GREMLIN Database
Q97UM3 - Epimerase, putative
UniProt: Q97UM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (270)
Sequences: 62606 (44375)
Seq/√Len: 2700.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G29_V3.0881.00
229_D290_I2.9761.00
19_Y199_K2.6171.00
200_A215_I2.5401.00
79_Y83_Q2.4921.00
211_D276_K2.4531.00
61_C205_C2.4151.00
103_I201_I2.3231.00
53_D94_Q2.3071.00
288_V291_E2.2731.00
19_Y202_E2.2531.00
213_F280_E2.1751.00
73_D76_E2.1361.00
19_Y23_K2.1231.00
30_Y44_I2.1201.00
64_Y102_Y2.1151.00
233_A294_K2.0661.00
232_K290_I2.0611.00
99_K151_N2.0381.00
120_A123_S2.0321.00
199_K286_E1.9761.00
48_I51_S1.9441.00
63_V205_C1.9371.00
224_T228_S1.9331.00
6_F64_Y1.8961.00
44_I51_S1.8631.00
229_D232_K1.8541.00
157_F201_I1.8541.00
195_R295_E1.8361.00
86_T145_N1.8281.00
278_E284_I1.8151.00
222_N225_S1.7691.00
218_K278_E1.7661.00
5_T17_V1.7591.00
155_L204_A1.7411.00
199_K203_L1.7281.00
146_I152_Y1.7081.00
161_Y292_T1.7051.00
23_K202_E1.7011.00
28_L59_I1.6941.00
140_L144_R1.6741.00
49_V90_R1.6631.00
78_E141_E1.6341.00
53_D91_K1.6271.00
202_E206_K1.6131.00
23_K206_K1.5921.00
86_T90_R1.5811.00
175_W179_H1.5771.00
83_Q86_T1.5701.00
193_S295_E1.5511.00
16_F198_S1.5431.00
274_Y278_E1.5181.00
47_N79_Y1.5151.00
19_Y22_S1.4991.00
229_D233_A1.4941.00
60_D98_G1.4861.00
16_F63_V1.4841.00
85_P142_G1.4731.00
99_K153_V1.4691.00
277_A281_L1.4561.00
16_F65_F1.4461.00
75_R79_Y1.4421.00
19_Y198_S1.4391.00
49_V87_E1.4291.00
51_S54_N1.4251.00
28_L42_Q1.4121.00
28_L40_A1.4091.00
135_H139_K1.4081.00
17_V29_V1.3941.00
62_L92_F1.3931.00
203_L207_Y1.3881.00
129_L140_L1.3811.00
121_E276_K1.3781.00
176_L181_I1.3721.00
104_S108_V1.3711.00
54_N58_D1.3641.00
12_V160_V1.3491.00
65_F103_I1.3451.00
157_F197_T1.3401.00
3_I25_H1.3331.00
89_G149_F1.3301.00
188_M220_P1.3251.00
103_I157_F1.3241.00
57_K95_V1.2931.00
53_D95_V1.2881.00
49_V53_D1.2841.00
25_H206_K1.2751.00
193_S292_T1.2751.00
225_S228_S1.2701.00
26_D40_A1.2691.00
147_S154_I1.2671.00
194_T198_S1.2591.00
8_G17_V1.2561.00
155_L201_I1.2531.00
158_P272_Y1.2511.00
63_V201_I1.2201.00
4_L59_I1.2181.00
144_R147_S1.2121.00
18_R164_Y1.2021.00
20_A202_E1.1971.00
192_V197_T1.1941.00
137_I141_E1.1941.00
291_E294_K1.1881.00
109_S214_Y1.1851.00
90_R93_F1.1821.00
145_N148_K1.1801.00
239_R243_P1.1771.00
64_Y85_P1.1751.00
102_Y142_G1.1611.00
120_A273_S1.1571.00
46_A84_F1.1561.00
81_Q138_T1.1491.00
243_P246_V1.1491.00
276_K280_E1.1481.00
4_L30_Y1.1301.00
169_M173_F1.1301.00
33_S41_L1.1271.00
186_D224_T1.1241.00
291_E295_E1.1231.00
61_C99_K1.1181.00
54_N57_K1.1131.00
19_Y195_R1.1001.00
211_D280_E1.0901.00
119_I123_S1.0881.00
156_R212_Y1.0821.00
190_S218_K1.0811.00
102_Y146_I1.0811.00
200_A277_A1.0791.00
274_Y285_P1.0751.00
92_F100_F1.0591.00
147_S152_Y1.0561.00
122_E276_K1.0551.00
101_V155_L1.0541.00
186_D222_N1.0521.00
9_T31_A1.0481.00
88_I100_F1.0471.00
46_A66_I1.0471.00
15_N195_R1.0401.00
40_A59_I1.0321.00
221_A289_R1.0321.00
3_I20_A1.0291.00
290_I294_K1.0231.00
231_V238_I1.0221.00
15_N194_T1.0211.00
147_S212_Y1.0181.00
11_F162_G1.0161.00
231_V237_E1.0091.00
221_A225_S1.0091.00
228_S231_V1.0081.00
18_R22_S1.0081.00
68_A80_L1.0051.00
89_G100_F1.0041.00
172_A175_W1.0021.00
216_T272_Y1.0011.00
90_R94_Q1.0011.00
203_L281_L1.0001.00
91_K94_Q0.9881.00
53_D57_K0.9831.00
199_K283_Y0.9811.00
220_P271_V0.9721.00
92_F97_S0.9701.00
83_Q87_E0.9681.00
102_Y154_I0.9651.00
234_I297_A0.9621.00
233_A297_A0.9591.00
87_E90_R0.9581.00
77_F138_T0.9541.00
91_K95_V0.9531.00
6_F88_I0.9521.00
188_M222_N0.9511.00
220_P269_E0.9501.00
78_E82_V0.9471.00
172_A176_L0.9471.00
52_Y91_K0.9461.00
90_R149_F0.9431.00
3_I61_C0.9421.00
203_L206_K0.9391.00
82_V141_E0.9371.00
78_E83_Q0.9331.00
65_F201_I0.9311.00
100_F146_I0.9231.00
151_N209_R0.9151.00
141_E144_R0.9121.00
33_S36_D0.9081.00
30_Y55_Y0.9071.00
56_L91_K0.9061.00
168_L171_R0.8981.00
153_V204_A0.8971.00
15_N18_R0.8941.00
50_F54_N0.8901.00
114_S123_S0.8901.00
156_R214_Y0.8901.00
99_K208_K0.8871.00
80_L84_F0.8851.00
157_F160_V0.8831.00
55_Y59_I0.8821.00
11_F194_T0.8821.00
56_L59_I0.8791.00
188_M269_E0.8791.00
240_S243_P0.8771.00
213_F276_K0.8721.00
50_F53_D0.8711.00
114_S120_A0.8701.00
160_V197_T0.8691.00
56_L62_L0.8691.00
28_L58_D0.8671.00
89_G146_I0.8671.00
196_N217_D0.8661.00
14_S164_Y0.8651.00
193_S196_N0.8631.00
200_A283_Y0.8571.00
143_E156_R0.8571.00
16_F20_A0.8561.00
233_A290_I0.8541.00
244_F247_K0.8501.00
93_F149_F0.8501.00
175_W178_S0.8371.00
199_K202_E0.8351.00
155_L215_I0.8351.00
154_I212_Y0.8341.00
161_Y193_S0.8301.00
62_L88_I0.8281.00
231_V236_R0.8271.00
15_N19_Y0.8261.00
68_A76_E0.8251.00
30_Y52_Y0.8201.00
87_E91_K0.8191.00
21_I27_V0.8191.00
216_T274_Y0.8191.00
30_Y51_S0.8171.00
243_P247_K0.8141.00
17_V27_V0.8041.00
34_M43_N0.8021.00
6_F66_I0.8001.00
51_S55_Y0.7991.00
56_L95_V0.7981.00
104_S143_E0.7961.00
49_V94_Q0.7911.00
219_E288_V0.7871.00
33_S43_N0.7861.00
176_L180_G0.7841.00
25_H60_D0.7811.00
225_S229_D0.7781.00
218_K274_Y0.7781.00
204_A281_L0.7761.00
160_V192_V0.7711.00
106_I158_P0.7701.00
3_I63_V0.7651.00
85_P146_I0.7631.00
144_R148_K0.7611.00
242_L245_S0.7591.00
48_I52_Y0.7561.00
242_L247_K0.7541.00
47_N80_L0.7521.00
185_N224_T0.7521.00
68_A77_F0.7511.00
42_Q58_D0.7481.00
169_M172_A0.7371.00
141_E145_N0.7361.00
106_I272_Y0.7341.00
76_E79_Y0.7311.00
275_K278_E0.7301.00
89_G145_N0.7301.00
198_S202_E0.7281.00
32_R45_G0.7251.00
3_I205_C0.7251.00
203_L283_Y0.7211.00
241_W244_F0.7211.00
133_T136_G0.7181.00
42_Q59_I0.7151.00
15_N198_S0.7121.00
167_I171_R0.7121.00
177_V231_V0.7111.00
131_P136_G0.7101.00
74_P137_I0.7091.00
233_A293_F0.7061.00
85_P89_G0.7051.00
64_Y88_I0.7021.00
117_R123_S0.6971.00
52_Y87_E0.6971.00
84_F87_E0.6971.00
33_S38_T0.6911.00
31_A41_L0.6901.00
242_L246_V0.6851.00
168_L172_A0.6841.00
98_G151_N0.6841.00
169_M177_V0.6831.00
196_N199_K0.6821.00
145_N149_F0.6821.00
78_E138_T0.6781.00
203_L282_N0.6761.00
45_G48_I0.6741.00
173_F176_L0.6741.00
62_L100_F0.6711.00
16_F201_I0.6691.00
12_V197_T0.6661.00
118_P273_S0.6621.00
134_L137_I0.6581.00
14_S18_R0.6571.00
110_E130_K0.6571.00
176_L179_H0.6561.00
56_L92_F0.6541.00
61_C101_V0.6511.00
25_H61_C0.6501.00
76_E80_L0.6491.00
221_A226_L0.6481.00
142_G146_I0.6451.00
224_T242_L0.6421.00
204_A277_A0.6421.00
278_E285_P0.6401.00
150_P210_S0.6381.00
152_Y210_S0.6371.00
228_S232_K0.6331.00
118_P271_V0.6301.00
113_E123_S0.6291.00
169_M176_L0.6271.00
171_R177_V0.6271.00
241_W247_K0.6251.00
121_E277_A0.6241.00
20_A205_C0.6231.00
180_G236_R0.6231.00
167_I172_A0.6211.00
229_D289_R0.6201.00
64_Y100_F0.6191.00
239_R242_L0.6181.00
78_E137_I0.6171.00
44_I52_Y0.6151.00
163_P295_E0.6031.00
163_P193_S0.6021.00
15_N164_Y0.6011.00
112_I119_I0.5991.00
226_L289_R0.5961.00
113_E117_R0.5941.00
137_I144_R0.5921.00
4_L44_I0.5921.00
267_S270_L0.5911.00
188_M271_V0.5901.00
177_V180_G0.5901.00
42_Q55_Y0.5881.00
4_L62_L0.5871.00
120_A275_K0.5871.00
171_R176_L0.5871.00
108_V143_E0.5851.00
231_V234_I0.5831.00
23_K203_L0.5821.00
190_S220_P0.5821.00
196_N286_E0.5811.00
74_P134_L0.5751.00
92_F95_V0.5751.00
158_P216_T0.5741.00
147_S150_P0.5741.00
101_V205_C0.5711.00
131_P140_L0.5701.00
55_Y58_D0.5701.00
178_S181_I0.5691.00
175_W181_I0.5681.00
138_T142_G0.5641.00
227_F231_V0.5631.00
67_G81_Q0.5631.00
5_T20_A0.5631.00
221_A229_D0.5621.00
17_V21_I0.5601.00
171_R175_W0.5591.00
235_N238_I0.5551.00
134_L138_T0.5541.00
135_H138_T0.5501.00
101_V204_A0.5481.00
24_G27_V0.5481.00
137_I148_K0.5471.00
215_I277_A0.5451.00
239_R246_V0.5441.00
187_N223_L0.5421.00
219_E290_I0.5401.00
101_V201_I0.5391.00
286_E291_E0.5381.00
11_F15_N0.5371.00
16_F202_E0.5351.00
9_T29_V0.5341.00
49_V91_K0.5341.00
190_S217_D0.5331.00
68_A81_Q0.5321.00
82_V86_T0.5321.00
173_F177_V0.5321.00
23_K199_K0.5311.00
4_L55_Y0.5311.00
61_C98_G0.5291.00
9_T33_S0.5291.00
201_I204_A0.5261.00
174_M297_A0.5251.00
277_A285_P0.5231.00
105_S139_K0.5221.00
117_R269_E0.5191.00
153_V213_F0.5171.00
92_F96_N0.5171.00
239_R247_K0.5151.00
209_R213_F0.5131.00
46_A52_Y0.5121.00
86_T149_F0.5101.00
89_G93_F0.5081.00
114_S117_R0.5031.00
155_L200_A0.5031.00
154_I210_S0.5031.00
52_Y56_L0.5011.00
239_R245_S0.5011.00
197_T215_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9406 100 0.238 Contact Map
3m2pA 2 0.9208 100 0.239 Contact Map
3rufA 2 0.9241 100 0.241 Contact Map
1rkxA 3 0.9142 100 0.243 Contact Map
1rpnA 4 0.9307 100 0.243 Contact Map
2pzmA 2 0.9274 100 0.246 Contact Map
2z1mA 4 0.9802 100 0.249 Contact Map
1n7hA 4 0.934 100 0.249 Contact Map
2c5aA 2 0.934 100 0.256 Contact Map
3slgA 4 0.9406 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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