GREMLIN Database
Q97UK2 - Carbon monoxide dehydrogenase, large chain (CutA-7)
UniProt: Q97UK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 723 (700)
Sequences: 5511 (3643)
Seq/√Len: 137.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_E270_K4.2891.00
40_I102_V4.2571.00
35_L58_A4.0331.00
91_D94_K3.9441.00
370_E398_K3.6971.00
44_Y47_A3.5961.00
158_E268_K3.5801.00
274_D278_K3.4341.00
273_F357_G3.3551.00
283_E322_K3.3341.00
470_A510_V3.2151.00
152_Y274_D3.2021.00
152_Y275_K3.1891.00
50_K105_E3.1381.00
363_V371_V3.1381.00
449_I476_V3.1061.00
146_S150_K3.1011.00
143_D146_S3.0931.00
279_L354_L3.0861.00
48_K107_E3.0691.00
40_I99_A2.9701.00
156_E268_K2.9011.00
44_Y108_P2.8451.00
403_S406_E2.8421.00
473_V515_I2.8361.00
58_A90_E2.8211.00
285_T324_K2.8051.00
47_A106_Y2.7731.00
317_K378_S2.7711.00
51_S105_E2.6511.00
367_E371_V2.6441.00
46_H109_L2.6131.00
270_K283_E2.6081.00
88_L238_L2.5961.00
185_V199_L2.5531.00
90_E94_K2.5131.00
511_Y515_I2.5101.00
601_E665_E2.4791.00
37_A248_W2.4061.00
184_T214_V2.3901.00
696_L712_T2.3721.00
709_T716_L2.3381.00
90_E244_K2.3371.00
116_E266_R2.3331.00
278_K371_V2.3321.00
50_K107_E2.3261.00
182_R489_D2.3131.00
699_V712_T2.3031.00
148_F272_A2.2741.00
363_V368_I2.2421.00
177_Y186_W2.2411.00
285_T326_L2.2311.00
589_E600_L2.2261.00
212_R487_D2.2221.00
289_D332_K2.2221.00
551_S554_D2.1581.00
357_G368_I2.1161.00
117_E120_K2.1011.00
271_A353_I2.0701.00
140_E322_K2.0681.00
39_F234_I2.0621.00
399_I667_K2.0491.00
160_I709_T2.0471.00
399_I402_P2.0331.00
448_R480_K2.0251.00
37_A86_V2.0111.00
53_R103_E2.0071.00
151_A272_A2.0051.00
400_A585_M1.9881.00
43_Q84_L1.9861.00
367_E370_E1.9761.00
278_K317_K1.9541.00
586_A694_T1.9451.00
370_E401_K1.9421.00
625_A664_V1.9401.00
443_L517_L1.9391.00
441_V451_V1.9211.00
626_L661_A1.9181.00
518_K522_L1.9121.00
54_C60_C1.9051.00
48_K75_E1.8921.00
27_Y247_K1.8811.00
9_V478_V1.8691.00
153_K275_K1.8681.00
269_F353_I1.8501.00
114_N117_E1.8481.00
375_D394_R1.8321.00
398_K402_P1.8291.00
375_D378_S1.8291.00
153_K273_F1.8241.00
421_A589_E1.8161.00
48_K76_E1.8121.00
448_R482_D1.8101.00
532_R535_E1.7841.00
88_L242_T1.7831.00
469_I507_G1.7831.00
542_K549_E1.7801.00
477_D480_K1.7711.00
503_L612_V1.7541.00
89_A95_A1.7531.00
173_G249_F1.7451.00
467_A483_V1.7421.00
182_R210_D1.7341.00
444_T450_Q1.7301.00
597_V717_I1.7261.00
366_F401_K1.7251.00
444_T448_R1.7231.00
37_A246_I1.7141.00
44_Y106_Y1.6961.00
274_D280_L1.6921.00
58_A244_K1.6761.00
617_A683_I1.6761.00
31_F34_T1.6731.00
10_K615_L1.6721.00
151_A280_L1.6571.00
359_R700_E1.6391.00
392_K395_E1.6341.00
158_E266_R1.6301.00
168_A224_S1.6281.00
418_G591_D1.6271.00
167_S650_F1.6271.00
86_V238_L1.6171.00
59_L241_L1.6021.00
449_I474_F1.6021.00
419_K589_E1.6011.00
610_V670_A1.5991.00
145_N322_K1.5961.00
57_G89_A1.5871.00
140_E143_D1.5721.00
271_A279_L1.5711.00
271_A357_G1.5671.00
608_V611_V1.5651.00
584_H602_Y1.5651.00
136_Q324_K1.5611.00
602_Y625_A1.5611.00
145_N149_K1.5591.00
406_E409_R1.5581.00
586_A602_Y1.5551.00
713_K716_L1.5541.00
268_K285_T1.5501.00
611_V668_S1.5421.00
148_F270_K1.5361.00
394_R398_K1.5251.00
473_V678_L1.5241.00
451_V470_A1.5221.00
86_V234_I1.5191.00
99_A102_V1.5071.00
441_V514_S1.5031.00
370_E394_R1.4941.00
46_H76_E1.4931.00
617_A668_S1.4901.00
26_V173_G1.4881.00
153_K360_A1.4851.00
184_T212_R1.4721.00
420_L592_R1.4611.00
536_I543_F1.4611.00
97_D101_Q1.4601.00
439_A510_V1.4581.00
154_V270_K1.4581.00
428_V582_G1.4561.00
568_E572_Y1.4531.00
64_K75_E1.4501.00
601_E663_K1.4481.00
31_F177_Y1.4351.00
630_S656_P1.4231.00
160_I266_R1.4191.00
599_V629_I1.4131.00
516_R519_E1.4111.00
568_E574_I1.4111.00
204_S207_G1.4091.00
39_F248_W1.4071.00
355_N697_H1.4051.00
512_E516_R1.4021.00
359_R701_D1.4011.00
400_A583_I1.3971.00
199_L211_V1.3971.00
396_A583_I1.3881.00
207_G210_D1.3871.00
471_A481_V1.3841.00
290_L301_S1.3811.00
49_I52_I1.3801.00
522_L536_I1.3801.00
628_G691_S1.3791.00
153_K274_D1.3741.00
34_T247_K1.3661.00
466_F510_V1.3641.00
148_F281_G1.3631.00
473_V511_Y1.3601.00
94_K98_L1.3591.00
276_E371_V1.3591.00
539_K544_Y1.3541.00
200_L211_V1.3491.00
35_L244_K1.3461.00
561_R566_P1.3451.00
603_K665_E1.3431.00
76_E127_S1.3381.00
61_Y242_T1.3371.00
27_Y249_F1.3341.00
147_A281_G1.3321.00
597_V699_V1.3321.00
405_H408_L1.3311.00
144_V148_F1.3281.00
465_A503_L1.3271.00
537_E544_Y1.3271.00
147_A320_A1.3111.00
153_K361_L1.3091.00
181_R210_D1.3041.00
206_Y211_V1.3031.00
157_A356_L1.3021.00
338_Y627_Q1.3001.00
279_L318_V1.2971.00
523_R533_P1.2941.00
23_G217_F1.2871.00
545_H548_G1.2831.00
153_K357_G1.2791.00
273_F361_L1.2781.00
611_V617_A1.2741.00
351_E369_R1.2731.00
197_D208_V1.2721.00
136_Q326_L1.2691.00
595_G717_I1.2651.00
469_I503_L1.2611.00
61_Y238_L1.2581.00
203_L236_S1.2491.00
49_I104_V1.2481.00
361_L368_I1.2461.00
38_V99_A1.2441.00
413_E417_K1.2431.00
43_Q106_Y1.2431.00
267_L349_F1.2381.00
78_I82_Q1.2301.00
176_A185_V1.2281.00
404_Y585_M1.2281.00
176_A235_I1.2251.00
84_L104_V1.2241.00
238_L246_I1.2201.00
63_A74_K1.2191.00
183_L236_S1.2161.00
638_V647_T1.2141.00
57_G98_L1.2141.00
157_A360_A1.2141.00
183_L206_Y1.2131.00
46_H110_P1.2121.00
17_S22_K1.2121.00
418_G592_R1.2081.00
355_N365_Q1.2071.00
138_N322_K1.2051.00
176_A239_A1.2051.00
264_D289_D1.2031.00
373_I397_L1.1961.00
41_R254_E1.1951.00
148_F154_V1.1941.00
145_N283_E1.1941.00
605_F667_K1.1911.00
348_Y696_L1.1881.00
569_Q572_Y1.1881.00
38_V96_R1.1871.00
31_F175_V1.1871.00
260_N336_G1.1861.00
144_V147_A1.1841.00
440_R452_V1.1811.00
287_I326_L1.1750.99
400_A605_F1.1750.99
76_E109_L1.1740.99
356_L708_Y1.1720.99
588_V699_V1.1720.99
403_S665_E1.1710.99
146_S149_K1.1660.99
590_V597_V1.1660.99
167_S655_I1.1630.99
51_S103_E1.1620.99
48_K109_L1.1610.99
273_F368_I1.1600.99
508_S511_Y1.1590.99
570_Y574_I1.1540.99
621_V625_A1.1530.99
531_V545_H1.1510.99
38_V92_E1.1490.99
30_D34_T1.1470.99
597_V633_L1.1450.99
468_Q613_N1.1420.99
34_T175_V1.1410.99
16_P20_T1.1400.99
186_W214_V1.1390.99
46_H331_N1.1390.99
535_E546_K1.1370.99
516_R520_K1.1350.99
408_L411_R1.1280.99
404_Y407_L1.1280.99
418_G593_E1.1260.99
531_V535_E1.1250.99
528_K558_E1.1220.99
168_A255_E1.1210.99
126_K329_A1.1200.99
138_N324_K1.1190.99
535_E547_K1.1160.99
66_L237_Y1.1150.99
399_I605_F1.1120.99
62_T72_L1.1100.99
522_L538_Y1.1080.99
525_V555_T1.1050.99
221_A458_H1.1050.99
467_A478_V1.1040.99
159_I353_I1.0970.99
586_A695_I1.0950.99
396_A605_F1.0940.99
707_I712_T1.0910.99
568_E571_S1.0910.99
38_V95_A1.0880.99
57_G95_A1.0870.99
61_Y241_L1.0840.99
354_L368_I1.0840.99
271_A282_I1.0830.99
519_E523_R1.0780.99
58_A88_L1.0770.99
480_K541_G1.0740.99
586_A599_V1.0720.99
72_L234_I1.0720.99
178_F240_V1.0680.99
470_A514_S1.0680.99
395_E399_I1.0660.99
98_L101_Q1.0660.99
84_L106_Y1.0650.99
561_R564_V1.0650.99
515_I519_E1.0640.99
715_E719_K1.0630.99
405_H409_R1.0630.99
52_I104_V1.0610.99
413_E416_A1.0590.99
305_A325_V1.0560.99
452_V484_L1.0550.99
150_K280_L1.0540.99
115_V287_I1.0510.99
607_D671_L1.0500.99
47_A109_L1.0440.99
39_F86_V1.0430.99
77_A106_Y1.0410.99
419_K591_D1.0410.99
59_L242_T1.0390.99
640_S644_S1.0360.99
58_A94_K1.0340.99
712_T717_I1.0320.99
116_E158_E1.0300.99
119_L328_I1.0300.99
147_A272_A1.0290.99
144_V283_E1.0280.99
633_L695_I1.0260.99
450_Q484_L1.0220.99
524_V555_T1.0210.99
174_A235_I1.0160.98
272_A281_G1.0140.98
92_E96_R1.0140.98
273_F279_L1.0120.98
155_V360_A1.0110.98
639_Y645_L1.0100.98
196_K208_V1.0080.98
272_A280_L1.0070.98
33_G244_K1.0070.98
116_E160_I1.0050.98
629_I661_A1.0030.98
49_I84_L1.0030.98
366_F425_V1.0000.98
152_Y280_L0.9990.98
373_I394_R0.9970.98
35_L242_T0.9960.98
188_S225_K0.9950.98
419_K598_K0.9950.98
404_Y409_R0.9950.98
309_A323_V0.9910.98
421_A587_L0.9900.98
177_Y184_T0.9890.98
85_A102_V0.9850.98
54_C102_V0.9830.98
178_F239_A0.9830.98
451_V481_V0.9820.98
535_E545_H0.9790.98
464_T468_Q0.9780.98
155_V271_A0.9770.98
649_N652_D0.9770.98
87_V99_A0.9750.98
712_T716_L0.9750.98
46_H111_S0.9750.98
148_F283_E0.9740.98
287_I328_I0.9740.98
521_L555_T0.9730.98
155_V273_F0.9730.98
473_V514_S0.9700.98
538_Y543_F0.9690.98
165_I637_T0.9690.98
473_V518_K0.9680.98
530_G545_H0.9680.98
52_I102_V0.9670.98
634_Y660_E0.9660.98
150_K274_D0.9630.98
60_C85_A0.9630.98
166_P224_S0.9580.98
218_V458_H0.9580.98
206_Y240_V0.9540.98
119_L287_I0.9530.98
144_V320_A0.9530.98
144_V281_G0.9480.98
571_S574_I0.9480.98
37_A238_L0.9460.98
56_E98_L0.9450.98
177_Y239_A0.9410.98
55_P90_E0.9400.98
395_E669_L0.9390.97
263_R345_E0.9340.97
82_Q293_P0.9310.97
61_Y88_L0.9210.97
480_K553_A0.9200.97
537_E546_K0.9190.97
8_P618_E0.9150.97
206_Y210_D0.9150.97
512_E515_I0.9130.97
40_I85_A0.9130.97
85_A104_V0.9130.97
450_Q482_D0.9120.97
95_A99_A0.9110.97
235_I248_W0.9110.97
587_L601_E0.9080.97
604_A625_A0.9080.97
39_F83_P0.9060.97
521_L552_L0.9040.97
636_E716_L0.9020.97
47_A104_V0.9010.97
190_Q221_A0.9000.97
395_E398_K0.8980.97
355_N369_R0.8980.97
442_Q452_V0.8980.97
212_R489_D0.8960.97
588_V599_V0.8950.97
409_R412_D0.8940.97
253_T648_S0.8900.97
455_F502_T0.8900.97
265_M288_M0.8870.96
618_E622_H0.8860.96
366_F397_L0.8840.96
397_L425_V0.8830.96
628_G688_T0.8830.96
401_K405_H0.8820.96
618_E668_S0.8780.96
524_V559_A0.8780.96
470_A481_V0.8770.96
283_E324_K0.8750.96
403_S407_L0.8740.96
63_A75_E0.8740.96
421_A600_L0.8740.96
178_F181_R0.8730.96
461_G616_L0.8710.96
40_I104_V0.8700.96
316_Y369_R0.8700.96
115_V266_R0.8680.96
519_E533_P0.8680.96
316_Y351_E0.8670.96
17_S463_A0.8640.96
443_L552_L0.8640.96
226_I498_G0.8640.96
265_M308_A0.8630.96
36_Y247_K0.8620.96
147_A280_L0.8620.96
567_E572_Y0.8600.96
270_K322_K0.8570.96
94_K97_D0.8570.96
89_A98_L0.8550.96
468_Q614_P0.8540.96
542_K551_S0.8520.96
112_V118_A0.8520.96
49_I106_Y0.8520.96
154_V272_A0.8520.96
188_S218_V0.8510.96
637_T645_L0.8500.95
113_I643_G0.8490.95
420_L590_V0.8470.95
518_K538_Y0.8460.95
409_R413_E0.8460.95
54_C62_T0.8450.95
427_I583_I0.8410.95
569_Q574_I0.8400.95
18_L25_F0.8400.95
47_A77_A0.8390.95
645_L648_S0.8380.95
567_E571_S0.8350.95
211_V236_S0.8340.95
144_V322_K0.8340.95
608_V617_A0.8330.95
44_Y77_A0.8330.95
8_P615_L0.8330.95
460_Q497_T0.8320.95
41_R258_S0.8310.95
78_I293_P0.8270.95
159_I356_L0.8240.95
465_A616_L0.8230.95
469_I612_V0.8220.95
356_L706_N0.8200.95
476_V480_K0.8200.95
455_F462_D0.8190.94
544_Y549_E0.8170.94
17_S217_F0.8160.94
352_R696_L0.8120.94
172_R255_E0.8090.94
61_Y237_Y0.8090.94
561_R565_Y0.8050.94
151_A281_G0.8040.94
183_L240_V0.8030.94
156_E283_E0.8000.94
348_Y710_M0.7990.94
700_E706_N0.7990.94
277_G363_V0.7990.94
640_S646_I0.7980.94
273_F353_I0.7980.94
441_V470_A0.7970.94
449_I517_L0.7960.94
96_R251_T0.7960.94
443_L449_I0.7940.94
267_L284_G0.7940.94
179_D182_R0.7940.94
64_K74_K0.7930.93
63_A67_P0.7930.93
147_A151_A0.7930.93
73_A77_A0.7920.93
291_G334_F0.7890.93
353_I357_G0.7890.93
56_E90_E0.7890.93
65_D241_L0.7890.93
608_V683_I0.7890.93
348_Y352_R0.7860.93
567_E574_I0.7860.93
441_V517_L0.7860.93
159_I352_R0.7850.93
36_Y92_E0.7840.93
661_A664_V0.7840.93
203_L237_Y0.7830.93
397_L427_I0.7820.93
407_L410_K0.7820.93
52_I84_L0.7810.93
650_F655_I0.7800.93
5_I472_E0.7790.93
250_N255_E0.7780.93
181_R240_V0.7770.93
238_L242_T0.7760.93
465_A612_V0.7720.93
114_N266_R0.7720.93
269_F349_F0.7720.93
588_V597_V0.7710.93
398_K401_K0.7710.93
112_V331_N0.7700.92
313_V321_I0.7690.92
143_D320_A0.7680.92
555_T559_A0.7680.92
282_I318_V0.7680.92
470_A473_V0.7680.92
584_H690_A0.7670.92
159_I708_Y0.7670.92
92_E251_T0.7660.92
602_Y664_V0.7650.92
26_V29_I0.7650.92
546_K549_E0.7630.92
399_I403_S0.7630.92
280_L320_A0.7620.92
591_D596_F0.7620.92
292_A331_N0.7620.92
697_H706_N0.7620.92
189_T195_L0.7610.92
195_L199_L0.7610.92
187_S195_L0.7600.92
381_N387_Y0.7600.92
112_V123_K0.7590.92
363_V367_E0.7580.92
175_V247_K0.7580.92
392_K669_L0.7570.92
9_V467_A0.7570.92
602_Y691_S0.7570.92
148_F280_L0.7560.92
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355_N706_N0.5560.74
627_Q630_S0.5550.74
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35_L59_L0.5520.74
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373_I393_Y0.5400.72
437_G494_G0.5390.72
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309_A325_V0.5310.71
358_A363_V0.5310.71
124_K127_S0.5310.71
191_N194_G0.5310.71
203_L206_Y0.5300.71
6_G468_Q0.5300.71
280_L319_N0.5300.71
358_A368_I0.5290.70
164_V338_Y0.5290.70
354_L361_L0.5280.70
278_K319_N0.5280.70
39_F235_I0.5280.70
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340_G688_T0.5240.70
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370_E397_L0.5230.70
442_Q450_Q0.5220.69
382_T579_S0.5220.69
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307_T311_L0.5210.69
53_R105_E0.5210.69
148_F152_Y0.5210.69
707_I717_I0.5210.69
449_I475_D0.5210.69
458_H462_D0.5210.69
178_F211_V0.5200.69
621_V687_P0.5200.69
111_S331_N0.5200.69
186_W216_P0.5190.69
271_A354_L0.5180.69
431_I579_S0.5180.69
72_L83_P0.5170.69
606_D686_L0.5170.69
341_A499_G0.5170.69
221_A454_G0.5170.69
411_R415_R0.5170.69
63_A72_L0.5160.69
273_F360_A0.5160.69
35_L88_L0.5160.69
150_K320_A0.5160.69
666_W693_P0.5150.68
312_L323_V0.5150.68
392_K671_L0.5150.68
414_L417_K0.5150.68
78_I329_A0.5140.68
605_F669_L0.5140.68
360_A363_V0.5140.68
374_I378_S0.5140.68
118_A125_A0.5130.68
382_T388_Y0.5130.68
521_L556_A0.5130.68
175_V186_W0.5120.68
155_V361_L0.5110.68
388_Y581_Y0.5110.68
265_M345_E0.5110.68
557_R560_L0.5110.68
602_Y695_I0.5110.68
189_T215_Q0.5100.68
55_P94_K0.5100.68
457_P462_D0.5080.67
512_E570_Y0.5080.67
200_L206_Y0.5080.67
438_T492_S0.5080.67
64_K68_E0.5080.67
463_A483_V0.5070.67
526_G529_L0.5070.67
631_Q710_M0.5060.67
622_H664_V0.5060.67
300_D499_G0.5060.67
42_S94_K0.5060.67
525_V536_I0.5060.67
115_V328_I0.5050.67
475_D540_N0.5050.67
108_P642_E0.5050.67
199_L233_V0.5040.67
634_Y655_I0.5040.67
165_I261_H0.5030.67
463_A485_W0.5030.67
628_G632_A0.5030.67
599_V695_I0.5030.67
553_A556_A0.5030.67
276_E280_L0.5030.67
194_G226_I0.5030.67
141_I317_K0.5030.67
42_S84_L0.5020.66
469_I510_V0.5010.66
277_G371_V0.5010.66
14_E18_L0.5000.66
269_F354_L0.5000.66
455_F497_T0.5000.66
525_V543_F0.5000.66
690_A694_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3qB 2 0.9903 100 0.101 Contact Map
1rm6A 2 0.9793 100 0.103 Contact Map
1ffvB 2 0.9889 100 0.108 Contact Map
1n62B 2 0.9917 100 0.111 Contact Map
2w3sB 2 0.9765 100 0.128 Contact Map
3uncA 2 0.9516 100 0.142 Contact Map
3nvzC 2 0.9488 100 0.151 Contact Map
3zyvA 3 0.9502 100 0.154 Contact Map
4usaA 2 0.9516 100 0.156 Contact Map
1dgjA 1 0.9502 100 0.158 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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