GREMLIN Database
Q97UK3 - Dehydrogenase, putative
UniProt: Q97UK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (324)
Sequences: 22105 (16455)
Seq/√Len: 914.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_S88_L3.0721.00
137_I197_E2.8541.00
83_L118_E2.8161.00
87_K122_L2.8031.00
159_R291_P2.8021.00
4_G28_E2.7801.00
217_T258_T2.7571.00
37_L41_K2.7261.00
144_R147_E2.6971.00
117_K368_L2.6841.00
146_R150_W2.6631.00
94_S122_L2.5841.00
151_E156_N2.5231.00
216_K260_E2.4421.00
6_A64_M2.3861.00
83_L115_E2.3541.00
255_T377_A2.3321.00
87_K118_E2.3281.00
90_A128_L2.3281.00
379_L383_N2.2881.00
87_K94_S2.2631.00
77_V85_Y2.2611.00
101_H129_L2.2101.00
60_D63_K2.2091.00
31_G58_Y2.2001.00
147_E151_E2.1581.00
124_E365_Y2.1271.00
81_V85_Y2.0841.00
121_R125_K2.0771.00
56_K67_D2.0661.00
117_K372_Q1.9951.00
41_K45_M1.9721.00
352_E356_S1.9641.00
83_L87_K1.9571.00
90_A123_V1.9411.00
72_A350_M1.9351.00
144_R148_A1.9231.00
86_T105_I1.8801.00
157_S290_G1.8781.00
117_K121_R1.8581.00
122_L126_A1.8361.00
84_E88_L1.8311.00
26_N355_I1.8231.00
217_T388_S1.8041.00
36_N39_S1.7731.00
6_A70_I1.7611.00
259_Y269_A1.7551.00
217_T386_K1.7311.00
70_I97_R1.7231.00
113_V375_M1.7231.00
77_V81_V1.7161.00
94_S126_A1.7111.00
101_H128_L1.6721.00
86_T119_M1.6631.00
21_L74_W1.6511.00
5_I72_A1.6471.00
73_V89_I1.6341.00
219_Y386_K1.6271.00
112_N115_E1.6091.00
222_T381_A1.6061.00
145_A295_V1.5901.00
59_S63_K1.5851.00
130_H364_W1.5781.00
94_S125_K1.5761.00
148_A156_N1.5571.00
129_L357_R1.5571.00
120_I368_L1.5541.00
133_L346_E1.5251.00
65_L89_I1.5241.00
66_S95_Q1.5171.00
27_V351_V1.5011.00
58_Y67_D1.4991.00
63_K66_S1.4871.00
216_K258_T1.4851.00
61_I88_L1.4641.00
122_L125_K1.4571.00
24_V348_R1.4461.00
120_I364_W1.4421.00
83_L119_M1.4321.00
146_R201_F1.4171.00
205_D265_N1.4161.00
62_S66_S1.4141.00
161_Y291_P1.4111.00
111_R115_E1.4111.00
369_L372_Q1.4071.00
88_L94_S1.4061.00
58_Y64_M1.3761.00
40_S57_V1.3741.00
4_G30_K1.3641.00
203_L267_V1.3621.00
42_E49_Q1.3571.00
352_E358_K1.3501.00
205_D260_E1.3441.00
90_A126_A1.3441.00
116_A368_L1.3351.00
221_E258_T1.3331.00
164_R287_E1.3241.00
157_S293_Y1.3161.00
349_H361_F1.3151.00
63_K67_D1.2971.00
4_G71_N1.2841.00
200_R369_L1.2691.00
110_A116_A1.2691.00
160_P288_V1.2661.00
37_L59_S1.2581.00
196_L373_L1.2541.00
113_V372_Q1.2541.00
10_S32_V1.2511.00
349_H353_S1.2481.00
206_P215_P1.2431.00
88_L95_Q1.2371.00
118_E121_R1.2341.00
75_L86_T1.2321.00
200_R259_Y1.2301.00
110_A119_M1.2281.00
15_K49_Q1.2211.00
33_Y61_I1.2191.00
287_E296_N1.2191.00
68_K97_R1.2171.00
113_V117_K1.2161.00
120_I365_Y1.2091.00
33_Y64_M1.2051.00
61_I85_Y1.1931.00
69_E97_R1.1921.00
376_H387_I1.1871.00
75_L85_Y1.1831.00
44_A57_V1.1731.00
89_I103_I1.1661.00
38_N41_K1.1571.00
363_N366_D1.1511.00
148_A151_E1.1471.00
379_L382_E1.1341.00
176_W180_P1.1321.00
64_M70_I1.1301.00
348_R352_E1.1211.00
349_H358_K1.1181.00
31_G64_M1.1151.00
116_A371_V1.1011.00
42_E45_M1.0941.00
163_A203_L1.0941.00
61_I65_L1.0931.00
90_A122_L1.0911.00
351_V355_I1.0901.00
206_P260_E1.0871.00
164_R272_R1.0831.00
121_R124_E1.0821.00
26_N348_R1.0781.00
157_S160_P1.0771.00
96_G126_A1.0741.00
110_A115_E1.0741.00
200_R206_P1.0701.00
375_M379_L1.0581.00
118_E122_L1.0501.00
376_H379_L1.0491.00
3_L72_A1.0471.00
26_N352_E1.0421.00
8_V85_Y1.0381.00
285_S296_N1.0321.00
137_I366_D1.0271.00
200_R366_D1.0251.00
31_G70_I1.0251.00
199_T269_A1.0241.00
101_H357_R1.0231.00
109_L116_A1.0231.00
101_H354_F1.0191.00
157_S295_V1.0171.00
115_E118_E1.0151.00
120_I124_E1.0141.00
87_K119_M1.0121.00
23_G344_Q1.0081.00
5_I27_V1.0081.00
78_P81_V1.0051.00
65_L88_L1.0041.00
40_S59_S1.0031.00
163_A269_A1.0001.00
40_S44_A0.9981.00
3_L355_I0.9931.00
219_Y256_I0.9911.00
105_I130_H0.9871.00
147_E150_W0.9861.00
19_R23_G0.9831.00
167_E171_G0.9821.00
142_V201_F0.9741.00
160_P290_G0.9721.00
160_P203_L0.9691.00
65_L95_Q0.9681.00
67_D70_I0.9671.00
176_W179_R0.9651.00
104_T133_L0.9601.00
383_N387_I0.9601.00
138_F349_H0.9601.00
38_N42_E0.9491.00
17_H74_W0.9411.00
109_L364_W0.9371.00
90_A103_I0.9321.00
216_K388_S0.9291.00
114_K118_E0.9291.00
3_L354_F0.9271.00
145_A297_I0.9261.00
39_S42_E0.9231.00
114_K117_K0.9211.00
119_M130_H0.9181.00
85_Y88_L0.9091.00
104_T346_E0.9091.00
32_V43_F0.9011.00
352_E357_R0.9001.00
19_R49_Q0.8931.00
220_A377_A0.8931.00
167_E170_S0.8921.00
378_Y382_E0.8911.00
345_G348_R0.8911.00
97_R101_H0.8891.00
123_V126_A0.8871.00
131_G350_M0.8841.00
109_L130_H0.8781.00
113_V368_L0.8751.00
221_E268_L0.8701.00
56_K69_E0.8651.00
10_S34_S0.8641.00
41_K44_A0.8631.00
5_I21_L0.8631.00
67_D97_R0.8611.00
86_T103_I0.8611.00
74_W347_D0.8601.00
41_K57_V0.8571.00
86_T90_A0.8561.00
37_L40_S0.8521.00
349_H352_E0.8451.00
7_F18_L0.8451.00
83_L110_A0.8421.00
150_W204_T0.8401.00
6_A31_G0.8391.00
163_A288_V0.8371.00
196_L374_M0.8341.00
205_D369_L0.8341.00
365_Y369_L0.8331.00
353_S356_S0.8321.00
135_N342_G0.8321.00
123_V364_W0.8311.00
129_L354_F0.8301.00
34_S40_S0.8291.00
177_F180_P0.8271.00
81_V84_E0.8261.00
217_T384_G0.8261.00
163_A199_T0.8231.00
158_G293_Y0.8231.00
359_M363_N0.8221.00
79_N190_D0.8221.00
215_P259_Y0.8211.00
117_K120_I0.8171.00
166_A285_S0.8151.00
58_Y63_K0.8121.00
18_L29_V0.8111.00
34_S39_S0.8051.00
30_K69_E0.8021.00
185_G189_I0.8011.00
193_C370_I0.8011.00
165_A286_V0.7991.00
37_L57_V0.7991.00
254_L270_E0.7961.00
199_T259_Y0.7951.00
123_V130_H0.7931.00
344_Q348_R0.7931.00
105_I119_M0.7871.00
14_A76_T0.7851.00
13_S76_T0.7851.00
30_K56_K0.7841.00
4_G70_I0.7831.00
90_A130_H0.7811.00
24_V27_V0.7781.00
44_A54_K0.7721.00
143_V147_E0.7721.00
75_L89_I0.7711.00
149_I290_G0.7711.00
21_L27_V0.7661.00
129_L353_S0.7661.00
180_P248_P0.7641.00
164_R270_E0.7641.00
258_T386_K0.7631.00
8_V61_I0.7591.00
151_E155_R0.7581.00
21_L347_D0.7581.00
6_A33_Y0.7541.00
123_V128_L0.7471.00
200_R370_I0.7461.00
219_Y380_S0.7461.00
180_P382_E0.7451.00
308_F311_N0.7451.00
343_Y346_E0.7451.00
353_S358_K0.7431.00
13_S343_Y0.7411.00
372_Q376_H0.7401.00
206_P369_L0.7371.00
257_V269_A0.7371.00
223_K258_T0.7301.00
131_G353_S0.7301.00
165_A195_S0.7291.00
45_M49_Q0.7291.00
105_I109_L0.7271.00
134_E193_C0.7271.00
187_A273_T0.7261.00
368_L372_Q0.7261.00
221_E256_I0.7261.00
6_A73_V0.7251.00
285_S298_N0.7241.00
158_G290_G0.7191.00
179_R248_P0.7191.00
256_I268_L0.7151.00
30_K70_I0.7131.00
143_V361_F0.7101.00
8_V77_V0.7081.00
260_E265_N0.7071.00
350_M354_F0.7061.00
10_S40_S0.7061.00
17_H347_D0.7051.00
379_L387_I0.6931.00
14_A19_R0.6931.00
304_L307_F0.6921.00
13_S17_H0.6911.00
132_Y367_G0.6881.00
109_L132_Y0.6861.00
97_R128_L0.6841.00
353_S360_P0.6841.00
220_A255_T0.6821.00
83_L122_L0.6801.00
190_D275_W0.6771.00
202_L288_V0.6771.00
64_M67_D0.6741.00
159_R292_E0.6731.00
26_N351_V0.6711.00
287_E294_S0.6701.00
149_I288_V0.6661.00
136_Q139_M0.6651.00
90_A119_M0.6631.00
36_N41_K0.6621.00
87_K90_A0.6621.00
30_K67_D0.6601.00
8_V33_Y0.6581.00
250_E378_Y0.6581.00
203_L259_Y0.6571.00
129_L359_M0.6571.00
104_T131_G0.6551.00
304_L308_F0.6551.00
111_R184_G0.6551.00
366_D369_L0.6541.00
5_I74_W0.6511.00
192_T273_T0.6511.00
10_S43_F0.6501.00
371_V375_M0.6491.00
72_A101_H0.6491.00
134_E197_E0.6451.00
116_A120_I0.6451.00
142_V198_A0.6451.00
5_I351_V0.6441.00
105_I132_Y0.6421.00
364_W367_G0.6421.00
217_T221_E0.6411.00
137_I201_F0.6401.00
166_A272_R0.6391.00
226_K251_D0.6381.00
302_S306_V0.6381.00
149_I202_L0.6361.00
72_A354_F0.6361.00
289_L294_S0.6361.00
259_Y265_N0.6341.00
18_L43_F0.6341.00
296_N305_S0.6321.00
188_L253_A0.6311.00
160_P267_V0.6301.00
162_L268_L0.6291.00
220_A253_A0.6241.00
61_I89_I0.6221.00
376_H380_S0.6221.00
84_E118_E0.6211.00
349_H360_P0.6201.00
58_Y68_K0.6191.00
13_S106_E0.6191.00
129_L360_P0.6171.00
134_E370_I0.6111.00
188_L374_M0.6111.00
143_V345_G0.6101.00
175_S178_W0.6101.00
146_R202_L0.6101.00
258_T268_L0.6091.00
306_V309_S0.6091.00
82_H105_I0.6031.00
215_P257_V0.6011.00
206_P257_V0.6011.00
174_N178_W0.6001.00
259_Y267_V0.5991.00
174_N179_R0.5991.00
222_T253_A0.5961.00
176_W181_T0.5941.00
251_D276_N0.5931.00
192_T195_S0.5911.00
109_L119_M0.5901.00
334_I337_E0.5891.00
159_R265_N0.5881.00
197_E370_I0.5871.00
260_E266_S0.5861.00
156_N308_F0.5861.00
43_F49_Q0.5841.00
186_G250_E0.5841.00
4_G69_E0.5831.00
274_S277_Y0.5831.00
221_E386_K0.5811.00
168_E171_G0.5791.00
203_L206_P0.5791.00
73_V97_R0.5791.00
225_L251_D0.5791.00
255_T271_T0.5781.00
120_I123_V0.5771.00
174_N177_F0.5721.00
96_G128_L0.5711.00
71_N355_I0.5711.00
62_S84_E0.5691.00
17_H21_L0.5691.00
112_N375_M0.5691.00
257_V271_T0.5691.00
32_V57_V0.5681.00
28_E55_P0.5681.00
165_A199_T0.5671.00
15_K19_R0.5661.00
131_G346_E0.5651.00
374_M378_Y0.5601.00
252_Y274_S0.5581.00
14_A43_F0.5571.00
200_R373_L0.5551.00
379_L385_R0.5541.00
370_I374_M0.5541.00
301_Q304_L0.5531.00
196_L377_A0.5511.00
94_S118_E0.5511.00
32_V40_S0.5501.00
135_N343_Y0.5491.00
43_F50_L0.5481.00
167_E173_H0.5481.00
145_A202_L0.5461.00
156_N159_R0.5421.00
19_R22_V0.5401.00
155_R290_G0.5401.00
84_E87_K0.5391.00
304_L309_S0.5381.00
39_S43_F0.5371.00
131_G349_H0.5361.00
200_R205_D0.5341.00
155_R159_R0.5341.00
136_Q142_V0.5321.00
31_G56_K0.5311.00
304_L310_R0.5301.00
303_E306_V0.5271.00
146_R204_T0.5261.00
340_V344_Q0.5261.00
194_H197_E0.5241.00
15_K42_E0.5221.00
136_Q197_E0.5221.00
104_T350_M0.5221.00
138_F362_E0.5211.00
24_V351_V0.5201.00
106_E133_L0.5201.00
162_L272_R0.5171.00
24_V344_Q0.5161.00
187_A250_E0.5151.00
134_E194_H0.5141.00
86_T123_V0.5141.00
203_L265_N0.5131.00
11_G76_T0.5131.00
189_I375_M0.5131.00
220_A381_A0.5121.00
129_L350_M0.5111.00
302_S309_S0.5101.00
163_A286_V0.5091.00
86_T130_H0.5081.00
74_W104_T0.5081.00
179_R183_S0.5081.00
7_F74_W0.5081.00
33_Y58_Y0.5081.00
11_G14_A0.5061.00
177_F190_D0.5061.00
188_L255_T0.5041.00
197_E201_F0.5041.00
8_V73_V0.5041.00
199_T271_T0.5031.00
162_L289_L0.5021.00
75_L82_H0.5011.00
215_P260_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h6dA 8 0.8337 100 0.283 Contact Map
3v5nA 4 0.802 100 0.29 Contact Map
2nvwA 3 0.8435 100 0.292 Contact Map
3dtyA 4 0.8264 100 0.293 Contact Map
1zh8A 2 0.7702 100 0.301 Contact Map
3db2A 2 0.8264 100 0.304 Contact Map
3oqbA 4 0.8606 100 0.306 Contact Map
3ceaA 4 0.8166 100 0.308 Contact Map
3btvA 2 0.8557 100 0.308 Contact Map
4gqaA 4 0.8729 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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