GREMLIN Database
PMK - Phosphomevalonate kinase
UniProt: Q97UL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (289)
Sequences: 5099 (3811)
Seq/√Len: 224.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_S32_R5.0331.00
239_K270_E4.6291.00
230_K233_E3.6591.00
38_R84_D3.6251.00
46_L84_D3.5651.00
123_D126_E3.5211.00
35_C109_S3.2371.00
277_A290_A3.0831.00
222_A234_A3.0211.00
33_V105_A2.9621.00
235_V276_V2.6811.00
40_I84_D2.5861.00
115_Y121_K2.5581.00
180_D294_D2.5411.00
233_E236_E2.5131.00
245_L257_L2.4771.00
37_L113_C2.3651.00
262_E288_I2.3371.00
217_E221_M2.2561.00
196_V199_F2.2271.00
224_K228_L2.1621.00
292_G298_V2.1591.00
302_W306_G2.1541.00
13_I222_A2.1231.00
108_V152_V2.0921.00
300_E304_K2.0571.00
6_A109_S2.0441.00
225_L233_E2.0021.00
111_T127_I1.9601.00
184_G290_A1.9521.00
39_E81_Y1.8771.00
77_L80_G1.8671.00
267_K271_E1.8601.00
4_V116_Y1.8531.00
178_N294_D1.8401.00
221_M233_E1.8391.00
243_K270_E1.8191.00
190_S282_A1.7901.00
192_T196_V1.7781.00
225_L230_K1.7711.00
125_F129_K1.7631.00
264_E268_I1.7401.00
296_N299_R1.7231.00
49_H52_Y1.6711.00
243_K247_Y1.6581.00
258_V263_E1.6421.00
72_E75_S1.6401.00
128_H152_V1.6371.00
170_Y227_K1.6291.00
115_Y120_G1.6201.00
210_E214_L1.5931.00
246_N263_E1.5931.00
266_I277_A1.5881.00
76_Q133_I1.5721.00
133_I137_K1.5721.00
182_M298_V1.5651.00
296_N300_E1.5541.00
108_V131_A1.5511.00
87_N106_A1.5421.00
51_S88_D1.4761.00
236_E240_L1.4681.00
188_K259_S1.4651.00
65_S68_D1.4531.00
297_R301_A1.4491.00
223_I227_K1.4381.00
156_I160_R1.4091.00
209_K248_I1.4071.00
81_Y118_I1.3951.00
242_R266_I1.3751.00
112_A124_L1.3711.00
16_Y19_V1.3691.00
37_L83_I1.3651.00
23_I220_Y1.3551.00
221_M224_K1.3511.00
207_D210_E1.3441.00
71_R75_S1.3441.00
209_K213_R1.3311.00
295_L299_R1.3151.00
195_L284_G1.3141.00
299_R303_S1.2991.00
73_R77_L1.2981.00
124_L152_V1.2901.00
65_S69_T1.2791.00
301_A304_K1.2771.00
184_G288_I1.2751.00
210_E213_R1.2621.00
207_D214_L1.2491.00
115_Y122_L1.2331.00
45_S83_I1.2241.00
259_S262_E1.2241.00
262_E279_S1.2231.00
265_L288_I1.2181.00
234_A291_L1.2141.00
37_L117_A1.2021.00
225_L237_H1.2011.00
156_I161_F1.1991.00
39_E117_A1.1941.00
115_Y127_I1.1921.00
191_E194_G1.1921.00
36_S86_Y1.1841.00
186_T265_L1.1801.00
301_A305_R1.1791.00
240_L243_K1.1761.00
188_K261_M1.1721.00
214_L217_E1.1711.00
125_F153_F1.1621.00
232_D293_N1.1601.00
69_T73_R1.1561.00
297_R300_E1.1541.00
85_L110_L1.1541.00
214_L240_L1.1511.00
64_N67_L1.1491.00
26_V150_S1.1451.00
169_F172_E1.1411.00
197_R200_V1.1401.00
166_K169_F1.1401.00
219_N222_A1.1291.00
268_I272_E1.1271.00
40_I82_E1.1261.00
180_D295_L1.1171.00
18_V144_S1.1151.00
258_V279_S1.1131.00
268_I271_E1.1071.00
62_L65_S1.1051.00
42_E82_E1.1051.00
150_S154_G1.1041.00
217_E220_Y1.1041.00
108_V151_A1.1021.00
11_L26_V1.1001.00
9_K144_S1.0861.00
213_R248_I1.0771.00
9_K18_V1.0711.00
72_E76_Q1.0681.00
277_A288_I1.0621.00
139_Q143_G1.0621.00
66_V110_L1.0541.00
210_E244_Y1.0491.00
184_G269_A1.0481.00
142_I198_K1.0471.00
15_S245_L1.0271.00
8_G91_F1.0241.00
192_T195_L1.0231.00
157_V160_R1.0221.00
17_S216_D1.0201.00
35_C85_L1.0201.00
243_K246_N1.0041.00
260_K264_E0.9971.00
135_N286_D0.9951.00
35_C87_N0.9951.00
65_S73_R0.9951.00
50_T86_Y0.9921.00
105_A151_A0.9861.00
87_N110_L0.9831.00
136_Y143_G0.9831.00
11_L15_S0.9771.00
222_A226_I0.9751.00
66_V69_T0.9711.00
112_A127_I0.9631.00
24_S146_F0.9541.00
5_S34_S0.9521.00
302_W307_I0.9501.00
17_S20_F0.9471.00
264_E305_R0.9461.00
34_S88_D0.9431.00
172_E223_I0.9391.00
263_E267_K0.9341.00
35_C113_C0.9341.00
132_Q143_G0.9281.00
266_I270_E0.9251.00
239_K243_K0.9251.00
10_I289_F0.9180.99
207_D250_E0.9040.99
213_R217_E0.9040.99
48_F86_Y0.9030.99
68_D71_R0.8980.99
172_E227_K0.8970.99
195_L199_F0.8930.99
184_G265_L0.8890.99
295_L298_V0.8850.99
45_S82_E0.8850.99
193_V196_V0.8830.99
238_I276_V0.8820.99
141_G192_T0.8800.99
158_Y161_F0.8770.99
73_R76_Q0.8760.99
272_E298_V0.8760.99
232_D236_E0.8710.99
205_L209_K0.8640.99
10_I27_I0.8610.99
149_A153_F0.8560.99
242_R246_N0.8540.99
107_T134_A0.8530.99
73_R78_P0.8520.99
26_V146_F0.8500.99
105_A109_S0.8490.99
196_V200_V0.8490.99
169_F174_L0.8450.99
304_K308_F0.8410.99
22_G213_R0.8400.99
37_L85_L0.8370.99
56_K60_N0.8360.99
184_G302_W0.8350.99
128_H132_Q0.8320.99
184_G277_A0.8320.99
111_T131_A0.8300.99
144_S148_I0.8290.99
40_I43_K0.8240.99
104_S143_G0.8210.99
269_A298_V0.8150.99
74_L78_P0.8140.99
6_A151_A0.8140.99
298_V302_W0.8130.99
268_I301_A0.8110.99
238_I289_F0.8010.99
111_T130_L0.8010.99
269_A277_A0.8000.99
89_K105_A0.8000.99
237_H241_G0.8000.99
268_I305_R0.7990.99
241_G244_Y0.7960.99
69_T72_E0.7900.98
136_Y139_Q0.7890.98
22_G216_D0.7870.98
186_T285_G0.7840.98
60_N63_I0.7830.98
11_L146_F0.7810.98
36_S88_D0.7780.98
10_I280_P0.7770.98
157_V161_F0.7720.98
9_K101_G0.7710.98
126_E129_K0.7680.98
124_L127_I0.7640.98
127_I152_V0.7640.98
126_E130_L0.7620.98
38_R86_Y0.7610.98
33_V109_S0.7590.98
206_D210_E0.7570.98
23_I216_D0.7570.98
25_H219_N0.7560.98
195_L198_K0.7560.98
192_T200_V0.7540.98
275_L293_N0.7500.98
206_D250_E0.7480.98
166_K172_E0.7450.98
242_R258_V0.7430.98
132_Q136_Y0.7430.98
66_V70_F0.7360.98
135_N148_I0.7330.98
220_Y224_K0.7330.98
274_A293_N0.7320.98
11_L16_Y0.7260.97
261_M264_E0.7250.97
141_G282_A0.7250.97
271_E301_A0.7220.97
145_G149_A0.7200.97
263_E266_I0.7190.97
246_N267_K0.7180.97
69_T111_T0.7140.97
32_R91_F0.7130.97
48_F84_D0.7110.97
13_I237_H0.7090.97
224_K227_K0.7090.97
192_T199_F0.7080.97
216_D220_Y0.7070.97
280_P287_S0.7070.97
160_R170_Y0.7070.97
85_L113_C0.7050.97
182_M269_A0.7050.97
50_T88_D0.7020.97
233_E237_H0.6990.97
104_S131_A0.6970.97
235_V238_I0.6960.97
298_V301_A0.6950.97
172_E175_N0.6920.97
271_E305_R0.6900.96
221_M237_H0.6870.96
208_F211_I0.6860.96
4_V109_S0.6810.96
242_R279_S0.6800.96
221_M225_L0.6790.96
128_H148_I0.6740.96
246_N258_V0.6720.96
28_A151_A0.6720.96
7_P28_A0.6710.96
70_F114_L0.6700.96
10_I29_V0.6700.96
60_N67_L0.6690.96
295_L306_G0.6690.96
112_A115_Y0.6660.96
40_I45_S0.6650.96
211_I244_Y0.6640.96
204_N208_F0.6630.96
158_Y223_I0.6620.96
157_V223_I0.6620.96
160_R223_I0.6580.95
272_E275_L0.6580.95
68_D73_R0.6580.95
59_G63_I0.6580.95
25_H222_A0.6570.95
107_T131_A0.6530.95
237_H240_L0.6480.95
280_P289_F0.6480.95
65_S74_L0.6470.95
108_V127_I0.6440.95
218_E237_H0.6440.95
299_R302_W0.6430.95
27_I181_M0.6410.95
143_G148_I0.6410.95
235_V239_K0.6370.94
74_L77_L0.6360.94
74_L79_Q0.6320.94
132_Q145_G0.6310.94
221_M240_L0.6300.94
264_E267_K0.6290.94
106_A110_L0.6280.94
40_I46_L0.6270.94
158_Y162_T0.6250.94
98_T185_F0.6250.94
129_K132_Q0.6240.94
178_N293_N0.6240.94
101_G144_S0.6230.94
269_A290_A0.6170.93
25_H223_I0.6170.93
182_M292_G0.6160.93
238_I291_L0.6160.93
198_K284_G0.6070.93
9_K148_I0.6070.93
11_L280_P0.6070.93
258_V262_E0.6050.93
131_A152_V0.6030.93
69_T134_A0.6020.93
41_K81_Y0.6010.93
63_I67_L0.6010.93
50_T53_G0.6010.93
107_T143_G0.6000.93
134_A139_Q0.5970.92
260_K263_E0.5960.92
115_Y126_E0.5920.92
69_T77_L0.5920.92
167_M175_N0.5910.92
17_S22_G0.5910.92
18_V24_S0.5890.92
298_V306_G0.5870.92
65_S72_E0.5850.92
39_E118_I0.5830.91
6_A108_V0.5830.91
109_S113_C0.5820.91
4_V112_A0.5820.91
72_E137_K0.5800.91
181_M289_F0.5790.91
71_R74_L0.5790.91
62_L66_V0.5760.91
73_R120_G0.5750.91
67_L70_F0.5710.91
104_S282_A0.5710.91
207_D213_R0.5710.91
33_V91_F0.5700.91
136_Y142_I0.5700.91
135_N144_S0.5700.91
62_L68_D0.5690.90
267_K270_E0.5690.90
56_K59_G0.5680.90
281_G285_G0.5680.90
266_I288_I0.5680.90
58_S228_L0.5670.90
272_E297_R0.5660.90
272_E301_A0.5650.90
29_V100_L0.5640.90
76_Q130_L0.5640.90
68_D72_E0.5640.90
155_S171_F0.5630.90
104_S141_G0.5620.90
23_I219_N0.5620.90
205_L214_L0.5600.90
18_V148_I0.5590.90
23_I160_R0.5580.90
112_A152_V0.5570.90
292_G295_L0.5570.90
184_G289_F0.5560.89
115_Y130_L0.5560.89
128_H149_A0.5540.89
66_V72_E0.5520.89
49_H53_G0.5510.89
72_E133_I0.5500.89
240_L247_Y0.5480.89
269_A273_G0.5480.89
11_L144_S0.5470.89
48_F54_H0.5460.89
115_Y118_I0.5450.88
160_R172_E0.5420.88
11_L18_V0.5410.88
219_N223_I0.5410.88
47_I66_V0.5390.88
16_Y245_L0.5390.88
193_V200_V0.5380.88
149_A161_F0.5360.88
259_S284_G0.5340.87
193_V197_R0.5340.87
141_G193_V0.5320.87
11_L101_G0.5310.87
211_I219_N0.5310.87
9_K147_D0.5300.87
156_I175_N0.5290.87
156_I162_T0.5260.87
111_T134_A0.5250.87
65_S71_R0.5230.86
171_F174_L0.5230.86
148_I286_D0.5220.86
122_L126_E0.5220.86
149_A169_F0.5210.86
76_Q126_E0.5210.86
242_R245_L0.5190.86
270_E274_A0.5190.86
239_K266_I0.5180.86
129_K133_I0.5170.86
263_E276_V0.5160.86
222_A238_I0.5160.86
263_E279_S0.5150.86
42_E45_S0.5150.86
10_I287_S0.5150.86
92_I286_D0.5140.85
13_I234_A0.5130.85
194_G197_R0.5120.85
190_S195_L0.5090.85
60_N64_N0.5080.85
186_T288_I0.5080.85
8_G16_Y0.5070.85
100_L183_L0.5060.85
269_A288_I0.5050.84
128_H146_F0.5040.84
186_T262_E0.5020.84
107_T148_I0.5010.84
179_Y275_L0.5010.84
83_I114_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pieA 1 0.9536 100 0.298 Contact Map
2a2cA 1 0.9505 100 0.309 Contact Map
3v2uC 2 0.9474 100 0.316 Contact Map
1wuuA 2 0.9474 100 0.327 Contact Map
4n3oA 2 0.9226 100 0.331 Contact Map
3k85A 3 0.8669 100 0.337 Contact Map
2cz9A 1 0.9257 100 0.338 Contact Map
1kvkA 2 0.9319 100 0.338 Contact Map
4hacA 2 0.9164 100 0.343 Contact Map
1kkhA 1 0.904 100 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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