Q97UK3 - SULSO - GREMLIN Contacts

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Q97UK3 - Dehydrogenase, putative

UniProt:	Q97UK3	Sequences: MTLGIAFVGSGFSAKFHLRGLVGVRNVEVKGVYSRNLNSSKEFAMLSEQLGLGKPKVYSDISKMLSDKEINAVWLTVPNDVHLEYTKLIAEEVSQGRSNIHGITIEKPLARNVKEAKEMIRLVEKAGLLHGYLENQIFMPSVVRAREAIWEIGSRNSGRPYLARAAEEHSGPHNSWFWRPTISGGGALIDMTCHSLEATRFLLTDPAKTKSSLKPKTVYAETKTLKWNKKEYAQYLKEKYNVDFLKEPAEDYALTIVTYEDDLGNSVLAETRTSWNYVGPGLRLSVEVLGPEYSVNINTLQSELSVFFSRNIKLPQSEAFVEKQNADQGLMPIILDEAVVYGYQGEDRHMVESFISRKMPFENWYDGLLIVQLMMHAYLSAENGRKISFDPQKVEDFIPKVARGLYSAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	409 (324)
Sequences:	22105 (16455)
Seq/√Len:	914.2

ECOLI - YHHX YCJS YGJR YJHC YDGJ YCEM
BACSU - IOLG YRBE YFII NTDC IOLX IOLW YULF YTET
SULSO - Q97UK3 Q97UJ6 Q97UH0 Q97UK0 Q97UJ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_S	88_L	3.072	1.00
137_I	197_E	2.854	1.00
83_L	118_E	2.816	1.00
87_K	122_L	2.803	1.00
159_R	291_P	2.802	1.00
4_G	28_E	2.780	1.00
217_T	258_T	2.757	1.00
37_L	41_K	2.726	1.00
144_R	147_E	2.697	1.00
117_K	368_L	2.684	1.00
146_R	150_W	2.663	1.00
94_S	122_L	2.584	1.00
151_E	156_N	2.523	1.00
216_K	260_E	2.442	1.00
6_A	64_M	2.386	1.00
83_L	115_E	2.354	1.00
255_T	377_A	2.332	1.00
87_K	118_E	2.328	1.00
90_A	128_L	2.328	1.00
379_L	383_N	2.288	1.00
87_K	94_S	2.263	1.00
77_V	85_Y	2.261	1.00
101_H	129_L	2.210	1.00
60_D	63_K	2.209	1.00
31_G	58_Y	2.200	1.00
147_E	151_E	2.158	1.00
124_E	365_Y	2.127	1.00
81_V	85_Y	2.084	1.00
121_R	125_K	2.077	1.00
56_K	67_D	2.066	1.00
117_K	372_Q	1.995	1.00
41_K	45_M	1.972	1.00
352_E	356_S	1.964	1.00
83_L	87_K	1.957	1.00
90_A	123_V	1.941	1.00
72_A	350_M	1.935	1.00
144_R	148_A	1.923	1.00
86_T	105_I	1.880	1.00
157_S	290_G	1.878	1.00
117_K	121_R	1.858	1.00
122_L	126_A	1.836	1.00
84_E	88_L	1.831	1.00
26_N	355_I	1.823	1.00
217_T	388_S	1.804	1.00
36_N	39_S	1.773	1.00
6_A	70_I	1.761	1.00
259_Y	269_A	1.755	1.00
217_T	386_K	1.731	1.00
70_I	97_R	1.723	1.00
113_V	375_M	1.723	1.00
77_V	81_V	1.716	1.00
94_S	126_A	1.711	1.00
101_H	128_L	1.672	1.00
86_T	119_M	1.663	1.00
21_L	74_W	1.651	1.00
5_I	72_A	1.647	1.00
73_V	89_I	1.634	1.00
219_Y	386_K	1.627	1.00
112_N	115_E	1.609	1.00
222_T	381_A	1.606	1.00
145_A	295_V	1.590	1.00
59_S	63_K	1.585	1.00
130_H	364_W	1.578	1.00
94_S	125_K	1.576	1.00
148_A	156_N	1.557	1.00
129_L	357_R	1.557	1.00
120_I	368_L	1.554	1.00
133_L	346_E	1.525	1.00
65_L	89_I	1.524	1.00
66_S	95_Q	1.517	1.00
27_V	351_V	1.501	1.00
58_Y	67_D	1.499	1.00
63_K	66_S	1.487	1.00
216_K	258_T	1.485	1.00
61_I	88_L	1.464	1.00
122_L	125_K	1.457	1.00
24_V	348_R	1.446	1.00
120_I	364_W	1.442	1.00
83_L	119_M	1.432	1.00
146_R	201_F	1.417	1.00
205_D	265_N	1.416	1.00
62_S	66_S	1.414	1.00
161_Y	291_P	1.411	1.00
111_R	115_E	1.411	1.00
369_L	372_Q	1.407	1.00
88_L	94_S	1.406	1.00
58_Y	64_M	1.376	1.00
40_S	57_V	1.374	1.00
4_G	30_K	1.364	1.00
203_L	267_V	1.362	1.00
42_E	49_Q	1.357	1.00
352_E	358_K	1.350	1.00
205_D	260_E	1.344	1.00
90_A	126_A	1.344	1.00
116_A	368_L	1.335	1.00
221_E	258_T	1.333	1.00
164_R	287_E	1.324	1.00
157_S	293_Y	1.316	1.00
349_H	361_F	1.315	1.00
63_K	67_D	1.297	1.00
4_G	71_N	1.284	1.00
200_R	369_L	1.269	1.00
110_A	116_A	1.269	1.00
160_P	288_V	1.266	1.00
37_L	59_S	1.258	1.00
196_L	373_L	1.254	1.00
113_V	372_Q	1.254	1.00
10_S	32_V	1.251	1.00
349_H	353_S	1.248	1.00
206_P	215_P	1.243	1.00
88_L	95_Q	1.237	1.00
118_E	121_R	1.234	1.00
75_L	86_T	1.232	1.00
200_R	259_Y	1.230	1.00
110_A	119_M	1.228	1.00
15_K	49_Q	1.221	1.00
33_Y	61_I	1.219	1.00
287_E	296_N	1.219	1.00
68_K	97_R	1.217	1.00
113_V	117_K	1.216	1.00
120_I	365_Y	1.209	1.00
33_Y	64_M	1.205	1.00
61_I	85_Y	1.193	1.00
69_E	97_R	1.192	1.00
376_H	387_I	1.187	1.00
75_L	85_Y	1.183	1.00
44_A	57_V	1.173	1.00
89_I	103_I	1.166	1.00
38_N	41_K	1.157	1.00
363_N	366_D	1.151	1.00
148_A	151_E	1.147	1.00
379_L	382_E	1.134	1.00
176_W	180_P	1.132	1.00
64_M	70_I	1.130	1.00
348_R	352_E	1.121	1.00
349_H	358_K	1.118	1.00
31_G	64_M	1.115	1.00
116_A	371_V	1.101	1.00
42_E	45_M	1.094	1.00
163_A	203_L	1.094	1.00
61_I	65_L	1.093	1.00
90_A	122_L	1.091	1.00
351_V	355_I	1.090	1.00
206_P	260_E	1.087	1.00
164_R	272_R	1.083	1.00
121_R	124_E	1.082	1.00
26_N	348_R	1.078	1.00
157_S	160_P	1.077	1.00
96_G	126_A	1.074	1.00
110_A	115_E	1.074	1.00
200_R	206_P	1.070	1.00
375_M	379_L	1.058	1.00
118_E	122_L	1.050	1.00
376_H	379_L	1.049	1.00
3_L	72_A	1.047	1.00
26_N	352_E	1.042	1.00
8_V	85_Y	1.038	1.00
285_S	296_N	1.032	1.00
137_I	366_D	1.027	1.00
200_R	366_D	1.025	1.00
31_G	70_I	1.025	1.00
199_T	269_A	1.024	1.00
101_H	357_R	1.023	1.00
109_L	116_A	1.023	1.00
101_H	354_F	1.019	1.00
157_S	295_V	1.017	1.00
115_E	118_E	1.015	1.00
120_I	124_E	1.014	1.00
87_K	119_M	1.012	1.00
23_G	344_Q	1.008	1.00
5_I	27_V	1.008	1.00
78_P	81_V	1.005	1.00
65_L	88_L	1.004	1.00
40_S	59_S	1.003	1.00
163_A	269_A	1.000	1.00
40_S	44_A	0.998	1.00
3_L	355_I	0.993	1.00
219_Y	256_I	0.991	1.00
105_I	130_H	0.987	1.00
147_E	150_W	0.986	1.00
19_R	23_G	0.983	1.00
167_E	171_G	0.982	1.00
142_V	201_F	0.974	1.00
160_P	290_G	0.972	1.00
160_P	203_L	0.969	1.00
65_L	95_Q	0.968	1.00
67_D	70_I	0.967	1.00
176_W	179_R	0.965	1.00
104_T	133_L	0.960	1.00
383_N	387_I	0.960	1.00
138_F	349_H	0.960	1.00
38_N	42_E	0.949	1.00
17_H	74_W	0.941	1.00
109_L	364_W	0.937	1.00
90_A	103_I	0.932	1.00
216_K	388_S	0.929	1.00
114_K	118_E	0.929	1.00
3_L	354_F	0.927	1.00
145_A	297_I	0.926	1.00
39_S	42_E	0.923	1.00
114_K	117_K	0.921	1.00
119_M	130_H	0.918	1.00
85_Y	88_L	0.909	1.00
104_T	346_E	0.909	1.00
32_V	43_F	0.901	1.00
352_E	357_R	0.900	1.00
19_R	49_Q	0.893	1.00
220_A	377_A	0.893	1.00
167_E	170_S	0.892	1.00
378_Y	382_E	0.891	1.00
345_G	348_R	0.891	1.00
97_R	101_H	0.889	1.00
123_V	126_A	0.887	1.00
131_G	350_M	0.884	1.00
109_L	130_H	0.878	1.00
113_V	368_L	0.875	1.00
221_E	268_L	0.870	1.00
56_K	69_E	0.865	1.00
10_S	34_S	0.864	1.00
41_K	44_A	0.863	1.00
5_I	21_L	0.863	1.00
67_D	97_R	0.861	1.00
86_T	103_I	0.861	1.00
74_W	347_D	0.860	1.00
41_K	57_V	0.857	1.00
86_T	90_A	0.856	1.00
37_L	40_S	0.852	1.00
349_H	352_E	0.845	1.00
7_F	18_L	0.845	1.00
83_L	110_A	0.842	1.00
150_W	204_T	0.840	1.00
6_A	31_G	0.839	1.00
163_A	288_V	0.837	1.00
196_L	374_M	0.834	1.00
205_D	369_L	0.834	1.00
365_Y	369_L	0.833	1.00
353_S	356_S	0.832	1.00
135_N	342_G	0.832	1.00
123_V	364_W	0.831	1.00
129_L	354_F	0.830	1.00
34_S	40_S	0.829	1.00
177_F	180_P	0.827	1.00
81_V	84_E	0.826	1.00
217_T	384_G	0.826	1.00
163_A	199_T	0.823	1.00
158_G	293_Y	0.823	1.00
359_M	363_N	0.822	1.00
79_N	190_D	0.822	1.00
215_P	259_Y	0.821	1.00
117_K	120_I	0.817	1.00
166_A	285_S	0.815	1.00
58_Y	63_K	0.812	1.00
18_L	29_V	0.811	1.00
34_S	39_S	0.805	1.00
30_K	69_E	0.802	1.00
185_G	189_I	0.801	1.00
193_C	370_I	0.801	1.00
165_A	286_V	0.799	1.00
37_L	57_V	0.799	1.00
254_L	270_E	0.796	1.00
199_T	259_Y	0.795	1.00
123_V	130_H	0.793	1.00
344_Q	348_R	0.793	1.00
105_I	119_M	0.787	1.00
14_A	76_T	0.785	1.00
13_S	76_T	0.785	1.00
30_K	56_K	0.784	1.00
4_G	70_I	0.783	1.00
90_A	130_H	0.781	1.00
24_V	27_V	0.778	1.00
44_A	54_K	0.772	1.00
143_V	147_E	0.772	1.00
75_L	89_I	0.771	1.00
149_I	290_G	0.771	1.00
21_L	27_V	0.766	1.00
129_L	353_S	0.766	1.00
180_P	248_P	0.764	1.00
164_R	270_E	0.764	1.00
258_T	386_K	0.763	1.00
8_V	61_I	0.759	1.00
151_E	155_R	0.758	1.00
21_L	347_D	0.758	1.00
6_A	33_Y	0.754	1.00
123_V	128_L	0.747	1.00
200_R	370_I	0.746	1.00
219_Y	380_S	0.746	1.00
180_P	382_E	0.745	1.00
308_F	311_N	0.745	1.00
343_Y	346_E	0.745	1.00
353_S	358_K	0.743	1.00
13_S	343_Y	0.741	1.00
372_Q	376_H	0.740	1.00
206_P	369_L	0.737	1.00
257_V	269_A	0.737	1.00
223_K	258_T	0.730	1.00
131_G	353_S	0.730	1.00
165_A	195_S	0.729	1.00
45_M	49_Q	0.729	1.00
105_I	109_L	0.727	1.00
134_E	193_C	0.727	1.00
187_A	273_T	0.726	1.00
368_L	372_Q	0.726	1.00
221_E	256_I	0.726	1.00
6_A	73_V	0.725	1.00
285_S	298_N	0.724	1.00
158_G	290_G	0.719	1.00
179_R	248_P	0.719	1.00
256_I	268_L	0.715	1.00
30_K	70_I	0.713	1.00
143_V	361_F	0.710	1.00
8_V	77_V	0.708	1.00
260_E	265_N	0.707	1.00
350_M	354_F	0.706	1.00
10_S	40_S	0.706	1.00
17_H	347_D	0.705	1.00
379_L	387_I	0.693	1.00
14_A	19_R	0.693	1.00
304_L	307_F	0.692	1.00
13_S	17_H	0.691	1.00
132_Y	367_G	0.688	1.00
109_L	132_Y	0.686	1.00
97_R	128_L	0.684	1.00
353_S	360_P	0.684	1.00
220_A	255_T	0.682	1.00
83_L	122_L	0.680	1.00
190_D	275_W	0.677	1.00
202_L	288_V	0.677	1.00
64_M	67_D	0.674	1.00
159_R	292_E	0.673	1.00
26_N	351_V	0.671	1.00
287_E	294_S	0.670	1.00
149_I	288_V	0.666	1.00
136_Q	139_M	0.665	1.00
90_A	119_M	0.663	1.00
36_N	41_K	0.662	1.00
87_K	90_A	0.662	1.00
30_K	67_D	0.660	1.00
8_V	33_Y	0.658	1.00
250_E	378_Y	0.658	1.00
203_L	259_Y	0.657	1.00
129_L	359_M	0.657	1.00
104_T	131_G	0.655	1.00
304_L	308_F	0.655	1.00
111_R	184_G	0.655	1.00
366_D	369_L	0.654	1.00
5_I	74_W	0.651	1.00
192_T	273_T	0.651	1.00
10_S	43_F	0.650	1.00
371_V	375_M	0.649	1.00
72_A	101_H	0.649	1.00
134_E	197_E	0.645	1.00
116_A	120_I	0.645	1.00
142_V	198_A	0.645	1.00
5_I	351_V	0.644	1.00
105_I	132_Y	0.642	1.00
364_W	367_G	0.642	1.00
217_T	221_E	0.641	1.00
137_I	201_F	0.640	1.00
166_A	272_R	0.639	1.00
226_K	251_D	0.638	1.00
302_S	306_V	0.638	1.00
149_I	202_L	0.636	1.00
72_A	354_F	0.636	1.00
289_L	294_S	0.636	1.00
259_Y	265_N	0.634	1.00
18_L	43_F	0.634	1.00
296_N	305_S	0.632	1.00
188_L	253_A	0.631	1.00
160_P	267_V	0.630	1.00
162_L	268_L	0.629	1.00
220_A	253_A	0.624	1.00
61_I	89_I	0.622	1.00
376_H	380_S	0.622	1.00
84_E	118_E	0.621	1.00
349_H	360_P	0.620	1.00
58_Y	68_K	0.619	1.00
13_S	106_E	0.619	1.00
129_L	360_P	0.617	1.00
134_E	370_I	0.611	1.00
188_L	374_M	0.611	1.00
143_V	345_G	0.610	1.00
175_S	178_W	0.610	1.00
146_R	202_L	0.610	1.00
258_T	268_L	0.609	1.00
306_V	309_S	0.609	1.00
82_H	105_I	0.603	1.00
215_P	257_V	0.601	1.00
206_P	257_V	0.601	1.00
174_N	178_W	0.600	1.00
259_Y	267_V	0.599	1.00
174_N	179_R	0.599	1.00
222_T	253_A	0.596	1.00
176_W	181_T	0.594	1.00
251_D	276_N	0.593	1.00
192_T	195_S	0.591	1.00
109_L	119_M	0.590	1.00
334_I	337_E	0.589	1.00
159_R	265_N	0.588	1.00
197_E	370_I	0.587	1.00
260_E	266_S	0.586	1.00
156_N	308_F	0.586	1.00
43_F	49_Q	0.584	1.00
186_G	250_E	0.584	1.00
4_G	69_E	0.583	1.00
274_S	277_Y	0.583	1.00
221_E	386_K	0.581	1.00
168_E	171_G	0.579	1.00
203_L	206_P	0.579	1.00
73_V	97_R	0.579	1.00
225_L	251_D	0.579	1.00
255_T	271_T	0.578	1.00
120_I	123_V	0.577	1.00
174_N	177_F	0.572	1.00
96_G	128_L	0.571	1.00
71_N	355_I	0.571	1.00
62_S	84_E	0.569	1.00
17_H	21_L	0.569	1.00
112_N	375_M	0.569	1.00
257_V	271_T	0.569	1.00
32_V	57_V	0.568	1.00
28_E	55_P	0.568	1.00
165_A	199_T	0.567	1.00
15_K	19_R	0.566	1.00
131_G	346_E	0.565	1.00
374_M	378_Y	0.560	1.00
252_Y	274_S	0.558	1.00
14_A	43_F	0.557	1.00
200_R	373_L	0.555	1.00
379_L	385_R	0.554	1.00
370_I	374_M	0.554	1.00
301_Q	304_L	0.553	1.00
196_L	377_A	0.551	1.00
94_S	118_E	0.551	1.00
32_V	40_S	0.550	1.00
135_N	343_Y	0.549	1.00
43_F	50_L	0.548	1.00
167_E	173_H	0.548	1.00
145_A	202_L	0.546	1.00
156_N	159_R	0.542	1.00
19_R	22_V	0.540	1.00
155_R	290_G	0.540	1.00
84_E	87_K	0.539	1.00
304_L	309_S	0.538	1.00
39_S	43_F	0.537	1.00
131_G	349_H	0.536	1.00
200_R	205_D	0.534	1.00
155_R	159_R	0.534	1.00
136_Q	142_V	0.532	1.00
31_G	56_K	0.531	1.00
304_L	310_R	0.530	1.00
303_E	306_V	0.527	1.00
146_R	204_T	0.526	1.00
340_V	344_Q	0.526	1.00
194_H	197_E	0.524	1.00
15_K	42_E	0.522	1.00
136_Q	197_E	0.522	1.00
104_T	350_M	0.522	1.00
138_F	362_E	0.521	1.00
24_V	351_V	0.520	1.00
106_E	133_L	0.520	1.00
162_L	272_R	0.517	1.00
24_V	344_Q	0.516	1.00
187_A	250_E	0.515	1.00
134_E	194_H	0.514	1.00
86_T	123_V	0.514	1.00
203_L	265_N	0.513	1.00
11_G	76_T	0.513	1.00
189_I	375_M	0.513	1.00
220_A	381_A	0.512	1.00
129_L	350_M	0.511	1.00
302_S	309_S	0.510	1.00
163_A	286_V	0.509	1.00
86_T	130_H	0.508	1.00
74_W	104_T	0.508	1.00
179_R	183_S	0.508	1.00
7_F	74_W	0.508	1.00
33_Y	58_Y	0.508	1.00
11_G	14_A	0.506	1.00
177_F	190_D	0.506	1.00
188_L	255_T	0.504	1.00
197_E	201_F	0.504	1.00
8_V	73_V	0.504	1.00
199_T	271_T	0.503	1.00
162_L	289_L	0.502	1.00
75_L	82_H	0.501	1.00
215_P	260_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h6dA	8	0.8337	100	0.283	Contact Map
3v5nA	4	0.802	100	0.29	Contact Map
2nvwA	3	0.8435	100	0.292	Contact Map
3dtyA	4	0.8264	100	0.293	Contact Map
1zh8A	2	0.7702	100	0.301	Contact Map
3db2A	2	0.8264	100	0.304	Contact Map
3oqbA	4	0.8606	100	0.306	Contact Map
3ceaA	4	0.8166	100	0.308	Contact Map
3btvA	2	0.8557	100	0.308	Contact Map
4gqaA	4	0.8729	100	0.308	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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