GREMLIN Database
Q97UK8 - Uncharacterized protein
UniProt: Q97UK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (334)
Sequences: 4313 (2020)
Seq/√Len: 110.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_D308_T4.0921.00
22_V84_A3.5241.00
312_V339_E3.3811.00
59_K62_R3.2571.00
246_N281_L3.0431.00
74_S300_Y3.0281.00
13_A34_E3.0171.00
253_K285_Q3.0091.00
244_N247_T2.9821.00
303_K307_N2.8791.00
136_L236_M2.8751.00
280_K284_S2.7821.00
27_K96_Y2.5901.00
212_L257_P2.5701.00
332_L336_Y2.5631.00
148_R152_T2.5621.00
192_D213_K2.4951.00
42_K46_S2.4851.00
158_G233_V2.4391.00
63_I89_L2.4371.00
140_K154_N2.4181.00
55_E66_K2.3171.00
228_S231_D2.2731.00
61_N328_R2.2711.00
302_F313_W2.2651.00
87_I323_I2.2191.00
138_W234_E2.1961.00
65_E69_Y2.1281.00
342_P363_T2.1051.00
327_R361_A2.0761.00
274_S301_Q2.0151.00
91_D353_A1.9381.00
251_I255_L1.9301.00
249_I267_M1.8971.00
46_S50_Q1.8801.00
223_K228_S1.8791.00
26_S57_A1.8681.00
119_H218_M1.8661.00
296_L310_V1.8561.00
249_I281_L1.8321.00
215_I219_V1.8321.00
150_I153_N1.8081.00
219_V229_V1.8001.00
11_F21_F1.7981.00
116_V120_G1.7931.00
250_R285_Q1.7901.00
256_E287_S1.7651.00
296_L305_L1.7641.00
268_P274_S1.7361.00
8_F52_L1.7231.00
253_K256_E1.7021.00
243_Y248_A1.7001.00
12_V149_L1.7001.00
289_P365_G1.6741.00
248_A252_C1.6701.00
220_D223_K1.6311.00
254_A257_P1.6311.00
116_V119_H1.6311.00
222_V235_I1.5951.00
239_L252_C1.5921.00
12_V36_G1.5831.00
174_Y224_A1.5771.00
331_E335_M1.5711.00
55_E62_R1.5551.00
234_E261_R1.5471.00
283_T311_R1.5281.00
266_P282_L1.5241.00
330_A361_A1.5221.00
245_L278_E1.5141.00
236_M262_W1.5091.00
48_F70_A1.4831.00
175_A220_D1.4531.00
250_R253_K1.4521.00
331_E334_A1.4471.00
302_F329_I1.4431.00
117_D120_G1.4291.00
24_I89_L1.4241.00
11_F23_R1.4231.00
280_K309_G1.4211.00
330_A342_P1.4211.00
7_D49_I1.4131.00
39_P42_K1.4101.00
23_R32_T1.4081.00
154_N233_V1.4061.00
277_D308_T1.3961.00
115_Y119_H1.3841.00
309_G338_I1.3611.00
217_Y220_D1.3601.00
111_E115_Y1.3461.00
282_L286_C1.3421.00
153_N157_H1.3381.00
30_Y34_E1.3341.00
353_A357_V1.3311.00
115_Y118_A1.3291.00
247_T250_R1.3231.00
112_I115_Y1.3211.00
303_K332_L1.3211.00
159_R370_H1.3201.00
25_Y30_Y1.3170.99
47_E50_Q1.3140.99
21_F32_T1.3090.99
342_P358_G1.3090.99
115_Y120_G1.3000.99
105_L360_I1.2990.99
266_P290_I1.2980.99
212_L216_D1.2980.99
29_L34_E1.2980.99
100_P103_K1.2970.99
216_D258_Y1.2960.99
281_L284_S1.2920.99
61_N324_T1.2830.99
105_L327_R1.2760.99
222_V229_V1.2760.99
70_A77_T1.2700.99
90_Y323_I1.2680.99
13_A349_I1.2660.99
7_D25_Y1.2650.99
275_N278_E1.2620.99
9_K25_Y1.2460.99
146_T154_N1.2410.99
82_I322_G1.2250.99
280_K308_T1.2210.99
315_P330_A1.2140.99
299_V329_I1.2100.99
61_N110_T1.2090.99
111_E120_G1.2040.99
252_C263_L1.1960.99
43_G47_E1.1860.99
61_N65_E1.1850.99
299_V332_L1.1830.99
48_F85_I1.1720.99
279_L290_I1.1720.99
111_E116_V1.1690.99
48_F77_T1.1680.99
175_A217_Y1.1660.99
246_N250_R1.1640.99
282_L290_I1.1540.99
34_E349_I1.1530.99
163_E187_K1.1470.99
57_A89_L1.1430.99
67_L322_G1.1430.99
250_R254_A1.1340.98
29_L95_K1.1340.98
281_L285_Q1.1330.98
220_D224_A1.1320.98
49_I53_I1.1310.98
62_R66_K1.1280.98
126_A190_K1.1260.98
58_F97_L1.1250.98
317_I357_V1.1220.98
317_I323_I1.1200.98
29_L33_G1.1160.98
276_Y309_G1.1120.98
130_L239_L1.1090.98
242_R268_P1.1080.98
248_A267_M1.1060.98
165_W217_Y1.1010.98
52_L55_E1.0860.98
327_R357_V1.0830.98
127_I194_D1.0810.98
161_S164_K1.0650.98
301_Q304_D1.0590.98
296_L338_I1.0560.98
133_P214_D1.0470.97
212_L254_A1.0380.97
146_T150_I1.0380.97
117_D218_M1.0360.97
60_V104_L1.0360.97
8_F49_I1.0270.97
91_D352_M1.0260.97
111_E114_V1.0240.97
301_Q309_G1.0230.97
57_A93_I1.0220.97
52_L89_L1.0150.97
29_L96_Y1.0060.97
223_K229_V0.9940.96
302_F338_I0.9860.96
136_L341_S0.9810.96
30_Y33_G0.9790.96
76_T325_E0.9760.96
267_M278_E0.9740.96
305_L310_V0.9720.96
111_E118_A0.9650.96
249_I285_Q0.9650.96
340_Y363_T0.9650.96
146_T153_N0.9610.96
161_S224_A0.9600.96
299_V328_R0.9540.96
51_L66_K0.9480.95
313_W329_I0.9470.95
44_M84_A0.9450.95
334_A340_Y0.9450.95
130_L255_L0.9430.95
111_E119_H0.9410.95
159_R181_M0.9410.95
127_I190_K0.9410.95
47_E51_L0.9400.95
173_A176_K0.9390.95
283_T338_I0.9380.95
11_F32_T0.9350.95
320_A329_I0.9350.95
90_Y105_L0.9330.95
154_N227_E0.9310.95
229_V235_I0.9180.95
112_I119_H0.9110.94
67_L82_I0.9050.94
262_W289_P0.9050.94
66_K69_Y0.9050.94
310_V338_I0.9030.94
87_I327_R0.8970.94
38_A149_L0.8920.94
115_Y155_P0.8910.94
41_L45_E0.8890.94
91_D95_K0.8880.93
112_I118_A0.8870.93
51_L70_A0.8830.93
23_R30_Y0.8750.93
306_L336_Y0.8730.93
302_F333_A0.8690.93
26_S29_L0.8560.92
114_V118_A0.8550.92
9_K45_E0.8520.92
125_E163_E0.8500.92
128_N194_D0.8490.92
330_A334_A0.8450.92
147_N150_I0.8440.92
295_N301_Q0.8430.92
117_D155_P0.8420.92
140_K146_T0.8420.92
136_L234_E0.8350.91
130_L251_I0.8340.91
6_T25_Y0.8330.91
165_W220_D0.8320.91
164_K173_A0.8290.91
149_L152_T0.8280.91
17_F160_L0.8270.91
99_V104_L0.8230.91
114_V119_H0.8170.90
330_A340_Y0.8160.90
164_K224_A0.8140.90
298_T320_A0.8100.90
140_K232_E0.8100.90
274_S304_D0.8080.90
10_V44_M0.8080.90
52_L63_I0.8080.90
323_I353_A0.8050.90
174_Y177_R0.8040.90
58_F96_Y0.8010.89
110_T328_R0.7990.89
267_M282_L0.7940.89
79_Y83_S0.7940.89
151_T155_P0.7910.89
190_K194_D0.7890.89
219_V222_V0.7830.88
29_L35_A0.7820.88
262_W365_G0.7820.88
8_F24_I0.7810.88
127_I191_F0.7780.88
114_V117_D0.7780.88
99_V107_G0.7770.88
127_I130_L0.7770.88
317_I326_G0.7750.88
14_Q152_T0.7740.88
112_I116_V0.7740.88
94_G101_I0.7730.88
179_L228_S0.7720.88
108_D327_R0.7710.88
125_E128_N0.7690.87
105_L342_P0.7690.87
191_F217_Y0.7650.87
87_I353_A0.7610.87
253_K287_S0.7560.87
93_I104_L0.7560.87
65_E328_R0.7550.86
31_G34_E0.7540.86
68_R322_G0.7510.86
111_E117_D0.7510.86
55_E63_I0.7510.86
105_L361_A0.7470.86
128_N190_K0.7460.86
194_D255_L0.7460.86
9_K23_R0.7450.86
186_Y189_M0.7450.86
12_V38_A0.7440.86
43_G77_T0.7380.85
252_C255_L0.7370.85
110_T362_N0.7360.85
14_Q153_N0.7350.85
134_V291_E0.7340.85
313_W338_I0.7340.85
267_M286_C0.7330.85
105_L353_A0.7310.85
157_H227_E0.7300.85
313_W333_A0.7290.84
33_G87_I0.7260.84
277_D280_K0.7250.84
35_A84_A0.7250.84
7_D53_I0.7240.84
164_K174_Y0.7240.84
106_G109_K0.7230.84
304_D307_N0.7230.84
255_L260_L0.7230.84
154_N232_E0.7220.84
63_I68_R0.7210.84
239_L248_A0.7180.84
165_W224_A0.7170.84
327_R363_T0.7170.84
334_A362_N0.7150.83
158_G161_S0.7120.83
328_R331_E0.7100.83
112_I120_G0.7090.83
87_I91_D0.7070.83
105_L108_D0.7060.83
246_N249_I0.7050.82
89_L93_I0.7050.82
315_P326_G0.7050.82
114_V120_G0.7020.82
323_I357_V0.7010.82
245_L267_M0.6970.82
125_E178_A0.6940.81
251_I254_A0.6930.81
122_K239_L0.6910.81
299_V303_K0.6860.81
300_Y304_D0.6850.81
140_K151_T0.6840.81
110_T331_E0.6840.81
245_L249_I0.6840.81
342_P357_V0.6760.80
8_F85_I0.6760.80
177_R180_K0.6720.79
191_F214_D0.6680.79
152_T156_V0.6660.79
358_G366_F0.6660.79
112_I117_D0.6660.79
213_K216_D0.6660.79
37_P40_G0.6630.78
130_L237_F0.6630.78
68_R76_T0.6620.78
22_V44_M0.6590.78
129_A193_L0.6580.78
215_I237_F0.6570.78
136_L155_P0.6570.78
239_L268_P0.6570.78
329_I340_Y0.6550.78
176_K179_L0.6540.78
306_L332_L0.6540.78
125_E173_A0.6530.77
26_S96_Y0.6500.77
266_P279_L0.6450.77
90_Y353_A0.6440.76
38_A42_K0.6440.76
239_L263_L0.6430.76
45_E49_I0.6400.76
266_P309_G0.6390.76
182_K189_M0.6380.76
191_F194_D0.6380.76
183_N186_Y0.6380.76
307_N332_L0.6360.76
130_L214_D0.6330.75
26_S92_L0.6330.75
130_L194_D0.6310.75
249_I282_L0.6290.75
95_K98_N0.6280.75
216_D219_V0.6280.75
340_Y361_A0.6270.75
57_A96_Y0.6270.75
155_P233_V0.6260.74
121_G124_L0.6260.74
193_L213_K0.6250.74
289_P339_E0.6220.74
122_K129_A0.6210.74
46_S51_L0.6200.74
12_V156_V0.6200.74
127_I193_L0.6190.74
62_R65_E0.6180.73
41_L44_M0.6160.73
177_R192_D0.6160.73
276_Y301_Q0.6160.73
241_W268_P0.6140.73
56_D96_Y0.6110.73
45_E50_Q0.6040.72
34_E91_D0.6040.72
194_D239_L0.6030.72
290_I309_G0.6030.72
218_M235_I0.5990.71
56_D59_K0.5980.71
228_S232_E0.5960.71
295_N305_L0.5950.71
312_V341_S0.5940.71
51_L55_E0.5930.70
276_Y304_D0.5910.70
289_P341_S0.5900.70
162_M182_K0.5890.70
127_I192_D0.5880.70
27_K57_A0.5880.70
46_S53_I0.5860.69
323_I327_R0.5850.69
40_G43_G0.5830.69
132_L344_N0.5830.69
252_C282_L0.5780.68
56_D93_I0.5780.68
219_V258_Y0.5770.68
175_A178_A0.5770.68
219_V223_K0.5750.68
129_A194_D0.5750.68
127_I177_R0.5740.68
61_N331_E0.5720.68
175_A213_K0.5720.68
13_A350_G0.5700.67
97_L104_L0.5690.67
253_K286_C0.5680.67
302_F315_P0.5680.67
103_K148_R0.5680.67
173_A177_R0.5670.67
27_K98_N0.5650.67
99_V103_K0.5640.67
31_G35_A0.5630.66
30_Y95_K0.5630.66
116_V136_L0.5600.66
65_E324_T0.5590.66
262_W341_S0.5590.66
327_R331_E0.5590.66
46_S49_I0.5590.66
31_G95_K0.5570.66
176_K180_K0.5560.65
122_K268_P0.5560.65
31_G92_L0.5540.65
219_V257_P0.5530.65
166_N217_Y0.5530.65
20_A44_M0.5520.65
9_K244_N0.5510.65
135_N218_M0.5510.65
174_Y180_K0.5500.65
114_V136_L0.5480.64
308_T338_I0.5470.64
194_D243_Y0.5460.64
10_V20_A0.5450.64
330_A363_T0.5440.64
47_E77_T0.5420.64
114_V341_S0.5420.64
122_K173_A0.5420.64
58_F89_L0.5410.63
20_A84_A0.5410.63
354_H357_V0.5400.63
242_R274_S0.5400.63
174_Y178_A0.5390.63
43_G81_L0.5360.63
125_E166_N0.5360.63
231_D234_E0.5340.62
139_I154_N0.5340.62
150_I154_N0.5340.62
23_R31_G0.5340.62
24_I88_A0.5330.62
22_V89_L0.5320.62
303_K336_Y0.5310.62
249_I286_C0.5310.62
124_L129_A0.5310.62
67_L85_I0.5300.62
63_I66_K0.5290.62
138_W261_R0.5280.62
97_L100_P0.5270.61
299_V302_F0.5260.61
103_K108_D0.5260.61
35_A83_S0.5250.61
177_R190_K0.5240.61
301_Q305_L0.5230.61
122_K125_E0.5210.61
66_K70_A0.5200.60
235_I239_L0.5200.60
68_R325_E0.5190.60
127_I180_K0.5190.60
357_V363_T0.5190.60
63_I85_I0.5180.60
163_E166_N0.5180.60
6_T9_K0.5170.60
279_L310_V0.5170.60
175_A190_K0.5170.60
135_N158_G0.5150.60
278_E286_C0.5150.60
344_N355_A0.5150.60
243_Y251_I0.5140.59
50_Q53_I0.5140.59
216_D223_K0.5130.59
242_R301_Q0.5110.59
52_L66_K0.5100.59
71_T76_T0.5100.59
14_Q156_V0.5100.59
26_S129_A0.5090.59
246_N277_D0.5070.58
140_K150_I0.5060.58
252_C288_V0.5050.58
32_T95_K0.5020.58
216_D254_A0.5020.58
64_A86_N0.5020.58
7_D45_E0.5020.58
111_E362_N0.5020.58
39_P43_G0.5010.58
315_P342_P0.5010.58
274_S370_H0.5010.58
10_V45_E0.5000.57
43_G50_Q0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dipA 5 0.8496 100 0.377 Contact Map
4mksA 3 0.852 100 0.385 Contact Map
3rcyA 5 0.8687 100 0.393 Contact Map
2qq6A 5 0.9069 100 0.394 Contact Map
3t6cA 5 0.8663 100 0.395 Contact Map
3p0wA 2 0.8783 100 0.395 Contact Map
3go2A 5 0.8854 100 0.401 Contact Map
2gl5A 5 0.895 100 0.401 Contact Map
4a35A 2 0.9141 100 0.402 Contact Map
3otrA 2 0.895 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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