GREMLIN Database
DMD - Diphosphomevalonate decarboxylase
UniProt: Q97UL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (300)
Sequences: 999 (685)
Seq/√Len: 39.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_T48_K4.7021.00
222_V237_L4.1961.00
154_N167_Y3.8331.00
9_A112_A3.7261.00
22_R29_L3.7071.00
276_A288_I3.6691.00
45_V109_A3.1911.00
185_L266_I3.1641.00
8_S46_I3.1081.00
152_V223_I2.8351.00
127_K130_E2.7701.00
222_V234_F2.6151.00
291_T294_N2.4991.00
160_D163_D2.4591.00
263_S280_F2.4241.00
224_E228_N2.4061.00
96_S109_A2.3651.00
25_E199_I2.3391.00
6_T46_I2.3081.00
259_L267_M2.3031.00
225_A237_L2.2821.00
221_E233_K2.2681.00
8_S44_S2.2641.00
56_I91_K2.2641.00
183_P266_I2.2621.00
209_E213_K2.2341.00
94_S110_G2.1750.99
56_I63_I2.1140.99
22_R161_G2.1030.99
243_N278_Y2.0770.99
90_V121_L2.0720.99
77_L92_V2.0520.99
50_T93_E2.0140.99
267_M278_Y2.0080.99
35_L219_F1.9540.99
230_D233_K1.9280.99
80_F118_L1.8950.98
232_K236_Y1.8520.98
234_F237_L1.8490.98
218_T241_H1.7910.98
259_L263_S1.7820.98
239_M274_G1.7780.97
25_E28_N1.7780.97
58_I63_I1.7510.97
55_N81_K1.7400.97
96_S100_I1.7320.97
175_W229_R1.7230.97
32_N215_I1.7130.97
236_Y253_W1.6970.97
241_H245_M1.6710.96
104_L182_I1.6430.96
140_G153_W1.6310.96
7_V120_E1.6140.95
137_L161_G1.6110.95
59_V100_I1.5920.95
248_V251_D1.5790.95
231_E291_T1.5760.95
235_Y277_G1.5720.95
196_K199_I1.5560.94
207_L251_D1.5500.94
78_D81_K1.5490.94
177_E292_E1.5360.94
259_L264_I1.5360.94
196_K200_R1.5280.94
50_T91_K1.5200.94
201_S251_D1.5100.94
179_V292_E1.5080.93
179_V295_I1.4840.93
271_H278_Y1.4830.93
261_D264_I1.4770.93
177_E291_T1.4730.93
72_Y77_L1.4710.93
27_L156_G1.4600.92
79_T83_I1.4520.92
33_N216_E1.4450.92
129_E147_F1.4390.92
57_V64_L1.4370.92
48_K93_E1.4310.92
207_L244_S1.4310.92
211_R241_H1.4270.91
49_V117_S1.4080.91
171_R174_Y1.3940.90
77_L90_V1.3910.90
217_K221_E1.3850.90
280_F286_P1.3790.90
59_V94_S1.3720.90
133_K161_G1.3670.90
222_V238_M1.3670.90
90_V118_L1.3210.88
33_N152_V1.3130.88
201_S248_V1.3100.87
51_L122_L1.3090.87
33_N154_N1.3050.87
157_E160_D1.3000.87
270_I276_A1.2910.87
197_G256_F1.2820.86
233_K237_L1.2800.86
211_R287_H1.2740.86
83_I130_E1.2630.85
153_W285_N1.2610.85
290_T298_I1.2540.85
270_I288_I1.2480.85
249_I256_F1.2350.84
201_S249_I1.2350.84
195_R280_F1.2310.84
12_N19_W1.2280.84
207_L248_V1.2250.84
143_C153_W1.2240.84
77_L118_L1.2080.83
46_I95_K1.2000.82
105_A282_A1.1940.82
272_D275_K1.1880.82
194_S282_A1.1810.81
178_L234_F1.1760.81
37_I150_F1.1730.81
273_Y301_F1.1710.81
225_A233_K1.1650.80
157_E163_D1.1620.80
51_L121_L1.1610.80
221_E237_L1.1480.79
46_I266_I1.1260.78
31_L208_M1.1200.78
67_D70_K1.1190.78
75_R79_T1.1180.78
66_E69_M1.1100.77
236_Y240_R1.1070.77
53_D89_H1.1060.77
28_N195_R1.1000.76
181_I290_T1.0930.76
178_L289_F1.0830.75
226_I234_F1.0690.74
14_A19_W1.0590.74
243_N251_D1.0560.73
153_W164_S1.0520.73
72_Y76_V1.0340.72
44_S97_K1.0320.72
129_E165_Y1.0280.71
241_H287_H1.0140.70
214_Y244_S1.0130.70
80_F90_V1.0040.70
119_N122_L0.9970.69
66_E70_K0.9970.69
262_T265_R0.9960.69
22_R163_D0.9930.69
279_T289_F0.9870.68
69_M72_Y0.9840.68
259_L278_Y0.9800.68
252_S255_S0.9740.67
239_M242_S0.9720.67
170_F174_Y0.9720.67
45_V96_S0.9690.67
249_I257_F0.9600.66
290_T294_N0.9550.66
12_N21_K0.9540.66
201_S208_M0.9510.65
242_S274_G0.9510.65
282_A285_N0.9480.65
49_V55_N0.9440.65
273_Y297_D0.9420.65
15_V234_F0.9360.64
57_V94_S0.9340.64
67_D82_K0.9340.64
177_E293_R0.9240.63
245_M287_H0.9230.63
219_F237_L0.9210.63
31_L212_L0.9190.63
174_Y229_R0.9160.62
13_I39_L0.9150.62
69_M76_V0.9140.62
266_I270_I0.9120.62
180_D287_H0.9100.62
77_L81_K0.9090.62
132_S136_R0.9060.62
98_F211_R0.9050.61
35_L226_I0.8900.60
211_R218_T0.8870.60
52_N91_K0.8850.60
288_I302_L0.8840.60
11_S43_L0.8830.60
168_Q171_R0.8820.59
155_K216_E0.8810.59
14_A21_K0.8800.59
247_A250_L0.8790.59
22_R157_E0.8790.59
14_A105_A0.8770.59
116_F120_E0.8760.59
54_K270_I0.8720.59
105_A194_S0.8720.59
184_I187_E0.8690.58
12_N18_Y0.8640.58
150_F226_I0.8640.58
11_S249_I0.8610.58
269_W272_D0.8610.58
11_S98_F0.8600.57
223_I227_R0.8590.57
233_K236_Y0.8590.57
79_T82_K0.8540.57
49_V90_V0.8530.57
82_K275_K0.8510.57
76_V80_F0.8470.56
79_T298_I0.8470.56
49_V114_L0.8460.56
171_R226_I0.8450.56
231_E234_F0.8270.55
51_L90_V0.8260.54
300_E304_S0.8230.54
57_V109_A0.8170.54
239_M277_G0.8090.53
79_T137_L0.8090.53
100_I109_A0.8090.53
156_G164_S0.8080.53
275_K300_E0.8060.53
224_E233_K0.8050.53
292_E295_I0.8040.52
21_K105_A0.8000.52
152_V219_F0.7980.52
239_M278_Y0.7960.52
49_V121_L0.7910.51
132_S135_A0.7900.51
200_R240_R0.7870.51
198_M287_H0.7840.51
90_V122_L0.7830.51
245_M279_T0.7800.50
118_L121_L0.7780.50
21_K282_A0.7750.50
9_A114_L0.7680.49
106_S139_S0.7670.49
11_S97_K0.7650.49
79_T300_E0.7640.49
179_V290_T0.7600.48
13_I19_W0.7580.48
266_I302_L0.7580.48
62_R65_S0.7570.48
306_E309_R0.7560.48
68_E72_Y0.7560.48
37_I178_L0.7550.48
163_D167_Y0.7470.47
69_M73_A0.7460.47
58_I61_D0.7440.47
75_R78_D0.7440.47
81_K117_S0.7430.47
80_F122_L0.7430.47
59_V96_S0.7410.47
70_K73_A0.7370.46
38_T148_G0.7370.46
190_K194_S0.7310.46
8_S97_K0.7300.46
11_S257_F0.7260.45
15_V289_F0.7260.45
239_M243_N0.7250.45
12_N39_L0.7250.45
181_I302_L0.7230.45
14_A17_K0.7200.45
12_N282_A0.7200.45
214_Y217_K0.7190.45
98_F241_H0.7160.44
12_N17_K0.7160.44
99_P282_A0.7140.44
64_L69_M0.7140.44
7_V117_S0.7130.44
49_V80_F0.7090.44
50_T109_A0.7080.44
150_F175_W0.7020.43
27_L164_S0.7020.43
119_N131_L0.6980.43
130_E133_K0.6960.43
35_L169_I0.6960.43
290_T295_I0.6930.42
211_R251_D0.6930.42
35_L222_V0.6880.42
13_I279_T0.6860.42
16_V237_L0.6860.42
280_F287_H0.6840.42
303_K309_R0.6840.42
240_R244_S0.6830.41
39_L114_L0.6820.41
242_S280_F0.6800.41
12_N285_N0.6800.41
213_K298_I0.6760.41
6_T69_M0.6720.41
274_G286_P0.6700.40
186_S260_N0.6700.40
227_R304_S0.6650.40
26_R29_L0.6650.40
12_N246_H0.6620.40
274_G277_G0.6610.40
143_C151_V0.6600.39
43_L182_I0.6590.39
210_C214_Y0.6570.39
194_S285_N0.6550.39
72_Y75_R0.6540.39
18_Y21_K0.6530.39
37_I180_D0.6530.39
153_W263_S0.6520.39
209_E212_L0.6510.39
145_S246_H0.6490.39
222_V226_I0.6490.39
21_K38_T0.6480.38
192_I196_K0.6460.38
148_G288_I0.6440.38
140_G246_H0.6430.38
218_T244_S0.6430.38
45_V49_V0.6430.38
234_F238_M0.6400.38
266_I286_P0.6380.38
111_I138_G0.6380.38
102_A198_M0.6380.38
86_K122_L0.6360.37
21_K198_M0.6360.37
53_D91_K0.6350.37
110_G200_R0.6330.37
131_L146_M0.6320.37
80_F119_N0.6320.37
82_K87_E0.6300.37
46_I97_K0.6290.37
115_A135_A0.6280.37
173_D230_D0.6280.37
213_K220_N0.6270.37
249_I274_G0.6260.37
99_P105_A0.6250.36
162_E305_L0.6220.36
54_K221_E0.6220.36
12_N105_A0.6200.36
200_R252_S0.6200.36
53_D56_I0.6180.36
40_D44_S0.6180.36
43_L198_M0.6170.36
298_I305_L0.6170.36
57_V92_V0.6160.36
80_F84_V0.6140.36
32_N153_W0.6140.36
248_V255_S0.6130.35
21_K194_S0.6120.35
178_L291_T0.6110.35
247_A251_D0.6110.35
199_I203_E0.6060.35
92_V177_E0.6060.35
92_V272_D0.6050.35
59_V64_L0.6050.35
243_N274_G0.6030.35
182_I276_A0.6030.35
19_W282_A0.6020.35
105_A285_N0.6010.34
168_Q172_H0.6000.34
32_N163_D0.6000.34
33_N155_K0.5980.34
237_L241_H0.5970.34
11_S256_F0.5950.34
205_S252_S0.5950.34
12_N36_S0.5940.34
15_V219_F0.5940.34
151_V168_Q0.5920.34
212_L215_I0.5890.33
32_N263_S0.5890.33
238_M255_S0.5890.33
233_K300_E0.5880.33
297_D301_F0.5870.33
296_G300_E0.5870.33
200_R203_E0.5870.33
12_N145_S0.5860.33
231_E267_M0.5840.33
72_Y79_T0.5790.33
294_N298_I0.5780.33
129_E133_K0.5770.32
47_T96_S0.5750.32
10_P32_N0.5720.32
13_I145_S0.5720.32
54_K227_R0.5710.32
176_S288_I0.5690.32
33_N215_I0.5690.32
16_V35_L0.5680.32
27_L163_D0.5640.31
255_S271_H0.5630.31
22_R27_L0.5630.31
243_N255_S0.5630.31
279_T282_A0.5620.31
266_I297_D0.5620.31
108_A145_S0.5610.31
179_V291_T0.5600.31
132_S166_C0.5590.31
14_A18_Y0.5590.31
106_S194_S0.5580.31
81_K84_V0.5570.31
295_I299_L0.5550.31
211_R245_M0.5550.31
262_T302_L0.5550.31
276_A290_T0.5540.31
19_W105_A0.5530.31
102_A282_A0.5530.31
10_P98_F0.5530.31
276_A298_I0.5520.31
80_F83_I0.5510.30
101_N250_L0.5510.30
300_E307_I0.5500.30
218_T287_H0.5500.30
56_I78_D0.5490.30
39_L279_T0.5490.30
128_S297_D0.5450.30
17_K20_G0.5450.30
45_V237_L0.5450.30
251_D255_S0.5430.30
115_A146_M0.5420.30
176_S292_E0.5400.30
267_M287_H0.5380.29
262_T305_L0.5370.29
175_W184_I0.5370.29
211_R215_I0.5370.29
256_F286_P0.5350.29
21_K39_L0.5330.29
257_F264_I0.5320.29
32_N211_R0.5300.29
191_K265_R0.5300.29
198_M211_R0.5290.29
244_S251_D0.5280.29
15_V40_D0.5280.29
12_N140_G0.5280.29
56_I62_R0.5270.29
7_V113_A0.5270.29
78_D85_G0.5260.29
5_V116_F0.5260.29
75_R82_K0.5240.28
80_F134_I0.5240.28
7_V116_F0.5240.28
44_S94_S0.5220.28
151_V166_C0.5220.28
252_S256_F0.5210.28
240_R253_W0.5200.28
21_K285_N0.5180.28
22_R156_G0.5150.28
73_A92_V0.5150.28
155_K167_Y0.5140.28
169_I303_K0.5140.28
32_N255_S0.5130.28
268_E275_K0.5130.28
175_W234_F0.5130.28
245_M282_A0.5130.28
156_G163_D0.5120.28
78_D82_K0.5120.28
22_R155_K0.5080.27
56_I87_E0.5070.27
58_I64_L0.5070.27
69_M80_F0.5060.27
10_P234_F0.5060.27
12_N99_P0.5060.27
262_T266_I0.5030.27
143_C192_I0.5030.27
105_A138_G0.5030.27
230_D236_Y0.5020.27
19_W198_M0.5020.27
204_T255_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fi4A 2 0.9877 100 0.545 Contact Map
3f0nA 2 0.9754 100 0.55 Contact Map
2hkeA 1 0.9785 100 0.564 Contact Map
3qt5A 2 0.9754 100 0.581 Contact Map
4rksA 1 0.9354 100 0.594 Contact Map
2gs8A 1 0.9385 100 0.634 Contact Map
3ltoA 2 0.9138 100 0.637 Contact Map
1h72C 2 0.8738 99.9 0.778 Contact Map
3pyfA 1 0.8831 99.9 0.785 Contact Map
4p52A 2 0.8831 99.9 0.788 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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