Q97UK9 - SULSO - GREMLIN Contacts

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Q97UK9 - 3-hydroxyacyl-CoA dehydrogenase (Hdb-3)

UniProt:	Q97UK9	Sequences: MSIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIKEKPEDIMKRIEFSTSYDVMRDADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSIPISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSDETIEVTIDLAKKMNKIPVKLKVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVAVDLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDPARLISLAVNEGAWLIQNGIVNAKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYSKGYVAYRPNSLIEELINTSKGFYM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	384 (354)
Sequences:	3079 (1728)
Seq/√Len:	91.8

ECOLI - FADB FADJ PAAH
BACSU - HBD FADN
HALSA - Q9HQ61 Q9HRI4
SULSO - Q97UK9 Q97UX0 Q97VU5 Q7LXQ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_W	40_N	4.633	1.00
98_K	102_T	3.413	1.00
131_R	134_K	3.237	1.00
61_E	64_E	3.216	1.00
23_A	70_I	2.950	1.00
301_A	354_H	2.930	1.00
150_V	170_A	2.924	1.00
180_L	188_V	2.875	1.00
7_G	79_M	2.676	1.00
238_D	273_K	2.551	1.00
85_V	107_T	2.550	1.00
213_E	296_S	2.511	1.00
107_T	111_T	2.453	1.00
104_D	130_K	2.453	1.00
89_V	99_V	2.451	1.00
22_S	169_L	2.449	1.00
115_S	122_I	2.430	1.00
54_Y	59_I	2.420	1.00
54_Y	63_P	2.397	1.00
6_I	22_S	2.334	1.00
133_E	157_Y	2.318	1.00
93_I	124_T	2.312	1.00
7_G	82_A	2.283	1.00
104_D	129_T	2.258	1.00
136_I	166_T	2.207	1.00
100_F	113_L	2.171	1.00
241_V	265_F	2.131	1.00
97_R	128_V	2.096	1.00
5_K	81_D	2.084	1.00
51_N	63_P	2.077	1.00
311_G	340_M	1.992	1.00
110_H	134_K	1.970	1.00
124_T	127_E	1.965	1.00
354_H	357_D	1.963	1.00
123_S	156_K	1.943	1.00
219_R	230_E	1.926	1.00
308_V	342_I	1.909	1.00
159_S	162_T	1.845	1.00
295_T	298_V	1.845	1.00
101_E	128_V	1.821	1.00
218_A	303_L	1.784	1.00
199_E	206_D	1.779	1.00
270_L	274_T	1.776	1.00
170_A	177_P	1.771	1.00
73_S	78_V	1.761	1.00
204_V	214_V	1.760	1.00
269_E	276_K	1.759	1.00
75_S	78_V	1.750	1.00
65_D	69_R	1.741	1.00
50_L	66_I	1.727	1.00
297_K	301_A	1.723	1.00
349_R	353_N	1.723	1.00
322_A	344_D	1.723	1.00
329_M	339_L	1.723	1.00
6_I	84_F	1.716	1.00
138_M	166_T	1.680	1.00
210_T	213_E	1.674	1.00
28_N	69_R	1.673	1.00
47_M	51_N	1.671	1.00
95_L	99_V	1.671	1.00
51_N	55_E	1.664	1.00
63_P	67_M	1.655	1.00
356_V	359_Y	1.651	1.00
20_E	49_S	1.637	1.00
155_S	158_T	1.632	1.00
105_S	130_K	1.626	1.00
64_E	68_K	1.625	1.00
89_V	95_L	1.615	1.00
352_Y	356_V	1.612	1.00
305_S	346_L	1.590	1.00
129_T	135_I	1.582	1.00
24_L	66_I	1.580	1.00
40_N	44_E	1.563	1.00
62_K	65_D	1.538	1.00
79_M	82_A	1.536	1.00
97_R	101_E	1.527	1.00
263_R	267_A	1.516	1.00
11_A	42_A	1.506	1.00
6_I	27_Y	1.494	1.00
44_E	48_E	1.488	1.00
244_W	262_K	1.484	1.00
95_L	98_K	1.479	1.00
39_L	74_T	1.473	1.00
90_P	95_L	1.470	1.00
225_P	231_L	1.468	1.00
32_V	76_Y	1.463	1.00
93_I	125_I	1.453	1.00
282_P	285_G	1.446	0.99
119_S	243_L	1.429	0.99
184_V	319_I	1.416	0.99
154_P	160_D	1.402	0.99
343_A	351_I	1.401	0.99
188_V	328_V	1.394	0.99
353_N	356_V	1.393	0.99
83_D	108_P	1.389	0.99
350_N	353_N	1.388	0.99
315_I	325_I	1.380	0.99
41_R	45_R	1.377	0.99
320_V	325_I	1.355	0.99
84_F	138_M	1.354	0.99
50_L	63_P	1.354	0.99
93_I	120_I	1.353	0.99
301_A	305_S	1.351	0.99
11_A	33_D	1.350	0.99
5_K	28_N	1.346	0.99
241_V	266_E	1.336	0.99
94_E	98_K	1.333	0.99
93_I	97_R	1.329	0.99
312_A	343_A	1.325	0.99
241_V	262_K	1.324	0.99
123_S	183_E	1.319	0.99
325_I	340_M	1.315	0.99
217_A	300_P	1.315	0.99
167_I	179_K	1.313	0.99
241_V	245_N	1.313	0.99
245_N	249_S	1.305	0.99
94_E	97_R	1.301	0.99
32_V	102_T	1.300	0.99
36_W	74_T	1.290	0.99
270_L	273_K	1.287	0.99
262_K	266_E	1.286	0.99
206_D	302_R	1.283	0.99
178_V	328_V	1.274	0.99
112_F	162_T	1.272	0.99
276_K	280_N	1.263	0.99
125_I	135_I	1.261	0.99
245_N	262_K	1.258	0.99
43_K	47_M	1.257	0.99
138_M	170_A	1.250	0.98
203_E	208_E	1.250	0.98
108_P	111_T	1.246	0.98
353_N	357_D	1.244	0.98
114_A	136_I	1.239	0.98
97_R	125_I	1.239	0.98
308_V	343_A	1.239	0.98
100_F	125_I	1.206	0.98
152_I	167_I	1.206	0.98
76_Y	102_T	1.205	0.98
352_Y	355_L	1.203	0.98
43_K	72_F	1.198	0.98
202_R	205_E	1.197	0.98
193_F	231_L	1.192	0.98
163_I	179_K	1.185	0.98
133_E	159_S	1.183	0.98
84_F	169_L	1.175	0.98
188_V	339_L	1.172	0.98
39_L	72_F	1.163	0.98
107_T	113_L	1.162	0.98
102_T	105_S	1.154	0.97
126_A	135_I	1.140	0.97
251_G	254_Q	1.140	0.97
123_S	155_S	1.119	0.97
301_A	342_I	1.117	0.97
232_S	240_A	1.111	0.97
148_K	176_I	1.110	0.97
311_G	339_L	1.109	0.97
221_G	296_S	1.107	0.97
222_L	342_I	1.103	0.97
192_I	311_G	1.095	0.97
100_F	129_T	1.092	0.96
79_M	106_I	1.091	0.96
342_I	346_L	1.087	0.96
313_W	316_Q	1.085	0.96
47_M	67_M	1.084	0.96
180_L	328_V	1.078	0.96
188_V	320_V	1.077	0.96
109_S	130_K	1.076	0.96
44_E	47_M	1.075	0.96
51_N	54_Y	1.071	0.96
176_I	331_Y	1.070	0.96
62_K	69_R	1.063	0.96
76_Y	106_I	1.057	0.96
168_D	172_K	1.053	0.96
7_G	30_S	1.053	0.96
264_K	269_E	1.047	0.95
236_G	273_K	1.043	0.95
19_A	31_V	1.039	0.95
4_K	172_K	1.039	0.95
5_K	30_S	1.029	0.95
136_I	163_I	1.029	0.95
97_R	124_T	1.026	0.95
192_I	307_A	1.026	0.95
238_D	270_L	1.024	0.95
22_S	173_M	1.013	0.95
263_R	266_E	1.011	0.95
350_N	354_H	1.007	0.94
11_A	31_V	1.004	0.94
47_M	64_E	1.004	0.94
265_F	270_L	0.995	0.94
311_G	325_I	0.988	0.94
217_A	296_S	0.986	0.94
285_G	288_R	0.985	0.94
90_P	142_N	0.978	0.94
138_M	169_L	0.974	0.93
305_S	354_H	0.966	0.93
47_M	63_P	0.962	0.93
241_V	270_L	0.952	0.93
285_G	291_E	0.945	0.92
71_E	78_V	0.941	0.92
312_A	348_I	0.940	0.92
141_F	147_M	0.937	0.92
327_T	331_Y	0.935	0.92
16_H	45_R	0.933	0.92
208_E	213_E	0.930	0.92
154_P	179_K	0.927	0.92
53_F	56_K	0.924	0.91
208_E	294_V	0.921	0.91
218_A	228_I	0.920	0.91
28_N	71_E	0.917	0.91
137_G	153_V	0.916	0.91
252_T	255_D	0.916	0.91
242_D	246_V	0.916	0.91
122_I	137_G	0.915	0.91
13_T	239_V	0.913	0.91
9_V	103_L	0.910	0.91
340_M	343_A	0.908	0.91
292_L	298_V	0.908	0.91
282_P	287_Y	0.907	0.91
344_D	348_I	0.906	0.91
132_K	157_Y	0.905	0.91
37_D	40_N	0.905	0.91
51_N	61_E	0.904	0.91
77_D	80_R	0.901	0.90
22_S	86_I	0.896	0.90
52_K	55_E	0.895	0.90
189_S	333_F	0.895	0.90
168_D	171_K	0.886	0.90
321_N	324_D	0.886	0.90
38_F	41_R	0.885	0.90
346_L	351_I	0.882	0.89
77_D	106_I	0.877	0.89
346_L	350_N	0.875	0.89
134_K	159_S	0.871	0.89
351_I	355_L	0.870	0.89
35_S	38_F	0.869	0.89
149_L	332_G	0.867	0.89
103_L	107_T	0.866	0.89
305_S	351_I	0.866	0.89
24_L	50_L	0.866	0.89
48_E	51_N	0.861	0.88
199_E	302_R	0.861	0.88
185_P	246_V	0.860	0.88
312_A	344_D	0.854	0.88
300_P	304_I	0.851	0.88
30_S	73_S	0.850	0.88
237_I	265_F	0.848	0.88
59_I	62_K	0.844	0.87
297_K	300_P	0.843	0.87
113_L	129_T	0.843	0.87
32_V	73_S	0.842	0.87
251_G	255_D	0.841	0.87
5_K	82_A	0.840	0.87
287_Y	290_V	0.839	0.87
189_S	231_L	0.833	0.87
142_N	235_V	0.830	0.86
200_A	303_L	0.829	0.86
197_M	244_W	0.828	0.86
46_I	49_S	0.824	0.86
37_D	41_R	0.822	0.86
150_V	177_P	0.822	0.86
30_S	78_V	0.817	0.86
27_Y	169_L	0.815	0.85
246_V	250_S	0.815	0.85
195_R	198_Q	0.814	0.85
98_K	101_E	0.812	0.85
114_A	138_M	0.812	0.85
189_S	328_V	0.812	0.85
259_E	263_R	0.811	0.85
197_M	232_S	0.808	0.85
3_I	6_I	0.805	0.85
342_I	351_I	0.803	0.85
301_A	350_N	0.802	0.84
331_Y	337_K	0.798	0.84
92_I	242_D	0.792	0.84
327_T	330_I	0.791	0.84
193_F	307_A	0.791	0.84
3_I	165_V	0.788	0.83
105_S	108_P	0.788	0.83
148_K	331_Y	0.787	0.83
193_F	235_V	0.785	0.83
93_I	250_S	0.784	0.83
66_I	69_R	0.783	0.83
301_A	358_I	0.782	0.83
343_A	348_I	0.779	0.83
341_E	345_E	0.777	0.83
31_V	42_A	0.775	0.82
216_S	221_G	0.775	0.82
216_S	296_S	0.772	0.82
53_F	59_I	0.769	0.82
134_K	161_E	0.766	0.82
188_V	329_M	0.766	0.82
288_R	291_E	0.766	0.82
188_V	325_I	0.765	0.82
108_P	134_K	0.765	0.82
348_I	352_Y	0.760	0.81
136_I	162_T	0.758	0.81
341_E	344_D	0.756	0.81
340_M	344_D	0.751	0.80
134_K	162_T	0.749	0.80
8_V	19_A	0.748	0.80
14_M	116_N	0.748	0.80
138_M	150_V	0.741	0.79
259_E	262_K	0.738	0.79
213_E	294_V	0.737	0.79
20_E	24_L	0.736	0.79
16_H	42_A	0.735	0.79
294_V	299_D	0.733	0.79
310_E	317_N	0.731	0.79
149_L	175_K	0.730	0.78
129_T	134_K	0.728	0.78
305_S	358_I	0.727	0.78
184_V	190_N	0.725	0.78
140_F	173_M	0.725	0.78
326_D	344_D	0.722	0.78
97_R	127_E	0.721	0.78
219_R	227_G	0.720	0.78
3_I	27_Y	0.720	0.78
6_I	86_I	0.717	0.77
14_M	117_T	0.716	0.77
85_V	111_T	0.715	0.77
296_S	300_P	0.714	0.77
160_D	164_E	0.712	0.77
175_K	264_K	0.711	0.77
23_A	66_I	0.707	0.76
205_E	260_M	0.706	0.76
234_Y	272_V	0.702	0.76
197_M	201_C	0.701	0.76
205_E	258_C	0.700	0.76
100_F	103_L	0.699	0.75
158_T	162_T	0.698	0.75
287_Y	291_E	0.697	0.75
309_N	312_A	0.695	0.75
314_L	325_I	0.695	0.75
233_D	277_G	0.694	0.75
9_V	32_V	0.691	0.75
117_T	141_F	0.690	0.74
280_N	291_E	0.688	0.74
268_K	274_T	0.687	0.74
312_A	352_Y	0.685	0.74
215_D	227_G	0.683	0.74
53_F	58_Q	0.683	0.74
314_L	320_V	0.683	0.74
76_Y	99_V	0.683	0.74
309_N	355_L	0.682	0.74
222_L	308_V	0.681	0.73
39_L	42_A	0.681	0.73
62_K	66_I	0.679	0.73
277_G	281_Y	0.676	0.73
283_A	286_K	0.675	0.73
349_R	352_Y	0.675	0.73
30_S	81_D	0.674	0.73
226_M	234_Y	0.674	0.73
245_N	266_E	0.669	0.72
40_N	43_K	0.667	0.72
315_I	340_M	0.665	0.72
312_A	316_Q	0.664	0.72
81_D	108_P	0.664	0.72
121_P	183_E	0.664	0.72
76_Y	79_M	0.663	0.72
22_S	27_Y	0.657	0.71
309_N	313_W	0.656	0.71
40_N	47_M	0.655	0.71
350_N	356_V	0.655	0.71
46_I	70_I	0.655	0.71
195_R	243_L	0.654	0.70
231_L	235_V	0.651	0.70
235_V	240_A	0.650	0.70
224_L	307_A	0.648	0.70
25_A	174_N	0.646	0.70
13_T	142_N	0.646	0.70
224_L	336_P	0.646	0.70
286_K	291_E	0.646	0.70
45_R	48_E	0.644	0.69
20_E	145_P	0.642	0.69
233_D	271_G	0.641	0.69
240_A	243_L	0.641	0.69
103_L	113_L	0.640	0.69
117_T	187_F	0.640	0.69
196_L	228_I	0.636	0.68
215_D	339_L	0.636	0.68
285_G	289_K	0.634	0.68
346_L	354_H	0.634	0.68
16_H	49_S	0.633	0.68
16_H	39_L	0.633	0.68
304_I	342_I	0.630	0.68
119_S	239_V	0.630	0.68
130_K	157_Y	0.629	0.68
119_S	185_P	0.628	0.67
283_A	287_Y	0.628	0.67
16_H	41_R	0.627	0.67
161_E	165_V	0.625	0.67
112_F	165_V	0.625	0.67
107_T	110_H	0.621	0.67
30_S	71_E	0.620	0.66
240_A	261_Y	0.620	0.66
23_A	46_I	0.620	0.66
63_P	66_I	0.618	0.66
348_I	351_I	0.618	0.66
308_V	346_L	0.617	0.66
120_I	183_E	0.617	0.66
306_L	316_Q	0.617	0.66
116_N	190_N	0.616	0.66
3_I	112_F	0.616	0.66
204_V	260_M	0.615	0.66
60_K	313_W	0.615	0.66
126_A	132_K	0.615	0.66
141_F	149_L	0.614	0.66
153_V	187_F	0.614	0.66
20_E	46_I	0.613	0.66
101_E	105_S	0.612	0.65
49_S	53_F	0.612	0.65
27_Y	69_R	0.612	0.65
190_N	320_V	0.610	0.65
218_A	300_P	0.607	0.65
230_E	234_Y	0.605	0.65
158_T	163_I	0.604	0.64
121_P	124_T	0.603	0.64
235_V	337_K	0.601	0.64
181_K	184_V	0.601	0.64
185_P	247_I	0.601	0.64
23_A	43_K	0.600	0.64
185_P	243_L	0.599	0.64
141_F	187_F	0.598	0.64
111_T	131_R	0.597	0.63
49_S	145_P	0.596	0.63
352_Y	359_Y	0.595	0.63
104_D	135_I	0.593	0.63
127_E	157_Y	0.592	0.63
216_S	219_R	0.590	0.63
322_A	326_D	0.588	0.62
239_V	246_V	0.588	0.62
65_D	68_K	0.586	0.62
208_E	292_L	0.585	0.62
354_H	358_I	0.585	0.62
320_V	340_M	0.584	0.62
282_P	286_K	0.584	0.62
355_L	358_I	0.583	0.62
323_K	344_D	0.583	0.62
122_I	183_E	0.583	0.62
286_K	289_K	0.581	0.61
284_P	287_Y	0.579	0.61
101_E	130_K	0.575	0.61
11_A	88_A	0.572	0.60
275_G	286_K	0.569	0.60
6_I	173_M	0.568	0.60
154_P	163_I	0.566	0.59
286_K	290_V	0.566	0.59
78_V	81_D	0.566	0.59
203_E	206_D	0.564	0.59
254_Q	257_K	0.564	0.59
122_I	153_V	0.564	0.59
18_I	186_G	0.562	0.59
9_V	95_L	0.562	0.59
236_G	240_A	0.561	0.59
21_V	145_P	0.561	0.59
132_K	155_S	0.561	0.59
4_K	108_P	0.560	0.59
36_W	86_I	0.556	0.58
353_N	359_Y	0.556	0.58
54_Y	64_E	0.554	0.58
204_V	211_I	0.554	0.58
197_M	240_A	0.554	0.58
18_I	116_N	0.554	0.58
20_E	50_L	0.552	0.58
329_M	333_F	0.552	0.58
51_N	67_M	0.552	0.58
107_T	125_I	0.549	0.57
116_N	141_F	0.547	0.57
39_L	43_K	0.545	0.57
30_S	82_A	0.545	0.57
42_A	72_F	0.544	0.56
238_D	274_T	0.542	0.56
48_E	52_K	0.541	0.56
328_V	331_Y	0.541	0.56
42_A	49_S	0.541	0.56
142_N	147_M	0.541	0.56
213_E	299_D	0.540	0.56
104_D	131_R	0.539	0.56
16_H	23_A	0.539	0.56
11_A	19_A	0.536	0.55
239_V	243_L	0.536	0.55
13_T	238_D	0.536	0.55
271_G	277_G	0.535	0.55
168_D	297_K	0.535	0.55
3_I	172_K	0.535	0.55
40_N	74_T	0.534	0.55
260_M	278_F	0.533	0.55
261_Y	265_F	0.532	0.55
236_G	274_T	0.531	0.55
242_D	245_N	0.531	0.55
3_I	22_S	0.530	0.55
201_C	261_Y	0.529	0.54
201_C	229_F	0.528	0.54
307_A	333_F	0.528	0.54
100_F	135_I	0.528	0.54
80_R	101_E	0.527	0.54
135_I	224_L	0.527	0.54
14_M	187_F	0.526	0.54
307_A	329_M	0.525	0.54
45_R	145_P	0.525	0.54
59_I	66_I	0.524	0.54
126_A	155_S	0.521	0.53
52_K	56_K	0.521	0.53
236_G	239_V	0.520	0.53
280_N	285_G	0.520	0.53
237_I	270_L	0.517	0.53
193_F	222_L	0.517	0.53
53_F	146_I	0.517	0.53
349_R	357_D	0.516	0.53
230_E	287_Y	0.515	0.52
212_E	216_S	0.515	0.52
350_N	357_D	0.513	0.52
164_E	168_D	0.513	0.52
136_I	152_I	0.513	0.52
301_A	346_L	0.513	0.52
186_G	227_G	0.512	0.52
116_N	187_F	0.512	0.52
206_D	294_V	0.512	0.52
193_F	198_Q	0.512	0.52
191_R	310_E	0.510	0.52
233_D	281_Y	0.510	0.52
35_S	74_T	0.510	0.52
315_I	320_V	0.509	0.52
34_I	92_I	0.507	0.51
84_F	166_T	0.506	0.51
235_V	239_V	0.506	0.51
34_I	95_L	0.505	0.51
189_S	195_R	0.502	0.51
118_S	147_M	0.501	0.50
282_P	289_K	0.501	0.50
198_Q	255_D	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wdkA	2	0.9844	100	0.249	Contact Map
2wtbA	1	0.9271	100	0.251	Contact Map
4b3hA	1	0.9661	100	0.272	Contact Map
3zwcA	1	0.9896	100	0.274	Contact Map
3k6jA	1	0.9479	100	0.274	Contact Map
1zcjA	1	0.9896	100	0.284	Contact Map
3mogA	3	0.9948	100	0.335	Contact Map
4j0eA	2	0.7292	100	0.476	Contact Map
1f0yA	2	0.7318	100	0.493	Contact Map
4r1nA	2	0.7292	100	0.504	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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