Q97UJ5 - SULSO - GREMLIN Contacts

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Q97UJ5 - Uncharacterized protein

UniProt:	Q97UJ5	Sequences: MKSYYMGYVDAHTHVWFKETLPKDFFSNDSGYEYTPPSVQEIIKEMDSVNIDYIVIIAYPSREIWRTKEDFPIAMIKFLKEYGNRFSIVGGIEPNRISLNEAKDWLERQYEAGVSGFKLHPVHSHVKPNAYREEEGGLKQLELLYEFAQDHNLPVVIHTGTSVFLKARNKYADPIFVDDVAVDFPQLKIVLAHMGRPNYVPTAFQLVRIRRNLYGEISSIPPKKLLEYLPRLEEISYKTIYGSDYGGPGIKSISYNLREFLSLNISEKAKLDMGSNNPKALYKPLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (247)
Sequences:	8617 (6310)
Seq/√Len:	401.5

SULSO - Q97UJ5 Q97YW2 Q7LX84 Q97XR6 Q97Z10

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_E	183_D	4.402	1.00
271_L	276_N	3.637	1.00
149_Q	186_Q	3.506	1.00
266_S	269_A	3.499	1.00
47_D	85_R	3.450	1.00
107_E	147_F	3.398	1.00
237_Y	272_D	3.172	1.00
147_F	150_D	2.812	1.00
142_E	184_F	2.807	1.00
110_Y	153_L	2.730	1.00
89_V	116_G	2.598	1.00
272_D	276_N	2.556	1.00
275_S	279_K	2.471	1.00
226_L	230_P	2.396	1.00
149_Q	184_F	2.213	1.00
88_I	114_V	2.206	1.00
236_S	269_A	2.203	1.00
105_W	108_R	2.187	1.00
272_D	280_A	2.124	1.00
236_S	272_D	2.106	1.00
73_I	108_R	2.079	1.00
107_E	151_H	2.041	1.00
147_F	151_H	1.989	1.00
90_G	109_Q	1.940	1.00
190_V	281_L	1.832	1.00
149_Q	187_L	1.821	1.00
214_Y	281_L	1.809	1.00
181_A	189_I	1.787	1.00
240_I	277_N	1.777	1.00
13_T	54_I	1.770	1.00
103_K	147_F	1.764	1.00
146_E	150_D	1.736	1.00
87_S	115_S	1.723	1.00
188_K	281_L	1.709	1.00
79_L	88_I	1.708	1.00
269_A	272_D	1.685	1.00
146_E	184_F	1.680	1.00
53_Y	87_S	1.680	1.00
44_K	48_S	1.647	1.00
271_L	275_S	1.628	1.00
152_N	188_K	1.622	1.00
77_K	81_E	1.608	1.00
267_E	271_L	1.601	1.00
182_V	210_R	1.582	1.00
110_Y	151_H	1.566	1.00
38_S	41_E	1.564	1.00
106_L	144_L	1.562	1.00
52_D	275_S	1.548	1.00
188_K	214_Y	1.542	1.00
130_A	140_Q	1.501	1.00
152_N	186_Q	1.487	1.00
261_L	270_K	1.484	1.00
142_E	146_E	1.479	1.00
200_V	204_F	1.470	1.00
76_I	80_K	1.456	1.00
96_R	101_E	1.454	1.00
276_N	279_K	1.440	1.00
240_I	281_L	1.432	1.00
272_D	277_N	1.428	1.00
90_G	114_V	1.406	1.00
89_V	282_Y	1.403	1.00
43_I	82_Y	1.395	1.00
126_V	140_Q	1.395	1.00
145_Y	180_V	1.368	1.00
143_L	146_E	1.356	1.00
267_E	270_K	1.351	1.00
258_R	261_L	1.346	1.00
69_E	105_W	1.342	1.00
214_Y	280_A	1.330	1.00
76_I	112_A	1.322	1.00
148_A	155_V	1.304	1.00
117_F	148_A	1.302	1.00
69_E	73_I	1.285	1.00
9_V	53_Y	1.280	1.00
200_V	203_A	1.271	1.00
108_R	111_E	1.265	1.00
11_A	240_I	1.262	1.00
199_Y	202_T	1.250	1.00
108_R	112_A	1.240	1.00
107_E	150_D	1.233	1.00
11_A	282_Y	1.225	1.00
228_Y	232_L	1.218	1.00
109_Q	114_V	1.206	1.00
41_E	44_K	1.200	1.00
43_I	47_D	1.191	1.00
106_L	151_H	1.183	1.00
221_P	224_K	1.177	1.00
75_M	88_I	1.164	1.00
199_Y	203_A	1.157	1.00
227_E	230_P	1.156	1.00
77_K	80_K	1.153	1.00
227_E	231_R	1.146	1.00
74_A	77_K	1.145	1.00
107_E	111_E	1.138	1.00
76_I	114_V	1.136	1.00
149_Q	152_N	1.135	1.00
56_I	86_F	1.132	1.00
181_A	213_L	1.129	1.00
146_E	149_Q	1.127	1.00
104_D	107_E	1.112	1.00
223_K	227_E	1.106	1.00
154_P	281_L	1.091	1.00
172_A	191_L	1.090	1.00
53_Y	279_K	1.089	1.00
139_K	142_E	1.087	1.00
40_Q	81_E	1.083	1.00
103_K	107_E	1.076	1.00
236_S	273_M	1.071	1.00
214_Y	238_K	1.064	1.00
105_W	109_Q	1.061	1.00
265_I	270_K	1.056	1.00
8_Y	274_G	1.056	1.00
255_Y	258_R	1.055	1.00
181_A	212_N	1.053	1.00
106_L	117_F	1.051	1.00
260_F	274_G	1.048	1.00
129_N	179_D	1.048	1.00
158_H	244_D	1.037	1.00
254_S	258_R	1.036	1.00
46_M	54_I	1.031	1.00
145_Y	155_V	1.027	1.00
268_K	272_D	1.027	1.00
257_L	261_L	1.023	1.00
197_P	201_P	1.023	1.00
9_V	279_K	1.018	1.00
9_V	278_P	1.016	1.00
179_D	182_V	1.016	1.00
145_Y	184_F	1.016	1.00
74_A	78_F	1.014	1.00
55_V	87_S	1.001	1.00
92_I	102_A	0.995	1.00
253_I	256_N	0.992	1.00
270_K	274_G	0.992	1.00
126_V	130_A	0.990	1.00
278_P	282_Y	0.982	1.00
109_Q	112_A	0.974	1.00
45_E	48_S	0.965	1.00
266_S	270_K	0.963	1.00
42_I	54_I	0.958	1.00
265_I	269_A	0.953	1.00
202_T	206_L	0.952	1.00
190_V	240_I	0.952	1.00
258_R	262_S	0.951	1.00
141_L	145_Y	0.943	1.00
156_V	192_A	0.937	1.00
252_S	256_N	0.936	1.00
215_G	232_L	0.931	1.00
106_L	148_A	0.924	1.00
240_I	278_P	0.922	1.00
223_K	226_L	0.920	1.00
145_Y	187_L	0.919	1.00
11_A	278_P	0.916	1.00
222_P	226_L	0.916	1.00
43_I	85_R	0.911	1.00
17_F	20_T	0.909	1.00
252_S	255_Y	0.907	1.00
54_I	86_F	0.906	1.00
221_P	225_L	0.905	1.00
214_Y	277_N	0.899	1.00
192_A	216_E	0.895	1.00
8_Y	261_L	0.886	1.00
8_Y	51_I	0.884	1.00
224_K	228_Y	0.881	1.00
18_K	36_P	0.881	1.00
79_L	114_V	0.880	1.00
48_S	254_S	0.878	1.00
201_P	205_Q	0.876	1.00
179_D	183_D	0.876	1.00
199_Y	204_F	0.873	1.00
251_K	256_N	0.871	1.00
103_K	143_L	0.865	1.00
154_P	190_V	0.858	1.00
156_V	282_Y	0.854	1.00
89_V	156_V	0.845	1.00
101_E	104_D	0.845	1.00
237_Y	280_A	0.843	1.00
188_K	280_A	0.843	1.00
232_L	235_I	0.840	1.00
43_I	46_M	0.839	1.00
106_L	147_F	0.837	1.00
117_F	155_V	0.830	1.00
83_G	86_F	0.829	1.00
73_I	77_K	0.825	1.00
69_E	108_R	0.823	1.00
142_E	145_Y	0.818	1.00
11_A	190_V	0.816	1.00
143_L	147_F	0.813	1.00
276_N	280_A	0.813	1.00
205_Q	209_I	0.812	1.00
18_K	22_P	0.808	1.00
97_I	103_K	0.808	1.00
268_K	276_N	0.806	1.00
40_Q	44_K	0.804	1.00
37_P	45_E	0.803	1.00
56_I	75_M	0.803	1.00
39_V	81_E	0.798	1.00
224_K	227_E	0.797	1.00
256_N	259_E	0.793	1.00
202_T	205_Q	0.791	1.00
10_D	243_S	0.789	1.00
30_S	33_E	0.788	1.00
44_K	47_D	0.783	1.00
225_L	228_Y	0.775	1.00
9_V	275_S	0.771	1.00
13_T	42_I	0.771	1.00
191_L	213_L	0.767	1.00
172_A	213_L	0.763	1.00
103_K	150_D	0.761	1.00
46_M	51_I	0.755	1.00
94_P	144_L	0.752	1.00
275_S	278_P	0.751	1.00
178_D	182_V	0.747	1.00
90_G	117_F	0.746	1.00
241_Y	274_G	0.732	1.00
264_N	270_K	0.731	1.00
79_L	86_F	0.730	1.00
140_Q	143_L	0.727	1.00
158_H	196_R	0.727	1.00
12_H	216_E	0.724	1.00
12_H	193_H	0.723	1.00
53_Y	86_F	0.721	1.00
239_T	273_M	0.718	1.00
201_P	204_F	0.716	1.00
178_D	209_I	0.706	1.00
55_V	282_Y	0.705	1.00
156_V	190_V	0.703	1.00
226_L	229_L	0.702	1.00
117_F	153_L	0.701	1.00
49_V	254_S	0.700	1.00
17_F	36_P	0.698	1.00
39_V	43_I	0.696	1.00
73_I	105_W	0.695	1.00
261_L	274_G	0.693	1.00
177_V	191_L	0.689	1.00
236_S	277_N	0.689	1.00
70_D	73_I	0.688	1.00
215_G	239_T	0.688	1.00
119_L	155_V	0.684	1.00
15_V	75_M	0.683	0.99
265_I	273_M	0.683	0.99
72_P	76_I	0.679	0.99
53_Y	84_N	0.679	0.99
55_V	89_V	0.676	0.99
178_D	210_R	0.672	0.99
39_V	78_F	0.670	0.99
139_K	183_D	0.669	0.99
188_K	212_N	0.668	0.99
17_F	22_P	0.668	0.99
216_E	242_G	0.667	0.99
20_T	23_K	0.666	0.99
107_E	110_Y	0.665	0.99
188_K	238_K	0.659	0.99
8_Y	275_S	0.659	0.99
224_K	232_L	0.659	0.99
92_I	144_L	0.659	0.99
144_L	148_A	0.656	0.99
235_I	238_K	0.656	0.99
159_T	195_G	0.655	0.99
80_K	112_A	0.653	0.99
12_H	192_A	0.652	0.99
142_E	180_V	0.651	0.99
102_A	144_L	0.650	0.99
255_Y	259_E	0.648	0.99
197_P	206_L	0.648	0.99
92_I	96_R	0.646	0.99
277_N	280_A	0.645	0.99
235_I	269_A	0.643	0.99
93_E	105_W	0.642	0.99
272_D	275_S	0.641	0.99
175_I	181_A	0.641	0.99
197_P	202_T	0.641	0.99
201_P	206_L	0.641	0.99
116_G	156_V	0.640	0.99
227_E	232_L	0.637	0.99
203_A	206_L	0.633	0.99
217_I	239_T	0.631	0.99
127_K	130_A	0.630	0.99
97_I	102_A	0.630	0.99
181_A	210_R	0.629	0.99
194_M	232_L	0.627	0.99
162_S	173_D	0.627	0.99
46_M	85_R	0.626	0.99
217_I	273_M	0.621	0.99
194_M	228_Y	0.621	0.99
75_M	79_L	0.618	0.99
193_H	244_D	0.617	0.99
76_I	111_E	0.616	0.99
222_P	228_Y	0.615	0.99
15_V	39_V	0.614	0.99
148_A	151_H	0.612	0.99
199_Y	207_V	0.612	0.99
106_L	110_Y	0.609	0.99
35_T	41_E	0.607	0.99
118_K	193_H	0.602	0.99
42_I	253_I	0.601	0.99
71_F	74_A	0.600	0.99
194_M	220_I	0.598	0.99
253_I	257_L	0.597	0.99
222_P	262_S	0.593	0.99
229_L	239_T	0.590	0.99
97_I	101_E	0.589	0.99
171_Y	174_P	0.586	0.98
203_A	207_V	0.586	0.98
259_E	262_S	0.583	0.98
218_S	242_G	0.581	0.98
197_P	203_A	0.579	0.98
229_L	235_I	0.579	0.98
57_I	156_V	0.578	0.98
14_H	158_H	0.578	0.98
72_P	88_I	0.576	0.98
110_Y	147_F	0.574	0.98
178_D	206_L	0.571	0.98
10_D	13_T	0.568	0.98
260_F	263_L	0.567	0.98
204_F	208_R	0.567	0.98
175_I	179_D	0.565	0.98
256_N	260_F	0.561	0.98
46_M	86_F	0.561	0.98
199_Y	206_L	0.560	0.98
41_E	45_E	0.558	0.98
82_Y	85_R	0.557	0.98
57_I	89_V	0.552	0.98
190_V	282_Y	0.546	0.98
72_P	105_W	0.545	0.98
9_V	55_V	0.544	0.98
154_P	188_K	0.542	0.97
110_Y	115_S	0.542	0.97
150_D	186_Q	0.541	0.97
11_A	55_V	0.538	0.97
215_G	218_S	0.538	0.97
277_N	281_L	0.537	0.97
221_P	232_L	0.534	0.97
19_E	70_D	0.534	0.97
200_V	206_L	0.533	0.97
226_L	264_N	0.533	0.97
200_V	207_V	0.532	0.97
156_V	216_E	0.530	0.97
45_E	245_Y	0.529	0.97
222_P	227_E	0.526	0.97
92_I	117_F	0.526	0.97
40_Q	82_Y	0.525	0.97
257_L	274_G	0.524	0.97
157_I	189_I	0.523	0.97
82_Y	86_F	0.521	0.97
178_D	181_A	0.521	0.97
49_V	257_L	0.520	0.97
159_T	177_V	0.518	0.97
241_Y	257_L	0.517	0.97
118_K	192_A	0.516	0.97
202_T	207_V	0.516	0.97
154_P	282_Y	0.515	0.97
260_F	270_K	0.512	0.96
31_G	34_Y	0.512	0.96
206_L	210_R	0.512	0.96
148_A	153_L	0.511	0.96
89_V	190_V	0.510	0.96
73_I	112_A	0.510	0.96
211_R	216_E	0.510	0.96
211_R	217_I	0.510	0.96
184_F	187_L	0.509	0.96
229_L	236_S	0.508	0.96
126_V	141_L	0.508	0.96
19_E	23_K	0.507	0.96
55_V	116_G	0.504	0.96
14_H	244_D	0.504	0.96
90_G	106_L	0.504	0.96
264_N	273_M	0.502	0.96
45_E	49_V	0.501	0.96
229_L	232_L	0.501	0.96
103_K	109_Q	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hbvA	3	0.9231	100	0.332	Contact Map
4lanA	2	0.9371	100	0.343	Contact Map
3irsA	3	0.9091	100	0.346	Contact Map
4dziA	2	0.9336	100	0.348	Contact Map
4ofcA	4	0.9301	100	0.349	Contact Map
2f6kA	4	0.9301	100	0.35	Contact Map
2gwgA	2	0.9301	100	0.351	Contact Map
4qrnA	2	0.9301	100	0.351	Contact Map
3nurA	2	0.8846	100	0.359	Contact Map
4l6dA	4	0.9266	100	0.359	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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