GREMLIN Database
Q97UJ5 - Uncharacterized protein
UniProt: Q97UJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (247)
Sequences: 8617 (6310)
Seq/√Len: 401.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_E183_D4.4021.00
271_L276_N3.6371.00
149_Q186_Q3.5061.00
266_S269_A3.4991.00
47_D85_R3.4501.00
107_E147_F3.3981.00
237_Y272_D3.1721.00
147_F150_D2.8121.00
142_E184_F2.8071.00
110_Y153_L2.7301.00
89_V116_G2.5981.00
272_D276_N2.5561.00
275_S279_K2.4711.00
226_L230_P2.3961.00
149_Q184_F2.2131.00
88_I114_V2.2061.00
236_S269_A2.2031.00
105_W108_R2.1871.00
272_D280_A2.1241.00
236_S272_D2.1061.00
73_I108_R2.0791.00
107_E151_H2.0411.00
147_F151_H1.9891.00
90_G109_Q1.9401.00
190_V281_L1.8321.00
149_Q187_L1.8211.00
214_Y281_L1.8091.00
181_A189_I1.7871.00
240_I277_N1.7771.00
13_T54_I1.7701.00
103_K147_F1.7641.00
146_E150_D1.7361.00
87_S115_S1.7231.00
188_K281_L1.7091.00
79_L88_I1.7081.00
269_A272_D1.6851.00
146_E184_F1.6801.00
53_Y87_S1.6801.00
44_K48_S1.6471.00
271_L275_S1.6281.00
152_N188_K1.6221.00
77_K81_E1.6081.00
267_E271_L1.6011.00
182_V210_R1.5821.00
110_Y151_H1.5661.00
38_S41_E1.5641.00
106_L144_L1.5621.00
52_D275_S1.5481.00
188_K214_Y1.5421.00
130_A140_Q1.5011.00
152_N186_Q1.4871.00
261_L270_K1.4841.00
142_E146_E1.4791.00
200_V204_F1.4701.00
76_I80_K1.4561.00
96_R101_E1.4541.00
276_N279_K1.4401.00
240_I281_L1.4321.00
272_D277_N1.4281.00
90_G114_V1.4061.00
89_V282_Y1.4031.00
43_I82_Y1.3951.00
126_V140_Q1.3951.00
145_Y180_V1.3681.00
143_L146_E1.3561.00
267_E270_K1.3511.00
258_R261_L1.3461.00
69_E105_W1.3421.00
214_Y280_A1.3301.00
76_I112_A1.3221.00
148_A155_V1.3041.00
117_F148_A1.3021.00
69_E73_I1.2851.00
9_V53_Y1.2801.00
200_V203_A1.2711.00
108_R111_E1.2651.00
11_A240_I1.2621.00
199_Y202_T1.2501.00
108_R112_A1.2401.00
107_E150_D1.2331.00
11_A282_Y1.2251.00
228_Y232_L1.2181.00
109_Q114_V1.2061.00
41_E44_K1.2001.00
43_I47_D1.1911.00
106_L151_H1.1831.00
221_P224_K1.1771.00
75_M88_I1.1641.00
199_Y203_A1.1571.00
227_E230_P1.1561.00
77_K80_K1.1531.00
227_E231_R1.1461.00
74_A77_K1.1451.00
107_E111_E1.1381.00
76_I114_V1.1361.00
149_Q152_N1.1351.00
56_I86_F1.1321.00
181_A213_L1.1291.00
146_E149_Q1.1271.00
104_D107_E1.1121.00
223_K227_E1.1061.00
154_P281_L1.0911.00
172_A191_L1.0901.00
53_Y279_K1.0891.00
139_K142_E1.0871.00
40_Q81_E1.0831.00
103_K107_E1.0761.00
236_S273_M1.0711.00
214_Y238_K1.0641.00
105_W109_Q1.0611.00
265_I270_K1.0561.00
8_Y274_G1.0561.00
255_Y258_R1.0551.00
181_A212_N1.0531.00
106_L117_F1.0511.00
260_F274_G1.0481.00
129_N179_D1.0481.00
158_H244_D1.0371.00
254_S258_R1.0361.00
46_M54_I1.0311.00
145_Y155_V1.0271.00
268_K272_D1.0271.00
257_L261_L1.0231.00
197_P201_P1.0231.00
9_V279_K1.0181.00
9_V278_P1.0161.00
179_D182_V1.0161.00
145_Y184_F1.0161.00
74_A78_F1.0141.00
55_V87_S1.0011.00
92_I102_A0.9951.00
253_I256_N0.9921.00
270_K274_G0.9921.00
126_V130_A0.9901.00
278_P282_Y0.9821.00
109_Q112_A0.9741.00
45_E48_S0.9651.00
266_S270_K0.9631.00
42_I54_I0.9581.00
265_I269_A0.9531.00
202_T206_L0.9521.00
190_V240_I0.9521.00
258_R262_S0.9511.00
141_L145_Y0.9431.00
156_V192_A0.9371.00
252_S256_N0.9361.00
215_G232_L0.9311.00
106_L148_A0.9241.00
240_I278_P0.9221.00
223_K226_L0.9201.00
145_Y187_L0.9191.00
11_A278_P0.9161.00
222_P226_L0.9161.00
43_I85_R0.9111.00
17_F20_T0.9091.00
252_S255_Y0.9071.00
54_I86_F0.9061.00
221_P225_L0.9051.00
214_Y277_N0.8991.00
192_A216_E0.8951.00
8_Y261_L0.8861.00
8_Y51_I0.8841.00
224_K228_Y0.8811.00
18_K36_P0.8811.00
79_L114_V0.8801.00
48_S254_S0.8781.00
201_P205_Q0.8761.00
179_D183_D0.8761.00
199_Y204_F0.8731.00
251_K256_N0.8711.00
103_K143_L0.8651.00
154_P190_V0.8581.00
156_V282_Y0.8541.00
89_V156_V0.8451.00
101_E104_D0.8451.00
237_Y280_A0.8431.00
188_K280_A0.8431.00
232_L235_I0.8401.00
43_I46_M0.8391.00
106_L147_F0.8371.00
117_F155_V0.8301.00
83_G86_F0.8291.00
73_I77_K0.8251.00
69_E108_R0.8231.00
142_E145_Y0.8181.00
11_A190_V0.8161.00
143_L147_F0.8131.00
276_N280_A0.8131.00
205_Q209_I0.8121.00
18_K22_P0.8081.00
97_I103_K0.8081.00
268_K276_N0.8061.00
40_Q44_K0.8041.00
37_P45_E0.8031.00
56_I75_M0.8031.00
39_V81_E0.7981.00
224_K227_E0.7971.00
256_N259_E0.7931.00
202_T205_Q0.7911.00
10_D243_S0.7891.00
30_S33_E0.7881.00
44_K47_D0.7831.00
225_L228_Y0.7751.00
9_V275_S0.7711.00
13_T42_I0.7711.00
191_L213_L0.7671.00
172_A213_L0.7631.00
103_K150_D0.7611.00
46_M51_I0.7551.00
94_P144_L0.7521.00
275_S278_P0.7511.00
178_D182_V0.7471.00
90_G117_F0.7461.00
241_Y274_G0.7321.00
264_N270_K0.7311.00
79_L86_F0.7301.00
140_Q143_L0.7271.00
158_H196_R0.7271.00
12_H216_E0.7241.00
12_H193_H0.7231.00
53_Y86_F0.7211.00
239_T273_M0.7181.00
201_P204_F0.7161.00
178_D209_I0.7061.00
55_V282_Y0.7051.00
156_V190_V0.7031.00
226_L229_L0.7021.00
117_F153_L0.7011.00
49_V254_S0.7001.00
17_F36_P0.6981.00
39_V43_I0.6961.00
73_I105_W0.6951.00
261_L274_G0.6931.00
177_V191_L0.6891.00
236_S277_N0.6891.00
70_D73_I0.6881.00
215_G239_T0.6881.00
119_L155_V0.6841.00
15_V75_M0.6830.99
265_I273_M0.6830.99
72_P76_I0.6790.99
53_Y84_N0.6790.99
55_V89_V0.6760.99
178_D210_R0.6720.99
39_V78_F0.6700.99
139_K183_D0.6690.99
188_K212_N0.6680.99
17_F22_P0.6680.99
216_E242_G0.6670.99
20_T23_K0.6660.99
107_E110_Y0.6650.99
188_K238_K0.6590.99
8_Y275_S0.6590.99
224_K232_L0.6590.99
92_I144_L0.6590.99
144_L148_A0.6560.99
235_I238_K0.6560.99
159_T195_G0.6550.99
80_K112_A0.6530.99
12_H192_A0.6520.99
142_E180_V0.6510.99
102_A144_L0.6500.99
255_Y259_E0.6480.99
197_P206_L0.6480.99
92_I96_R0.6460.99
277_N280_A0.6450.99
235_I269_A0.6430.99
93_E105_W0.6420.99
272_D275_S0.6410.99
175_I181_A0.6410.99
197_P202_T0.6410.99
201_P206_L0.6410.99
116_G156_V0.6400.99
227_E232_L0.6370.99
203_A206_L0.6330.99
217_I239_T0.6310.99
127_K130_A0.6300.99
97_I102_A0.6300.99
181_A210_R0.6290.99
194_M232_L0.6270.99
162_S173_D0.6270.99
46_M85_R0.6260.99
217_I273_M0.6210.99
194_M228_Y0.6210.99
75_M79_L0.6180.99
193_H244_D0.6170.99
76_I111_E0.6160.99
222_P228_Y0.6150.99
15_V39_V0.6140.99
148_A151_H0.6120.99
199_Y207_V0.6120.99
106_L110_Y0.6090.99
35_T41_E0.6070.99
118_K193_H0.6020.99
42_I253_I0.6010.99
71_F74_A0.6000.99
194_M220_I0.5980.99
253_I257_L0.5970.99
222_P262_S0.5930.99
229_L239_T0.5900.99
97_I101_E0.5890.99
171_Y174_P0.5860.98
203_A207_V0.5860.98
259_E262_S0.5830.98
218_S242_G0.5810.98
197_P203_A0.5790.98
229_L235_I0.5790.98
57_I156_V0.5780.98
14_H158_H0.5780.98
72_P88_I0.5760.98
110_Y147_F0.5740.98
178_D206_L0.5710.98
10_D13_T0.5680.98
260_F263_L0.5670.98
204_F208_R0.5670.98
175_I179_D0.5650.98
256_N260_F0.5610.98
46_M86_F0.5610.98
199_Y206_L0.5600.98
41_E45_E0.5580.98
82_Y85_R0.5570.98
57_I89_V0.5520.98
190_V282_Y0.5460.98
72_P105_W0.5450.98
9_V55_V0.5440.98
154_P188_K0.5420.97
110_Y115_S0.5420.97
150_D186_Q0.5410.97
11_A55_V0.5380.97
215_G218_S0.5380.97
277_N281_L0.5370.97
221_P232_L0.5340.97
19_E70_D0.5340.97
200_V206_L0.5330.97
226_L264_N0.5330.97
200_V207_V0.5320.97
156_V216_E0.5300.97
45_E245_Y0.5290.97
222_P227_E0.5260.97
92_I117_F0.5260.97
40_Q82_Y0.5250.97
257_L274_G0.5240.97
157_I189_I0.5230.97
82_Y86_F0.5210.97
178_D181_A0.5210.97
49_V257_L0.5200.97
159_T177_V0.5180.97
241_Y257_L0.5170.97
118_K192_A0.5160.97
202_T207_V0.5160.97
154_P282_Y0.5150.97
260_F270_K0.5120.96
31_G34_Y0.5120.96
206_L210_R0.5120.96
148_A153_L0.5110.96
89_V190_V0.5100.96
73_I112_A0.5100.96
211_R216_E0.5100.96
211_R217_I0.5100.96
184_F187_L0.5090.96
229_L236_S0.5080.96
126_V141_L0.5080.96
19_E23_K0.5070.96
55_V116_G0.5040.96
14_H244_D0.5040.96
90_G106_L0.5040.96
264_N273_M0.5020.96
45_E49_V0.5010.96
229_L232_L0.5010.96
103_K109_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hbvA 3 0.9231 100 0.332 Contact Map
4lanA 2 0.9371 100 0.343 Contact Map
3irsA 3 0.9091 100 0.346 Contact Map
4dziA 2 0.9336 100 0.348 Contact Map
4ofcA 4 0.9301 100 0.349 Contact Map
2f6kA 4 0.9301 100 0.35 Contact Map
2gwgA 2 0.9301 100 0.351 Contact Map
4qrnA 2 0.9301 100 0.351 Contact Map
3nurA 2 0.8846 100 0.359 Contact Map
4l6dA 4 0.9266 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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