Q97UK6 - SULSO - GREMLIN Contacts

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Q97UK6 - 3-oxoacyl-(Acyl carrier protein) reductase (FabG-9)

UniProt:	Q97UK6	Sequences: MKKVSIITGGAKGIGAAIGYRLGKQGYAVVIADVDEEAGKYRENHFRGEGIDSFFIKTDVSSEMDVSNMVEKVYGRYGRIDVLVNNAGIGFSGKSIEEQTLDEWRRVIETNLTGVWLCSKYAVKYMKNNGGVIVNIASTRAFQSEPNTEPYSASKGGIIALTHSLAVSLSKYNIRVVSISPGWIDTSRWQVPPRESTLSGLDHGQHLTRRVGKPEDVASLVTFLVSDDASWISGVNFTIDGGMTVKMIYIDENVIQDSLTMLFNDVEVSYQIRKLIEKIKKADNKENIKSKLDELLRSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (242)
Sequences:	86849 (57805)
Seq/√Len:	3715.8

ECOLI - SRLD YOHF YGHA IDNO KDUD YGCW HDHA HCAB YGFF UCPA FABG YBBO FABI ENTA YDFG YCIK BDCA FOLM
BACSU - YHXD YXBG UXUB GS39 YWFH YXJF DHG DHBA YHXC FABL YKVO DHG2 YHDF YVAG YTKK FABG FADH YMFI FABI YXNA YVRD YJDA KDUD BACC YOXD YUSZ YUXG DLTE YQJQ BZRD
HALSA - Q9HNC5 Q9HQ41 Q9HRV8 Q9HSR4 Q9HRZ2 Q9HMA5 Q9HPP2 Q9HS80 Q9HP93
SULSO - Q97UK6 Q97ZE4 Q97WF0 Q97VV6 Q97UA4 Q97Y09 Q97WD7 Q97VG2 Q97ZA0 Q97WL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_R	113_T	3.320	1.00
105_R	109_E	2.714	1.00
156_G	160_A	2.671	1.00
132_V	175_R	2.632	1.00
74_Y	125_Y	2.523	1.00
5_S	82_V	2.501	1.00
67_S	121_Y	2.498	1.00
62_S	65_D	2.475	1.00
135_N	162_T	2.422	1.00
127_K	172_Y	2.376	1.00
119_S	165_L	2.310	1.00
109_E	113_T	2.256	1.00
82_V	225_V	2.242	1.00
180_S	236_N	2.207	1.00
32_A	58_T	2.158	1.00
63_E	101_L	2.155	1.00
16_A	20_Y	2.103	1.00
21_R	219_S	2.101	1.00
219_S	228_D	2.059	1.00
123_V	169_L	2.021	1.00
235_V	238_T	2.001	1.00
28_A	52_D	1.979	1.00
70_V	122_A	1.979	1.00
85_N	135_N	1.965	1.00
36_E	40_K	1.964	1.00
54_F	76_R	1.936	1.00
185_D	213_K	1.921	1.00
137_A	159_I	1.900	1.00
16_A	45_H	1.868	1.00
21_R	222_T	1.868	1.00
16_A	42_R	1.863	1.00
39_G	55_F	1.844	1.00
212_G	231_W	1.808	1.00
11_A	33_D	1.806	1.00
20_Y	45_H	1.763	1.00
21_R	25_Q	1.751	1.00
30_V	73_V	1.739	1.00
162_T	178_S	1.735	1.00
32_A	69_M	1.730	1.00
220_L	237_F	1.727	1.00
4_V	28_A	1.698	1.00
22_L	225_V	1.687	1.00
58_T	65_D	1.667	1.00
18_I	221_V	1.657	1.00
72_K	76_R	1.639	1.00
10_G	31_I	1.627	1.00
25_Q	222_T	1.622	1.00
2_K	27_Y	1.594	1.00
30_V	77_Y	1.581	1.00
56_I	72_K	1.565	1.00
43_E	47_R	1.557	1.00
36_E	57_K	1.553	1.00
101_L	117_L	1.532	1.00
142_F	238_T	1.528	1.00
35_D	38_A	1.494	1.00
27_Y	82_V	1.493	1.00
21_R	24_K	1.472	1.00
83_L	118_C	1.435	1.00
68_N	72_K	1.435	1.00
91_F	106_R	1.429	1.00
113_T	117_L	1.425	1.00
111_N	154_S	1.400	1.00
84_V	136_I	1.398	1.00
43_E	55_F	1.386	1.00
185_D	190_Q	1.367	1.00
58_T	69_M	1.366	1.00
112_L	157_G	1.363	1.00
108_I	112_L	1.362	1.00
66_V	118_C	1.359	1.00
115_V	158_I	1.352	1.00
44_N	48_G	1.347	1.00
63_E	117_L	1.341	1.00
12_K	38_A	1.334	1.00
14_I	184_I	1.330	1.00
100_T	103_E	1.326	1.00
20_Y	49_E	1.326	1.00
71_E	75_G	1.318	1.00
28_A	51_I	1.312	1.00
63_E	67_S	1.305	1.00
4_V	79_R	1.292	1.00
83_L	122_A	1.281	1.00
72_K	75_G	1.278	1.00
5_S	22_L	1.277	1.00
24_K	49_E	1.262	1.00
22_L	27_Y	1.253	1.00
137_A	178_S	1.237	1.00
65_D	68_N	1.223	1.00
220_L	239_I	1.218	1.00
159_I	236_N	1.211	1.00
125_Y	129_N	1.208	1.00
5_S	27_Y	1.186	1.00
30_V	54_F	1.180	1.00
67_S	71_E	1.176	1.00
54_F	77_Y	1.165	1.00
4_V	30_V	1.159	1.00
19_G	31_I	1.158	1.00
33_D	39_G	1.153	1.00
85_N	119_S	1.151	1.00
104_W	113_T	1.148	1.00
21_R	218_A	1.148	1.00
86_N	136_I	1.146	1.00
44_N	47_R	1.143	1.00
12_K	187_S	1.138	1.00
40_K	44_N	1.134	1.00
165_L	176_V	1.133	1.00
17_A	20_Y	1.128	1.00
95_S	98_E	1.127	1.00
119_S	133_I	1.125	1.00
97_E	127_K	1.106	1.00
80_I	122_A	1.104	1.00
79_R	129_N	1.102	1.00
178_S	236_N	1.097	1.00
179_I	221_V	1.091	1.00
101_L	113_T	1.089	1.00
61_S	106_R	1.089	1.00
132_V	177_V	1.088	1.00
20_Y	24_K	1.085	1.00
89_I	110_T	1.082	1.00
28_A	54_F	1.080	1.00
40_K	43_E	1.076	1.00
91_F	103_E	1.073	1.00
99_Q	150_P	1.073	1.00
18_I	84_V	1.070	1.00
41_Y	45_H	1.061	1.00
56_I	69_M	1.059	1.00
136_I	221_V	1.057	1.00
94_K	103_E	1.054	1.00
30_V	56_I	1.052	1.00
162_T	176_V	1.051	1.00
17_A	215_E	1.047	1.00
89_I	106_R	1.041	1.00
108_I	113_T	1.032	1.00
21_R	215_E	1.030	1.00
31_I	53_S	1.019	1.00
125_Y	128_N	1.016	1.00
132_V	230_S	1.003	1.00
115_V	135_N	0.996	1.00
6_I	69_M	0.985	1.00
56_I	76_R	0.975	1.00
223_F	229_A	0.965	1.00
23_G	51_I	0.965	1.00
43_E	53_S	0.962	1.00
119_S	161_L	0.957	1.00
184_I	212_G	0.956	1.00
47_R	52_D	0.950	1.00
84_V	221_V	0.946	1.00
38_A	41_Y	0.945	1.00
102_D	106_R	0.944	1.00
4_V	77_Y	0.939	1.00
63_E	120_K	0.937	1.00
64_M	68_N	0.930	1.00
101_L	105_R	0.926	1.00
68_N	71_E	0.922	1.00
41_Y	44_N	0.921	1.00
210_R	216_D	0.920	1.00
61_S	109_E	0.917	1.00
36_E	55_F	0.912	1.00
74_Y	128_N	0.911	1.00
60_V	114_G	0.910	1.00
215_E	219_S	0.908	1.00
116_W	161_L	0.898	1.00
14_I	18_I	0.895	1.00
17_A	214_P	0.884	1.00
46_F	53_S	0.877	1.00
45_H	49_E	0.877	1.00
22_L	222_T	0.876	1.00
54_F	72_K	0.876	1.00
121_Y	124_K	0.876	1.00
18_I	218_A	0.866	1.00
57_K	65_D	0.866	1.00
73_V	77_Y	0.866	1.00
232_I	237_F	0.861	1.00
6_I	32_A	0.860	1.00
152_S	160_A	0.860	1.00
223_F	232_I	0.857	1.00
119_S	135_N	0.845	1.00
12_K	35_D	0.842	1.00
42_R	45_H	0.837	1.00
23_G	46_F	0.834	1.00
10_G	32_A	0.834	1.00
151_Y	155_K	0.828	1.00
17_A	218_A	0.828	1.00
141_A	159_I	0.827	1.00
111_N	155_K	0.823	1.00
16_A	41_Y	0.814	1.00
28_A	77_Y	0.813	1.00
187_S	190_Q	0.811	1.00
12_K	16_A	0.809	1.00
63_E	121_Y	0.804	1.00
133_I	176_V	0.801	1.00
142_F	159_I	0.801	1.00
58_T	66_V	0.798	1.00
46_F	51_I	0.790	1.00
142_F	180_S	0.787	1.00
25_Q	228_D	0.787	1.00
103_E	106_R	0.787	1.00
6_I	80_I	0.781	1.00
126_M	129_N	0.779	1.00
85_N	118_C	0.778	1.00
220_L	223_F	0.777	1.00
8_T	118_C	0.777	1.00
37_E	40_K	0.776	1.00
240_D	244_T	0.775	1.00
23_G	53_S	0.774	1.00
64_M	67_S	0.771	1.00
144_S	160_A	0.764	1.00
37_E	41_Y	0.764	1.00
3_K	81_D	0.763	1.00
96_I	165_L	0.762	1.00
149_E	168_S	0.758	1.00
97_E	169_L	0.755	1.00
101_L	120_K	0.748	1.00
112_L	153_A	0.746	1.00
134_V	225_V	0.745	1.00
3_K	227_D	0.743	1.00
169_L	172_Y	0.742	1.00
122_A	126_M	0.737	1.00
104_W	116_W	0.734	1.00
108_I	153_A	0.726	1.00
159_I	178_S	0.724	1.00
45_H	48_G	0.715	1.00
194_R	198_L	0.715	1.00
96_I	169_L	0.714	1.00
70_V	121_Y	0.713	1.00
66_V	117_L	0.712	1.00
81_D	129_N	0.711	1.00
166_A	233_S	0.709	1.00
159_I	163_H	0.707	1.00
138_S	151_Y	0.702	1.00
71_E	121_Y	0.699	1.00
83_L	133_I	0.696	1.00
108_I	154_S	0.694	1.00
206_H	231_W	0.688	1.00
135_N	176_V	0.687	1.00
127_K	169_L	0.687	1.00
115_V	119_S	0.686	1.00
201_L	204_G	0.686	1.00
194_R	197_T	0.680	1.00
80_I	125_Y	0.679	1.00
184_I	217_V	0.678	1.00
20_Y	46_F	0.674	1.00
33_D	55_F	0.673	1.00
238_T	244_T	0.673	1.00
21_R	228_D	0.668	1.00
156_G	163_H	0.667	1.00
183_W	189_W	0.666	1.00
159_I	180_S	0.665	1.00
71_E	125_Y	0.664	1.00
106_R	109_E	0.663	1.00
113_T	116_W	0.661	1.00
134_V	221_V	0.659	1.00
149_E	161_L	0.658	1.00
126_M	131_G	0.655	1.00
140_R	152_S	0.653	1.00
231_W	241_G	0.652	1.00
208_T	233_S	0.650	1.00
123_V	127_K	0.645	1.00
33_D	57_K	0.645	1.00
4_V	73_V	0.645	1.00
66_V	121_Y	0.641	1.00
17_A	21_R	0.640	1.00
71_E	74_Y	0.638	1.00
88_G	111_N	0.635	1.00
147_N	168_S	0.633	1.00
107_V	154_S	0.633	1.00
170_S	233_S	0.631	1.00
152_S	156_G	0.627	1.00
91_F	94_K	0.626	1.00
117_L	121_Y	0.625	1.00
123_V	172_Y	0.624	1.00
79_R	125_Y	0.624	1.00
85_N	115_V	0.622	1.00
25_Q	226_S	0.621	1.00
166_A	234_G	0.621	1.00
69_M	118_C	0.618	1.00
107_V	150_P	0.617	1.00
227_D	230_S	0.616	1.00
177_V	224_L	0.616	1.00
195_E	198_L	0.614	1.00
124_K	128_N	0.614	1.00
152_S	164_S	0.614	1.00
210_R	230_S	0.612	1.00
60_V	87_A	0.611	1.00
15_G	86_N	0.611	1.00
216_D	230_S	0.610	1.00
70_V	118_C	0.608	1.00
13_G	186_T	0.606	1.00
22_L	221_V	0.604	1.00
7_I	19_G	0.603	1.00
89_I	154_S	0.603	1.00
232_I	239_I	0.603	1.00
63_E	102_D	0.602	1.00
52_D	76_R	0.602	1.00
22_L	82_V	0.601	1.00
74_Y	79_R	0.600	1.00
40_K	55_F	0.598	1.00
67_S	124_K	0.597	1.00
23_G	52_D	0.596	1.00
160_A	163_H	0.592	1.00
203_H	211_V	0.590	1.00
218_A	222_T	0.588	1.00
164_S	168_S	0.587	1.00
137_A	180_S	0.583	1.00
11_A	39_G	0.582	1.00
213_K	216_D	0.579	1.00
39_G	57_K	0.576	1.00
34_V	59_D	0.576	1.00
47_R	50_G	0.575	1.00
193_P	196_S	0.573	1.00
104_W	112_L	0.572	1.00
31_I	55_F	0.572	1.00
73_V	76_R	0.572	1.00
104_W	150_P	0.569	1.00
24_K	215_E	0.569	1.00
12_K	33_D	0.568	1.00
142_F	236_N	0.568	1.00
195_E	199_S	0.567	1.00
8_T	86_N	0.566	1.00
116_W	120_K	0.565	1.00
89_I	188_R	0.565	1.00
115_V	118_C	0.564	1.00
169_L	176_V	0.563	1.00
193_P	197_T	0.563	1.00
110_T	114_G	0.560	1.00
20_Y	215_E	0.560	1.00
199_S	203_H	0.555	1.00
61_S	110_T	0.552	1.00
32_A	60_V	0.549	1.00
143_Q	243_M	0.548	1.00
33_D	36_E	0.547	1.00
149_E	164_S	0.545	1.00
111_N	151_Y	0.544	1.00
226_S	229_A	0.542	1.00
121_Y	125_Y	0.537	1.00
94_K	98_E	0.532	1.00
42_R	46_F	0.532	1.00
219_S	230_S	0.531	1.00
39_G	43_E	0.530	1.00
112_L	154_S	0.529	1.00
32_A	73_V	0.526	1.00
223_F	226_S	0.524	1.00
175_R	230_S	0.524	1.00
67_S	120_K	0.521	1.00
156_G	159_I	0.520	1.00
189_W	193_P	0.519	1.00
170_S	208_T	0.519	1.00
232_I	235_V	0.519	1.00
87_A	114_G	0.517	1.00
46_F	49_E	0.516	1.00
33_D	38_A	0.515	1.00
10_G	19_G	0.515	1.00
59_D	62_S	0.512	1.00
153_A	161_L	0.511	1.00
190_Q	194_R	0.511	1.00
112_L	158_I	0.510	1.00
47_R	53_S	0.507	1.00
93_G	103_E	0.507	1.00
91_F	107_V	0.505	1.00
23_G	29_V	0.505	1.00
20_Y	42_R	0.505	1.00
31_I	42_R	0.504	1.00
132_V	225_V	0.504	1.00
104_W	108_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qedA	4	0.8227	100	0.213	Contact Map
1vl8A	4	0.8194	100	0.216	Contact Map
3wtcA	4	0.8194	100	0.217	Contact Map
1gegA	5	0.8194	100	0.217	Contact Map
3a28C	4	0.8161	100	0.22	Contact Map
1zemA	4	0.8094	100	0.221	Contact Map
3v8bA	4	0.8261	100	0.222	Contact Map
2et6A	1	0.903	100	0.223	Contact Map
4j2hA	4	0.8227	100	0.223	Contact Map
3ucxA	4	0.8227	100	0.223	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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