GREMLIN Database
Q97UM6 - Putative methylthioribose-1-phosphate isomerase
UniProt: Q97UM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (317)
Sequences: 3042 (2004)
Seq/√Len: 112.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_V342_I3.5281.00
273_Y282_L3.2191.00
117_R144_E3.0861.00
300_N303_E3.0191.00
40_K228_E2.7661.00
35_L41_V2.7511.00
276_A341_Y2.7321.00
52_A104_A2.6771.00
35_L39_Q2.6201.00
53_L57_N2.5581.00
47_D50_S2.5481.00
176_Q210_P2.4391.00
27_T44_D2.4321.00
98_K119_L2.4291.00
281_E341_Y2.4171.00
196_K229_E2.3841.00
77_A97_A2.3641.00
171_D252_S2.3641.00
98_K115_T2.3631.00
167_L252_S2.3481.00
159_M289_L2.3451.00
242_G274_K2.2711.00
58_M215_W2.2151.00
209_A233_V2.1781.00
29_T44_D2.1261.00
117_R151_E2.1231.00
281_E340_K2.1171.00
168_N171_D2.0761.00
254_M289_L2.0681.00
206_S234_T2.0591.00
255_V272_T2.0251.00
235_L327_V2.0151.00
31_L40_K2.0081.00
72_Y149_F2.0051.00
260_I290_A1.9621.00
34_S59_Q1.9611.00
102_D116_S1.9551.00
52_A100_I1.9531.00
102_D112_V1.9281.00
43_V59_Q1.9091.00
237_T240_A1.9061.00
174_L210_P1.8681.00
49_D100_I1.8411.00
118_M141_M1.8271.00
235_L323_A1.8251.00
139_D143_V1.8021.00
95_T119_L1.7881.00
233_V327_V1.7841.00
75_V142_K1.7641.00
172_T251_N1.7491.00
31_L42_Y1.7421.00
321_P325_E1.7201.00
223_V235_L1.7111.00
253_V279_A1.7001.00
133_T136_E1.6971.00
174_L250_V1.6921.00
34_S57_N1.6841.00
150_D154_D1.6821.00
267_F304_I1.6801.00
45_L51_T1.6671.00
40_K224_Y1.6581.00
164_L201_L1.6511.00
208_I250_V1.6481.00
240_A332_P1.6381.00
161_L197_L1.6251.00
172_T206_S1.5991.00
265_H339_P1.5781.00
169_D204_N1.5751.00
154_D158_Q1.5741.00
287_Y344_G1.5541.00
53_L59_Q1.5521.00
257_A290_A1.5511.00
158_Q161_L1.5471.00
237_T314_V1.5361.00
94_L122_A1.5191.00
257_A260_I1.5141.00
246_Y302_N1.5031.00
285_P343_A1.5001.00
112_V116_S1.5001.00
27_T46_K1.4961.00
86_T89_E1.4691.00
72_Y146_K1.4651.00
74_M98_K1.4431.00
295_F352_I1.4401.00
206_S232_K1.4231.00
308_E330_Y1.4211.00
255_V288_A1.4161.00
144_E147_R1.4131.00
171_D251_N1.4041.00
312_N315_R1.4011.00
172_T208_I1.3931.00
95_T123_K1.3771.00
255_V286_F1.3631.00
266_V288_A1.3521.00
56_K100_I1.3501.00
244_V330_Y1.3481.00
174_L275_E1.3401.00
315_R326_N1.3331.00
261_L299_S1.3311.00
102_D115_T1.3271.00
292_T348_E1.3201.00
165_E201_L1.3101.00
152_E156_E1.3060.99
272_T337_T1.3050.99
197_L200_A1.2950.99
263_D301_V1.2680.99
46_K50_S1.2670.99
197_L201_L1.2610.99
215_W220_R1.2470.99
164_L203_M1.2400.99
311_P329_V1.2370.99
169_D203_M1.2210.99
194_P289_L1.2170.99
232_K328_N1.2150.99
157_I161_L1.2060.99
143_V147_R1.1970.99
99_A103_S1.1910.99
199_K204_N1.1820.99
30_I45_L1.1790.99
93_E96_R1.1720.99
146_K149_F1.1620.99
243_L246_Y1.1590.99
227_M327_V1.1530.99
115_T119_L1.1510.99
241_V275_E1.1370.99
112_V115_T1.1330.99
171_D203_M1.1310.99
353_Y356_F1.1250.98
312_N316_T1.1250.98
252_S344_G1.1230.98
273_Y338_P1.1220.98
241_V274_K1.1200.98
113_W293_S1.1170.98
352_I356_F1.1120.98
30_I59_Q1.1020.98
167_L171_D1.1010.98
165_E351_I1.0960.98
89_E93_E1.0950.98
121_L144_E1.0940.98
52_A103_S1.0920.98
142_K146_K1.0900.98
100_I103_S1.0860.98
245_M279_A1.0820.98
277_V281_E1.0800.98
242_G277_V1.0790.98
95_T99_A1.0790.98
209_A222_T1.0770.98
157_I200_A1.0750.98
207_V226_L1.0740.98
155_A292_T1.0720.98
170_S204_N1.0720.98
210_P241_V1.0660.98
161_L165_E1.0620.98
280_H283_G1.0580.98
198_A252_S1.0570.98
210_P275_E1.0500.98
166_K344_G1.0500.98
74_M118_M1.0470.98
162_Y165_E1.0390.97
171_D198_A1.0350.97
245_M253_V1.0340.97
51_T69_T1.0330.97
243_L330_Y1.0320.97
215_W333_V1.0290.97
104_A112_V1.0290.97
146_K150_D1.0280.97
352_I355_P1.0250.97
125_A140_L1.0180.97
90_A138_I1.0140.97
314_V329_V0.9990.97
193_S197_L0.9980.97
200_A229_E0.9930.97
242_G278_I0.9910.97
68_I149_F0.9910.97
224_Y228_E0.9880.97
160_G197_L0.9850.96
236_I244_V0.9840.96
198_A205_V0.9760.96
344_G351_I0.9760.96
299_S303_E0.9760.96
195_V231_I0.9750.96
73_G76_L0.9710.96
265_H336_V0.9640.96
144_E148_I0.9590.96
243_L247_R0.9560.96
34_S215_W0.9490.96
92_R96_R0.9460.96
176_Q275_E0.9370.95
173_V204_N0.9370.95
28_L31_L0.9340.95
32_D41_V0.9330.95
259_R296_D0.9320.95
144_E151_E0.9310.95
242_G282_L0.9270.95
164_L197_L0.9260.95
309_R313_E0.9180.95
170_S205_V0.9080.94
217_Q269_K0.9060.94
287_Y343_A0.9040.94
179_A233_V0.8980.94
157_I197_L0.8940.94
72_Y75_V0.8920.94
41_V44_D0.8910.94
245_M284_I0.8900.94
247_R308_E0.8900.94
193_S196_K0.8890.94
253_V275_E0.8890.94
292_T349_K0.8870.94
120_T123_K0.8810.94
309_R333_V0.8780.93
134_I138_I0.8780.93
315_R321_P0.8730.93
35_L43_V0.8710.93
48_V100_I0.8680.93
163_G194_P0.8680.93
38_F321_P0.8660.93
29_T42_Y0.8630.93
172_T205_V0.8610.93
242_G273_Y0.8600.93
207_V231_I0.8580.93
260_I345_I0.8500.92
211_E238_D0.8500.92
195_V205_V0.8490.92
253_V286_F0.8460.92
66_I114_A0.8460.92
287_Y346_I0.8450.92
244_V250_V0.8380.92
199_K232_K0.8360.92
147_R151_E0.8340.92
30_I60_V0.8320.91
171_D205_V0.8310.91
104_A115_T0.8280.91
215_W240_A0.8270.91
167_L173_V0.8260.91
48_V97_A0.8240.91
91_I123_K0.8200.91
52_A56_K0.8180.91
241_V278_I0.8180.91
121_L125_A0.8160.91
280_H340_K0.8110.90
315_R329_V0.8080.90
119_L122_A0.8070.90
274_K278_I0.8040.90
206_S233_V0.8030.90
179_A194_P0.7960.90
194_P197_L0.7960.90
158_Q162_Y0.7950.90
245_M282_L0.7930.89
312_N321_P0.7910.89
74_M94_L0.7900.89
183_A225_E0.7880.89
288_A342_I0.7850.89
119_L123_K0.7810.89
179_A193_S0.7780.88
64_P184_T0.7730.88
116_S120_T0.7720.88
135_N139_D0.7680.88
160_G193_S0.7640.88
30_I69_T0.7630.88
68_I156_E0.7610.87
234_T328_N0.7560.87
196_K231_I0.7540.87
317_I322_I0.7540.87
265_H301_V0.7540.87
257_A345_I0.7530.87
249_M330_Y0.7510.87
32_D59_Q0.7500.87
195_V207_V0.7470.86
208_I249_M0.7450.86
239_T314_V0.7400.86
163_G289_L0.7390.86
167_L203_M0.7390.86
316_T321_P0.7380.86
147_R150_D0.7370.86
28_L72_Y0.7360.86
318_R322_I0.7330.85
30_I43_V0.7310.85
179_A294_S0.7270.85
28_L149_F0.7210.84
78_L81_N0.7170.84
219_S235_L0.7160.84
162_Y350_G0.7140.84
173_V195_V0.7130.84
257_A266_V0.7100.83
75_V79_T0.7080.83
227_M233_V0.7050.83
223_V324_P0.7050.83
195_V199_K0.7000.83
113_W117_R0.6990.83
177_C268_N0.6990.83
319_G322_I0.6940.82
194_P254_M0.6940.82
155_A159_M0.6930.82
117_R148_I0.6910.82
161_L201_L0.6890.82
121_L140_L0.6850.81
178_N183_A0.6820.81
114_A118_M0.6810.81
90_A134_I0.6790.81
120_T124_N0.6770.80
167_L205_V0.6740.80
136_E139_D0.6720.80
163_G346_I0.6700.80
316_T322_I0.6680.80
277_V282_L0.6670.80
291_P294_S0.6670.80
52_A115_T0.6660.79
177_C269_K0.6640.79
266_V345_I0.6640.79
72_Y76_L0.6620.79
252_S287_Y0.6620.79
53_L56_K0.6600.79
215_W331_N0.6580.79
91_I95_T0.6580.79
97_A104_A0.6570.78
91_I122_A0.6560.78
56_K103_S0.6540.78
209_A235_L0.6510.78
156_E193_S0.6450.77
82_K138_I0.6450.77
244_V249_M0.6420.77
173_V252_S0.6420.77
116_S298_K0.6410.77
169_D205_V0.6400.77
172_T244_V0.6400.77
164_L351_I0.6370.76
252_S285_P0.6370.76
118_M122_A0.6360.76
45_L50_S0.6350.76
261_L301_V0.6340.76
74_M115_T0.6340.76
198_A204_N0.6320.76
209_A223_V0.6300.76
208_I236_I0.6290.75
227_M324_P0.6280.75
292_T295_F0.6280.75
258_D334_F0.6250.75
305_K308_E0.6250.75
82_K93_E0.6240.75
280_H341_Y0.6220.75
166_K287_Y0.6200.74
72_Y79_T0.6200.74
159_M194_P0.6200.74
93_E97_A0.6190.74
273_Y277_V0.6170.74
269_K334_F0.6160.74
92_R95_T0.6150.74
311_P328_N0.6120.73
235_L332_P0.6120.73
125_A137_L0.6100.73
138_I142_K0.6100.73
155_A348_E0.6100.73
216_L219_S0.6090.73
107_T307_E0.6060.73
72_Y142_K0.6010.72
29_T40_K0.6010.72
99_A102_D0.6000.72
258_D269_K0.5990.72
194_P287_Y0.5990.72
90_A236_I0.5950.71
177_C212_T0.5940.71
346_I351_I0.5930.71
101_L115_T0.5930.71
213_R218_G0.5910.71
149_F153_Y0.5910.71
48_V77_A0.5890.71
71_G114_A0.5870.70
315_R323_A0.5870.70
213_R331_N0.5860.70
56_K104_A0.5850.70
29_T38_F0.5850.70
43_V53_L0.5840.70
309_R331_N0.5840.70
211_E235_L0.5830.70
214_P238_D0.5810.70
177_C307_E0.5810.70
153_Y157_I0.5800.69
166_K353_Y0.5800.69
274_K277_V0.5790.69
50_S53_L0.5790.69
84_V93_E0.5770.69
199_K229_E0.5750.69
182_L224_Y0.5750.69
285_P354_P0.5750.69
79_T142_K0.5750.69
166_K351_I0.5730.69
267_F301_V0.5720.68
29_T35_L0.5720.68
212_T269_K0.5710.68
81_N93_E0.5710.68
75_V138_I0.5710.68
90_A137_L0.5700.68
72_Y148_I0.5700.68
179_A266_V0.5700.68
258_D309_R0.5680.68
242_G281_E0.5680.68
174_L253_V0.5660.68
30_I34_S0.5650.67
39_Q44_D0.5630.67
35_L318_R0.5630.67
98_K102_D0.5600.67
99_A119_L0.5590.67
168_N252_S0.5570.66
321_P324_P0.5550.66
31_L60_V0.5550.66
140_L143_V0.5550.66
84_V89_E0.5520.66
49_D53_L0.5500.65
58_M333_V0.5500.65
223_V327_V0.5490.65
258_D268_N0.5490.65
105_R269_K0.5490.65
168_N251_N0.5490.65
295_F347_T0.5490.65
91_I137_L0.5470.65
267_F336_V0.5470.65
61_R64_P0.5450.65
48_V52_A0.5450.65
67_G113_W0.5450.65
92_R143_V0.5440.65
85_K89_E0.5430.64
206_S328_N0.5410.64
316_T325_E0.5400.64
211_E214_P0.5390.64
239_T275_E0.5380.64
240_A278_I0.5380.64
257_A342_I0.5370.64
263_D339_P0.5360.63
179_A234_T0.5350.63
310_D315_R0.5350.63
317_I320_I0.5340.63
177_C217_Q0.5340.63
69_T73_G0.5340.63
178_N221_L0.5320.63
193_S229_E0.5310.63
107_T309_R0.5300.63
66_I108_A0.5280.62
194_P346_I0.5280.62
69_T76_L0.5260.62
51_T76_L0.5250.62
183_A221_L0.5240.62
307_E334_F0.5240.62
114_A148_I0.5230.62
87_L91_I0.5220.61
227_M326_N0.5210.61
79_T82_K0.5200.61
31_L36_L0.5190.61
27_T38_F0.5190.61
269_K307_E0.5180.61
30_I54_A0.5180.61
102_D119_L0.5170.61
339_P356_F0.5170.61
79_T230_G0.5160.61
167_L198_A0.5160.61
154_D157_I0.5150.60
213_R314_V0.5130.60
32_D43_V0.5120.60
98_K342_I0.5120.60
151_E154_D0.5110.60
172_T248_G0.5110.60
262_R299_S0.5090.59
118_M145_A0.5090.59
179_A327_V0.5080.59
168_N203_M0.5070.59
75_V78_L0.5070.59
288_A344_G0.5070.59
89_E92_R0.5060.59
46_K79_T0.5050.59
34_S58_M0.5040.59
226_L231_I0.5040.59
75_V80_S0.5040.59
255_V337_T0.5040.59
313_E333_V0.5010.58
276_A286_F0.5010.58
282_L341_Y0.5000.58
52_A97_A0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldrA 2 0.9481 100 0.134 Contact Map
2yvkA 2 0.9481 100 0.139 Contact Map
1t5oA 2 0.929 100 0.139 Contact Map
2a0uA 2 0.9617 100 0.153 Contact Map
1t9kA 2 0.9317 100 0.161 Contact Map
3a11A 4 0.8525 100 0.215 Contact Map
3ecsA 4 0.7978 100 0.317 Contact Map
1vb5A 3 0.7486 100 0.385 Contact Map
1w2wB 2 0.4481 100 0.505 Contact Map
1w2wA 1 0.5082 100 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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