GREMLIN Database
Q97UL0 - Manganese transporter, putative
UniProt: Q97UL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (380)
Sequences: 3942 (2519)
Seq/√Len: 129.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_K76_E9.1001.00
164_V167_E5.3261.00
360_K375_M4.3141.00
77_R361_D3.5511.00
359_V370_Y3.5461.00
372_R376_L3.4841.00
362_K369_A3.2571.00
372_R375_M3.2211.00
259_Y262_S3.2051.00
370_Y375_M2.9521.00
353_V386_L2.8671.00
356_G378_Y2.8561.00
53_I381_T2.7761.00
262_S267_P2.7731.00
84_L88_L2.7451.00
353_V382_V2.5041.00
64_V368_Y2.4521.00
371_G374_R2.4271.00
56_E60_R2.4011.00
315_E319_A2.3731.00
41_I236_V2.3611.00
31_A35_E2.3451.00
172_F236_V2.3171.00
200_S294_W2.3051.00
236_V240_M2.2651.00
308_F311_L2.2641.00
353_V357_M2.2431.00
308_F312_Y2.2221.00
61_L359_V2.2001.00
171_Y174_P2.1821.00
108_G278_I2.1661.00
50_P381_T2.1331.00
168_N240_M2.1271.00
315_E318_P2.1061.00
165_N168_N2.0991.00
262_S270_P2.0741.00
28_T184_A2.0701.00
78_Y357_M2.0371.00
170_L174_P2.0141.00
115_P118_I2.0061.00
357_M361_D1.9691.00
109_G112_L1.9501.00
52_Y225_L1.9331.00
360_K370_Y1.9301.00
81_K85_L1.9261.00
307_N311_L1.9181.00
123_F278_I1.9011.00
88_L92_V1.9001.00
256_E259_Y1.8781.00
36_Y175_S1.8411.00
57_A370_Y1.8081.00
218_K222_I1.7721.00
311_L315_E1.7671.00
246_S251_P1.7631.00
68_K73_I1.7431.00
56_E221_S1.7421.00
175_S178_F1.7391.00
323_T326_F1.7381.00
105_I123_F1.7291.00
167_E171_Y1.7191.00
53_I374_R1.7181.00
69_G72_E1.7161.00
137_E141_K1.7071.00
321_V325_L1.6921.00
376_L379_W1.6771.00
61_L73_I1.6681.00
352_C382_V1.6641.00
106_A116_P1.6621.00
246_S249_V1.6471.00
148_L152_V1.6381.00
157_Q241_A1.6031.00
316_S319_A1.5871.00
379_W383_A1.5641.00
383_A387_I1.5621.00
319_A322_I1.5251.00
180_F339_T1.5181.00
36_Y178_F1.4981.00
38_Y244_G1.4841.00
180_F342_S1.4721.00
229_I233_L1.4701.00
165_N169_V1.4671.00
155_V237_A1.4591.00
315_E322_I1.4521.00
60_R370_Y1.4441.00
361_D364_L1.4421.00
149_L275_I1.4361.00
222_I226_I1.4331.00
358_L364_L1.4281.00
169_V173_S1.4171.00
45_L232_E1.4161.00
14_W227_G1.4121.00
6_V222_I1.4071.00
54_I352_C1.3951.00
307_N312_Y1.3901.00
357_M379_W1.3891.00
59_G220_S1.3831.00
356_G382_V1.3761.00
305_F311_L1.3731.00
253_N256_E1.3671.00
164_V168_N1.3471.00
166_G169_V1.3411.00
80_G84_L1.3381.00
369_A372_R1.3371.00
57_A378_Y1.3371.00
163_I168_N1.3241.00
64_V217_I1.3181.00
268_F272_I1.3061.00
20_D231_S1.3051.00
126_F129_V1.2931.00
79_S82_I1.2891.00
320_L324_L1.2861.00
44_L239_E1.2761.00
367_N371_G1.2591.00
373_T376_L1.2441.00
27_L257_I1.2401.00
356_G360_K1.2331.00
311_L314_S1.2331.00
141_K144_L1.2331.00
161_R244_G1.2301.00
305_F308_F1.2261.00
252_L256_E1.2241.00
309_I313_I1.2221.00
126_F282_F1.2030.99
89_S347_I1.1970.99
289_S293_A1.1970.99
370_Y374_R1.1960.99
29_G235_M1.1950.99
159_M163_I1.1940.99
50_P186_I1.1880.99
19_A287_V1.1870.99
271_Y275_I1.1870.99
314_S318_P1.1860.99
322_I325_L1.1820.99
17_M21_V1.1780.99
158_A240_M1.1770.99
360_K379_W1.1770.99
259_Y263_L1.1710.99
332_N335_N1.1700.99
327_T336_F1.1670.99
382_V386_L1.1640.99
96_F340_L1.1570.99
36_Y177_S1.1570.99
376_L383_A1.1440.99
47_L189_V1.1440.99
71_G295_G1.1380.99
114_I119_T1.1380.99
32_N185_N1.1300.99
318_P322_I1.1290.99
100_V340_L1.1270.99
74_I86_A1.1270.99
339_T343_I1.1250.99
161_R265_S1.1100.99
101_E104_G1.1020.99
356_G375_M1.1010.99
362_K367_N1.0910.99
55_Q71_G1.0870.99
109_G119_T1.0790.99
114_I118_I1.0770.99
147_S283_L1.0700.99
352_C381_T1.0690.99
55_Q190_I1.0680.99
376_L380_I1.0680.99
149_L279_C1.0610.99
248_S251_P1.0580.99
188_A191_M1.0510.99
94_D295_G1.0490.98
30_V257_I1.0430.98
93_V347_I1.0430.98
169_V172_F1.0420.98
370_Y373_T1.0370.98
53_I377_V1.0350.98
167_E170_L1.0320.98
109_G278_I1.0320.98
63_A220_S1.0310.98
15_I287_V1.0300.98
158_A237_A1.0200.98
13_A17_M1.0180.98
23_A281_A1.0120.98
78_Y358_L1.0110.98
121_P320_L1.0110.98
140_E205_K1.0090.98
166_G170_L1.0060.98
49_I53_I1.0050.98
356_G379_W0.9980.98
97_T101_E0.9930.98
202_T205_K0.9920.98
69_G203_S0.9840.98
75_R83_A0.9840.98
311_L327_T0.9790.98
310_L313_I0.9700.97
247_P250_D0.9660.97
129_V133_T0.9650.97
192_P344_A0.9650.97
265_S272_I0.9610.97
157_Q160_L0.9530.97
210_E367_N0.9520.97
156_L272_I0.9460.97
154_F234_I0.9400.97
309_I312_Y0.9360.97
306_N311_L0.9350.97
305_F312_Y0.9320.97
159_M162_G0.9310.97
21_V150_L0.9310.97
57_A61_L0.9290.97
366_M369_A0.9260.97
26_V276_G0.9240.97
349_V386_L0.9230.97
68_K72_E0.9190.97
117_Y324_L0.9170.96
336_F340_L0.9150.96
121_P125_V0.9110.96
371_G375_M0.9100.96
153_A272_I0.9070.96
369_A375_M0.9070.96
312_Y318_P0.9070.96
58_A62_G0.9060.96
380_I383_A0.9040.96
307_N313_I0.9000.96
346_F389_G0.8890.96
117_Y121_P0.8880.96
66_N73_I0.8870.96
57_A359_V0.8860.96
311_L318_P0.8840.96
311_L322_I0.8820.96
25_S29_G0.8820.96
32_N181_L0.8810.96
100_V337_A0.8800.96
156_L160_L0.8800.96
194_M287_V0.8780.95
94_D292_S0.8770.95
112_L271_Y0.8750.95
312_Y315_E0.8710.95
155_V159_M0.8710.95
310_L314_S0.8700.95
97_T100_V0.8700.95
146_I279_C0.8690.95
109_G114_I0.8680.95
66_N364_L0.8660.95
247_P251_P0.8640.95
307_N310_L0.8610.95
101_E188_A0.8500.95
118_I121_P0.8500.95
102_Y124_F0.8460.94
38_Y164_V0.8450.94
322_I328_N0.8440.94
138_K141_K0.8390.94
313_I320_L0.8390.94
308_F315_E0.8380.94
170_L173_S0.8380.94
13_A108_G0.8380.94
386_L390_I0.8340.94
181_L338_L0.8330.94
163_I240_M0.8320.94
22_D25_S0.8310.94
31_A334_V0.8310.94
384_M387_I0.8310.94
125_V129_V0.8300.94
17_M63_A0.8290.94
71_G196_F0.8270.94
118_I169_V0.8260.94
45_L172_F0.8240.94
102_Y119_T0.8190.93
260_A276_G0.8190.93
73_I358_L0.8170.93
135_K138_K0.8140.93
312_Y327_T0.8110.93
311_L319_A0.8100.93
156_L159_M0.8100.93
258_S270_P0.8080.93
315_E323_T0.8050.93
306_N310_L0.8050.93
70_L196_F0.8040.93
302_K310_L0.8010.93
325_L328_N0.8010.93
79_S361_D0.8000.93
311_L328_N0.7990.93
314_S319_A0.7930.92
169_V174_P0.7930.92
189_V341_M0.7920.92
312_Y322_I0.7910.92
20_D193_F0.7900.92
313_I317_I0.7870.92
193_F199_T0.7820.92
225_L229_I0.7790.92
38_Y171_Y0.7780.92
271_Y274_G0.7770.92
194_M198_Q0.7770.92
306_N312_Y0.7750.91
18_M147_S0.7750.91
263_L269_S0.7730.91
24_A341_M0.7730.91
48_S232_E0.7730.91
30_V254_Y0.7730.91
324_L327_T0.7710.91
59_G198_Q0.7690.91
73_I364_L0.7670.91
118_I125_V0.7670.91
29_G238_I0.7670.91
266_G269_S0.7650.91
32_N44_L0.7650.91
27_L337_A0.7640.91
35_E177_S0.7610.91
374_R378_Y0.7590.91
367_N372_R0.7530.90
19_A26_V0.7510.90
267_P367_N0.7510.90
317_I322_I0.7500.90
251_P256_E0.7460.90
344_A348_V0.7440.90
267_P270_P0.7410.90
28_T341_M0.7400.89
126_F308_F0.7380.89
12_P223_E0.7340.89
51_L189_V0.7330.89
55_Q196_F0.7330.89
53_I378_Y0.7310.89
307_N320_L0.7310.89
61_L358_L0.7310.89
315_E326_F0.7300.89
306_N309_I0.7300.89
273_F338_L0.7290.89
52_Y229_I0.7260.89
114_I122_I0.7260.89
55_Q189_V0.7240.88
322_I329_N0.7220.88
308_F322_I0.7190.88
44_L185_N0.7170.88
49_I52_Y0.7160.88
98_Y101_E0.7160.88
313_I316_S0.7140.88
186_I349_V0.7140.88
154_F261_L0.7140.88
217_I221_S0.7140.88
191_M198_Q0.7130.88
11_G223_E0.7120.88
20_D51_L0.7110.88
92_V137_E0.7090.87
67_G208_N0.7090.87
145_P156_L0.7080.87
152_V259_Y0.7070.87
101_E284_A0.7040.87
230_V234_I0.7040.87
309_I327_T0.7000.87
17_M223_E0.6990.87
345_P389_G0.6980.87
319_A323_T0.6970.87
238_I261_L0.6970.87
21_V234_I0.6970.87
19_A192_P0.6960.86
316_S322_I0.6950.86
162_G170_L0.6950.86
191_M344_A0.6950.86
188_A341_M0.6930.86
377_V381_T0.6910.86
55_Q192_P0.6840.85
290_L294_W0.6840.85
18_M22_D0.6830.85
16_V224_T0.6830.85
89_S350_I0.6810.85
129_V200_S0.6800.85
76_E362_K0.6800.85
194_M197_Y0.6790.85
359_V365_M0.6790.85
29_G97_T0.6780.85
223_E227_G0.6770.85
127_H285_L0.6760.85
190_I277_L0.6730.85
317_I325_L0.6710.84
69_G298_E0.6700.84
21_V29_G0.6680.84
168_N172_F0.6680.84
178_F182_V0.6670.84
158_A165_N0.6650.84
73_I76_E0.6640.84
322_I326_F0.6630.84
158_A241_A0.6610.83
276_G280_A0.6610.83
201_A204_Y0.6600.83
104_G163_I0.6600.83
191_M195_I0.6580.83
15_I194_M0.6570.83
59_G63_A0.6550.83
20_D25_S0.6540.83
250_D384_M0.6530.83
179_T391_L0.6530.83
78_Y82_I0.6520.83
15_I18_M0.6510.83
16_V195_I0.6510.83
192_P200_S0.6480.82
171_Y175_S0.6480.82
373_T377_V0.6480.82
56_E217_I0.6480.82
216_K219_W0.6480.82
375_M379_W0.6470.82
6_V10_F0.6450.82
289_S318_P0.6440.82
21_V154_F0.6430.82
150_L279_C0.6430.82
143_L286_I0.6420.82
120_L124_F0.6420.82
44_L241_A0.6420.82
153_A265_S0.6400.82
335_N339_T0.6400.82
253_N334_V0.6390.81
310_L318_P0.6380.81
82_I354_L0.6360.81
129_V321_V0.6350.81
22_D29_G0.6320.81
22_D101_E0.6310.81
162_G165_N0.6280.80
237_A265_S0.6260.80
15_I383_A0.6250.80
313_I383_A0.6250.80
21_V283_L0.6230.80
110_L254_Y0.6230.80
25_S188_A0.6210.80
145_P271_Y0.6180.79
60_R280_A0.6170.79
87_S91_F0.6170.79
384_M388_G0.6150.79
119_T122_I0.6130.79
25_S191_M0.6130.79
23_A337_A0.6110.78
64_V203_S0.6090.78
97_T344_A0.6080.78
154_F257_I0.6070.78
23_A100_V0.6060.78
347_I351_P0.6060.78
22_D97_T0.6060.78
232_E236_V0.6050.78
157_Q161_R0.6050.78
279_C283_L0.6050.78
72_E203_S0.6030.78
195_I352_C0.6020.77
318_P326_F0.6010.77
191_M341_M0.6010.77
62_G70_L0.6000.77
267_P271_Y0.6000.77
234_I238_I0.5990.77
142_F366_M0.5980.77
23_A198_Q0.5970.77
94_D288_E0.5970.77
164_V383_A0.5960.77
306_N325_L0.5950.77
158_A272_I0.5940.76
387_I391_L0.5910.76
57_A60_R0.5910.76
224_T228_A0.5910.76
120_L323_T0.5910.76
379_W382_V0.5910.76
22_D284_A0.5880.76
297_L307_N0.5880.76
321_V326_F0.5880.76
15_I19_A0.5870.76
373_T383_A0.5870.76
35_E39_R0.5860.76
312_Y316_S0.5850.75
19_A195_I0.5850.75
325_L346_F0.5840.75
313_I319_A0.5820.75
351_P354_L0.5820.75
314_S317_I0.5820.75
31_A252_L0.5780.75
95_V296_T0.5780.75
101_E193_F0.5770.74
237_A241_A0.5760.74
100_V341_M0.5760.74
125_V166_G0.5760.74
51_L228_A0.5750.74
19_A351_P0.5750.74
39_R43_L0.5750.74
185_N239_E0.5740.74
35_E152_V0.5740.74
25_S235_M0.5730.74
193_F196_F0.5720.74
223_E351_P0.5710.74
97_T341_M0.5710.74
54_I381_T0.5700.74
305_F314_S0.5700.74
236_V239_E0.5700.74
61_L355_I0.5670.73
166_G173_S0.5670.73
361_D369_A0.5660.73
36_Y181_L0.5660.73
289_S296_T0.5660.73
74_I299_A0.5620.72
148_L230_V0.5610.72
147_S150_L0.5590.72
104_G108_G0.5580.72
48_S229_I0.5580.72
319_A327_T0.5580.72
316_S320_L0.5570.72
159_M373_T0.5570.72
93_V337_A0.5560.72
13_A227_G0.5560.72
325_L380_I0.5550.72
305_F318_P0.5540.71
191_M235_M0.5540.71
81_K84_L0.5540.71
147_S151_A0.5530.71
59_G67_G0.5530.71
321_V324_L0.5520.71
23_A104_G0.5520.71
315_E327_T0.5520.71
46_L384_M0.5520.71
108_G366_M0.5520.71
155_V233_L0.5520.71
359_V375_M0.5510.71
10_F169_V0.5500.71
312_Y323_T0.5490.71
166_G316_S0.5490.71
380_I387_I0.5470.70
77_R81_K0.5470.70
166_G301_G0.5450.70
51_L231_S0.5440.70
48_S52_Y0.5420.70
164_V169_V0.5420.70
148_L162_G0.5420.70
329_N332_N0.5420.70
307_N318_P0.5410.70
246_S250_D0.5390.69
161_R386_L0.5390.69
97_T340_L0.5380.69
101_E192_P0.5380.69
7_I12_P0.5330.69
45_L357_M0.5310.68
10_F14_W0.5300.68
170_L210_E0.5300.68
22_D283_L0.5300.68
356_G370_Y0.5280.68
221_S387_I0.5270.68
305_F309_I0.5270.68
145_P383_A0.5260.68
306_N314_S0.5260.68
34_Q37_G0.5260.68
16_V194_M0.5250.67
30_V238_I0.5240.67
110_L274_G0.5230.67
89_S94_D0.5220.67
7_I267_P0.5220.67
293_A297_L0.5210.67
208_N371_G0.5200.67
156_L358_L0.5190.66
176_K380_I0.5160.66
40_L179_T0.5140.66
217_I220_S0.5140.66
93_V96_F0.5140.66
95_V98_Y0.5140.66
143_L283_L0.5130.66
60_R221_S0.5130.66
71_G298_E0.5120.65
316_S327_T0.5110.65
185_N189_V0.5110.65
184_A189_V0.5100.65
142_F286_I0.5100.65
108_G274_G0.5100.65
222_I225_L0.5090.65
281_A284_A0.5090.65
86_A354_L0.5090.65
155_V172_F0.5080.65
150_L281_A0.5070.65
19_A295_G0.5070.65
250_D357_M0.5060.65
64_V365_M0.5060.65
103_V106_A0.5050.64
317_I321_V0.5040.64
86_A351_P0.5020.64
50_P227_G0.5010.64
122_I125_V0.5010.64
309_I319_A0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wgvA 2 0.9467 100 0.182 Contact Map
3dh4A 3 0.9239 99.1 0.853 Contact Map
2xq2A 2 0.9264 98.8 0.868 Contact Map
3giaA 1 0.9239 98.7 0.874 Contact Map
3l1lA 2 0.901 98.7 0.876 Contact Map
2jlnA 1 0.9442 98.3 0.89 Contact Map
4djkA 2 0.9086 98.1 0.893 Contact Map
4us3A 1 0.9442 97.3 0.911 Contact Map
4xp4A 1 0.9543 96.7 0.919 Contact Map
2a65A 2 0.9442 96.4 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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