GREMLIN Database
Q97UJ7 - Oxidoreductase
UniProt: Q97UJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (290)
Sequences: 24975 (15981)
Seq/√Len: 938.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_R322_E3.5751.00
46_K91_E3.5041.00
130_K170_L3.0921.00
94_K137_G2.9741.00
286_L336_Y2.9321.00
55_R59_E2.6501.00
285_E339_R2.6481.00
126_L168_N2.5991.00
333_R336_Y2.5531.00
129_I165_L2.5361.00
12_N19_K2.4391.00
105_T141_I2.2451.00
163_N167_N2.2031.00
145_F201_V2.1581.00
11_V22_Q2.1431.00
126_L164_S2.1171.00
84_N87_R2.1161.00
285_E336_Y2.0661.00
280_K284_S2.0651.00
140_Y172_Y2.0351.00
24_A63_F1.9831.00
45_D48_T1.9751.00
334_D338_K1.9691.00
97_D100_S1.9531.00
59_E322_E1.9201.00
164_S167_N1.9161.00
107_V125_I1.8771.00
145_F229_M1.8571.00
56_A61_V1.8511.00
122_R164_S1.8421.00
300_K337_M1.8201.00
59_E325_L1.8041.00
27_T64_I1.7971.00
103_I138_T1.7801.00
50_L92_F1.7681.00
129_I141_I1.7631.00
288_I330_I1.7611.00
129_I144_Y1.7541.00
104_S145_F1.7401.00
220_I224_F1.7371.00
122_R126_L1.7161.00
50_L95_T1.7071.00
281_D339_R1.7071.00
296_S330_I1.7011.00
278_G281_D1.6681.00
216_D219_I1.6381.00
326_S329_N1.6221.00
164_S168_N1.6191.00
107_V144_Y1.6001.00
289_T323_D1.5921.00
163_N197_E1.5831.00
53_L92_F1.5741.00
10_Y19_K1.5691.00
105_T132_S1.5641.00
338_K342_Q1.5621.00
185_M189_Q1.5541.00
161_T164_S1.5541.00
318_I322_E1.5531.00
55_R318_I1.5401.00
141_I171_V1.5321.00
127_W131_E1.5301.00
68_N128_Q1.5131.00
87_R135_R1.5061.00
222_K302_G1.5021.00
48_T51_K1.5001.00
50_L91_E1.4991.00
171_V174_L1.4961.00
288_I292_Q1.4961.00
46_K50_L1.4941.00
185_M223_R1.4831.00
18_V102_V1.4771.00
126_L161_T1.4621.00
50_L54_K1.4601.00
9_K22_Q1.4601.00
126_L130_K1.4571.00
64_I89_V1.4361.00
221_A228_I1.4311.00
57_Y101_V1.3761.00
180_S183_D1.3721.00
165_L171_V1.3701.00
289_T292_Q1.3621.00
301_R341_E1.3581.00
131_E135_R1.3541.00
149_P183_D1.3221.00
98_R138_T1.3211.00
131_E134_K1.3171.00
319_E322_E1.3011.00
87_R134_K1.2991.00
288_I293_L1.2951.00
146_I162_L1.2941.00
208_M340_I1.2931.00
339_R342_Q1.2891.00
52_I321_L1.2881.00
18_V173_Y1.2831.00
282_V293_L1.2801.00
12_N17_G1.2801.00
185_M220_I1.2721.00
62_N102_V1.2631.00
173_Y200_I1.2621.00
222_K303_E1.2581.00
181_A220_I1.2541.00
55_R58_D1.2531.00
143_V201_V1.2521.00
188_L224_F1.2471.00
90_G137_G1.2441.00
86_E132_S1.2311.00
204_E228_I1.2291.00
278_G339_R1.2261.00
91_E137_G1.2221.00
102_V143_V1.2181.00
98_R140_Y1.2161.00
54_K58_D1.2151.00
122_R160_R1.2121.00
298_L311_P1.2111.00
68_N124_H1.2081.00
162_L174_L1.2081.00
281_D285_E1.2031.00
188_L220_I1.1971.00
130_K168_N1.1881.00
205_K210_E1.1811.00
122_R157_E1.1671.00
322_E326_S1.1611.00
227_A310_I1.1521.00
51_K318_I1.1371.00
315_A321_L1.1351.00
21_S61_V1.1351.00
292_Q326_S1.1331.00
53_L64_I1.1301.00
54_K92_F1.1241.00
176_V199_F1.1181.00
63_F104_S1.1161.00
87_R91_E1.1111.00
292_Q323_D1.1071.00
47_E51_K1.1071.00
27_T89_V1.0961.00
280_K290_L1.0941.00
277_L280_K1.0911.00
54_K95_T1.0901.00
160_R164_S1.0861.00
93_L101_V1.0831.00
321_L325_L1.0811.00
296_S300_K1.0791.00
315_A320_H1.0781.00
9_K331_N1.0751.00
174_L199_F1.0611.00
123_K127_W1.0601.00
277_L281_D1.0561.00
156_L186_E1.0551.00
208_M294_A1.0541.00
22_Q299_L1.0511.00
27_T85_A1.0441.00
21_S62_N1.0371.00
130_K134_K1.0351.00
166_V197_E1.0331.00
51_K55_R1.0291.00
136_L141_I1.0281.00
227_A309_V1.0221.00
184_V226_L1.0141.00
16_S200_I1.0121.00
165_L170_L1.0111.00
48_T318_I1.0041.00
301_R337_M1.0031.00
63_F229_M0.9981.00
178_N231_Y0.9951.00
165_L168_N0.9941.00
219_I223_R0.9941.00
270_E274_R0.9941.00
293_L330_I0.9941.00
211_R214_E0.9941.00
218_A228_I0.9921.00
156_L190_L0.9901.00
126_L129_I0.9891.00
279_L290_L0.9871.00
201_V229_M0.9851.00
282_V286_L0.9781.00
281_D284_S0.9771.00
142_D172_Y0.9761.00
57_Y97_D0.9691.00
22_Q328_L0.9681.00
46_K84_N0.9681.00
110_K119_G0.9641.00
24_A313_I0.9551.00
335_D338_K0.9551.00
166_V200_I0.9531.00
59_E326_S0.9491.00
157_E160_R0.9431.00
244_V280_K0.9431.00
163_N166_V0.9421.00
213_I228_I0.9351.00
230_A311_P0.9251.00
126_L165_L0.9181.00
185_M224_F0.9171.00
148_W178_N0.9111.00
104_S143_V0.9101.00
155_K190_L0.9091.00
25_I56_A0.9081.00
186_E189_Q0.9021.00
133_L170_L0.8951.00
161_T165_L0.8921.00
52_I318_I0.8911.00
124_H127_W0.8851.00
299_L327_A0.8831.00
158_T161_T0.8761.00
53_L57_Y0.8761.00
319_E323_D0.8741.00
122_R161_T0.8731.00
160_R163_N0.8601.00
335_D339_R0.8571.00
61_V325_L0.8571.00
128_Q131_E0.8501.00
159_L174_L0.8491.00
233_P313_I0.8431.00
25_I30_L0.8411.00
206_Y301_R0.8371.00
159_L199_F0.8371.00
10_Y62_N0.8341.00
176_V184_V0.8281.00
300_K334_D0.8261.00
274_R277_L0.8221.00
99_E140_Y0.8221.00
323_D326_S0.8211.00
120_L146_I0.8211.00
338_K341_E0.8161.00
159_L187_F0.8151.00
214_E219_I0.8091.00
245_D277_L0.8071.00
317_K320_H0.8051.00
286_L333_R0.8041.00
221_A226_L0.7981.00
332_L337_M0.7981.00
155_K158_T0.7941.00
107_V120_L0.7881.00
181_A185_M0.7881.00
53_L89_V0.7861.00
30_L52_I0.7861.00
273_L277_L0.7851.00
162_L166_V0.7801.00
176_V179_H0.7761.00
244_V277_L0.7761.00
316_S320_H0.7741.00
206_Y211_R0.7681.00
23_V299_L0.7661.00
215_K219_I0.7661.00
20_V63_F0.7641.00
66_T89_V0.7611.00
274_R278_G0.7571.00
51_K54_K0.7541.00
286_L293_L0.7531.00
176_V202_M0.7501.00
186_E190_L0.7461.00
30_L49_T0.7461.00
68_N135_R0.7451.00
282_V339_R0.7441.00
238_F276_L0.7441.00
125_I165_L0.7431.00
166_V171_V0.7381.00
119_G124_H0.7351.00
273_L276_L0.7341.00
13_L227_A0.7341.00
54_K97_D0.7331.00
129_I161_T0.7301.00
16_S173_Y0.7281.00
279_L340_I0.7281.00
288_I296_S0.7231.00
83_G135_R0.7221.00
332_L336_Y0.7201.00
47_E50_L0.7191.00
209_L238_F0.7171.00
213_I218_A0.7121.00
266_R270_E0.7091.00
283_A293_L0.7081.00
293_L340_I0.7071.00
125_I158_T0.7071.00
86_E105_T0.7071.00
112_G117_G0.7051.00
24_A310_I0.7021.00
57_Y62_N0.6971.00
121_S124_H0.6971.00
282_V336_Y0.6941.00
202_M221_A0.6911.00
46_K88_I0.6911.00
84_N88_I0.6901.00
97_D101_V0.6881.00
276_L280_K0.6881.00
127_W130_K0.6881.00
66_T85_A0.6871.00
10_Y21_S0.6861.00
57_Y100_S0.6851.00
291_S323_D0.6841.00
188_L226_L0.6831.00
24_A312_L0.6831.00
285_E333_R0.6811.00
300_K331_N0.6801.00
286_L330_I0.6791.00
211_R341_E0.6781.00
15_E225_G0.6781.00
9_K329_N0.6771.00
296_S327_A0.6751.00
86_E135_R0.6751.00
186_E223_R0.6741.00
31_P85_A0.6731.00
284_S287_G0.6731.00
64_I93_L0.6701.00
206_Y214_E0.6701.00
320_H323_D0.6661.00
104_S229_M0.6621.00
217_K221_A0.6591.00
49_T88_I0.6591.00
28_W232_S0.6581.00
219_I222_K0.6581.00
230_A233_P0.6581.00
220_I223_R0.6571.00
50_L88_I0.6571.00
318_I321_L0.6561.00
65_D203_Q0.6561.00
218_A222_K0.6531.00
188_L198_K0.6501.00
149_P178_N0.6501.00
279_L294_A0.6471.00
92_F95_T0.6451.00
241_G244_V0.6441.00
288_I326_S0.6421.00
91_E95_T0.6411.00
163_N174_L0.6411.00
57_Y64_I0.6381.00
174_L197_E0.6361.00
233_P298_L0.6331.00
182_V185_M0.6311.00
141_I144_Y0.6281.00
53_L93_L0.6221.00
126_L170_L0.6211.00
145_F175_G0.6171.00
149_P179_H0.6161.00
213_I216_D0.6151.00
264_K267_Y0.6151.00
293_L336_Y0.6141.00
299_L311_P0.6131.00
120_L158_T0.6121.00
150_D153_T0.6101.00
245_D270_E0.6091.00
144_Y171_V0.6031.00
296_S331_N0.6021.00
295_I327_A0.6011.00
206_Y298_L0.6011.00
63_F102_V0.6001.00
185_M188_L0.5981.00
181_A216_D0.5971.00
143_V175_G0.5951.00
166_V174_L0.5951.00
293_L332_L0.5941.00
233_P295_I0.5931.00
179_H184_V0.5921.00
52_I315_A0.5901.00
124_H128_Q0.5901.00
168_N171_V0.5891.00
189_Q224_F0.5851.00
175_G201_V0.5841.00
265_K268_F0.5841.00
244_V247_N0.5841.00
44_V49_T0.5831.00
238_F272_N0.5821.00
125_I161_T0.5791.00
68_N131_E0.5791.00
93_L97_D0.5771.00
98_R142_D0.5771.00
240_T243_Y0.5771.00
204_E230_A0.5771.00
56_A64_I0.5771.00
229_M310_I0.5751.00
271_A274_R0.5751.00
295_I324_N0.5751.00
25_I52_I0.5741.00
106_K147_H0.5711.00
146_I158_T0.5711.00
71_H84_N0.5711.00
292_Q330_I0.5701.00
282_V285_E0.5681.00
67_A147_H0.5681.00
129_I133_L0.5671.00
86_E147_H0.5661.00
57_Y92_F0.5661.00
23_V328_L0.5661.00
105_T147_H0.5631.00
176_V187_F0.5631.00
130_K165_L0.5631.00
13_L16_S0.5621.00
315_A324_N0.5601.00
48_T319_E0.5591.00
213_I219_I0.5561.00
96_V101_V0.5541.00
132_S144_Y0.5521.00
59_E321_L0.5511.00
107_V128_Q0.5471.00
187_F199_F0.5461.00
294_A298_L0.5461.00
261_E264_K0.5451.00
129_I170_L0.5441.00
133_L139_S0.5431.00
109_G148_W0.5401.00
69_R109_G0.5371.00
151_P183_D0.5371.00
93_L103_I0.5361.00
133_L138_T0.5341.00
52_I316_S0.5321.00
44_V316_S0.5321.00
295_I313_I0.5321.00
21_S63_F0.5311.00
245_D273_L0.5301.00
199_F226_L0.5291.00
62_N100_S0.5281.00
326_S330_I0.5261.00
206_Y218_A0.5251.00
336_Y339_R0.5241.00
264_K268_F0.5221.00
213_I217_K0.5211.00
220_I226_L0.5201.00
166_V198_K0.5191.00
245_D274_R0.5181.00
104_S201_V0.5181.00
20_V102_V0.5181.00
55_R325_L0.5171.00
288_I329_N0.5171.00
183_D186_E0.5161.00
153_T158_T0.5131.00
182_V223_R0.5111.00
56_A321_L0.5111.00
167_N170_L0.5091.00
262_D265_K0.5091.00
87_R137_G0.5081.00
204_E217_K0.5051.00
24_A229_M0.5041.00
271_A275_I0.5031.00
242_K320_H0.5011.00
105_T144_Y0.5011.00
184_V217_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.8953 100 0.156 Contact Map
4xk2A 5 0.8488 100 0.157 Contact Map
1pz1A 1 0.8953 100 0.163 Contact Map
3erpA 6 0.8634 100 0.169 Contact Map
3n2tA 1 0.8953 100 0.169 Contact Map
3v0sA 1 0.782 100 0.173 Contact Map
1lqaA 2 0.9186 100 0.181 Contact Map
3n6qA 5 0.8663 100 0.183 Contact Map
3eauA 3 0.9012 100 0.186 Contact Map
3lutA 3 0.8983 100 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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