GREMLIN Database
Q97UK6 - 3-oxoacyl-(Acyl carrier protein) reductase (FabG-9)
UniProt: Q97UK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (242)
Sequences: 86849 (57805)
Seq/√Len: 3715.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_R113_T3.3201.00
105_R109_E2.7141.00
156_G160_A2.6711.00
132_V175_R2.6321.00
74_Y125_Y2.5231.00
5_S82_V2.5011.00
67_S121_Y2.4981.00
62_S65_D2.4751.00
135_N162_T2.4221.00
127_K172_Y2.3761.00
119_S165_L2.3101.00
109_E113_T2.2561.00
82_V225_V2.2421.00
180_S236_N2.2071.00
32_A58_T2.1581.00
63_E101_L2.1551.00
16_A20_Y2.1031.00
21_R219_S2.1011.00
219_S228_D2.0591.00
123_V169_L2.0211.00
235_V238_T2.0011.00
28_A52_D1.9791.00
70_V122_A1.9791.00
85_N135_N1.9651.00
36_E40_K1.9641.00
54_F76_R1.9361.00
185_D213_K1.9211.00
137_A159_I1.9001.00
16_A45_H1.8681.00
21_R222_T1.8681.00
16_A42_R1.8631.00
39_G55_F1.8441.00
212_G231_W1.8081.00
11_A33_D1.8061.00
20_Y45_H1.7631.00
21_R25_Q1.7511.00
30_V73_V1.7391.00
162_T178_S1.7351.00
32_A69_M1.7301.00
220_L237_F1.7271.00
4_V28_A1.6981.00
22_L225_V1.6871.00
58_T65_D1.6671.00
18_I221_V1.6571.00
72_K76_R1.6391.00
10_G31_I1.6271.00
25_Q222_T1.6221.00
2_K27_Y1.5941.00
30_V77_Y1.5811.00
56_I72_K1.5651.00
43_E47_R1.5571.00
36_E57_K1.5531.00
101_L117_L1.5321.00
142_F238_T1.5281.00
35_D38_A1.4941.00
27_Y82_V1.4931.00
21_R24_K1.4721.00
83_L118_C1.4351.00
68_N72_K1.4351.00
91_F106_R1.4291.00
113_T117_L1.4251.00
111_N154_S1.4001.00
84_V136_I1.3981.00
43_E55_F1.3861.00
185_D190_Q1.3671.00
58_T69_M1.3661.00
112_L157_G1.3631.00
108_I112_L1.3621.00
66_V118_C1.3591.00
115_V158_I1.3521.00
44_N48_G1.3471.00
63_E117_L1.3411.00
12_K38_A1.3341.00
14_I184_I1.3301.00
100_T103_E1.3261.00
20_Y49_E1.3261.00
71_E75_G1.3181.00
28_A51_I1.3121.00
63_E67_S1.3051.00
4_V79_R1.2921.00
83_L122_A1.2811.00
72_K75_G1.2781.00
5_S22_L1.2771.00
24_K49_E1.2621.00
22_L27_Y1.2531.00
137_A178_S1.2371.00
65_D68_N1.2231.00
220_L239_I1.2181.00
159_I236_N1.2111.00
125_Y129_N1.2081.00
5_S27_Y1.1861.00
30_V54_F1.1801.00
67_S71_E1.1761.00
54_F77_Y1.1651.00
4_V30_V1.1591.00
19_G31_I1.1581.00
33_D39_G1.1531.00
85_N119_S1.1511.00
104_W113_T1.1481.00
21_R218_A1.1481.00
86_N136_I1.1461.00
44_N47_R1.1431.00
12_K187_S1.1381.00
40_K44_N1.1341.00
165_L176_V1.1331.00
17_A20_Y1.1281.00
95_S98_E1.1271.00
119_S133_I1.1251.00
97_E127_K1.1061.00
80_I122_A1.1041.00
79_R129_N1.1021.00
178_S236_N1.0971.00
179_I221_V1.0911.00
101_L113_T1.0891.00
61_S106_R1.0891.00
132_V177_V1.0881.00
20_Y24_K1.0851.00
89_I110_T1.0821.00
28_A54_F1.0801.00
40_K43_E1.0761.00
91_F103_E1.0731.00
99_Q150_P1.0731.00
18_I84_V1.0701.00
41_Y45_H1.0611.00
56_I69_M1.0591.00
136_I221_V1.0571.00
94_K103_E1.0541.00
30_V56_I1.0521.00
162_T176_V1.0511.00
17_A215_E1.0471.00
89_I106_R1.0411.00
108_I113_T1.0321.00
21_R215_E1.0301.00
31_I53_S1.0191.00
125_Y128_N1.0161.00
132_V230_S1.0031.00
115_V135_N0.9961.00
6_I69_M0.9851.00
56_I76_R0.9751.00
223_F229_A0.9651.00
23_G51_I0.9651.00
43_E53_S0.9621.00
119_S161_L0.9571.00
184_I212_G0.9561.00
47_R52_D0.9501.00
84_V221_V0.9461.00
38_A41_Y0.9451.00
102_D106_R0.9441.00
4_V77_Y0.9391.00
63_E120_K0.9371.00
64_M68_N0.9301.00
101_L105_R0.9261.00
68_N71_E0.9221.00
41_Y44_N0.9211.00
210_R216_D0.9201.00
61_S109_E0.9171.00
36_E55_F0.9121.00
74_Y128_N0.9111.00
60_V114_G0.9101.00
215_E219_S0.9081.00
116_W161_L0.8981.00
14_I18_I0.8951.00
17_A214_P0.8841.00
46_F53_S0.8771.00
45_H49_E0.8771.00
22_L222_T0.8761.00
54_F72_K0.8761.00
121_Y124_K0.8761.00
18_I218_A0.8661.00
57_K65_D0.8661.00
73_V77_Y0.8661.00
232_I237_F0.8611.00
6_I32_A0.8601.00
152_S160_A0.8601.00
223_F232_I0.8571.00
119_S135_N0.8451.00
12_K35_D0.8421.00
42_R45_H0.8371.00
23_G46_F0.8341.00
10_G32_A0.8341.00
151_Y155_K0.8281.00
17_A218_A0.8281.00
141_A159_I0.8271.00
111_N155_K0.8231.00
16_A41_Y0.8141.00
28_A77_Y0.8131.00
187_S190_Q0.8111.00
12_K16_A0.8091.00
63_E121_Y0.8041.00
133_I176_V0.8011.00
142_F159_I0.8011.00
58_T66_V0.7981.00
46_F51_I0.7901.00
142_F180_S0.7871.00
25_Q228_D0.7871.00
103_E106_R0.7871.00
6_I80_I0.7811.00
126_M129_N0.7791.00
85_N118_C0.7781.00
220_L223_F0.7771.00
8_T118_C0.7771.00
37_E40_K0.7761.00
240_D244_T0.7751.00
23_G53_S0.7741.00
64_M67_S0.7711.00
144_S160_A0.7641.00
37_E41_Y0.7641.00
3_K81_D0.7631.00
96_I165_L0.7621.00
149_E168_S0.7581.00
97_E169_L0.7551.00
101_L120_K0.7481.00
112_L153_A0.7461.00
134_V225_V0.7451.00
3_K227_D0.7431.00
169_L172_Y0.7421.00
122_A126_M0.7371.00
104_W116_W0.7341.00
108_I153_A0.7261.00
159_I178_S0.7241.00
45_H48_G0.7151.00
194_R198_L0.7151.00
96_I169_L0.7141.00
70_V121_Y0.7131.00
66_V117_L0.7121.00
81_D129_N0.7111.00
166_A233_S0.7091.00
159_I163_H0.7071.00
138_S151_Y0.7021.00
71_E121_Y0.6991.00
83_L133_I0.6961.00
108_I154_S0.6941.00
206_H231_W0.6881.00
135_N176_V0.6871.00
127_K169_L0.6871.00
115_V119_S0.6861.00
201_L204_G0.6861.00
194_R197_T0.6801.00
80_I125_Y0.6791.00
184_I217_V0.6781.00
20_Y46_F0.6741.00
33_D55_F0.6731.00
238_T244_T0.6731.00
21_R228_D0.6681.00
156_G163_H0.6671.00
183_W189_W0.6661.00
159_I180_S0.6651.00
71_E125_Y0.6641.00
106_R109_E0.6631.00
113_T116_W0.6611.00
134_V221_V0.6591.00
149_E161_L0.6581.00
126_M131_G0.6551.00
140_R152_S0.6531.00
231_W241_G0.6521.00
208_T233_S0.6501.00
123_V127_K0.6451.00
33_D57_K0.6451.00
4_V73_V0.6451.00
66_V121_Y0.6411.00
17_A21_R0.6401.00
71_E74_Y0.6381.00
88_G111_N0.6351.00
147_N168_S0.6331.00
107_V154_S0.6331.00
170_S233_S0.6311.00
152_S156_G0.6271.00
91_F94_K0.6261.00
117_L121_Y0.6251.00
123_V172_Y0.6241.00
79_R125_Y0.6241.00
85_N115_V0.6221.00
25_Q226_S0.6211.00
166_A234_G0.6211.00
69_M118_C0.6181.00
107_V150_P0.6171.00
227_D230_S0.6161.00
177_V224_L0.6161.00
195_E198_L0.6141.00
124_K128_N0.6141.00
152_S164_S0.6141.00
210_R230_S0.6121.00
60_V87_A0.6111.00
15_G86_N0.6111.00
216_D230_S0.6101.00
70_V118_C0.6081.00
13_G186_T0.6061.00
22_L221_V0.6041.00
7_I19_G0.6031.00
89_I154_S0.6031.00
232_I239_I0.6031.00
63_E102_D0.6021.00
52_D76_R0.6021.00
22_L82_V0.6011.00
74_Y79_R0.6001.00
40_K55_F0.5981.00
67_S124_K0.5971.00
23_G52_D0.5961.00
160_A163_H0.5921.00
203_H211_V0.5901.00
218_A222_T0.5881.00
164_S168_S0.5871.00
137_A180_S0.5831.00
11_A39_G0.5821.00
213_K216_D0.5791.00
39_G57_K0.5761.00
34_V59_D0.5761.00
47_R50_G0.5751.00
193_P196_S0.5731.00
104_W112_L0.5721.00
31_I55_F0.5721.00
73_V76_R0.5721.00
104_W150_P0.5691.00
24_K215_E0.5691.00
12_K33_D0.5681.00
142_F236_N0.5681.00
195_E199_S0.5671.00
8_T86_N0.5661.00
116_W120_K0.5651.00
89_I188_R0.5651.00
115_V118_C0.5641.00
169_L176_V0.5631.00
193_P197_T0.5631.00
110_T114_G0.5601.00
20_Y215_E0.5601.00
199_S203_H0.5551.00
61_S110_T0.5521.00
32_A60_V0.5491.00
143_Q243_M0.5481.00
33_D36_E0.5471.00
149_E164_S0.5451.00
111_N151_Y0.5441.00
226_S229_A0.5421.00
121_Y125_Y0.5371.00
94_K98_E0.5321.00
42_R46_F0.5321.00
219_S230_S0.5311.00
39_G43_E0.5301.00
112_L154_S0.5291.00
32_A73_V0.5261.00
223_F226_S0.5241.00
175_R230_S0.5241.00
67_S120_K0.5211.00
156_G159_I0.5201.00
189_W193_P0.5191.00
170_S208_T0.5191.00
232_I235_V0.5191.00
87_A114_G0.5171.00
46_F49_E0.5161.00
33_D38_A0.5151.00
10_G19_G0.5151.00
59_D62_S0.5121.00
153_A161_L0.5111.00
190_Q194_R0.5111.00
112_L158_I0.5101.00
47_R53_S0.5071.00
93_G103_E0.5071.00
91_F107_V0.5051.00
23_G29_V0.5051.00
20_Y42_R0.5051.00
31_I42_R0.5041.00
132_V225_V0.5041.00
104_W108_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qedA 4 0.8227 100 0.213 Contact Map
1vl8A 4 0.8194 100 0.216 Contact Map
3wtcA 4 0.8194 100 0.217 Contact Map
1gegA 5 0.8194 100 0.217 Contact Map
3a28C 4 0.8161 100 0.22 Contact Map
1zemA 4 0.8094 100 0.221 Contact Map
3v8bA 4 0.8261 100 0.222 Contact Map
2et6A 1 0.903 100 0.223 Contact Map
4j2hA 4 0.8227 100 0.223 Contact Map
3ucxA 4 0.8227 100 0.223 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.