Q97UK8 - SULSO - GREMLIN Contacts

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Q97UK8 - Uncharacterized protein

UniProt:	Q97UK8	Sequences: MELKITDFKVFVAQANFEWAFVRIYSKDLYGTGEAGPAPGLKGMESEFIQLLIGEDAFKVNRIAEKLRYATLYSGTTVYHLISAINIALYDLIGKYLNVPIYKLLGGDKTEIPVYVDAHGGKGLEAINALHLPVNLPWIKEAEVETNRLITTNNPVHGRLSMEKWNEDYSPEAYAKRALKMKNEGYKAMKFDLDVPTPYIDLRRVRNGDLSLKDIDYMVDIVKAVRESVGDEVEIMFDLHWRYNLNTAIRICKALEPYRLRWLEDPMPAIMAVSNYDELKLLTSQCSVPIETGENLYTVYQFKDLLNTGVRVWAPDIVKAGGITEGRRIAELAAMYDIEYSPHNIASPIGTMAHAHVGSIANTFGFVEFHGHDVPFWNEIVKPKRKIIEDGVIKLTDDPGLGIDLDDEVMRKYWPTYEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	419 (334)
Sequences:	4313 (2020)
Seq/√Len:	110.5

ECOLI - RSPA DGOD GUDX GUDD RHMD ENO
BACSU - GUDD YITF AEEP ENO MENC
HALSA - Q9HS20 ENO Q9HP25
SULSO - Q97UK8 GAD Q97VG1 ARAD ENO Q97YL9 Q97YR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
304_D	308_T	4.092	1.00
22_V	84_A	3.524	1.00
312_V	339_E	3.381	1.00
59_K	62_R	3.257	1.00
246_N	281_L	3.043	1.00
74_S	300_Y	3.028	1.00
13_A	34_E	3.017	1.00
253_K	285_Q	3.009	1.00
244_N	247_T	2.982	1.00
303_K	307_N	2.879	1.00
136_L	236_M	2.875	1.00
280_K	284_S	2.782	1.00
27_K	96_Y	2.590	1.00
212_L	257_P	2.570	1.00
332_L	336_Y	2.563	1.00
148_R	152_T	2.562	1.00
192_D	213_K	2.495	1.00
42_K	46_S	2.485	1.00
158_G	233_V	2.439	1.00
63_I	89_L	2.437	1.00
140_K	154_N	2.418	1.00
55_E	66_K	2.317	1.00
228_S	231_D	2.273	1.00
61_N	328_R	2.271	1.00
302_F	313_W	2.265	1.00
87_I	323_I	2.219	1.00
138_W	234_E	2.196	1.00
65_E	69_Y	2.128	1.00
342_P	363_T	2.105	1.00
327_R	361_A	2.076	1.00
274_S	301_Q	2.015	1.00
91_D	353_A	1.938	1.00
251_I	255_L	1.930	1.00
249_I	267_M	1.897	1.00
46_S	50_Q	1.880	1.00
223_K	228_S	1.879	1.00
26_S	57_A	1.868	1.00
119_H	218_M	1.866	1.00
296_L	310_V	1.856	1.00
249_I	281_L	1.832	1.00
215_I	219_V	1.832	1.00
150_I	153_N	1.808	1.00
219_V	229_V	1.800	1.00
11_F	21_F	1.798	1.00
116_V	120_G	1.793	1.00
250_R	285_Q	1.790	1.00
256_E	287_S	1.765	1.00
296_L	305_L	1.764	1.00
268_P	274_S	1.736	1.00
8_F	52_L	1.723	1.00
253_K	256_E	1.702	1.00
243_Y	248_A	1.700	1.00
12_V	149_L	1.700	1.00
289_P	365_G	1.674	1.00
248_A	252_C	1.670	1.00
220_D	223_K	1.631	1.00
254_A	257_P	1.631	1.00
116_V	119_H	1.631	1.00
222_V	235_I	1.595	1.00
239_L	252_C	1.592	1.00
12_V	36_G	1.583	1.00
174_Y	224_A	1.577	1.00
331_E	335_M	1.571	1.00
55_E	62_R	1.555	1.00
234_E	261_R	1.547	1.00
283_T	311_R	1.528	1.00
266_P	282_L	1.524	1.00
330_A	361_A	1.522	1.00
245_L	278_E	1.514	1.00
236_M	262_W	1.509	1.00
48_F	70_A	1.483	1.00
175_A	220_D	1.453	1.00
250_R	253_K	1.452	1.00
331_E	334_A	1.447	1.00
302_F	329_I	1.443	1.00
117_D	120_G	1.429	1.00
24_I	89_L	1.424	1.00
11_F	23_R	1.423	1.00
280_K	309_G	1.421	1.00
330_A	342_P	1.421	1.00
7_D	49_I	1.413	1.00
39_P	42_K	1.410	1.00
23_R	32_T	1.408	1.00
154_N	233_V	1.406	1.00
277_D	308_T	1.396	1.00
115_Y	119_H	1.384	1.00
309_G	338_I	1.361	1.00
217_Y	220_D	1.360	1.00
111_E	115_Y	1.346	1.00
282_L	286_C	1.342	1.00
153_N	157_H	1.338	1.00
30_Y	34_E	1.334	1.00
353_A	357_V	1.331	1.00
115_Y	118_A	1.329	1.00
247_T	250_R	1.323	1.00
112_I	115_Y	1.321	1.00
303_K	332_L	1.321	1.00
159_R	370_H	1.320	1.00
25_Y	30_Y	1.317	0.99
47_E	50_Q	1.314	0.99
21_F	32_T	1.309	0.99
342_P	358_G	1.309	0.99
115_Y	120_G	1.300	0.99
105_L	360_I	1.299	0.99
266_P	290_I	1.298	0.99
212_L	216_D	1.298	0.99
29_L	34_E	1.298	0.99
100_P	103_K	1.297	0.99
216_D	258_Y	1.296	0.99
281_L	284_S	1.292	0.99
61_N	324_T	1.283	0.99
105_L	327_R	1.276	0.99
222_V	229_V	1.276	0.99
70_A	77_T	1.270	0.99
90_Y	323_I	1.268	0.99
13_A	349_I	1.266	0.99
7_D	25_Y	1.265	0.99
275_N	278_E	1.262	0.99
9_K	25_Y	1.246	0.99
146_T	154_N	1.241	0.99
82_I	322_G	1.225	0.99
280_K	308_T	1.221	0.99
315_P	330_A	1.214	0.99
299_V	329_I	1.210	0.99
61_N	110_T	1.209	0.99
111_E	120_G	1.204	0.99
252_C	263_L	1.196	0.99
43_G	47_E	1.186	0.99
61_N	65_E	1.185	0.99
299_V	332_L	1.183	0.99
48_F	85_I	1.172	0.99
279_L	290_I	1.172	0.99
111_E	116_V	1.169	0.99
48_F	77_T	1.168	0.99
175_A	217_Y	1.166	0.99
246_N	250_R	1.164	0.99
282_L	290_I	1.154	0.99
34_E	349_I	1.153	0.99
163_E	187_K	1.147	0.99
57_A	89_L	1.143	0.99
67_L	322_G	1.143	0.99
250_R	254_A	1.134	0.98
29_L	95_K	1.134	0.98
281_L	285_Q	1.133	0.98
220_D	224_A	1.132	0.98
49_I	53_I	1.131	0.98
62_R	66_K	1.128	0.98
126_A	190_K	1.126	0.98
58_F	97_L	1.125	0.98
317_I	357_V	1.122	0.98
317_I	323_I	1.120	0.98
29_L	33_G	1.116	0.98
276_Y	309_G	1.112	0.98
130_L	239_L	1.109	0.98
242_R	268_P	1.108	0.98
248_A	267_M	1.106	0.98
165_W	217_Y	1.101	0.98
52_L	55_E	1.086	0.98
327_R	357_V	1.083	0.98
127_I	194_D	1.081	0.98
161_S	164_K	1.065	0.98
301_Q	304_D	1.059	0.98
296_L	338_I	1.056	0.98
133_P	214_D	1.047	0.97
212_L	254_A	1.038	0.97
146_T	150_I	1.038	0.97
117_D	218_M	1.036	0.97
60_V	104_L	1.036	0.97
8_F	49_I	1.027	0.97
91_D	352_M	1.026	0.97
111_E	114_V	1.024	0.97
301_Q	309_G	1.023	0.97
57_A	93_I	1.022	0.97
52_L	89_L	1.015	0.97
29_L	96_Y	1.006	0.97
223_K	229_V	0.994	0.96
302_F	338_I	0.986	0.96
136_L	341_S	0.981	0.96
30_Y	33_G	0.979	0.96
76_T	325_E	0.976	0.96
267_M	278_E	0.974	0.96
305_L	310_V	0.972	0.96
111_E	118_A	0.965	0.96
249_I	285_Q	0.965	0.96
340_Y	363_T	0.965	0.96
146_T	153_N	0.961	0.96
161_S	224_A	0.960	0.96
299_V	328_R	0.954	0.96
51_L	66_K	0.948	0.95
313_W	329_I	0.947	0.95
44_M	84_A	0.945	0.95
334_A	340_Y	0.945	0.95
130_L	255_L	0.943	0.95
111_E	119_H	0.941	0.95
159_R	181_M	0.941	0.95
127_I	190_K	0.941	0.95
47_E	51_L	0.940	0.95
173_A	176_K	0.939	0.95
283_T	338_I	0.938	0.95
11_F	32_T	0.935	0.95
320_A	329_I	0.935	0.95
90_Y	105_L	0.933	0.95
154_N	227_E	0.931	0.95
229_V	235_I	0.918	0.95
112_I	119_H	0.911	0.94
67_L	82_I	0.905	0.94
262_W	289_P	0.905	0.94
66_K	69_Y	0.905	0.94
310_V	338_I	0.903	0.94
87_I	327_R	0.897	0.94
38_A	149_L	0.892	0.94
115_Y	155_P	0.891	0.94
41_L	45_E	0.889	0.94
91_D	95_K	0.888	0.93
112_I	118_A	0.887	0.93
51_L	70_A	0.883	0.93
23_R	30_Y	0.875	0.93
306_L	336_Y	0.873	0.93
302_F	333_A	0.869	0.93
26_S	29_L	0.856	0.92
114_V	118_A	0.855	0.92
9_K	45_E	0.852	0.92
125_E	163_E	0.850	0.92
128_N	194_D	0.849	0.92
330_A	334_A	0.845	0.92
147_N	150_I	0.844	0.92
295_N	301_Q	0.843	0.92
117_D	155_P	0.842	0.92
140_K	146_T	0.842	0.92
136_L	234_E	0.835	0.91
130_L	251_I	0.834	0.91
6_T	25_Y	0.833	0.91
165_W	220_D	0.832	0.91
164_K	173_A	0.829	0.91
149_L	152_T	0.828	0.91
17_F	160_L	0.827	0.91
99_V	104_L	0.823	0.91
114_V	119_H	0.817	0.90
330_A	340_Y	0.816	0.90
164_K	224_A	0.814	0.90
298_T	320_A	0.810	0.90
140_K	232_E	0.810	0.90
274_S	304_D	0.808	0.90
10_V	44_M	0.808	0.90
52_L	63_I	0.808	0.90
323_I	353_A	0.805	0.90
174_Y	177_R	0.804	0.90
58_F	96_Y	0.801	0.89
110_T	328_R	0.799	0.89
267_M	282_L	0.794	0.89
79_Y	83_S	0.794	0.89
151_T	155_P	0.791	0.89
190_K	194_D	0.789	0.89
219_V	222_V	0.783	0.88
29_L	35_A	0.782	0.88
262_W	365_G	0.782	0.88
8_F	24_I	0.781	0.88
127_I	191_F	0.778	0.88
114_V	117_D	0.778	0.88
99_V	107_G	0.777	0.88
127_I	130_L	0.777	0.88
317_I	326_G	0.775	0.88
14_Q	152_T	0.774	0.88
112_I	116_V	0.774	0.88
94_G	101_I	0.773	0.88
179_L	228_S	0.772	0.88
108_D	327_R	0.771	0.88
125_E	128_N	0.769	0.87
105_L	342_P	0.769	0.87
191_F	217_Y	0.765	0.87
87_I	353_A	0.761	0.87
253_K	287_S	0.756	0.87
93_I	104_L	0.756	0.87
65_E	328_R	0.755	0.86
31_G	34_E	0.754	0.86
68_R	322_G	0.751	0.86
111_E	117_D	0.751	0.86
55_E	63_I	0.751	0.86
105_L	361_A	0.747	0.86
128_N	190_K	0.746	0.86
194_D	255_L	0.746	0.86
9_K	23_R	0.745	0.86
186_Y	189_M	0.745	0.86
12_V	38_A	0.744	0.86
43_G	77_T	0.738	0.85
252_C	255_L	0.737	0.85
110_T	362_N	0.736	0.85
14_Q	153_N	0.735	0.85
134_V	291_E	0.734	0.85
313_W	338_I	0.734	0.85
267_M	286_C	0.733	0.85
105_L	353_A	0.731	0.85
157_H	227_E	0.730	0.85
313_W	333_A	0.729	0.84
33_G	87_I	0.726	0.84
277_D	280_K	0.725	0.84
35_A	84_A	0.725	0.84
7_D	53_I	0.724	0.84
164_K	174_Y	0.724	0.84
106_G	109_K	0.723	0.84
304_D	307_N	0.723	0.84
255_L	260_L	0.723	0.84
154_N	232_E	0.722	0.84
63_I	68_R	0.721	0.84
239_L	248_A	0.718	0.84
165_W	224_A	0.717	0.84
327_R	363_T	0.717	0.84
334_A	362_N	0.715	0.83
158_G	161_S	0.712	0.83
328_R	331_E	0.710	0.83
112_I	120_G	0.709	0.83
87_I	91_D	0.707	0.83
105_L	108_D	0.706	0.83
246_N	249_I	0.705	0.82
89_L	93_I	0.705	0.82
315_P	326_G	0.705	0.82
114_V	120_G	0.702	0.82
323_I	357_V	0.701	0.82
245_L	267_M	0.697	0.82
125_E	178_A	0.694	0.81
251_I	254_A	0.693	0.81
122_K	239_L	0.691	0.81
299_V	303_K	0.686	0.81
300_Y	304_D	0.685	0.81
140_K	151_T	0.684	0.81
110_T	331_E	0.684	0.81
245_L	249_I	0.684	0.81
342_P	357_V	0.676	0.80
8_F	85_I	0.676	0.80
177_R	180_K	0.672	0.79
191_F	214_D	0.668	0.79
152_T	156_V	0.666	0.79
358_G	366_F	0.666	0.79
112_I	117_D	0.666	0.79
213_K	216_D	0.666	0.79
37_P	40_G	0.663	0.78
130_L	237_F	0.663	0.78
68_R	76_T	0.662	0.78
22_V	44_M	0.659	0.78
129_A	193_L	0.658	0.78
215_I	237_F	0.657	0.78
136_L	155_P	0.657	0.78
239_L	268_P	0.657	0.78
329_I	340_Y	0.655	0.78
176_K	179_L	0.654	0.78
306_L	332_L	0.654	0.78
125_E	173_A	0.653	0.77
26_S	96_Y	0.650	0.77
266_P	279_L	0.645	0.77
90_Y	353_A	0.644	0.76
38_A	42_K	0.644	0.76
239_L	263_L	0.643	0.76
45_E	49_I	0.640	0.76
266_P	309_G	0.639	0.76
182_K	189_M	0.638	0.76
191_F	194_D	0.638	0.76
183_N	186_Y	0.638	0.76
307_N	332_L	0.636	0.76
130_L	214_D	0.633	0.75
26_S	92_L	0.633	0.75
130_L	194_D	0.631	0.75
249_I	282_L	0.629	0.75
95_K	98_N	0.628	0.75
216_D	219_V	0.628	0.75
340_Y	361_A	0.627	0.75
57_A	96_Y	0.627	0.75
155_P	233_V	0.626	0.74
121_G	124_L	0.626	0.74
193_L	213_K	0.625	0.74
289_P	339_E	0.622	0.74
122_K	129_A	0.621	0.74
46_S	51_L	0.620	0.74
12_V	156_V	0.620	0.74
127_I	193_L	0.619	0.74
62_R	65_E	0.618	0.73
41_L	44_M	0.616	0.73
177_R	192_D	0.616	0.73
276_Y	301_Q	0.616	0.73
241_W	268_P	0.614	0.73
56_D	96_Y	0.611	0.73
45_E	50_Q	0.604	0.72
34_E	91_D	0.604	0.72
194_D	239_L	0.603	0.72
290_I	309_G	0.603	0.72
218_M	235_I	0.599	0.71
56_D	59_K	0.598	0.71
228_S	232_E	0.596	0.71
295_N	305_L	0.595	0.71
312_V	341_S	0.594	0.71
51_L	55_E	0.593	0.70
276_Y	304_D	0.591	0.70
289_P	341_S	0.590	0.70
162_M	182_K	0.589	0.70
127_I	192_D	0.588	0.70
27_K	57_A	0.588	0.70
46_S	53_I	0.586	0.69
323_I	327_R	0.585	0.69
40_G	43_G	0.583	0.69
132_L	344_N	0.583	0.69
252_C	282_L	0.578	0.68
56_D	93_I	0.578	0.68
219_V	258_Y	0.577	0.68
175_A	178_A	0.577	0.68
219_V	223_K	0.575	0.68
129_A	194_D	0.575	0.68
127_I	177_R	0.574	0.68
61_N	331_E	0.572	0.68
175_A	213_K	0.572	0.68
13_A	350_G	0.570	0.67
97_L	104_L	0.569	0.67
253_K	286_C	0.568	0.67
302_F	315_P	0.568	0.67
103_K	148_R	0.568	0.67
173_A	177_R	0.567	0.67
27_K	98_N	0.565	0.67
99_V	103_K	0.564	0.67
31_G	35_A	0.563	0.66
30_Y	95_K	0.563	0.66
116_V	136_L	0.560	0.66
65_E	324_T	0.559	0.66
262_W	341_S	0.559	0.66
327_R	331_E	0.559	0.66
46_S	49_I	0.559	0.66
31_G	95_K	0.557	0.66
176_K	180_K	0.556	0.65
122_K	268_P	0.556	0.65
31_G	92_L	0.554	0.65
219_V	257_P	0.553	0.65
166_N	217_Y	0.553	0.65
20_A	44_M	0.552	0.65
9_K	244_N	0.551	0.65
135_N	218_M	0.551	0.65
174_Y	180_K	0.550	0.65
114_V	136_L	0.548	0.64
308_T	338_I	0.547	0.64
194_D	243_Y	0.546	0.64
10_V	20_A	0.545	0.64
330_A	363_T	0.544	0.64
47_E	77_T	0.542	0.64
114_V	341_S	0.542	0.64
122_K	173_A	0.542	0.64
58_F	89_L	0.541	0.63
20_A	84_A	0.541	0.63
354_H	357_V	0.540	0.63
242_R	274_S	0.540	0.63
174_Y	178_A	0.539	0.63
43_G	81_L	0.536	0.63
125_E	166_N	0.536	0.63
231_D	234_E	0.534	0.62
139_I	154_N	0.534	0.62
150_I	154_N	0.534	0.62
23_R	31_G	0.534	0.62
24_I	88_A	0.533	0.62
22_V	89_L	0.532	0.62
303_K	336_Y	0.531	0.62
249_I	286_C	0.531	0.62
124_L	129_A	0.531	0.62
67_L	85_I	0.530	0.62
63_I	66_K	0.529	0.62
138_W	261_R	0.528	0.62
97_L	100_P	0.527	0.61
299_V	302_F	0.526	0.61
103_K	108_D	0.526	0.61
35_A	83_S	0.525	0.61
177_R	190_K	0.524	0.61
301_Q	305_L	0.523	0.61
122_K	125_E	0.521	0.61
66_K	70_A	0.520	0.60
235_I	239_L	0.520	0.60
68_R	325_E	0.519	0.60
127_I	180_K	0.519	0.60
357_V	363_T	0.519	0.60
63_I	85_I	0.518	0.60
163_E	166_N	0.518	0.60
6_T	9_K	0.517	0.60
279_L	310_V	0.517	0.60
175_A	190_K	0.517	0.60
135_N	158_G	0.515	0.60
278_E	286_C	0.515	0.60
344_N	355_A	0.515	0.60
243_Y	251_I	0.514	0.59
50_Q	53_I	0.514	0.59
216_D	223_K	0.513	0.59
242_R	301_Q	0.511	0.59
52_L	66_K	0.510	0.59
71_T	76_T	0.510	0.59
14_Q	156_V	0.510	0.59
26_S	129_A	0.509	0.59
246_N	277_D	0.507	0.58
140_K	150_I	0.506	0.58
252_C	288_V	0.505	0.58
32_T	95_K	0.502	0.58
216_D	254_A	0.502	0.58
64_A	86_N	0.502	0.58
7_D	45_E	0.502	0.58
111_E	362_N	0.502	0.58
39_P	43_G	0.501	0.58
315_P	342_P	0.501	0.58
274_S	370_H	0.501	0.58
10_V	45_E	0.500	0.57
43_G	50_Q	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dipA	5	0.8496	100	0.377	Contact Map
4mksA	3	0.852	100	0.385	Contact Map
3rcyA	5	0.8687	100	0.393	Contact Map
2qq6A	5	0.9069	100	0.394	Contact Map
3t6cA	5	0.8663	100	0.395	Contact Map
3p0wA	2	0.8783	100	0.395	Contact Map
3go2A	5	0.8854	100	0.401	Contact Map
2gl5A	5	0.895	100	0.401	Contact Map
4a35A	2	0.9141	100	0.402	Contact Map
3otrA	2	0.895	100	0.405	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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