GREMLIN Database
Q97UM5 - Uncharacterized protein
UniProt: Q97UM5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (304)
Sequences: 335 (271)
Seq/√Len: 15.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_N106_D11.3981.00
117_K122_S5.2211.00
111_E114_P4.0641.00
41_I82_V3.4210.99
34_Y41_I3.1080.99
30_Y34_Y3.0970.98
213_S238_W3.0700.98
39_I117_K2.9290.98
9_E15_D2.8680.97
67_V71_S2.6420.96
110_K144_Y2.6050.95
30_Y80_V2.5830.95
34_Y39_I2.5500.95
131_S299_H2.5290.95
33_D78_G2.3790.93
34_Y80_V2.2800.91
9_E21_P2.2040.89
15_D21_P2.1440.88
7_E25_R2.1180.87
115_F119_K2.0960.87
105_E143_K2.0840.86
97_N103_M2.0520.86
157_D160_F2.0520.86
137_A153_D2.0110.84
117_K125_I1.9460.82
96_I212_Y1.9440.82
215_N220_E1.9120.81
39_I148_I1.8660.79
80_V121_K1.8610.79
31_P82_V1.8280.78
34_Y125_I1.8260.78
157_D242_D1.8250.78
222_P235_W1.8190.78
8_F112_L1.8130.77
118_D229_E1.8100.77
10_S111_E1.7810.76
74_G118_D1.7650.75
302_T305_R1.7320.74
24_R112_L1.7200.73
141_G151_I1.7050.73
68_E71_S1.6970.72
34_Y82_V1.6940.72
109_V140_L1.6540.70
29_I68_E1.6460.70
72_N287_G1.6300.69
153_D156_G1.6290.69
213_S234_V1.6230.69
179_K182_E1.6180.69
31_P125_I1.5990.68
169_P212_Y1.5880.67
132_S157_D1.5870.67
109_V148_I1.5820.67
246_M250_Y1.5670.66
302_T307_D1.5620.66
302_T306_Y1.5550.65
12_V111_E1.5510.65
238_W299_H1.5420.65
282_K286_Y1.5410.65
39_I80_V1.5070.63
33_D36_G1.4960.62
260_I283_L1.4930.62
189_W193_N1.4730.61
167_T170_R1.4710.61
39_I122_S1.4710.61
43_L155_A1.4680.61
30_Y121_K1.4510.60
45_G155_A1.4350.59
130_H156_G1.4240.58
244_V248_D1.4090.58
112_L116_L1.3890.56
120_F196_H1.3850.56
88_T136_G1.3830.56
34_Y122_S1.3620.55
303_N307_D1.3500.54
154_H263_D1.3490.54
16_N243_P1.3430.54
157_D210_A1.3370.54
13_L20_D1.3320.53
166_P175_L1.3300.53
11_N111_E1.3210.53
113_I117_K1.3170.52
12_V103_M1.3110.52
25_R85_D1.3020.52
160_F242_D1.2830.50
4_T30_Y1.2820.50
168_F235_W1.2530.49
103_M106_D1.2480.48
19_N68_E1.2450.48
277_R294_E1.2420.48
39_I149_K1.2370.48
94_Q132_S1.2340.48
238_W243_P1.2190.47
178_F182_E1.2160.47
117_K211_F1.2160.47
6_I115_F1.2150.47
110_K255_K1.2150.47
131_S238_W1.2050.46
43_L136_G1.2000.46
155_A299_H1.1940.45
224_D228_G1.1930.45
41_I122_S1.1850.45
213_S272_I1.1780.44
98_S134_G1.1780.44
152_A295_F1.1780.44
280_H284_Q1.1660.44
45_G131_S1.1570.43
259_F312_L1.1510.43
41_I148_I1.1500.43
41_I149_K1.1490.43
155_A301_H1.1430.42
92_G136_G1.1430.42
292_Y297_D1.1420.42
305_R309_S1.1400.42
44_S48_S1.1380.42
34_Y117_K1.1350.42
186_E190_K1.1330.42
132_S242_D1.1190.41
98_S102_G1.1150.41
104_Y130_H1.1130.41
81_I120_F1.1100.41
117_K279_L1.1040.40
32_K287_G1.0980.40
302_T308_I1.0920.40
30_Y39_I1.0790.39
70_L76_M1.0750.39
125_I148_I1.0750.39
151_I237_K1.0730.39
16_N24_R1.0730.39
5_I25_R1.0670.38
93_N101_V1.0610.38
209_S221_L1.0600.38
138_L153_D1.0580.38
160_F169_P1.0570.38
33_D77_K1.0550.38
30_Y117_K1.0480.37
111_E268_D1.0420.37
168_F173_E1.0390.37
151_I260_I1.0380.37
80_V151_I1.0360.37
31_P34_Y1.0320.36
35_E303_N1.0310.36
161_E168_F1.0310.36
9_E23_K1.0230.36
266_K296_N1.0200.36
185_L188_Y1.0160.36
158_A161_E1.0150.36
41_I117_K1.0060.35
95_Y106_D1.0040.35
214_P283_L1.0030.35
283_L288_I0.9990.35
43_L95_Y0.9990.35
208_M212_Y0.9910.34
118_D284_Q0.9890.34
95_Y136_G0.9880.34
233_D284_Q0.9850.34
44_S49_S0.9850.34
253_N256_M0.9780.34
109_V114_P0.9770.34
30_Y190_K0.9750.33
184_W188_Y0.9730.33
142_M246_M0.9720.33
75_K119_K0.9690.33
16_N20_D0.9680.33
34_Y121_K0.9670.33
126_G216_N0.9660.33
262_I280_H0.9650.33
98_S299_H0.9630.33
19_N125_I0.9590.33
13_L131_S0.9490.32
156_G309_S0.9470.32
131_S134_G0.9460.32
16_N172_I0.9460.32
120_F194_K0.9420.32
40_L128_F0.9420.32
24_R293_E0.9410.32
254_L262_I0.9390.32
210_A272_I0.9310.31
169_P208_M0.9290.31
94_Q157_D0.9270.31
102_G133_G0.9250.31
140_L209_S0.9220.31
10_S114_P0.9160.31
105_E144_Y0.9110.30
45_G130_H0.9110.30
210_A268_D0.9050.30
29_I104_Y0.9020.30
269_E298_G0.8980.30
188_Y270_F0.8950.30
229_E233_D0.8940.29
190_K193_N0.8930.29
45_G299_H0.8920.29
187_N190_K0.8830.29
131_S155_A0.8790.29
152_A156_G0.8780.29
54_I63_M0.8780.29
114_P149_K0.8770.29
170_R284_Q0.8760.29
39_I155_A0.8730.28
28_I31_P0.8690.28
20_D235_W0.8690.28
20_D24_R0.8690.28
82_V148_I0.8680.28
152_A203_L0.8600.28
97_N145_P0.8600.28
39_I310_L0.8590.28
169_P204_N0.8550.28
40_L120_F0.8550.28
88_T101_V0.8500.27
118_D233_D0.8430.27
93_N211_F0.8410.27
82_V115_F0.8390.27
65_S256_M0.8370.27
20_D243_P0.8340.27
130_H155_A0.8320.27
92_G132_S0.8320.27
41_I125_I0.8310.27
86_M93_N0.8310.27
77_K276_S0.8260.26
167_T241_K0.8250.26
30_Y257_L0.8240.26
303_N309_S0.8180.26
302_T309_S0.8150.26
10_S33_D0.8130.26
50_S264_V0.8120.26
236_K239_L0.8120.26
178_F181_P0.8070.26
192_E196_H0.8040.25
118_D281_K0.8020.25
93_N117_K0.8000.25
120_F245_R0.7990.25
11_N284_Q0.7990.25
204_N208_M0.7970.25
210_A228_G0.7970.25
146_N285_K0.7970.25
7_E23_K0.7960.25
163_V208_M0.7940.25
157_D272_I0.7930.25
4_T239_L0.7920.25
17_P100_A0.7910.25
40_L95_Y0.7900.25
39_I82_V0.7890.25
158_A300_L0.7840.25
95_Y126_G0.7790.24
281_K285_K0.7790.24
92_G155_A0.7770.24
292_Y296_N0.7770.24
294_E297_D0.7740.24
99_S260_I0.7730.24
146_N256_M0.7730.24
296_N301_H0.7660.24
29_I90_V0.7640.24
136_G295_F0.7630.24
235_W242_D0.7620.24
210_A242_D0.7610.24
188_Y279_L0.7590.23
167_T174_Q0.7580.23
47_L302_T0.7520.23
283_L292_Y0.7510.23
101_V148_I0.7500.23
228_G268_D0.7500.23
34_Y149_K0.7460.23
157_D224_D0.7430.23
93_N148_I0.7420.23
49_S52_T0.7410.23
191_K194_K0.7410.23
220_E231_L0.7400.23
238_W242_D0.7400.23
94_Q130_H0.7390.23
53_Q64_V0.7360.23
30_Y125_I0.7350.23
154_H295_F0.7340.22
157_D238_W0.7310.22
29_I136_G0.7290.22
6_I119_K0.7290.22
264_V272_I0.7240.22
129_G133_G0.7230.22
205_V223_F0.7220.22
77_K125_I0.7220.22
137_A196_H0.7210.22
114_P118_D0.7190.22
131_S157_D0.7190.22
63_M74_G0.7150.22
157_D268_D0.7130.22
163_V167_T0.7090.22
67_V70_L0.7060.21
298_G301_H0.7050.21
29_I85_D0.7040.21
40_L79_S0.7020.21
213_S299_H0.7010.21
28_I80_V0.7000.21
86_M108_L0.6950.21
218_K259_F0.6950.21
242_D268_D0.6950.21
19_N232_E0.6940.21
297_D304_Y0.6900.21
144_Y275_G0.6860.21
6_I270_F0.6850.21
33_D237_K0.6830.21
12_V255_K0.6830.21
171_A175_L0.6830.21
132_S160_F0.6820.20
157_D299_H0.6810.20
8_F22_Y0.6800.20
109_V144_Y0.6770.20
62_D269_E0.6770.20
93_N128_F0.6760.20
133_G268_D0.6750.20
108_L264_V0.6740.20
28_I281_K0.6740.20
13_L299_H0.6730.20
82_V113_I0.6710.20
155_A189_W0.6690.20
80_V197_R0.6690.20
10_S268_D0.6670.20
212_Y242_D0.6670.20
239_L245_R0.6670.20
160_F212_Y0.6670.20
184_W192_E0.6660.20
144_Y255_K0.6630.20
81_I198_E0.6600.20
35_E248_D0.6580.20
42_Y128_F0.6560.20
109_V127_I0.6550.19
85_D91_G0.6520.19
50_S297_D0.6520.19
230_I258_K0.6470.19
102_G268_D0.6460.19
31_P122_S0.6460.19
10_S13_L0.6440.19
131_S210_A0.6430.19
240_E266_K0.6420.19
152_A261_F0.6390.19
41_I93_N0.6380.19
47_L138_L0.6360.19
48_S54_I0.6360.19
19_N109_V0.6360.19
141_G259_F0.6340.19
104_Y298_G0.6340.19
157_D227_T0.6330.19
146_N254_L0.6330.19
91_G95_Y0.6320.19
242_D275_G0.6320.19
138_L277_R0.6270.19
81_I167_T0.6250.18
104_Y210_A0.6220.18
127_I137_A0.6200.18
50_S85_D0.6190.18
6_I279_L0.6180.18
85_D215_N0.6170.18
263_D295_F0.6160.18
307_D310_L0.6100.18
264_V292_Y0.6060.18
116_L122_S0.6040.18
8_F26_V0.6040.18
160_F208_M0.6030.18
148_I279_L0.6030.18
144_Y147_T0.6020.18
125_I211_F0.6020.18
122_S279_L0.6000.18
94_Q207_G0.5980.18
162_Y165_L0.5970.17
145_P223_F0.5960.17
42_Y53_Q0.5920.17
40_L73_E0.5910.17
32_K120_F0.5900.17
93_N132_S0.5900.17
184_W187_N0.5890.17
69_R74_G0.5890.17
80_V247_V0.5890.17
161_E164_Y0.5870.17
304_Y309_S0.5860.17
129_G134_G0.5830.17
6_I23_K0.5830.17
164_Y169_P0.5830.17
28_I115_F0.5830.17
221_L234_V0.5820.17
222_P243_P0.5810.17
233_D285_K0.5800.17
32_K41_I0.5790.17
210_A299_H0.5790.17
243_P279_L0.5780.17
26_V107_F0.5780.17
63_M68_E0.5770.17
128_F137_A0.5760.17
80_V190_K0.5760.17
132_S136_G0.5740.17
136_G263_D0.5740.17
23_K248_D0.5720.17
106_D153_D0.5710.17
242_D272_I0.5690.17
98_S234_V0.5650.16
10_S150_A0.5630.16
95_Y134_G0.5600.16
135_Y241_K0.5600.16
126_G266_K0.5590.16
12_V106_D0.5590.16
133_G265_G0.5550.16
215_N311_S0.5550.16
63_M306_Y0.5530.16
160_F270_F0.5530.16
284_Q290_H0.5510.16
185_L245_R0.5510.16
160_F268_D0.5490.16
265_G299_H0.5470.16
93_N200_L0.5450.16
97_N153_D0.5440.16
261_F292_Y0.5440.16
96_I242_D0.5410.16
222_P294_E0.5410.16
102_G265_G0.5400.16
103_M107_F0.5400.16
196_H199_D0.5400.16
24_R85_D0.5380.16
40_L148_I0.5380.16
21_P242_D0.5350.16
308_I311_S0.5320.15
95_Y132_S0.5310.15
35_E229_E0.5310.15
306_Y309_S0.5300.15
303_N308_I0.5280.15
134_G299_H0.5280.15
257_L260_I0.5240.15
157_D270_F0.5230.15
228_G264_V0.5220.15
11_N15_D0.5190.15
42_Y47_L0.5190.15
119_K288_I0.5190.15
160_F227_T0.5160.15
118_D198_E0.5160.15
21_P275_G0.5150.15
143_K250_Y0.5150.15
69_R73_E0.5150.15
192_E205_V0.5140.15
247_V286_Y0.5140.15
262_I266_K0.5130.15
77_K174_Q0.5110.15
98_S136_G0.5110.15
121_K236_K0.5110.15
164_Y235_W0.5110.15
84_P311_S0.5110.15
63_M83_L0.5110.15
40_L81_I0.5090.15
48_S302_T0.5080.15
167_T173_E0.5080.15
64_V68_E0.5080.15
30_Y115_F0.5080.15
71_S228_G0.5070.15
71_S76_M0.5070.15
230_I308_I0.5040.15
265_G272_I0.5040.15
131_S213_S0.5040.15
33_D125_I0.5030.15
42_Y90_V0.5030.15
35_E137_A0.5020.15
188_Y191_K0.5010.15
193_N197_R0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ls2A 2 0.7531 100 0.717 Contact Map
2uz0A 4 0.7438 100 0.723 Contact Map
4rotA 4 0.7531 100 0.724 Contact Map
4w9rA 2 0.6937 100 0.727 Contact Map
1jjfA 1 0.7031 100 0.731 Contact Map
4folA 2 0.7438 100 0.731 Contact Map
3c8dA 2 0.7063 100 0.733 Contact Map
3i6yA 1 0.75 100 0.734 Contact Map
3e4dA 3 0.7469 100 0.74 Contact Map
3gffA 2 0.7 99.9 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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