Q97UK2 - SULSO - GREMLIN Contacts

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Q97UK2 - Carbon monoxide dehydrogenase, large chain (CutA-7)

UniProt:	Q97UK2	Sequences: MAREIGRPVKRIIEDPSLITGKGRFVYDIDFKGTLYAVFIRSQYSHAKIKSIRCPEGALCYTAKDLPELIGLAKEEAIYQGQPLAVVLAEDEYKARDLAEQVEVEYEPLPSVINVEEALKDVKKAKSDLSSNIVLQDNVEIGDVNSAFKKAYKVVEAEIINQRVIPSAMEPRGAVAYFDGRRLTVWSSTQNVFGLKDTLLQFLSKYGVNDVRVVQPFVGGAFGSKIYIYPEEVIISYLAVLTGKPIKWFNTRTEEFMSTNHGRDMRLKFKAAFDKEGKLLGIEGTLIMDLGAPIMEIYEDSFGMATTAARLLVGRYKVNAIKVKVLGIATNKTFIGPYRGAGRPEATYFIERILNLGARALGVDQFEIREVNIIDEVSHYNTPTGMYYDSGKYREALKIAKPSYHELLRKRDELRAKGKLAGVGVAIVSEIASFGTGTARVQLTPNGRIQVVSGFTPHGQGDATAFAQIAAEVFDVDVGKVDVLWGDTDLISHGGLTGGSTTLTVGGSAVYEASIRLKEKLLRVVGEKLGVRPEEIEYKNGKFYHKKGEMSLADTAREALRMGVYPEEQYSYTIRPYTSPYGIHMALVEVDRETGFVKVLEYKAFDDVGVVVNPLLAEGQVHGGALQGISQALYEETVYSPEGSLITSNFSDYVIPTAMEAVKVEWKSLALAKSDTPLGSKGIGELPTIASTPTILHAVEDAIGKNIYTMPTKPELILKLLNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	723 (700)
Sequences:	5511 (3643)
Seq/√Len:	137.7

ECOLI - XDHD XDHA YAGR
BACSU - XDHD
SULSO - Q97UK2 Q7LX54 Q97V74 Q97VI4 Q97TZ2 Q7LXA2 Q97YU6 Q97UR0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
156_E	270_K	4.289	1.00
40_I	102_V	4.257	1.00
35_L	58_A	4.033	1.00
91_D	94_K	3.944	1.00
370_E	398_K	3.697	1.00
44_Y	47_A	3.596	1.00
158_E	268_K	3.580	1.00
274_D	278_K	3.434	1.00
273_F	357_G	3.355	1.00
283_E	322_K	3.334	1.00
470_A	510_V	3.215	1.00
152_Y	274_D	3.202	1.00
152_Y	275_K	3.189	1.00
50_K	105_E	3.138	1.00
363_V	371_V	3.138	1.00
449_I	476_V	3.106	1.00
146_S	150_K	3.101	1.00
143_D	146_S	3.093	1.00
279_L	354_L	3.086	1.00
48_K	107_E	3.069	1.00
40_I	99_A	2.970	1.00
156_E	268_K	2.901	1.00
44_Y	108_P	2.845	1.00
403_S	406_E	2.842	1.00
473_V	515_I	2.836	1.00
58_A	90_E	2.821	1.00
285_T	324_K	2.805	1.00
47_A	106_Y	2.773	1.00
317_K	378_S	2.771	1.00
51_S	105_E	2.651	1.00
367_E	371_V	2.644	1.00
46_H	109_L	2.613	1.00
270_K	283_E	2.608	1.00
88_L	238_L	2.596	1.00
185_V	199_L	2.553	1.00
90_E	94_K	2.513	1.00
511_Y	515_I	2.510	1.00
601_E	665_E	2.479	1.00
37_A	248_W	2.406	1.00
184_T	214_V	2.390	1.00
696_L	712_T	2.372	1.00
709_T	716_L	2.338	1.00
90_E	244_K	2.337	1.00
116_E	266_R	2.333	1.00
278_K	371_V	2.332	1.00
50_K	107_E	2.326	1.00
182_R	489_D	2.313	1.00
699_V	712_T	2.303	1.00
148_F	272_A	2.274	1.00
363_V	368_I	2.242	1.00
177_Y	186_W	2.241	1.00
285_T	326_L	2.231	1.00
589_E	600_L	2.226	1.00
212_R	487_D	2.222	1.00
289_D	332_K	2.222	1.00
551_S	554_D	2.158	1.00
357_G	368_I	2.116	1.00
117_E	120_K	2.101	1.00
271_A	353_I	2.070	1.00
140_E	322_K	2.068	1.00
39_F	234_I	2.062	1.00
399_I	667_K	2.049	1.00
160_I	709_T	2.047	1.00
399_I	402_P	2.033	1.00
448_R	480_K	2.025	1.00
37_A	86_V	2.011	1.00
53_R	103_E	2.007	1.00
151_A	272_A	2.005	1.00
400_A	585_M	1.988	1.00
43_Q	84_L	1.986	1.00
367_E	370_E	1.976	1.00
278_K	317_K	1.954	1.00
586_A	694_T	1.945	1.00
370_E	401_K	1.942	1.00
625_A	664_V	1.940	1.00
443_L	517_L	1.939	1.00
441_V	451_V	1.921	1.00
626_L	661_A	1.918	1.00
518_K	522_L	1.912	1.00
54_C	60_C	1.905	1.00
48_K	75_E	1.892	1.00
27_Y	247_K	1.881	1.00
9_V	478_V	1.869	1.00
153_K	275_K	1.868	1.00
269_F	353_I	1.850	1.00
114_N	117_E	1.848	1.00
375_D	394_R	1.832	1.00
398_K	402_P	1.829	1.00
375_D	378_S	1.829	1.00
153_K	273_F	1.824	1.00
421_A	589_E	1.816	1.00
48_K	76_E	1.812	1.00
448_R	482_D	1.810	1.00
532_R	535_E	1.784	1.00
88_L	242_T	1.783	1.00
469_I	507_G	1.783	1.00
542_K	549_E	1.780	1.00
477_D	480_K	1.771	1.00
503_L	612_V	1.754	1.00
89_A	95_A	1.753	1.00
173_G	249_F	1.745	1.00
467_A	483_V	1.742	1.00
182_R	210_D	1.734	1.00
444_T	450_Q	1.730	1.00
597_V	717_I	1.726	1.00
366_F	401_K	1.725	1.00
444_T	448_R	1.723	1.00
37_A	246_I	1.714	1.00
44_Y	106_Y	1.696	1.00
274_D	280_L	1.692	1.00
58_A	244_K	1.676	1.00
617_A	683_I	1.676	1.00
31_F	34_T	1.673	1.00
10_K	615_L	1.672	1.00
151_A	280_L	1.657	1.00
359_R	700_E	1.639	1.00
392_K	395_E	1.634	1.00
158_E	266_R	1.630	1.00
168_A	224_S	1.628	1.00
418_G	591_D	1.627	1.00
167_S	650_F	1.627	1.00
86_V	238_L	1.617	1.00
59_L	241_L	1.602	1.00
449_I	474_F	1.602	1.00
419_K	589_E	1.601	1.00
610_V	670_A	1.599	1.00
145_N	322_K	1.596	1.00
57_G	89_A	1.587	1.00
140_E	143_D	1.572	1.00
271_A	279_L	1.571	1.00
271_A	357_G	1.567	1.00
608_V	611_V	1.565	1.00
584_H	602_Y	1.565	1.00
136_Q	324_K	1.561	1.00
602_Y	625_A	1.561	1.00
145_N	149_K	1.559	1.00
406_E	409_R	1.558	1.00
586_A	602_Y	1.555	1.00
713_K	716_L	1.554	1.00
268_K	285_T	1.550	1.00
611_V	668_S	1.542	1.00
148_F	270_K	1.536	1.00
394_R	398_K	1.525	1.00
473_V	678_L	1.524	1.00
451_V	470_A	1.522	1.00
86_V	234_I	1.519	1.00
99_A	102_V	1.507	1.00
441_V	514_S	1.503	1.00
370_E	394_R	1.494	1.00
46_H	76_E	1.493	1.00
617_A	668_S	1.490	1.00
26_V	173_G	1.488	1.00
153_K	360_A	1.485	1.00
184_T	212_R	1.472	1.00
420_L	592_R	1.461	1.00
536_I	543_F	1.461	1.00
97_D	101_Q	1.460	1.00
439_A	510_V	1.458	1.00
154_V	270_K	1.458	1.00
428_V	582_G	1.456	1.00
568_E	572_Y	1.453	1.00
64_K	75_E	1.450	1.00
601_E	663_K	1.448	1.00
31_F	177_Y	1.435	1.00
630_S	656_P	1.423	1.00
160_I	266_R	1.419	1.00
599_V	629_I	1.413	1.00
516_R	519_E	1.411	1.00
568_E	574_I	1.411	1.00
204_S	207_G	1.409	1.00
39_F	248_W	1.407	1.00
355_N	697_H	1.405	1.00
512_E	516_R	1.402	1.00
359_R	701_D	1.401	1.00
400_A	583_I	1.397	1.00
199_L	211_V	1.397	1.00
396_A	583_I	1.388	1.00
207_G	210_D	1.387	1.00
471_A	481_V	1.384	1.00
290_L	301_S	1.381	1.00
49_I	52_I	1.380	1.00
522_L	536_I	1.380	1.00
628_G	691_S	1.379	1.00
153_K	274_D	1.374	1.00
34_T	247_K	1.366	1.00
466_F	510_V	1.364	1.00
148_F	281_G	1.363	1.00
473_V	511_Y	1.360	1.00
94_K	98_L	1.359	1.00
276_E	371_V	1.359	1.00
539_K	544_Y	1.354	1.00
200_L	211_V	1.349	1.00
35_L	244_K	1.346	1.00
561_R	566_P	1.345	1.00
603_K	665_E	1.343	1.00
76_E	127_S	1.338	1.00
61_Y	242_T	1.337	1.00
27_Y	249_F	1.334	1.00
147_A	281_G	1.332	1.00
597_V	699_V	1.332	1.00
405_H	408_L	1.331	1.00
144_V	148_F	1.328	1.00
465_A	503_L	1.327	1.00
537_E	544_Y	1.327	1.00
147_A	320_A	1.311	1.00
153_K	361_L	1.309	1.00
181_R	210_D	1.304	1.00
206_Y	211_V	1.303	1.00
157_A	356_L	1.302	1.00
338_Y	627_Q	1.300	1.00
279_L	318_V	1.297	1.00
523_R	533_P	1.294	1.00
23_G	217_F	1.287	1.00
545_H	548_G	1.283	1.00
153_K	357_G	1.279	1.00
273_F	361_L	1.278	1.00
611_V	617_A	1.274	1.00
351_E	369_R	1.273	1.00
197_D	208_V	1.272	1.00
136_Q	326_L	1.269	1.00
595_G	717_I	1.265	1.00
469_I	503_L	1.261	1.00
61_Y	238_L	1.258	1.00
203_L	236_S	1.249	1.00
49_I	104_V	1.248	1.00
361_L	368_I	1.246	1.00
38_V	99_A	1.244	1.00
413_E	417_K	1.243	1.00
43_Q	106_Y	1.243	1.00
267_L	349_F	1.238	1.00
78_I	82_Q	1.230	1.00
176_A	185_V	1.228	1.00
404_Y	585_M	1.228	1.00
176_A	235_I	1.225	1.00
84_L	104_V	1.224	1.00
238_L	246_I	1.220	1.00
63_A	74_K	1.219	1.00
183_L	236_S	1.216	1.00
638_V	647_T	1.214	1.00
57_G	98_L	1.214	1.00
157_A	360_A	1.214	1.00
183_L	206_Y	1.213	1.00
46_H	110_P	1.212	1.00
17_S	22_K	1.212	1.00
418_G	592_R	1.208	1.00
355_N	365_Q	1.207	1.00
138_N	322_K	1.205	1.00
176_A	239_A	1.205	1.00
264_D	289_D	1.203	1.00
373_I	397_L	1.196	1.00
41_R	254_E	1.195	1.00
148_F	154_V	1.194	1.00
145_N	283_E	1.194	1.00
605_F	667_K	1.191	1.00
348_Y	696_L	1.188	1.00
569_Q	572_Y	1.188	1.00
38_V	96_R	1.187	1.00
31_F	175_V	1.187	1.00
260_N	336_G	1.186	1.00
144_V	147_A	1.184	1.00
440_R	452_V	1.181	1.00
287_I	326_L	1.175	0.99
400_A	605_F	1.175	0.99
76_E	109_L	1.174	0.99
356_L	708_Y	1.172	0.99
588_V	699_V	1.172	0.99
403_S	665_E	1.171	0.99
146_S	149_K	1.166	0.99
590_V	597_V	1.166	0.99
167_S	655_I	1.163	0.99
51_S	103_E	1.162	0.99
48_K	109_L	1.161	0.99
273_F	368_I	1.160	0.99
508_S	511_Y	1.159	0.99
570_Y	574_I	1.154	0.99
621_V	625_A	1.153	0.99
531_V	545_H	1.151	0.99
38_V	92_E	1.149	0.99
30_D	34_T	1.147	0.99
597_V	633_L	1.145	0.99
468_Q	613_N	1.142	0.99
34_T	175_V	1.141	0.99
16_P	20_T	1.140	0.99
186_W	214_V	1.139	0.99
46_H	331_N	1.139	0.99
535_E	546_K	1.137	0.99
516_R	520_K	1.135	0.99
408_L	411_R	1.128	0.99
404_Y	407_L	1.128	0.99
418_G	593_E	1.126	0.99
531_V	535_E	1.125	0.99
528_K	558_E	1.122	0.99
168_A	255_E	1.121	0.99
126_K	329_A	1.120	0.99
138_N	324_K	1.119	0.99
535_E	547_K	1.116	0.99
66_L	237_Y	1.115	0.99
399_I	605_F	1.112	0.99
62_T	72_L	1.110	0.99
522_L	538_Y	1.108	0.99
525_V	555_T	1.105	0.99
221_A	458_H	1.105	0.99
467_A	478_V	1.104	0.99
159_I	353_I	1.097	0.99
586_A	695_I	1.095	0.99
396_A	605_F	1.094	0.99
707_I	712_T	1.091	0.99
568_E	571_S	1.091	0.99
38_V	95_A	1.088	0.99
57_G	95_A	1.087	0.99
61_Y	241_L	1.084	0.99
354_L	368_I	1.084	0.99
271_A	282_I	1.083	0.99
519_E	523_R	1.078	0.99
58_A	88_L	1.077	0.99
480_K	541_G	1.074	0.99
586_A	599_V	1.072	0.99
72_L	234_I	1.072	0.99
178_F	240_V	1.068	0.99
470_A	514_S	1.068	0.99
395_E	399_I	1.066	0.99
98_L	101_Q	1.066	0.99
84_L	106_Y	1.065	0.99
561_R	564_V	1.065	0.99
515_I	519_E	1.064	0.99
715_E	719_K	1.063	0.99
405_H	409_R	1.063	0.99
52_I	104_V	1.061	0.99
413_E	416_A	1.059	0.99
305_A	325_V	1.056	0.99
452_V	484_L	1.055	0.99
150_K	280_L	1.054	0.99
115_V	287_I	1.051	0.99
607_D	671_L	1.050	0.99
47_A	109_L	1.044	0.99
39_F	86_V	1.043	0.99
77_A	106_Y	1.041	0.99
419_K	591_D	1.041	0.99
59_L	242_T	1.039	0.99
640_S	644_S	1.036	0.99
58_A	94_K	1.034	0.99
712_T	717_I	1.032	0.99
116_E	158_E	1.030	0.99
119_L	328_I	1.030	0.99
147_A	272_A	1.029	0.99
144_V	283_E	1.028	0.99
633_L	695_I	1.026	0.99
450_Q	484_L	1.022	0.99
524_V	555_T	1.021	0.99
174_A	235_I	1.016	0.98
272_A	281_G	1.014	0.98
92_E	96_R	1.014	0.98
273_F	279_L	1.012	0.98
155_V	360_A	1.011	0.98
639_Y	645_L	1.010	0.98
196_K	208_V	1.008	0.98
272_A	280_L	1.007	0.98
33_G	244_K	1.007	0.98
116_E	160_I	1.005	0.98
629_I	661_A	1.003	0.98
49_I	84_L	1.003	0.98
366_F	425_V	1.000	0.98
152_Y	280_L	0.999	0.98
373_I	394_R	0.997	0.98
35_L	242_T	0.996	0.98
188_S	225_K	0.995	0.98
419_K	598_K	0.995	0.98
404_Y	409_R	0.995	0.98
309_A	323_V	0.991	0.98
421_A	587_L	0.990	0.98
177_Y	184_T	0.989	0.98
85_A	102_V	0.985	0.98
54_C	102_V	0.983	0.98
178_F	239_A	0.983	0.98
451_V	481_V	0.982	0.98
535_E	545_H	0.979	0.98
464_T	468_Q	0.978	0.98
155_V	271_A	0.977	0.98
649_N	652_D	0.977	0.98
87_V	99_A	0.975	0.98
712_T	716_L	0.975	0.98
46_H	111_S	0.975	0.98
148_F	283_E	0.974	0.98
287_I	328_I	0.974	0.98
521_L	555_T	0.973	0.98
155_V	273_F	0.973	0.98
473_V	514_S	0.970	0.98
538_Y	543_F	0.969	0.98
165_I	637_T	0.969	0.98
473_V	518_K	0.968	0.98
530_G	545_H	0.968	0.98
52_I	102_V	0.967	0.98
634_Y	660_E	0.966	0.98
150_K	274_D	0.963	0.98
60_C	85_A	0.963	0.98
166_P	224_S	0.958	0.98
218_V	458_H	0.958	0.98
206_Y	240_V	0.954	0.98
119_L	287_I	0.953	0.98
144_V	320_A	0.953	0.98
144_V	281_G	0.948	0.98
571_S	574_I	0.948	0.98
37_A	238_L	0.946	0.98
56_E	98_L	0.945	0.98
177_Y	239_A	0.941	0.98
55_P	90_E	0.940	0.98
395_E	669_L	0.939	0.97
263_R	345_E	0.934	0.97
82_Q	293_P	0.931	0.97
61_Y	88_L	0.921	0.97
480_K	553_A	0.920	0.97
537_E	546_K	0.919	0.97
8_P	618_E	0.915	0.97
206_Y	210_D	0.915	0.97
512_E	515_I	0.913	0.97
40_I	85_A	0.913	0.97
85_A	104_V	0.913	0.97
450_Q	482_D	0.912	0.97
95_A	99_A	0.911	0.97
235_I	248_W	0.911	0.97
587_L	601_E	0.908	0.97
604_A	625_A	0.908	0.97
39_F	83_P	0.906	0.97
521_L	552_L	0.904	0.97
636_E	716_L	0.902	0.97
47_A	104_V	0.901	0.97
190_Q	221_A	0.900	0.97
395_E	398_K	0.898	0.97
355_N	369_R	0.898	0.97
442_Q	452_V	0.898	0.97
212_R	489_D	0.896	0.97
588_V	599_V	0.895	0.97
409_R	412_D	0.894	0.97
253_T	648_S	0.890	0.97
455_F	502_T	0.890	0.97
265_M	288_M	0.887	0.96
618_E	622_H	0.886	0.96
366_F	397_L	0.884	0.96
397_L	425_V	0.883	0.96
628_G	688_T	0.883	0.96
401_K	405_H	0.882	0.96
618_E	668_S	0.878	0.96
524_V	559_A	0.878	0.96
470_A	481_V	0.877	0.96
283_E	324_K	0.875	0.96
403_S	407_L	0.874	0.96
63_A	75_E	0.874	0.96
421_A	600_L	0.874	0.96
178_F	181_R	0.873	0.96
461_G	616_L	0.871	0.96
40_I	104_V	0.870	0.96
316_Y	369_R	0.870	0.96
115_V	266_R	0.868	0.96
519_E	533_P	0.868	0.96
316_Y	351_E	0.867	0.96
17_S	463_A	0.864	0.96
443_L	552_L	0.864	0.96
226_I	498_G	0.864	0.96
265_M	308_A	0.863	0.96
36_Y	247_K	0.862	0.96
147_A	280_L	0.862	0.96
567_E	572_Y	0.860	0.96
270_K	322_K	0.857	0.96
94_K	97_D	0.857	0.96
89_A	98_L	0.855	0.96
468_Q	614_P	0.854	0.96
542_K	551_S	0.852	0.96
112_V	118_A	0.852	0.96
49_I	106_Y	0.852	0.96
154_V	272_A	0.852	0.96
188_S	218_V	0.851	0.96
637_T	645_L	0.850	0.95
113_I	643_G	0.849	0.95
420_L	590_V	0.847	0.95
518_K	538_Y	0.846	0.95
409_R	413_E	0.846	0.95
54_C	62_T	0.845	0.95
427_I	583_I	0.841	0.95
569_Q	574_I	0.840	0.95
18_L	25_F	0.840	0.95
47_A	77_A	0.839	0.95
645_L	648_S	0.838	0.95
567_E	571_S	0.835	0.95
211_V	236_S	0.834	0.95
144_V	322_K	0.834	0.95
608_V	617_A	0.833	0.95
44_Y	77_A	0.833	0.95
8_P	615_L	0.833	0.95
460_Q	497_T	0.832	0.95
41_R	258_S	0.831	0.95
78_I	293_P	0.827	0.95
159_I	356_L	0.824	0.95
465_A	616_L	0.823	0.95
469_I	612_V	0.822	0.95
356_L	706_N	0.820	0.95
476_V	480_K	0.820	0.95
455_F	462_D	0.819	0.94
544_Y	549_E	0.817	0.94
17_S	217_F	0.816	0.94
352_R	696_L	0.812	0.94
172_R	255_E	0.809	0.94
61_Y	237_Y	0.809	0.94
561_R	565_Y	0.805	0.94
151_A	281_G	0.804	0.94
183_L	240_V	0.803	0.94
156_E	283_E	0.800	0.94
348_Y	710_M	0.799	0.94
700_E	706_N	0.799	0.94
277_G	363_V	0.799	0.94
640_S	646_I	0.798	0.94
273_F	353_I	0.798	0.94
441_V	470_A	0.797	0.94
449_I	517_L	0.796	0.94
96_R	251_T	0.796	0.94
443_L	449_I	0.794	0.94
267_L	284_G	0.794	0.94
179_D	182_R	0.794	0.94
64_K	74_K	0.793	0.93
63_A	67_P	0.793	0.93
147_A	151_A	0.793	0.93
73_A	77_A	0.792	0.93
291_G	334_F	0.789	0.93
353_I	357_G	0.789	0.93
56_E	90_E	0.789	0.93
65_D	241_L	0.789	0.93
608_V	683_I	0.789	0.93
348_Y	352_R	0.786	0.93
567_E	574_I	0.786	0.93
441_V	517_L	0.786	0.93
159_I	352_R	0.785	0.93
36_Y	92_E	0.784	0.93
661_A	664_V	0.784	0.93
203_L	237_Y	0.783	0.93
397_L	427_I	0.782	0.93
407_L	410_K	0.782	0.93
52_I	84_L	0.781	0.93
650_F	655_I	0.780	0.93
5_I	472_E	0.779	0.93
250_N	255_E	0.778	0.93
181_R	240_V	0.777	0.93
238_L	242_T	0.776	0.93
465_A	612_V	0.772	0.93
114_N	266_R	0.772	0.93
269_F	349_F	0.772	0.93
588_V	597_V	0.771	0.93
398_K	401_K	0.771	0.93
112_V	331_N	0.770	0.92
313_V	321_I	0.769	0.92
143_D	320_A	0.768	0.92
555_T	559_A	0.768	0.92
282_I	318_V	0.768	0.92
470_A	473_V	0.768	0.92
584_H	690_A	0.767	0.92
159_I	708_Y	0.767	0.92
92_E	251_T	0.766	0.92
602_Y	664_V	0.765	0.92
26_V	29_I	0.765	0.92
546_K	549_E	0.763	0.92
399_I	403_S	0.763	0.92
280_L	320_A	0.762	0.92
591_D	596_F	0.762	0.92
292_A	331_N	0.762	0.92
697_H	706_N	0.762	0.92
189_T	195_L	0.761	0.92
195_L	199_L	0.761	0.92
187_S	195_L	0.760	0.92
381_N	387_Y	0.760	0.92
112_V	123_K	0.759	0.92
363_V	367_E	0.758	0.92
175_V	247_K	0.758	0.92
392_K	669_L	0.757	0.92
9_V	467_A	0.757	0.92
602_Y	691_S	0.757	0.92
148_F	280_L	0.756	0.92
368_I	371_V	0.754	0.92
350_I	353_I	0.753	0.92
183_L	211_V	0.753	0.92
141_I	321_I	0.752	0.92
45_S	111_S	0.751	0.92
552_L	556_A	0.750	0.91
353_I	356_L	0.749	0.91
179_D	184_T	0.748	0.91
45_S	80_Q	0.748	0.91
676_T	680_S	0.746	0.91
113_I	117_E	0.746	0.91
29_I	186_W	0.745	0.91
192_V	488_T	0.745	0.91
521_L	543_F	0.744	0.91
543_F	555_T	0.743	0.91
93_Y	97_D	0.742	0.91
550_M	558_E	0.742	0.91
522_L	543_F	0.742	0.91
425_V	585_M	0.740	0.91
212_R	488_T	0.736	0.91
156_E	360_A	0.736	0.91
443_L	521_L	0.734	0.91
356_L	360_A	0.733	0.91
451_V	510_V	0.732	0.90
530_G	535_E	0.732	0.90
404_Y	423_V	0.732	0.90
49_I	77_A	0.732	0.90
193_F	488_T	0.731	0.90
57_G	60_C	0.730	0.90
603_K	667_K	0.730	0.90
472_E	610_V	0.730	0.90
446_N	482_D	0.730	0.90
538_Y	552_L	0.729	0.90
98_L	102_V	0.729	0.90
529_L	550_M	0.729	0.90
147_A	150_K	0.726	0.90
148_F	151_A	0.726	0.90
171_P	249_F	0.725	0.90
373_I	427_I	0.725	0.90
62_T	65_D	0.725	0.90
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432_A	578_T	0.722	0.90
279_L	368_I	0.722	0.90
545_H	549_E	0.721	0.90
514_S	517_L	0.721	0.90
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419_K	592_R	0.720	0.90
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178_F	183_L	0.718	0.90
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477_D	541_G	0.717	0.90
290_L	327_G	0.716	0.89
301_S	327_G	0.716	0.89
629_I	695_I	0.716	0.89
458_H	497_T	0.715	0.89
40_I	43_Q	0.715	0.89
606_D	621_V	0.715	0.89
402_P	407_L	0.715	0.89
539_K	547_K	0.713	0.89
401_K	585_M	0.713	0.89
588_V	698_A	0.710	0.89
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164_V	631_Q	0.705	0.89
347_T	693_P	0.703	0.89
573_T	576_P	0.703	0.89
517_L	568_E	0.703	0.89
554_D	557_R	0.703	0.89
622_H	666_W	0.702	0.89
5_I	468_Q	0.700	0.88
272_A	283_E	0.699	0.88
520_K	523_R	0.698	0.88
439_A	509_A	0.698	0.88
157_A	708_Y	0.698	0.88
116_E	287_I	0.698	0.88
688_T	692_T	0.697	0.88
242_T	246_I	0.697	0.88
80_Q	644_S	0.697	0.88
638_V	646_I	0.695	0.88
125_A	331_N	0.695	0.88
308_A	346_A	0.693	0.88
412_D	416_A	0.693	0.88
119_L	266_R	0.693	0.88
437_G	506_G	0.692	0.88
567_E	570_Y	0.691	0.88
362_G	365_Q	0.691	0.88
202_F	233_V	0.690	0.88
516_R	568_E	0.689	0.88
282_I	353_I	0.688	0.88
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407_L	587_L	0.685	0.87
525_V	529_L	0.684	0.87
140_E	144_V	0.684	0.87
484_L	490_L	0.684	0.87
700_E	703_I	0.681	0.87
24_R	29_I	0.680	0.87
240_V	243_G	0.680	0.87
97_D	100_E	0.680	0.87
271_A	368_I	0.679	0.87
562_M	565_Y	0.678	0.87
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187_S	232_E	0.676	0.87
621_V	666_W	0.676	0.87
422_G	432_A	0.676	0.87
160_I	264_D	0.675	0.87
519_E	522_L	0.675	0.87
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281_G	320_A	0.672	0.86
462_D	502_T	0.671	0.86
396_A	669_L	0.671	0.86
418_G	422_G	0.670	0.86
152_Y	278_K	0.670	0.86
116_E	120_K	0.668	0.86
416_A	421_A	0.668	0.86
84_L	102_V	0.668	0.86
531_V	536_I	0.667	0.86
373_I	391_G	0.666	0.86
42_S	80_Q	0.664	0.86
11_R	18_L	0.664	0.86
37_A	235_I	0.664	0.86
279_L	357_G	0.664	0.86
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508_S	676_T	0.662	0.85
422_G	426_A	0.660	0.85
497_T	502_T	0.660	0.85
288_M	327_G	0.659	0.85
251_T	254_E	0.659	0.85
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410_K	587_L	0.655	0.85
30_D	247_K	0.655	0.85
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282_I	350_I	0.653	0.85
119_L	326_L	0.652	0.85
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17_S	23_G	0.652	0.85
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88_L	246_I	0.643	0.84
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550_M	555_T	0.642	0.84
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321_I	383_P	0.638	0.83
110_P	117_E	0.638	0.83
161_N	265_M	0.638	0.83
56_E	94_K	0.638	0.83
318_V	321_I	0.638	0.83
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530_G	547_K	0.637	0.83
143_D	147_A	0.637	0.83
703_I	717_I	0.635	0.83
29_I	216_P	0.635	0.83
634_Y	654_V	0.634	0.83
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286_L	308_A	0.633	0.83
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422_G	431_I	0.633	0.83
590_V	699_V	0.632	0.83
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162_Q	264_D	0.631	0.83
112_V	125_A	0.631	0.83
77_A	80_Q	0.630	0.83
359_R	706_N	0.630	0.83
29_I	175_V	0.629	0.82
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255_E	259_T	0.629	0.82
159_I	349_F	0.629	0.82
585_M	603_K	0.628	0.82
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618_E	666_W	0.625	0.82
468_Q	478_V	0.625	0.82
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49_I	73_A	0.623	0.82
433_S	499_G	0.621	0.82
284_G	349_F	0.621	0.82
406_E	410_K	0.621	0.82
8_P	468_Q	0.621	0.82
33_G	245_P	0.621	0.82
352_R	700_E	0.620	0.82
274_D	371_V	0.620	0.82
167_S	637_T	0.619	0.81
352_R	706_N	0.619	0.81
317_K	375_D	0.619	0.81
466_F	506_G	0.618	0.81
426_A	694_T	0.618	0.81
161_N	348_Y	0.616	0.81
544_Y	547_K	0.615	0.81
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475_D	538_Y	0.614	0.81
288_M	305_A	0.614	0.81
610_V	672_A	0.614	0.81
176_A	246_I	0.614	0.81
510_V	514_S	0.613	0.81
18_L	217_F	0.613	0.81
523_R	527_E	0.612	0.81
161_N	631_Q	0.612	0.81
495_G	498_G	0.611	0.81
256_F	650_F	0.611	0.81
404_Y	603_K	0.610	0.81
20_T	23_G	0.610	0.81
147_A	152_Y	0.610	0.81
352_R	697_H	0.610	0.81
474_F	514_S	0.609	0.80
288_M	308_A	0.609	0.80
282_I	312_L	0.609	0.80
269_F	357_G	0.608	0.80
165_I	256_F	0.608	0.80
466_F	470_A	0.608	0.80
332_K	639_Y	0.608	0.80
466_F	483_V	0.607	0.80
30_D	175_V	0.607	0.80
305_A	327_G	0.606	0.80
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357_G	360_A	0.604	0.80
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503_L	680_S	0.603	0.80
54_C	64_K	0.602	0.80
599_V	602_Y	0.602	0.80
705_K	717_I	0.602	0.80
530_G	536_I	0.601	0.80
108_P	111_S	0.599	0.79
15_D	18_L	0.598	0.79
60_C	87_V	0.597	0.79
347_T	689_I	0.595	0.79
60_C	64_K	0.595	0.79
607_D	672_A	0.594	0.79
403_S	667_K	0.593	0.79
185_V	236_S	0.593	0.79
401_K	404_Y	0.591	0.78
457_P	463_A	0.591	0.78
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277_G	368_I	0.587	0.78
155_V	357_G	0.587	0.78
474_F	481_V	0.586	0.78
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416_A	419_K	0.585	0.78
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49_I	63_A	0.585	0.78
528_K	550_M	0.585	0.78
196_K	200_L	0.585	0.78
430_E	689_I	0.584	0.78
400_A	603_K	0.584	0.78
55_P	58_A	0.584	0.78
163_R	637_T	0.584	0.78
284_G	312_L	0.583	0.77
264_D	335_I	0.582	0.77
38_V	254_E	0.582	0.77
15_D	19_I	0.582	0.77
621_V	668_S	0.581	0.77
343_R	430_E	0.580	0.77
365_Q	697_H	0.580	0.77
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524_V	528_K	0.577	0.77
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595_G	718_L	0.576	0.77
522_L	526_G	0.575	0.77
536_I	545_H	0.575	0.77
414_L	418_G	0.575	0.77
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410_K	413_E	0.574	0.76
469_I	678_L	0.574	0.76
146_S	320_A	0.572	0.76
563_G	566_P	0.572	0.76
435_G	501_T	0.571	0.76
560_L	563_G	0.571	0.76
365_Q	408_L	0.571	0.76
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404_Y	408_L	0.571	0.76
414_L	421_A	0.570	0.76
552_L	566_P	0.570	0.76
211_V	642_E	0.569	0.76
466_F	469_I	0.569	0.76
52_I	62_T	0.569	0.76
43_Q	77_A	0.569	0.76
417_K	592_R	0.569	0.76
360_A	706_N	0.568	0.76
304_M	345_E	0.568	0.76
214_V	487_D	0.568	0.76
532_R	547_K	0.568	0.76
153_K	363_V	0.567	0.76
527_E	562_M	0.567	0.76
597_V	714_P	0.567	0.76
80_Q	645_L	0.566	0.75
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626_L	629_I	0.565	0.75
140_E	145_N	0.564	0.75
654_V	657_T	0.564	0.75
422_G	590_V	0.563	0.75
716_L	719_K	0.563	0.75
300_D	341_A	0.563	0.75
164_V	262_G	0.562	0.75
192_V	456_T	0.562	0.75
99_A	103_E	0.562	0.75
147_A	319_N	0.561	0.75
57_G	101_Q	0.561	0.75
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174_A	230_P	0.561	0.75
462_D	497_T	0.560	0.75
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136_Q	140_E	0.558	0.74
264_D	332_K	0.558	0.74
539_K	542_K	0.558	0.74
494_G	506_G	0.558	0.74
551_S	555_T	0.558	0.74
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294_I	329_A	0.557	0.74
439_A	453_S	0.557	0.74
270_K	285_T	0.557	0.74
357_G	363_V	0.557	0.74
365_Q	369_R	0.556	0.74
46_H	123_K	0.556	0.74
52_I	106_Y	0.556	0.74
355_N	706_N	0.556	0.74
627_Q	630_S	0.555	0.74
280_L	368_I	0.555	0.74
51_S	275_K	0.554	0.74
35_L	246_I	0.553	0.74
402_P	405_H	0.553	0.74
422_G	701_D	0.552	0.74
35_L	59_L	0.552	0.74
521_L	559_A	0.552	0.74
116_E	119_L	0.551	0.73
161_N	267_L	0.551	0.73
157_A	353_I	0.550	0.73
199_L	228_I	0.549	0.73
376_E	394_R	0.548	0.73
237_Y	242_T	0.548	0.73
5_I	612_V	0.548	0.73
65_D	68_E	0.547	0.73
9_V	464_T	0.547	0.73
364_D	405_H	0.546	0.73
14_E	217_F	0.546	0.73
629_I	634_Y	0.543	0.72
525_V	528_K	0.543	0.72
582_G	606_D	0.542	0.72
188_S	195_L	0.541	0.72
188_S	221_A	0.540	0.72
373_I	393_Y	0.540	0.72
437_G	494_G	0.539	0.72
152_Y	273_F	0.539	0.72
105_E	108_P	0.538	0.72
87_V	95_A	0.538	0.72
361_L	371_V	0.537	0.72
119_L	122_V	0.536	0.71
172_R	259_T	0.536	0.71
504_T	675_D	0.535	0.71
146_S	275_K	0.535	0.71
560_L	564_V	0.535	0.71
37_A	88_L	0.535	0.71
442_Q	567_E	0.534	0.71
584_H	604_A	0.534	0.71
39_F	88_L	0.533	0.71
167_S	255_E	0.532	0.71
290_L	335_I	0.532	0.71
526_G	533_P	0.532	0.71
529_L	536_I	0.532	0.71
401_K	407_L	0.531	0.71
309_A	325_V	0.531	0.71
358_A	363_V	0.531	0.71
124_K	127_S	0.531	0.71
191_N	194_G	0.531	0.71
203_L	206_Y	0.530	0.71
6_G	468_Q	0.530	0.71
280_L	319_N	0.530	0.71
358_A	368_I	0.529	0.70
164_V	338_Y	0.529	0.70
354_L	361_L	0.528	0.70
278_K	319_N	0.528	0.70
39_F	235_I	0.528	0.70
199_L	204_S	0.528	0.70
24_R	30_D	0.526	0.70
410_K	423_V	0.526	0.70
364_D	368_I	0.526	0.70
682_G	687_P	0.525	0.70
340_G	688_T	0.524	0.70
89_A	94_K	0.523	0.70
59_L	238_L	0.523	0.70
370_E	397_L	0.523	0.70
442_Q	450_Q	0.522	0.69
382_T	579_S	0.522	0.69
117_E	122_V	0.521	0.69
307_T	311_L	0.521	0.69
53_R	105_E	0.521	0.69
148_F	152_Y	0.521	0.69
707_I	717_I	0.521	0.69
449_I	475_D	0.521	0.69
458_H	462_D	0.521	0.69
178_F	211_V	0.520	0.69
621_V	687_P	0.520	0.69
111_S	331_N	0.520	0.69
186_W	216_P	0.519	0.69
271_A	354_L	0.518	0.69
431_I	579_S	0.518	0.69
72_L	83_P	0.517	0.69
606_D	686_L	0.517	0.69
341_A	499_G	0.517	0.69
221_A	454_G	0.517	0.69
411_R	415_R	0.517	0.69
63_A	72_L	0.516	0.69
273_F	360_A	0.516	0.69
35_L	88_L	0.516	0.69
150_K	320_A	0.516	0.69
666_W	693_P	0.515	0.68
312_L	323_V	0.515	0.68
392_K	671_L	0.515	0.68
414_L	417_K	0.515	0.68
78_I	329_A	0.514	0.68
605_F	669_L	0.514	0.68
360_A	363_V	0.514	0.68
374_I	378_S	0.514	0.68
118_A	125_A	0.513	0.68
382_T	388_Y	0.513	0.68
521_L	556_A	0.513	0.68
175_V	186_W	0.512	0.68
155_V	361_L	0.511	0.68
388_Y	581_Y	0.511	0.68
265_M	345_E	0.511	0.68
557_R	560_L	0.511	0.68
602_Y	695_I	0.511	0.68
189_T	215_Q	0.510	0.68
55_P	94_K	0.510	0.68
457_P	462_D	0.508	0.67
512_E	570_Y	0.508	0.67
200_L	206_Y	0.508	0.67
438_T	492_S	0.508	0.67
64_K	68_E	0.508	0.67
463_A	483_V	0.507	0.67
526_G	529_L	0.507	0.67
631_Q	710_M	0.506	0.67
622_H	664_V	0.506	0.67
300_D	499_G	0.506	0.67
42_S	94_K	0.506	0.67
525_V	536_I	0.506	0.67
115_V	328_I	0.505	0.67
475_D	540_N	0.505	0.67
108_P	642_E	0.505	0.67
199_L	233_V	0.504	0.67
634_Y	655_I	0.504	0.67
165_I	261_H	0.503	0.67
463_A	485_W	0.503	0.67
628_G	632_A	0.503	0.67
599_V	695_I	0.503	0.67
553_A	556_A	0.503	0.67
276_E	280_L	0.503	0.67
194_G	226_I	0.503	0.67
141_I	317_K	0.503	0.67
42_S	84_L	0.502	0.66
469_I	510_V	0.501	0.66
277_G	371_V	0.501	0.66
14_E	18_L	0.500	0.66
269_F	354_L	0.500	0.66
455_F	497_T	0.500	0.66
525_V	543_F	0.500	0.66
690_A	694_T	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1t3qB	2	0.9903	100	0.101	Contact Map
1rm6A	2	0.9793	100	0.103	Contact Map
1ffvB	2	0.9889	100	0.108	Contact Map
1n62B	2	0.9917	100	0.111	Contact Map
2w3sB	2	0.9765	100	0.128	Contact Map
3uncA	2	0.9516	100	0.142	Contact Map
3nvzC	2	0.9488	100	0.151	Contact Map
3zyvA	3	0.9502	100	0.154	Contact Map
4usaA	2	0.9516	100	0.156	Contact Map
1dgjA	1	0.9502	100	0.158	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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