.0410.23
193_T420_A1.0370.22
305_L472_G1.0350.22
344_T436_D1.0340.22
165_A169_G1.0330.22
94_I425_G1.0330.22
233_F340_E1.0320.22
44_Q48_L1.0260.22
118_K414_I1.0250.22
172_L352_F1.0200.22
185_L343_Q1.0180.22
165_A234_F1.0110.22
102_Y462_K1.0050.22
141_L369_L1.0040.22
69_P287_K1.0010.21
193_T352_F0.9960.21
244_I481_R0.9930.21
194_G197_L0.9920.21
346_P356_Y0.9900.21
84_L303_I0.9900.21
62_I384_I0.9900.21
124_F383_F0.9890.21
165_A378_T0.9880.21
43_E46_N0.9880.21
195_L210_S0.9870.21
212_F353_L0.9850.21
203_F238_W0.9830.21
235_V375_V0.9820.21
321_N385_E0.9790.21
227_D354_F0.9700.21
56_L370_I0.9690.21
91_L352_F0.9670.20
67_L125_L0.9650.20
93_V125_L0.9600.20
312_F315_A0.9590.20
171_T479_E0.9590.20
424_P428_I0.9570.20
410_I414_I0.9570.20
387_Y414_I0.9550.20
92_E279_Q0.9550.20
266_Q413_F0.9530.20
100_A238_W0.9530.20
54_K62_I0.9520.20
51_R227_D0.9520.20
436_D484_S0.9480.20
177_L194_G0.9450.20
415_V420_A0.9410.20
90_I101_L0.9380.20
433_T460_L0.9380.20
196_N248_I0.9370.20
173_T201_M0.9360.20
194_G311_I0.9320.20
213_T370_I0.9320.20
78_D184_N0.9320.20
439_I444_F0.9300.19
302_M305_L0.9200.19
200_Y445_A0.9190.19
52_F455_A0.9190.19
109_Y418_V0.9150.19
212_F362_V0.9140.19
358_F440_F0.9130.19
60_L314_I0.9120.19
193_T214_V0.9100.19
239_I401_A0.9090.19
445_A450_L0.9070.19
111_S364_P0.9070.19
47_G240_V0.9030.19
193_T358_F0.9030.19
287_K420_A0.9020.19
318_I354_F0.9020.19
63_Y72_R0.9010.19
134_Y320_F0.9000.19
46_N50_D0.9000.19
371_F410_I0.8990.19
371_F416_N0.8980.19
405_I410_I0.8960.19
195_L199_S0.8940.19
95_T487_L0.8930.19
61_G398_L0.8900.18
353_L421_A0.8870.18
110_T244_I0.8860.18
191_T233_F0.8840.18
55_W197_L0.8830.18
361_S444_F0.8800.18
56_L353_L0.8770.18
90_I369_L0.8750.18
55_W193_T0.8740.18
235_V466_S0.8730.18
54_K144_M0.8720.18
138_F248_I0.8710.18
145_T378_T0.8690.18
201_M355_I0.8680.18
433_T436_D0.8600.18
372_L375_V0.8580.18
234_F238_W0.8560.18
118_K137_V0.8560.18
101_L451_L0.8550.18
208_L253_Y0.8540.18
86_L92_E0.8520.18
242_G346_P0.8500.17
197_L373_G0.8470.17
115_L125_L0.8450.17
399_R451_L0.8450.17
201_M240_V0.8430.17
98_L366_N0.8420.17
196_N223_M0.8410.17
55_W246_A0.8390.17
193_T356_Y0.8380.17
304_F307_T0.8380.17
240_V384_I0.8360.17
159_I280_D0.8360.17
168_A378_T0.8350.17
198_F201_M0.8340.17
101_L238_W0.8320.17
137_V407_T0.8310.17
316_G364_P0.8310.17
78_D81_L0.8290.17
80_W288_W0.8270.17
194_G352_F0.8270.17
91_L354_F0.8260.17
118_K353_L0.8250.17
323_V410_I0.8220.17
147_N252_L0.8190.17
105_P109_Y0.8150.17
431_I436_D0.8150.17
51_R451_L0.8120.17
229_L233_F0.8120.17
249_G256_E0.8110.17
366_N481_R0.8090.17
144_M168_A0.8070.16
95_T288_W0.8040.16
193_T372_L0.8020.16
394_P399_R0.8000.16
233_F416_N0.7980.16
145_T372_L0.7970.16
72_R258_H0.7970.16
141_L350_W0.7920.16
165_A228_P0.7890.16
137_V168_A0.7880.16
381_F410_I0.7870.16
359_Y419_W0.7840.16
194_G355_I0.7830.16
65_H335_A0.7820.16
165_A197_L0.7810.16
64_G242_G0.7760.16
305_L388_V0.7760.16
125_L380_L0.7760.16
43_E47_G0.7730.16
211_L249_G0.7730.16
228_P238_W0.7720.16
50_D309_G0.7720.16
173_T194_G0.7720.16
98_L102_Y0.7650.16
132_G370_I0.7640.16
60_L212_F0.7640.16
286_P387_Y0.7640.16
386_E409_F0.7630.15
197_L378_T0.7620.15
279_Q392_K0.7580.15
470_D475_I0.7580.15
314_I368_S0.7570.15
258_H291_Q0.7530.15
146_R202_P0.7510.15
267_V389_F0.7510.15
56_L444_F0.7490.15
254_I481_R0.7480.15
442_V477_Y0.7460.15
176_Y233_F0.7430.15
172_L354_F0.7410.15
65_H249_G0.7390.15
171_T361_S0.7380.15
111_S369_L0.7380.15
56_L377_V0.7360.15
414_I417_S0.7350.15
369_L373_G0.7340.15
166_G452_R0.7340.15
291_Q307_T0.7310.15
245_L248_I0.7290.15
355_I420_A0.7280.15
62_I383_F0.7270.15
459_V488_V0.7220.15
197_L409_F0.7220.15
244_I310_A0.7220.15
300_V303_I0.7220.15
194_G250_L0.7220.15
58_D311_I0.7210.15
292_P468_L0.7200.15
432_G480_R0.7150.14
54_K244_I0.7130.14
205_L407_T0.7120.14
48_L168_A0.7110.14
163_V249_G0.7100.14
310_A455_A0.7100.14
80_W424_P0.7090.14
454_V480_R0.7040.14
98_L417_S0.7030.14
98_L364_P0.7030.14
384_I439_I0.7010.14
411_V418_V0.7000.14
194_G418_V0.6990.14
97_A159_I0.6990.14
75_Y291_Q0.6980.14
177_L236_F0.6960.14
51_R317_A0.6940.14
323_V443_C0.6940.14
95_T365_T0.6930.14
155_Q313_L0.6930.14
193_T427_D0.6920.14
245_L420_A0.6920.14
209_I249_G0.6910.14
58_D140_L0.6900.14
207_Y366_N0.6900.14
48_L137_V0.6880.14
388_V428_I0.6880.14
287_K291_Q0.6870.14
114_Y399_R0.6870.14
323_V421_A0.6870.14
106_S200_Y0.6830.14
244_I386_E0.6830.14
90_I235_V0.6810.14
398_L457_P0.6780.14
266_Q291_Q0.6770.14
90_I203_F0.6760.14
135_A318_I0.6740.14
362_V437_G0.6730.14
64_G165_A0.6710.14
236_F239_I0.6710.14
55_W364_P0.6680.14
62_I388_V0.6680.14
144_M310_A0.6670.13
166_G236_F0.6600.13
189_V195_L0.6600.13
66_T70_A0.6570.13
291_Q309_G0.6570.13
229_L450_L0.6560.13
87_S291_Q0.6550.13
65_H69_P0.6540.13
201_M445_A0.6520.13
115_L207_Y0.6510.13
60_L481_R0.6510.13
384_I418_V0.6510.13
191_T209_I0.6470.13
238_W394_P0.6470.13
95_T306_L0.6450.13
58_D475_I0.6440.13
203_F280_D0.6440.13
137_V311_I0.6430.13
223_M228_P0.6430.13
172_L244_I0.6420.13
197_L355_I0.6420.13
305_L469_T0.6370.13
240_V250_L0.6370.13
442_V450_L0.6360.13
66_T420_A0.6360.13
109_Y171_T0.6340.13
169_G244_I0.6340.13
285_D292_P0.6340.13
238_W421_A0.6340.13
418_V454_V0.6320.13
361_S420_A0.6310.13
55_W386_E0.6290.13
173_T466_S0.6290.13
377_V424_P0.6280.13
257_K366_N0.6280.13
201_M378_T0.6270.13
312_F352_F0.6270.13
239_I365_T0.6270.13
207_Y410_I0.6260.13
407_T411_V0.6250.13
61_G388_V0.6240.13
280_D311_I0.6220.13
292_P477_Y0.6220.13
159_I335_A0.6210.13
44_Q203_F0.6150.13
95_T335_A0.6140.12
55_W466_S0.6130.12
125_L305_L0.6110.12
242_G292_P0.6090.12
199_S307_T0.6090.12
257_K343_Q0.6080.12
192_T460_L0.6080.12
371_F462_K0.6070.12
119_V245_L0.6070.12
142_V288_W0.6070.12
358_F372_L0.6050.12
61_G472_G0.6050.12
51_R58_D0.6030.12
167_L207_Y0.6030.12
93_V145_T0.6030.12
180_S192_T0.6020.12
101_L409_F0.6010.12
56_L200_Y0.5990.12
48_L238_W0.5990.12
144_M413_F0.5980.12
412_S445_A0.5970.12
359_Y421_A0.5960.12
61_G286_P0.5950.12
124_F279_Q0.5950.12
70_A189_V0.5950.12
300_V307_T0.5930.12
149_F406_G0.5920.12
318_I417_S0.5900.12
436_D470_D0.5900.12
408_G413_F0.5900.12
80_W172_L0.5890.12
101_L125_L0.5890.12
205_L306_L0.5880.12
145_T234_F0.5870.12
58_D163_V0.5860.12
43_E244_I0.5850.12
124_F439_I0.5840.12
137_V352_F0.5830.12
464_Q467_P0.5790.12
268_K434_E0.5790.12
58_D172_L0.5780.12
463_W467_P0.5780.12
484_S490_L0.5780.12
287_K355_I0.5760.12
76_S79_Y0.5760.12
49_F257_K0.5760.12
93_V376_V0.5740.12
97_A244_I0.5730.12
87_S263_P0.5730.12
66_T287_K0.5730.12
211_L454_V0.5720.12
286_P408_G0.5710.12
131_W154_R0.5700.12
457_P472_G0.5700.12
165_A428_I0.5700.12
355_I358_F0.5700.12
193_T359_Y0.5690.12
398_L431_I0.5690.12
48_L51_R0.5690.12
305_L346_P0.5680.12
147_N253_Y0.5680.12
236_F421_A0.5670.12
144_M180_S0.5650.12
128_L135_A0.5650.12
168_A336_F0.5650.12
56_L162_I0.5620.12
248_I373_G0.5620.12
235_V248_I0.5620.12
109_Y165_A0.5620.12
159_I383_F0.5600.12
185_L189_V0.5570.11
352_F422_L0.5570.11
89_F92_E0.5570.11
172_L246_A0.5550.11
64_G399_R0.5540.11
306_L445_A0.5530.11
229_L411_V0.5530.11
102_Y173_T0.5520.11
244_I355_I0.5520.11
246_A345_P0.5510.11
173_T355_I0.5510.11
405_I420_A0.5510.11
336_F359_Y0.5510.11
70_A101_L0.5500.11
128_L248_I0.5490.11
51_R67_L0.5490.11
194_G242_G0.5480.11
45_S388_V0.5470.11
55_W196_N0.5470.11
383_F388_V0.5450.11
48_L140_L0.5430.11
213_T459_V0.5420.11
75_Y285_D0.5420.11
318_I488_V0.5410.11
139_L350_W0.5400.11
407_T410_I0.5400.11
208_L394_P0.5400.11
48_L414_I0.5380.11
44_Q454_V0.5380.11
367_A373_G0.5380.11
322_I353_L0.5380.11
242_G245_L0.5370.11
95_T104_T0.5360.11
207_Y257_K0.5350.11
317_A401_A0.5350.11
486_L490_L0.5340.11
105_P465_S0.5320.11
91_L369_L0.5320.11
172_L378_T0.5300.11
66_T256_E0.5300.11
393_A477_Y0.5290.11
68_R256_E0.5270.11
169_G379_V0.5270.11
166_G169_G0.5250.11
48_L203_F0.5250.11
368_S372_L0.5240.11
171_T245_L0.5240.11
292_P308_F0.5240.11
141_L168_A0.5230.11
265_S268_K0.5220.11
388_V436_D0.5220.11
244_I419_W0.5200.11
71_P192_T0.5200.11
388_V394_P0.5190.11
162_I420_A0.5190.11
163_V247_L0.5180.11
132_G384_I0.5180.11
162_I414_I0.5170.11
458_R464_Q0.5170.11
69_P195_L0.5170.11
301_I305_L0.5170.11
62_I66_T0.5160.11
45_S155_Q0.5160.11
453_Y471_G0.5160.11
93_V248_I0.5150.11
109_Y310_A0.5150.11
112_T203_F0.5150.11
171_T312_F0.5140.11
244_I378_T0.5140.11
233_F364_P0.5130.11
135_A384_I0.5130.11
80_W356_Y0.5120.11
94_I459_V0.5120.11
94_I249_G0.5120.11
456_Q460_L0.5110.11
196_N359_Y0.5100.11
69_P258_H0.5100.11
168_A393_A0.5090.11
408_G419_W0.5090.11
93_V280_D0.5090.11
228_P249_G0.5090.11
194_G436_D0.5080.11
370_I405_I0.5070.11
80_W88_A0.5070.11
60_L254_I0.5070.11
235_V377_V0.5060.11
248_I315_A0.5050.11
194_G252_L0.5040.11
44_Q376_V0.5040.11
203_F384_I0.5040.11
166_G451_L0.5030.11
293_L391_H0.5030.11
223_M242_G0.5020.11
139_L369_L0.5020.11
102_Y138_F0.5000.11
258_H263_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.7304 100 0.624 Contact Map
3cx5C 2 0.6849 100 0.658 Contact Map
1pp9C 2 0.6576 100 0.67 Contact Map
4ogqA 2 0.3789 100 0.744 Contact Map
4ogqB 1 0.2823 99.6 0.924 Contact Map
1kqfC 3 0.3643 86.8 0.977 Contact Map
4gd3A 2 0.2769 80.4 0.979 Contact Map
2iiiA 2 0.0965 27.9 0.985 Contact Map
1vr7A 2 0.102 24.6 0.986 Contact Map
1zoyC 1 0.2222 9.8 0.988 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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