GREMLIN Database
Q97UK5 - Alpha-mannosidase
UniProt: Q97UK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 968 (755)
Sequences: 2012 (1417)
Seq/√Len: 51.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
934_D938_L6.7961.00
632_E652_K5.8821.00
222_V457_S5.4211.00
760_R771_E4.8791.00
379_V385_Y4.5821.00
332_N356_K4.3321.00
274_K326_N4.3231.00
803_A857_V4.2911.00
632_E637_R4.2711.00
271_E525_K4.1871.00
510_T905_V4.0661.00
274_K322_F4.0051.00
734_D844_S3.8531.00
256_D283_R3.7171.00
648_S657_E3.6701.00
241_R276_D3.4741.00
708_S725_R3.3591.00
738_T838_E3.3241.00
502_L527_V3.2781.00
842_I864_L3.2661.00
638_V649_L3.2401.00
255_L287_K3.1911.00
287_K292_K3.1601.00
932_S962_L3.1191.00
636_F733_I3.1011.00
633_N726_V3.0881.00
710_K723_I3.0741.00
322_F326_N3.0741.00
650_F655_N3.0381.00
698_E710_K3.0331.00
653_E731_R3.0311.00
349_I961_I2.9811.00
638_V733_I2.9481.00
259_D443_E2.9411.00
724_V735_F2.9211.00
220_V453_K2.8811.00
793_V812_A2.8601.00
379_V473_R2.8581.00
906_V965_S2.8531.00
287_K290_E2.8521.00
604_P607_G2.8161.00
356_K467_V2.7741.00
701_N706_V2.7661.00
273_V284_I2.7541.00
794_D848_H2.7171.00
813_T820_G2.7121.00
324_L330_L2.7121.00
286_E290_E2.6141.00
318_Y521_T2.5731.00
696_S712_T2.5651.00
901_D904_S2.5301.00
954_V964_I2.5301.00
708_S723_I2.5161.00
385_Y471_E2.5011.00
587_D602_R2.4841.00
738_T840_T2.4731.00
930_A964_I2.4721.00
320_Q330_L2.4681.00
646_V733_I2.4591.00
634_K729_D2.4291.00
580_V868_L2.3961.00
736_I840_T2.3891.00
519_V558_K2.3781.00
659_L663_S2.3641.00
270_Y293_W2.3241.00
332_N464_Q2.3161.00
742_R836_L2.3111.00
377_K385_Y2.3081.00
724_V733_I2.2931.00
603_V868_L2.2591.00
317_L899_E2.2591.00
710_K721_I2.2491.00
933_L963_T2.1931.00
252_L287_K2.1921.00
491_M548_A2.1771.00
646_V649_L2.1671.00
793_V819_V2.1671.00
711_F724_V2.1591.00
265_S268_I2.1551.00
589_E602_R2.1501.00
313_A935_L2.1441.00
527_V555_V2.1211.00
641_S645_Q2.1011.00
357_A467_V2.0921.00
911_E914_N2.0531.00
284_I293_W2.0391.00
736_I842_I2.0171.00
316_F353_G2.0141.00
266_A270_Y2.0131.00
255_L292_K2.0131.00
681_I747_L1.9851.00
821_L843_Y1.9531.00
502_L523_L1.9440.99
737_T843_Y1.9370.99
930_A966_V1.9180.99
747_L822_S1.9180.99
245_L277_S1.9090.99
721_I738_T1.9080.99
956_Y962_L1.8980.99
923_V966_V1.8940.99
256_D287_K1.8900.99
732_R844_S1.8740.99
650_F654_A1.8720.99
258_Y440_I1.8660.99
501_A563_A1.8350.99
930_A952_I1.8340.99
727_Y734_D1.8260.99
700_V710_K1.8180.99
890_L956_Y1.8100.99
253_T257_K1.7990.99
896_K937_E1.7880.99
895_V907_L1.7730.99
640_I709_I1.7690.99
227_A247_T1.7680.99
607_G881_S1.7630.99
745_E828_I1.7630.99
740_R838_E1.7580.99
316_F350_A1.7500.99
425_Y456_L1.7480.99
540_A544_V1.7250.99
220_V455_E1.7180.99
639_R648_S1.7170.99
330_L938_L1.7160.99
350_A386_L1.7150.99
638_V646_V1.7090.99
789_I812_A1.7080.99
860_R863_E1.7020.99
271_E275_A1.6930.99
750_S843_Y1.6920.99
588_R867_P1.6790.98
455_E461_S1.6660.98
734_D842_I1.6550.98
281_F326_N1.6480.98
654_A800_Y1.6460.98
354_G934_D1.6310.98
523_L558_K1.6170.98
267_A270_Y1.6140.98
297_A316_F1.6140.98
651_D800_Y1.6060.98
890_L919_A1.6050.98
844_S864_L1.6040.98
904_S965_S1.6000.98
244_V273_V1.5910.98
297_A355_V1.5910.98
515_Y897_V1.5740.98
630_L637_R1.5720.98
321_R900_D1.5600.98
706_V727_Y1.5510.97
751_W820_G1.5500.97
285_K289_K1.5360.97
735_F845_L1.5330.97
712_T721_I1.5310.97
909_L956_Y1.5250.97
505_A562_V1.5200.97
353_G935_L1.5100.97
501_A559_A1.5050.97
640_I724_V1.4970.97
361_H394_G1.4950.97
667_I751_W1.4940.97
920_Y951_R1.4920.97
265_S270_Y1.4860.97
767_F894_A1.4810.97
769_V792_F1.4810.97
253_T283_R1.4800.97
318_Y525_K1.4760.97
637_R652_K1.4730.97
859_K863_E1.4630.96
731_R860_R1.4590.96
931_R939_N1.4590.96
253_T256_D1.4540.96
932_S960_D1.4470.96
678_A827_P1.4350.96
257_K436_E1.4340.96
248_F293_W1.4230.96
321_R325_E1.4220.96
939_N965_S1.4160.96
521_T525_K1.4140.96
805_L864_L1.4050.95
375_V389_I1.4010.95
796_S848_H1.3990.95
480_T676_A1.3970.95
498_A555_V1.3970.95
582_N588_R1.3900.95
883_I923_V1.3860.95
750_S821_L1.3820.95
632_E726_V1.3810.95
420_P465_R1.3780.95
664_N722_Q1.3770.95
603_V607_G1.3690.95
932_S964_I1.3680.95
517_K521_T1.3660.95
883_I907_L1.3610.95
666_L750_S1.3590.95
807_N842_I1.3580.94
631_V636_F1.3560.94
285_K288_V1.3530.94
635_Y731_R1.3530.94
205_R209_S1.3520.94
722_Q737_T1.3490.94
274_K281_F1.3440.94
505_A566_A1.3440.94
725_R736_I1.3340.94
763_S787_V1.3300.94
498_A527_V1.3230.94
286_E289_K1.3200.94
634_K652_K1.3150.93
706_V725_R1.3060.93
918_E953_K1.3060.93
651_D654_A1.2990.93
498_A556_I1.2960.93
884_R922_E1.2910.93
656_R800_Y1.2900.93
588_R868_L1.2810.93
280_L283_R1.2740.92
749_K820_G1.2730.92
508_W583_S1.2680.92
669_Y820_G1.2630.92
630_L639_R1.2630.92
814_L819_V1.2610.92
801_G848_H1.2460.92
505_A559_A1.2430.91
320_Q936_L1.2340.91
244_V284_I1.2340.91
667_I820_G1.2330.91
505_A520_F1.2190.91
735_F843_Y1.2090.90
352_L935_L1.2010.90
483_G486_T1.1970.90
658_V800_Y1.1910.90
488_H831_D1.1900.90
649_L845_L1.1860.89
918_E955_K1.1820.89
409_E413_N1.1770.89
646_V663_S1.1710.89
659_L662_K1.1710.89
334_L350_A1.1700.89
542_K546_K1.1690.89
723_I738_T1.1660.89
921_V952_I1.1620.88
281_F322_F1.1620.88
725_R734_D1.1610.88
478_L481_H1.1600.88
786_E822_S1.1600.88
890_L909_L1.1590.88
248_F264_Q1.1560.88
932_S943_R1.1520.88
769_V959_R1.1500.88
509_S562_V1.1490.88
503_R507_L1.1450.88
231_T269_Y1.1440.88
239_E242_R1.1430.88
282_V285_K1.1430.88
367_D682_E1.1420.87
667_I813_T1.1400.87
318_Y528_L1.1380.87
919_A954_V1.1360.87
251_I434_P1.1340.87
567_M581_F1.1330.87
324_L938_L1.1310.87
351_K384_D1.1290.87
806_N865_N1.1290.87
493_L497_S1.1280.87
952_I964_I1.1280.87
282_V286_E1.1270.87
491_M549_Y1.1260.87
957_K960_D1.1260.87
608_F877_V1.1250.87
231_T300_V1.1240.87
745_E756_L1.1240.87
606_V892_L1.1240.87
586_W863_E1.1240.87
906_V937_E1.1230.87
885_I892_L1.1210.86
472_W780_W1.1210.86
408_L412_N1.1210.86
584_L588_R1.1190.86
523_L559_A1.1150.86
529_K551_E1.1120.86
640_I646_V1.1120.86
723_I736_I1.1100.86
923_V927_V1.1080.86
658_V754_F1.1060.86
796_S801_G1.1060.86
387_P466_I1.1050.86
307_V312_L1.1040.86
695_S712_T1.1030.86
526_V551_E1.0980.85
787_V793_V1.0970.85
622_I627_A1.0970.85
283_R287_K1.0970.85
222_V465_R1.0920.85
523_L562_V1.0910.85
583_S588_R1.0840.85
248_F284_I1.0820.84
677_D745_E1.0810.84
275_A522_K1.0790.84
956_Y964_I1.0780.84
584_L863_E1.0770.84
222_V420_P1.0760.84
340_F534_D1.0750.84
495_N531_Q1.0750.84
313_A349_I1.0700.84
302_S312_L1.0700.84
581_F608_F1.0690.84
404_A410_Q1.0680.84
560_N564_S1.0650.84
564_S568_Q1.0620.83
501_A560_N1.0620.83
523_L555_V1.0600.83
227_A264_Q1.0590.83
745_E754_F1.0570.83
240_T431_G1.0560.83
504_E583_S1.0510.83
804_L845_L1.0500.83
332_N460_N1.0450.82
504_E869_R1.0440.82
350_A355_V1.0410.82
224_T263_I1.0400.82
589_E600_K1.0390.82
862_Y893_E1.0390.82
313_A767_F1.0370.82
739_L841_F1.0340.82
793_V814_L1.0330.82
464_Q467_V1.0320.82
608_F881_S1.0290.81
590_E868_L1.0230.81
285_K326_N1.0210.81
694_A697_S1.0200.81
501_A556_I1.0200.81
457_S461_S1.0190.81
509_S516_D1.0180.81
359_A391_F1.0110.80
493_L808_G1.0110.80
505_A523_L1.0090.80
526_V555_V1.0090.80
369_N479_E1.0060.80
761_A787_V1.0060.80
931_R965_S1.0040.80
727_Y732_R1.0010.80
763_S814_L0.9980.79
321_R521_T0.9930.79
267_A323_Y0.9930.79
542_K833_S0.9890.79
428_G492_K0.9860.78
351_K356_K0.9860.78
369_N779_S0.9840.78
690_F746_L0.9830.78
920_Y953_K0.9820.78
929_E944_D0.9810.78
429_D432_G0.9760.78
405_S409_E0.9760.78
482_R785_F0.9750.78
927_V966_V0.9730.78
304_A339_T0.9730.78
775_W781_D0.9710.77
745_E749_K0.9700.77
898_A901_D0.9680.77
270_Y284_I0.9680.77
446_N449_P0.9640.77
369_N780_W0.9620.77
763_S793_V0.9620.77
767_F893_E0.9610.77
922_E951_R0.9600.77
802_A845_L0.9580.76
794_D801_G0.9560.76
732_R860_R0.9530.76
266_A269_Y0.9500.76
649_L659_L0.9470.76
509_S520_F0.9430.75
496_R810_Y0.9410.75
600_K611_L0.9400.75
509_S515_Y0.9380.75
407_V411_Y0.9370.75
794_D850_G0.9360.75
207_E210_K0.9350.75
313_A352_L0.9350.75
333_I357_A0.9350.75
800_Y847_P0.9350.75
243_K430_G0.9330.75
373_Y416_Q0.9310.74
505_A563_A0.9290.74
294_E460_N0.9260.74
425_Y434_P0.9260.74
945_I952_I0.9200.73
202_N206_S0.9200.73
921_V966_V0.9200.73
532_F535_V0.9160.73
539_S676_A0.9140.73
237_F535_V0.9120.73
356_K464_Q0.9110.73
381_P768_G0.9110.73
896_K899_E0.9100.73
588_R863_E0.9100.73
461_S464_Q0.9090.73
754_F819_V0.9080.72
737_T841_F0.9070.72
658_V802_A0.9070.72
359_A463_I0.9060.72
911_E917_G0.9050.72
522_K558_K0.9050.72
918_E944_D0.9050.72
404_A408_L0.9050.72
726_V733_I0.9020.72
320_Q331_A0.9010.72
457_S465_R0.9000.72
310_E314_R0.9000.72
886_N920_Y0.8990.72
481_H486_T0.8980.72
495_N552_L0.8980.72
313_A353_G0.8970.72
697_S711_F0.8970.72
330_L934_D0.8950.71
379_V471_E0.8930.71
883_I895_V0.8920.71
637_R726_V0.8920.71
283_R286_E0.8890.71
266_A339_T0.8820.70
481_H484_V0.8820.70
575_G872_K0.8810.70
353_G936_L0.8810.70
411_Y414_W0.8810.70
722_Q843_Y0.8810.70
237_F551_E0.8790.70
211_L216_G0.8780.70
289_K329_K0.8770.70
343_S766_P0.8750.70
646_V659_L0.8740.70
458_G461_S0.8720.69
400_S403_S0.8720.69
311_S499_E0.8720.69
513_R897_V0.8690.69
712_T719_E0.8660.69
734_D864_L0.8650.69
643_S647_L0.8640.69
654_A849_I0.8640.69
806_N810_Y0.8640.69
867_P883_I0.8640.69
502_L559_A0.8640.69
540_A545_Y0.8630.69
333_I460_N0.8620.69
304_A343_S0.8610.68
387_P467_V0.8610.68
497_S556_I0.8570.68
322_F327_F0.8570.68
889_K917_G0.8560.68
394_G429_D0.8530.68
553_E557_N0.8530.68
759_E771_E0.8490.67
677_D830_P0.8480.67
492_K772_R0.8470.67
893_E910_Y0.8460.67
362_K365_W0.8460.67
695_S714_K0.8440.67
636_F726_V0.8430.67
752_F756_L0.8420.67
235_W431_G0.8420.67
392_G397_G0.8400.66
336_L358_F0.8400.66
647_L663_S0.8400.66
508_W563_A0.8400.66
547_V551_E0.8390.66
232_A535_V0.8380.66
774_T816_G0.8370.66
635_Y653_E0.8370.66
389_I463_I0.8370.66
745_E752_F0.8360.66
243_K246_R0.8350.66
342_F364_F0.8350.66
669_Y813_T0.8330.66
507_L895_V0.8300.66
762_V771_E0.8300.66
202_N205_R0.8290.65
658_V756_L0.8290.65
526_V554_E0.8270.65
362_K372_P0.8260.65
252_L292_K0.8260.65
492_K534_D0.8250.65
897_V901_D0.8250.65
519_V562_V0.8240.65
668_A746_L0.8230.65
534_D538_G0.8230.65
244_V264_Q0.8220.65
268_I529_K0.8200.65
500_I791_K0.8190.65
311_S495_N0.8180.64
804_L812_A0.8180.64
805_L821_L0.8170.64
603_V611_L0.8170.64
804_L821_L0.8160.64
362_K679_W0.8160.64
384_D540_A0.8150.64
586_W859_K0.8140.64
601_V611_L0.8140.64
638_V883_I0.8130.64
309_G766_P0.8100.64
660_R817_S0.8100.64
340_F428_G0.8080.63
805_L846_Y0.8080.63
252_L284_I0.8080.63
655_N918_E0.8070.63
232_A548_A0.8050.63
506_E896_K0.8050.63
803_A846_Y0.8040.63
789_I806_N0.8030.63
491_M552_L0.8030.63
362_K785_F0.8030.63
334_L342_F0.7990.63
303_D492_K0.7990.63
339_T342_F0.7990.63
387_P469_V0.7980.62
261_H461_S0.7960.62
494_L549_Y0.7950.62
235_W243_K0.7940.62
256_D286_E0.7940.62
288_V327_F0.7940.62
804_L819_V0.7940.62
392_G396_G0.7930.62
357_A463_I0.7900.62
352_L961_I0.7900.62
509_S512_A0.7890.62
493_L840_T0.7880.62
352_L960_D0.7870.61
396_G429_D0.7870.61
440_I444_A0.7870.61
203_T206_S0.7860.61
667_I749_K0.7850.61
428_G534_D0.7840.61
284_I288_V0.7840.61
303_D340_F0.7840.61
247_T262_F0.7840.61
714_K719_E0.7820.61
490_K549_Y0.7810.61
789_I793_V0.7810.61
339_T350_A0.7790.61
503_R893_E0.7790.61
909_L921_V0.7790.61
592_I962_L0.7790.61
532_F537_P0.7790.61
309_G767_F0.7780.61
943_R955_K0.7770.60
503_R894_A0.7750.60
634_K728_A0.7730.60
310_E499_E0.7720.60
236_P239_E0.7720.60
227_A263_I0.7720.60
233_W340_F0.7710.60
361_H393_H0.7700.60
828_I836_L0.7690.60
270_Y323_Y0.7690.60
519_V561_N0.7670.59
764_D910_Y0.7660.59
512_A566_A0.7660.59
317_L937_E0.7650.59
224_T457_S0.7640.59
735_F750_S0.7620.59
393_H397_G0.7620.59
856_E859_K0.7600.59
765_I784_R0.7580.59
272_W529_K0.7580.59
248_F270_Y0.7550.58
441_R445_V0.7550.58
367_D684_G0.7530.58
707_A728_A0.7520.58
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580_V948_E0.5020.33
236_P240_T0.5020.33
242_R543_D0.5010.33
300_V315_Q0.5000.33
484_V785_F0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lvtA 2 0.7118 100 0.357 Contact Map
2wyhA 2 0.7655 100 0.362 Contact Map
3bvxA 1 0.811 100 0.41 Contact Map
1o7dA 1 0.249 100 0.782 Contact Map
1k1xA 2 0.5775 100 0.858 Contact Map
1o7dD 1 0.2479 100 0.893 Contact Map
2b5dX 3 0.3791 99.9 0.913 Contact Map
1o7dC 1 0.1033 99.9 0.913 Contact Map
3p0bA 1 0.3667 99.8 0.929 Contact Map
3n98A 1 0.3812 99.7 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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