GREMLIN Database
Q97UJ1 - Second ORF in transposase ISC1058
UniProt: Q97UJ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (189)
Sequences: 297 (173)
Seq/√Len: 12.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_V185_Y3.0350.96
189_V193_N3.0070.96
75_T100_V2.9990.96
121_H125_R2.9240.96
20_D23_G2.8440.95
50_I155_F2.6590.93
154_L157_A2.4610.89
26_T44_K2.4080.88
156_S160_R2.3340.87
45_F95_Y2.3080.86
124_R139_W2.2680.85
64_V178_A2.2280.84
96_D124_R2.2230.84
162_F181_K2.1430.81
28_T31_Q2.1300.81
16_E29_G2.1000.80
111_P115_A2.0780.79
110_P174_Q2.0310.78
93_K112_K2.0250.77
57_F154_L1.9750.76
189_V192_A1.9530.75
24_I178_A1.9280.74
57_F157_A1.9230.74
96_D139_W1.8790.72
178_A189_V1.8390.70
29_G33_I1.8210.69
44_K67_N1.7930.68
64_V166_V1.7870.68
45_F49_E1.7140.64
64_V175_V1.6940.63
97_A100_V1.6690.62
49_E71_S1.6560.62
18_I54_N1.6110.59
71_S186_A1.5890.58
17_V51_V1.5850.58
184_A188_M1.5720.57
74_K77_K1.5700.57
39_K43_S1.5300.55
27_N44_K1.5160.55
46_L157_A1.5130.54
36_K102_K1.4810.53
158_V166_V1.4780.53
28_T37_W1.4760.53
22_T151_V1.4690.52
61_N105_V1.4620.52
33_I150_R1.4320.50
25_S96_D1.4320.50
21_A78_D1.4290.50
52_M151_V1.4190.50
107_V127_A1.4080.49
24_I157_A1.3990.49
17_V60_V1.3870.48
80_Q85_K1.3760.47
35_A40_T1.3530.46
19_A44_K1.3310.45
49_E65_T1.3280.45
53_D112_K1.3190.44
24_I64_V1.3060.44
118_K146_G1.2970.43
133_K170_S1.2780.42
177_E186_A1.2710.42
146_G149_W1.2610.42
170_S173_G1.2480.41
24_I166_V1.2470.41
53_D94_T1.2430.41
10_E14_E1.2400.41
190_H193_N1.2380.40
175_V184_A1.2290.40
118_K122_L1.2290.40
25_S31_Q1.2250.40
107_V123_A1.2220.40
183_W187_W1.1930.38
171_F175_V1.1840.38
37_W45_F1.1810.38
18_I90_Y1.1450.36
22_T94_T1.1330.35
89_F107_V1.1300.35
151_V197_G1.1150.35
100_V118_K1.1140.34
70_E73_V1.1010.34
52_M150_R1.1010.34
12_S128_V1.1000.34
117_T128_V1.0940.34
143_K146_G1.0880.33
130_E134_L1.0820.33
150_R154_L1.0800.33
88_K171_F1.0720.33
140_R158_V1.0680.32
92_D148_R1.0640.32
43_S139_W1.0380.31
28_T96_D1.0370.31
19_A79_L1.0350.31
189_V194_S1.0320.31
68_E131_F1.0250.30
111_P131_F1.0220.30
94_T155_F1.0180.30
43_S194_S0.9940.29
166_V178_A0.9940.29
45_F186_A0.9800.29
41_R134_L0.9780.28
157_A185_Y0.9760.28
67_N129_R0.9760.28
42_D151_V0.9710.28
47_K71_S0.9690.28
172_A195_V0.9670.28
71_S78_D0.9610.28
174_Q186_A0.9590.28
117_T120_G0.9580.28
36_K128_V0.9530.27
119_R172_A0.9500.27
54_N94_T0.9460.27
181_K184_A0.9440.27
129_R135_G0.9420.27
141_E160_R0.9400.27
29_G146_G0.9340.27
32_Y49_E0.9340.27
70_E149_W0.9290.26
27_N41_R0.9170.26
95_Y110_P0.9150.26
34_V40_T0.9080.26
124_R135_G0.9030.25
26_T42_D0.8960.25
134_L138_R0.8920.25
33_I90_Y0.8900.25
141_E161_T0.8810.25
147_V194_S0.8790.24
126_K142_E0.8780.24
14_E65_T0.8710.24
79_L168_A0.8640.24
61_N86_V0.8540.24
35_A41_R0.8500.23
50_I94_T0.8490.23
45_F91_G0.8480.23
137_D143_K0.8430.23
111_P127_A0.8410.23
42_D46_L0.8400.23
51_V55_N0.8340.23
111_P124_R0.8340.23
81_D163_G0.8330.23
77_K129_R0.8280.23
65_T84_K0.8280.23
141_E195_V0.8240.22
72_A165_S0.8200.22
173_G180_L0.8140.22
30_G112_K0.8100.22
61_N165_S0.8070.22
53_D169_T0.8070.22
169_T194_S0.8010.22
28_T42_D0.7990.22
77_K113_K0.7980.22
19_A75_T0.7970.21
110_P166_V0.7970.21
185_Y188_M0.7920.21
89_F100_V0.7880.21
60_V178_A0.7870.21
113_K172_A0.7870.21
72_A106_E0.7850.21
164_E182_F0.7790.21
90_Y108_V0.7780.21
99_E129_R0.7740.21
46_L125_R0.7730.21
79_L133_K0.7670.20
16_E28_T0.7670.20
132_R142_E0.7640.20
30_G86_V0.7610.20
64_V158_V0.7550.20
96_D148_R0.7550.20
59_V105_V0.7530.20
65_T171_F0.7530.20
21_A32_Y0.7490.20
25_S37_W0.7440.20
170_S176_V0.7440.20
153_S194_S0.7400.20
65_T116_S0.7400.20
135_G139_W0.7390.20
28_T174_Q0.7280.19
66_S69_V0.7230.19
18_I156_S0.7170.19
53_D96_D0.7160.19
31_Q192_A0.7130.19
50_I140_R0.7110.19
58_N70_E0.7100.19
39_K165_S0.7090.19
140_R146_G0.7060.19
27_N50_I0.7050.18
137_D140_R0.7030.18
45_F71_S0.7030.18
66_S168_A0.6980.18
48_I111_P0.6970.18
12_S168_A0.6960.18
47_K131_F0.6960.18
113_K164_E0.6950.18
163_G187_W0.6950.18
101_Y110_P0.6940.18
64_V130_E0.6900.18
115_A128_V0.6890.18
21_A71_S0.6820.18
16_E54_N0.6780.18
49_E186_A0.6720.17
61_N136_Y0.6690.17
25_S155_F0.6680.17
79_L144_G0.6660.17
90_Y190_H0.6610.17
96_D135_G0.6550.17
22_T30_G0.6520.17
113_K116_S0.6510.17
49_E78_D0.6500.17
37_W146_G0.6490.17
65_T71_S0.6470.17
48_I91_G0.6400.17
180_L185_Y0.6390.17
178_A192_A0.6360.16
17_V31_Q0.6350.16
96_D112_K0.6300.16
53_D139_W0.6240.16
179_K189_V0.6180.16
164_E181_K0.6180.16
82_K85_K0.6160.16
50_I93_K0.6130.16
93_K96_D0.6070.16
51_V169_T0.6070.16
44_K162_F0.6060.16
115_A125_R0.5980.15
188_M196_V0.5980.15
157_A166_V0.5980.15
26_T38_G0.5930.15
31_Q34_V0.5900.15
81_D169_T0.5860.15
43_S54_N0.5840.15
33_I140_R0.5820.15
72_A135_G0.5820.15
113_K192_A0.5810.15
73_V140_R0.5810.15
185_Y190_H0.5790.15
110_P186_A0.5790.15
32_Y93_K0.5740.15
169_T174_Q0.5730.15
101_Y182_F0.5720.15
30_G115_A0.5720.15
10_E109_V0.5700.15
126_K129_R0.5690.15
29_G147_V0.5690.15
32_Y125_R0.5660.15
100_V158_V0.5660.15
16_E155_F0.5630.14
67_N98_N0.5630.14
55_N89_F0.5630.14
59_V134_L0.5630.14
26_T161_T0.5630.14
47_K92_D0.5570.14
70_E81_D0.5550.14
43_S169_T0.5500.14
37_W100_V0.5490.14
94_T107_V0.5480.14
11_A164_E0.5470.14
81_D109_V0.5460.14
145_Y152_E0.5440.14
26_T48_I0.5440.14
74_K113_K0.5420.14
22_T155_F0.5370.14
60_V133_K0.5360.14
26_T184_A0.5350.14
168_A176_V0.5340.14
97_A134_L0.5330.14
101_Y111_P0.5310.14
106_E143_K0.5310.14
45_F65_T0.5300.14
111_P157_A0.5280.14
22_T48_I0.5260.14
61_N79_L0.5260.14
40_T113_K0.5260.14
154_L193_N0.5210.13
18_I35_A0.5210.13
108_V180_L0.5200.13
62_A158_V0.5140.13
173_G193_N0.5120.13
11_A184_A0.5100.13
24_I27_N0.5060.13
154_L168_A0.5060.13
18_I26_T0.5050.13
94_T169_T0.5050.13
178_A190_H0.5030.13
118_K155_F0.5010.13
108_V190_H0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9461 97.2 0.9 Contact Map
4fw1A 2 0.7451 59.2 0.948 Contact Map
1bcoA 1 0.8333 27.8 0.957 Contact Map
4fw2A 2 0.7108 19 0.961 Contact Map
1c6vA 4 0.652 17.6 0.961 Contact Map
3l3uA 2 0.6863 17 0.961 Contact Map
3f9kA 5 0.75 15 0.963 Contact Map
1k6yA 4 0.6618 14.4 0.963 Contact Map
1cxqA 2 0.6569 13.9 0.963 Contact Map
4cf8A 2 0.6863 11.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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