GREMLIN Database
Q97UK9 - 3-hydroxyacyl-CoA dehydrogenase (Hdb-3)
UniProt: Q97UK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (354)
Sequences: 3079 (1728)
Seq/√Len: 91.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_W40_N4.6331.00
98_K102_T3.4131.00
131_R134_K3.2371.00
61_E64_E3.2161.00
23_A70_I2.9501.00
301_A354_H2.9301.00
150_V170_A2.9241.00
180_L188_V2.8751.00
7_G79_M2.6761.00
238_D273_K2.5511.00
85_V107_T2.5501.00
213_E296_S2.5111.00
107_T111_T2.4531.00
104_D130_K2.4531.00
89_V99_V2.4511.00
22_S169_L2.4491.00
115_S122_I2.4301.00
54_Y59_I2.4201.00
54_Y63_P2.3971.00
6_I22_S2.3341.00
133_E157_Y2.3181.00
93_I124_T2.3121.00
7_G82_A2.2831.00
104_D129_T2.2581.00
136_I166_T2.2071.00
100_F113_L2.1711.00
241_V265_F2.1311.00
97_R128_V2.0961.00
5_K81_D2.0841.00
51_N63_P2.0771.00
311_G340_M1.9921.00
110_H134_K1.9701.00
124_T127_E1.9651.00
354_H357_D1.9631.00
123_S156_K1.9431.00
219_R230_E1.9261.00
308_V342_I1.9091.00
159_S162_T1.8451.00
295_T298_V1.8451.00
101_E128_V1.8211.00
218_A303_L1.7841.00
199_E206_D1.7791.00
270_L274_T1.7761.00
170_A177_P1.7711.00
73_S78_V1.7611.00
204_V214_V1.7601.00
269_E276_K1.7591.00
75_S78_V1.7501.00
65_D69_R1.7411.00
50_L66_I1.7271.00
297_K301_A1.7231.00
349_R353_N1.7231.00
322_A344_D1.7231.00
329_M339_L1.7231.00
6_I84_F1.7161.00
138_M166_T1.6801.00
210_T213_E1.6741.00
28_N69_R1.6731.00
47_M51_N1.6711.00
95_L99_V1.6711.00
51_N55_E1.6641.00
63_P67_M1.6551.00
356_V359_Y1.6511.00
20_E49_S1.6371.00
155_S158_T1.6321.00
105_S130_K1.6261.00
64_E68_K1.6251.00
89_V95_L1.6151.00
352_Y356_V1.6121.00
305_S346_L1.5901.00
129_T135_I1.5821.00
24_L66_I1.5801.00
40_N44_E1.5631.00
62_K65_D1.5381.00
79_M82_A1.5361.00
97_R101_E1.5271.00
263_R267_A1.5161.00
11_A42_A1.5061.00
6_I27_Y1.4941.00
44_E48_E1.4881.00
244_W262_K1.4841.00
95_L98_K1.4791.00
39_L74_T1.4731.00
90_P95_L1.4701.00
225_P231_L1.4681.00
32_V76_Y1.4631.00
93_I125_I1.4531.00
282_P285_G1.4460.99
119_S243_L1.4290.99
184_V319_I1.4160.99
154_P160_D1.4020.99
343_A351_I1.4010.99
188_V328_V1.3940.99
353_N356_V1.3930.99
83_D108_P1.3890.99
350_N353_N1.3880.99
315_I325_I1.3800.99
41_R45_R1.3770.99
320_V325_I1.3550.99
84_F138_M1.3540.99
50_L63_P1.3540.99
93_I120_I1.3530.99
301_A305_S1.3510.99
11_A33_D1.3500.99
5_K28_N1.3460.99
241_V266_E1.3360.99
94_E98_K1.3330.99
93_I97_R1.3290.99
312_A343_A1.3250.99
241_V262_K1.3240.99
123_S183_E1.3190.99
325_I340_M1.3150.99
217_A300_P1.3150.99
167_I179_K1.3130.99
241_V245_N1.3130.99
245_N249_S1.3050.99
94_E97_R1.3010.99
32_V102_T1.3000.99
36_W74_T1.2900.99
270_L273_K1.2870.99
262_K266_E1.2860.99
206_D302_R1.2830.99
178_V328_V1.2740.99
112_F162_T1.2720.99
276_K280_N1.2630.99
125_I135_I1.2610.99
245_N262_K1.2580.99
43_K47_M1.2570.99
138_M170_A1.2500.98
203_E208_E1.2500.98
108_P111_T1.2460.98
353_N357_D1.2440.98
114_A136_I1.2390.98
97_R125_I1.2390.98
308_V343_A1.2390.98
100_F125_I1.2060.98
152_I167_I1.2060.98
76_Y102_T1.2050.98
352_Y355_L1.2030.98
43_K72_F1.1980.98
202_R205_E1.1970.98
193_F231_L1.1920.98
163_I179_K1.1850.98
133_E159_S1.1830.98
84_F169_L1.1750.98
188_V339_L1.1720.98
39_L72_F1.1630.98
107_T113_L1.1620.98
102_T105_S1.1540.97
126_A135_I1.1400.97
251_G254_Q1.1400.97
123_S155_S1.1190.97
301_A342_I1.1170.97
232_S240_A1.1110.97
148_K176_I1.1100.97
311_G339_L1.1090.97
221_G296_S1.1070.97
222_L342_I1.1030.97
192_I311_G1.0950.97
100_F129_T1.0920.96
79_M106_I1.0910.96
342_I346_L1.0870.96
313_W316_Q1.0850.96
47_M67_M1.0840.96
180_L328_V1.0780.96
188_V320_V1.0770.96
109_S130_K1.0760.96
44_E47_M1.0750.96
51_N54_Y1.0710.96
176_I331_Y1.0700.96
62_K69_R1.0630.96
76_Y106_I1.0570.96
168_D172_K1.0530.96
7_G30_S1.0530.96
264_K269_E1.0470.95
236_G273_K1.0430.95
19_A31_V1.0390.95
4_K172_K1.0390.95
5_K30_S1.0290.95
136_I163_I1.0290.95
97_R124_T1.0260.95
192_I307_A1.0260.95
238_D270_L1.0240.95
22_S173_M1.0130.95
263_R266_E1.0110.95
350_N354_H1.0070.94
11_A31_V1.0040.94
47_M64_E1.0040.94
265_F270_L0.9950.94
311_G325_I0.9880.94
217_A296_S0.9860.94
285_G288_R0.9850.94
90_P142_N0.9780.94
138_M169_L0.9740.93
305_S354_H0.9660.93
47_M63_P0.9620.93
241_V270_L0.9520.93
285_G291_E0.9450.92
71_E78_V0.9410.92
312_A348_I0.9400.92
141_F147_M0.9370.92
327_T331_Y0.9350.92
16_H45_R0.9330.92
208_E213_E0.9300.92
154_P179_K0.9270.92
53_F56_K0.9240.91
208_E294_V0.9210.91
218_A228_I0.9200.91
28_N71_E0.9170.91
137_G153_V0.9160.91
252_T255_D0.9160.91
242_D246_V0.9160.91
122_I137_G0.9150.91
13_T239_V0.9130.91
9_V103_L0.9100.91
340_M343_A0.9080.91
292_L298_V0.9080.91
282_P287_Y0.9070.91
344_D348_I0.9060.91
132_K157_Y0.9050.91
37_D40_N0.9050.91
51_N61_E0.9040.91
77_D80_R0.9010.90
22_S86_I0.8960.90
52_K55_E0.8950.90
189_S333_F0.8950.90
168_D171_K0.8860.90
321_N324_D0.8860.90
38_F41_R0.8850.90
346_L351_I0.8820.89
77_D106_I0.8770.89
346_L350_N0.8750.89
134_K159_S0.8710.89
351_I355_L0.8700.89
35_S38_F0.8690.89
149_L332_G0.8670.89
103_L107_T0.8660.89
305_S351_I0.8660.89
24_L50_L0.8660.89
48_E51_N0.8610.88
199_E302_R0.8610.88
185_P246_V0.8600.88
312_A344_D0.8540.88
300_P304_I0.8510.88
30_S73_S0.8500.88
237_I265_F0.8480.88
59_I62_K0.8440.87
297_K300_P0.8430.87
113_L129_T0.8430.87
32_V73_S0.8420.87
251_G255_D0.8410.87
5_K82_A0.8400.87
287_Y290_V0.8390.87
189_S231_L0.8330.87
142_N235_V0.8300.86
200_A303_L0.8290.86
197_M244_W0.8280.86
46_I49_S0.8240.86
37_D41_R0.8220.86
150_V177_P0.8220.86
30_S78_V0.8170.86
27_Y169_L0.8150.85
246_V250_S0.8150.85
195_R198_Q0.8140.85
98_K101_E0.8120.85
114_A138_M0.8120.85
189_S328_V0.8120.85
259_E263_R0.8110.85
197_M232_S0.8080.85
3_I6_I0.8050.85
342_I351_I0.8030.85
301_A350_N0.8020.84
331_Y337_K0.7980.84
92_I242_D0.7920.84
327_T330_I0.7910.84
193_F307_A0.7910.84
3_I165_V0.7880.83
105_S108_P0.7880.83
148_K331_Y0.7870.83
193_F235_V0.7850.83
93_I250_S0.7840.83
66_I69_R0.7830.83
301_A358_I0.7820.83
343_A348_I0.7790.83
341_E345_E0.7770.83
31_V42_A0.7750.82
216_S221_G0.7750.82
216_S296_S0.7720.82
53_F59_I0.7690.82
134_K161_E0.7660.82
188_V329_M0.7660.82
288_R291_E0.7660.82
188_V325_I0.7650.82
108_P134_K0.7650.82
348_I352_Y0.7600.81
136_I162_T0.7580.81
341_E344_D0.7560.81
340_M344_D0.7510.80
134_K162_T0.7490.80
8_V19_A0.7480.80
14_M116_N0.7480.80
138_M150_V0.7410.79
259_E262_K0.7380.79
213_E294_V0.7370.79
20_E24_L0.7360.79
16_H42_A0.7350.79
294_V299_D0.7330.79
310_E317_N0.7310.79
149_L175_K0.7300.78
129_T134_K0.7280.78
305_S358_I0.7270.78
184_V190_N0.7250.78
140_F173_M0.7250.78
326_D344_D0.7220.78
97_R127_E0.7210.78
219_R227_G0.7200.78
3_I27_Y0.7200.78
6_I86_I0.7170.77
14_M117_T0.7160.77
85_V111_T0.7150.77
296_S300_P0.7140.77
160_D164_E0.7120.77
175_K264_K0.7110.77
23_A66_I0.7070.76
205_E260_M0.7060.76
234_Y272_V0.7020.76
197_M201_C0.7010.76
205_E258_C0.7000.76
100_F103_L0.6990.75
158_T162_T0.6980.75
287_Y291_E0.6970.75
309_N312_A0.6950.75
314_L325_I0.6950.75
233_D277_G0.6940.75
9_V32_V0.6910.75
117_T141_F0.6900.74
280_N291_E0.6880.74
268_K274_T0.6870.74
312_A352_Y0.6850.74
215_D227_G0.6830.74
53_F58_Q0.6830.74
314_L320_V0.6830.74
76_Y99_V0.6830.74
309_N355_L0.6820.74
222_L308_V0.6810.73
39_L42_A0.6810.73
62_K66_I0.6790.73
277_G281_Y0.6760.73
283_A286_K0.6750.73
349_R352_Y0.6750.73
30_S81_D0.6740.73
226_M234_Y0.6740.73
245_N266_E0.6690.72
40_N43_K0.6670.72
315_I340_M0.6650.72
312_A316_Q0.6640.72
81_D108_P0.6640.72
121_P183_E0.6640.72
76_Y79_M0.6630.72
22_S27_Y0.6570.71
309_N313_W0.6560.71
40_N47_M0.6550.71
350_N356_V0.6550.71
46_I70_I0.6550.71
195_R243_L0.6540.70
231_L235_V0.6510.70
235_V240_A0.6500.70
224_L307_A0.6480.70
25_A174_N0.6460.70
13_T142_N0.6460.70
224_L336_P0.6460.70
286_K291_E0.6460.70
45_R48_E0.6440.69
20_E145_P0.6420.69
233_D271_G0.6410.69
240_A243_L0.6410.69
103_L113_L0.6400.69
117_T187_F0.6400.69
196_L228_I0.6360.68
215_D339_L0.6360.68
285_G289_K0.6340.68
346_L354_H0.6340.68
16_H49_S0.6330.68
16_H39_L0.6330.68
304_I342_I0.6300.68
119_S239_V0.6300.68
130_K157_Y0.6290.68
119_S185_P0.6280.67
283_A287_Y0.6280.67
16_H41_R0.6270.67
161_E165_V0.6250.67
112_F165_V0.6250.67
107_T110_H0.6210.67
30_S71_E0.6200.66
240_A261_Y0.6200.66
23_A46_I0.6200.66
63_P66_I0.6180.66
348_I351_I0.6180.66
308_V346_L0.6170.66
120_I183_E0.6170.66
306_L316_Q0.6170.66
116_N190_N0.6160.66
3_I112_F0.6160.66
204_V260_M0.6150.66
60_K313_W0.6150.66
126_A132_K0.6150.66
141_F149_L0.6140.66
153_V187_F0.6140.66
20_E46_I0.6130.66
101_E105_S0.6120.65
49_S53_F0.6120.65
27_Y69_R0.6120.65
190_N320_V0.6100.65
218_A300_P0.6070.65
230_E234_Y0.6050.65
158_T163_I0.6040.64
121_P124_T0.6030.64
235_V337_K0.6010.64
181_K184_V0.6010.64
185_P247_I0.6010.64
23_A43_K0.6000.64
185_P243_L0.5990.64
141_F187_F0.5980.64
111_T131_R0.5970.63
49_S145_P0.5960.63
352_Y359_Y0.5950.63
104_D135_I0.5930.63
127_E157_Y0.5920.63
216_S219_R0.5900.63
322_A326_D0.5880.62
239_V246_V0.5880.62
65_D68_K0.5860.62
208_E292_L0.5850.62
354_H358_I0.5850.62
320_V340_M0.5840.62
282_P286_K0.5840.62
355_L358_I0.5830.62
323_K344_D0.5830.62
122_I183_E0.5830.62
286_K289_K0.5810.61
284_P287_Y0.5790.61
101_E130_K0.5750.61
11_A88_A0.5720.60
275_G286_K0.5690.60
6_I173_M0.5680.60
154_P163_I0.5660.59
286_K290_V0.5660.59
78_V81_D0.5660.59
203_E206_D0.5640.59
254_Q257_K0.5640.59
122_I153_V0.5640.59
18_I186_G0.5620.59
9_V95_L0.5620.59
236_G240_A0.5610.59
21_V145_P0.5610.59
132_K155_S0.5610.59
4_K108_P0.5600.59
36_W86_I0.5560.58
353_N359_Y0.5560.58
54_Y64_E0.5540.58
204_V211_I0.5540.58
197_M240_A0.5540.58
18_I116_N0.5540.58
20_E50_L0.5520.58
329_M333_F0.5520.58
51_N67_M0.5520.58
107_T125_I0.5490.57
116_N141_F0.5470.57
39_L43_K0.5450.57
30_S82_A0.5450.57
42_A72_F0.5440.56
238_D274_T0.5420.56
48_E52_K0.5410.56
328_V331_Y0.5410.56
42_A49_S0.5410.56
142_N147_M0.5410.56
213_E299_D0.5400.56
104_D131_R0.5390.56
16_H23_A0.5390.56
11_A19_A0.5360.55
239_V243_L0.5360.55
13_T238_D0.5360.55
271_G277_G0.5350.55
168_D297_K0.5350.55
3_I172_K0.5350.55
40_N74_T0.5340.55
260_M278_F0.5330.55
261_Y265_F0.5320.55
236_G274_T0.5310.55
242_D245_N0.5310.55
3_I22_S0.5300.55
201_C261_Y0.5290.54
201_C229_F0.5280.54
307_A333_F0.5280.54
100_F135_I0.5280.54
80_R101_E0.5270.54
135_I224_L0.5270.54
14_M187_F0.5260.54
307_A329_M0.5250.54
45_R145_P0.5250.54
59_I66_I0.5240.54
126_A155_S0.5210.53
52_K56_K0.5210.53
236_G239_V0.5200.53
280_N285_G0.5200.53
237_I270_L0.5170.53
193_F222_L0.5170.53
53_F146_I0.5170.53
349_R357_D0.5160.53
230_E287_Y0.5150.52
212_E216_S0.5150.52
350_N357_D0.5130.52
164_E168_D0.5130.52
136_I152_I0.5130.52
301_A346_L0.5130.52
186_G227_G0.5120.52
116_N187_F0.5120.52
206_D294_V0.5120.52
193_F198_Q0.5120.52
191_R310_E0.5100.52
233_D281_Y0.5100.52
35_S74_T0.5100.52
315_I320_V0.5090.52
34_I92_I0.5070.51
84_F166_T0.5060.51
235_V239_V0.5060.51
34_I95_L0.5050.51
189_S195_R0.5020.51
118_S147_M0.5010.50
282_P289_K0.5010.50
198_Q255_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.9844 100 0.249 Contact Map
2wtbA 1 0.9271 100 0.251 Contact Map
4b3hA 1 0.9661 100 0.272 Contact Map
3zwcA 1 0.9896 100 0.274 Contact Map
3k6jA 1 0.9479 100 0.274 Contact Map
1zcjA 1 0.9896 100 0.284 Contact Map
3mogA 3 0.9948 100 0.335 Contact Map
4j0eA 2 0.7292 100 0.476 Contact Map
1f0yA 2 0.7318 100 0.493 Contact Map
4r1nA 2 0.7292 100 0.504 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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