Q97UI8 - SULSO - GREMLIN Contacts

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Q97UI8 - Uncharacterized protein

UniProt:	Q97UI8	Sequences: MDWKLGIISDEISQDFEHAVKVIKELGASYVEVRNLWNKNVTQLLDSEFSEMKRVVEKYGLIISNLDSPSFKIYIDDEKGYKEHLQILRKVIELSKKLDIAYTRIFTFWYQGELRYYIDKLAERFNSAIDIAQSEGVILVIENEYSCFVGTGKELRTFLDKIRTKWVKVLWDPGNAFFARETPYPDGYELIKGDIMHLHIKDAMVKDGHFIWMPVGKGMINYKEQFRALRGSAHVISLETHYRNSANDPEASTRESFNGIIKILKELS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	268 (231)
Sequences:	16575 (11769)
Seq/√Len:	774.4

ECOLI - ULAE FRLC SGBU YCJR YGBM YIHM HYI
BACSU - IOLH IOLI YFIH IOLE
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_K	196_M	3.083	1.00
89_R	131_I	3.072	1.00
21_K	59_Y	2.855	1.00
53_K	57_E	2.783	1.00
221_N	224_E	2.765	1.00
122_A	161_K	2.683	1.00
202_D	216_G	2.603	1.00
30_Y	235_V	2.446	1.00
93_E	135_E	2.442	1.00
54_R	58_K	2.400	1.00
138_I	196_M	2.329	1.00
189_E	228_A	2.300	1.00
93_E	131_I	2.266	1.00
138_I	168_K	2.102	1.00
15_D	18_H	2.092	1.00
140_V	196_M	2.084	1.00
17_E	55_V	2.054	1.00
96_K	135_E	2.017	1.00
118_I	157_T	1.999	1.00
157_T	161_K	1.957	1.00
130_D	164_T	1.939	1.00
85_L	127_S	1.891	1.00
102_Y	140_V	1.889	1.00
55_V	59_Y	1.864	1.00
156_R	190_L	1.857	1.00
82_K	86_Q	1.824	1.00
21_K	25_E	1.763	1.00
156_R	160_D	1.718	1.00
92_I	135_E	1.708	1.00
55_V	58_K	1.692	1.00
129_I	167_V	1.668	1.00
48_E	51_E	1.661	1.00
50_S	97_K	1.658	1.00
56_V	63_I	1.624	1.00
119_D	161_K	1.609	1.00
182_T	186_D	1.608	1.00
202_D	218_G	1.603	1.00
131_I	134_S	1.600	1.00
46_D	97_K	1.588	1.00
95_S	100_I	1.586	1.00
140_V	170_L	1.581	1.00
223_K	227_R	1.558	1.00
24_K	59_Y	1.549	1.00
81_Y	124_R	1.535	1.00
118_I	161_K	1.534	1.00
248_D	251_A	1.527	1.00
86_Q	90_K	1.525	1.00
80_G	83_E	1.505	1.00
113_E	116_Y	1.491	1.00
49_F	97_K	1.489	1.00
90_K	93_E	1.479	1.00
122_A	126_N	1.477	1.00
186_D	190_L	1.459	1.00
133_Q	166_W	1.440	1.00
231_G	234_H	1.431	1.00
130_D	134_S	1.427	1.00
131_I	135_E	1.422	1.00
119_D	123_E	1.412	1.00
22_V	25_E	1.398	1.00
51_E	54_R	1.396	1.00
123_E	126_N	1.393	1.00
116_Y	119_D	1.392	1.00
17_E	58_K	1.390	1.00
198_L	229_L	1.387	1.00
217_K	255_E	1.382	1.00
92_I	132_A	1.376	1.00
120_K	123_E	1.368	1.00
173_P	225_Q	1.354	1.00
18_H	21_K	1.348	1.00
102_Y	138_I	1.343	1.00
143_N	176_A	1.323	1.00
89_R	127_S	1.321	1.00
82_K	127_S	1.316	1.00
21_K	55_V	1.316	1.00
20_V	59_Y	1.313	1.00
168_K	194_D	1.296	1.00
86_Q	89_R	1.269	1.00
129_I	162_I	1.250	1.00
136_G	166_W	1.248	1.00
153_K	190_L	1.245	1.00
251_A	255_E	1.243	1.00
89_R	93_E	1.240	1.00
204_M	213_M	1.235	1.00
51_E	55_V	1.228	1.00
22_V	250_E	1.228	1.00
54_R	57_E	1.219	1.00
187_G	191_I	1.213	1.00
157_T	160_D	1.201	1.00
133_Q	164_T	1.189	1.00
151_T	154_E	1.185	1.00
85_L	89_R	1.179	1.00
92_I	137_V	1.171	1.00
126_N	162_I	1.169	1.00
171_W	176_A	1.166	1.00
92_I	131_I	1.164	1.00
155_L	169_V	1.160	1.00
224_E	228_A	1.152	1.00
160_D	194_D	1.149	1.00
122_A	162_I	1.149	1.00
88_L	128_A	1.146	1.00
50_S	54_R	1.146	1.00
150_G	154_E	1.145	1.00
126_N	163_R	1.132	1.00
127_S	130_D	1.131	1.00
63_I	66_L	1.123	1.00
214_P	217_K	1.120	1.00
17_E	51_E	1.119	1.00
24_K	60_G	1.119	1.00
133_Q	165_K	1.105	1.00
156_R	194_D	1.105	1.00
53_K	97_K	1.099	1.00
20_V	55_V	1.095	1.00
132_A	139_L	1.093	1.00
89_R	134_S	1.089	1.00
156_R	191_I	1.083	1.00
78_E	82_K	1.080	1.00
93_E	97_K	1.073	1.00
22_V	26_L	1.072	1.00
20_V	56_V	1.072	1.00
188_Y	192_K	1.055	1.00
28_A	238_L	1.049	1.00
56_V	61_L	1.034	1.00
17_E	21_K	1.023	1.00
30_Y	62_I	1.019	1.00
114_L	154_E	1.016	1.00
49_F	94_L	1.011	1.00
30_Y	64_S	1.010	1.00
23_I	28_A	1.009	1.00
118_I	122_A	1.006	1.00
129_I	164_T	1.005	1.00
46_D	50_S	0.994	1.00
102_Y	196_M	0.984	1.00
175_N	201_K	0.981	1.00
104_R	170_L	0.976	1.00
186_D	189_E	0.974	1.00
83_E	86_Q	0.970	1.00
159_L	194_D	0.965	1.00
220_I	225_Q	0.960	1.00
250_E	254_R	0.958	1.00
101_A	138_I	0.953	1.00
81_Y	123_E	0.952	1.00
93_E	96_K	0.951	1.00
126_N	164_T	0.951	1.00
130_D	133_Q	0.948	1.00
123_E	127_S	0.947	1.00
66_L	95_S	0.944	1.00
115_R	157_T	0.941	1.00
172_D	239_E	0.938	1.00
32_E	197_H	0.926	1.00
174_G	201_K	0.922	1.00
49_F	53_K	0.914	1.00
95_S	103_T	0.913	1.00
23_I	31_V	0.913	1.00
56_V	59_Y	0.913	1.00
24_K	29_S	0.911	1.00
177_F	219_M	0.909	1.00
33_V	63_I	0.903	1.00
126_N	130_D	0.899	1.00
89_R	135_E	0.899	1.00
162_I	167_V	0.897	1.00
62_I	101_A	0.897	1.00
47_S	51_E	0.897	1.00
226_F	230_R	0.895	1.00
115_R	119_D	0.882	1.00
129_I	166_W	0.880	1.00
188_Y	228_A	0.871	1.00
32_E	65_N	0.870	1.00
169_V	191_I	0.869	1.00
153_K	157_T	0.868	1.00
152_G	190_L	0.867	1.00
49_F	98_L	0.866	1.00
14_Q	22_V	0.864	1.00
81_Y	120_K	0.861	1.00
201_K	241_H	0.859	1.00
116_Y	120_K	0.856	1.00
118_I	154_E	0.855	1.00
201_K	212_W	0.852	1.00
96_K	137_V	0.837	1.00
125_F	167_V	0.836	1.00
192_K	195_I	0.833	1.00
45_L	48_E	0.829	1.00
144_E	147_C	0.827	1.00
224_E	227_R	0.826	1.00
138_I	166_W	0.824	1.00
142_E	239_E	0.824	1.00
114_L	117_Y	0.821	1.00
96_K	136_G	0.819	1.00
25_E	250_E	0.818	1.00
251_A	254_R	0.813	1.00
198_L	236_I	0.812	1.00
159_L	169_V	0.803	1.00
120_K	124_R	0.801	1.00
64_S	235_V	0.798	1.00
247_N	251_A	0.796	1.00
200_I	222_Y	0.791	1.00
213_M	217_K	0.790	1.00
152_G	181_E	0.787	1.00
50_S	53_K	0.782	1.00
197_H	237_S	0.780	1.00
53_K	99_D	0.774	1.00
94_L	98_L	0.773	1.00
204_M	219_M	0.763	1.00
21_K	58_K	0.763	1.00
173_P	222_Y	0.751	1.00
252_S	255_E	0.744	1.00
62_I	235_V	0.742	1.00
126_N	161_K	0.736	1.00
81_Y	85_L	0.735	1.00
32_E	237_S	0.734	1.00
174_G	203_A	0.729	1.00
121_L	158_F	0.724	1.00
28_A	253_T	0.723	1.00
170_L	197_H	0.721	1.00
177_F	220_I	0.718	1.00
85_L	124_R	0.718	1.00
29_S	62_I	0.714	1.00
154_E	157_T	0.712	1.00
249_P	252_S	0.707	1.00
125_F	158_F	0.707	1.00
19_A	23_I	0.702	1.00
90_K	94_L	0.699	1.00
192_K	228_A	0.697	1.00
127_S	131_I	0.696	1.00
222_Y	226_F	0.695	1.00
200_I	236_I	0.693	1.00
128_A	139_L	0.692	1.00
14_Q	18_H	0.691	1.00
102_Y	197_H	0.685	1.00
159_L	167_V	0.683	1.00
129_I	139_L	0.682	1.00
149_V	155_L	0.678	1.00
63_I	100_I	0.676	1.00
24_K	61_L	0.675	1.00
91_V	103_T	0.675	1.00
205_V	219_M	0.673	1.00
163_R	166_W	0.670	1.00
176_A	187_G	0.670	1.00
20_V	31_V	0.669	1.00
189_E	192_K	0.669	1.00
20_V	24_K	0.667	1.00
124_R	127_S	0.665	1.00
171_W	188_Y	0.663	1.00
188_Y	195_I	0.661	1.00
122_A	158_F	0.661	1.00
18_H	22_V	0.655	1.00
87_I	90_K	0.653	1.00
117_Y	120_K	0.652	1.00
21_K	24_K	0.651	1.00
105_I	139_L	0.648	1.00
79_K	83_E	0.646	1.00
17_E	59_Y	0.645	1.00
152_G	156_R	0.641	1.00
206_K	219_M	0.636	1.00
163_R	194_D	0.636	1.00
67_D	106_F	0.634	1.00
149_V	158_F	0.633	1.00
142_E	175_N	0.633	1.00
20_V	52_M	0.631	1.00
197_H	235_V	0.631	1.00
66_L	100_I	0.631	1.00
173_P	200_I	0.629	1.00
159_L	163_R	0.628	1.00
68_S	91_V	0.628	1.00
142_E	199_H	0.627	1.00
101_A	136_G	0.626	1.00
78_E	120_K	0.626	1.00
248_D	252_S	0.625	1.00
129_I	133_Q	0.624	1.00
143_N	155_L	0.621	1.00
226_F	236_I	0.617	1.00
45_L	49_F	0.613	1.00
92_I	103_T	0.604	1.00
229_L	232_S	0.602	1.00
85_L	128_A	0.602	1.00
140_V	168_K	0.601	1.00
69_P	72_K	0.600	1.00
103_T	132_A	0.600	1.00
118_I	158_F	0.599	1.00
79_K	82_K	0.592	1.00
162_I	165_K	0.591	1.00
121_L	125_F	0.588	1.00
172_D	201_K	0.585	1.00
187_G	192_K	0.585	1.00
188_Y	229_L	0.583	1.00
83_E	87_I	0.581	1.00
119_D	122_A	0.579	1.00
212_W	215_V	0.576	1.00
110_Y	113_E	0.575	1.00
164_T	167_V	0.574	1.00
20_V	61_L	0.572	1.00
81_Y	127_S	0.572	1.00
52_M	55_V	0.570	1.00
78_E	81_Y	0.569	1.00
132_A	137_V	0.569	1.00
130_D	166_W	0.567	1.00
85_L	131_I	0.566	1.00
57_E	99_D	0.564	1.00
230_R	236_I	0.562	1.00
198_L	232_S	0.562	1.00
171_W	187_G	0.560	1.00
199_H	237_S	0.560	1.00
43_Q	90_K	0.557	1.00
222_Y	225_Q	0.556	1.00
171_W	195_I	0.555	1.00
26_L	254_R	0.555	1.00
144_E	149_V	0.555	1.00
214_P	252_S	0.553	1.00
93_E	134_S	0.553	1.00
156_R	159_L	0.552	1.00
46_D	49_F	0.550	1.00
57_E	97_K	0.549	1.00
143_N	149_V	0.549	1.00
65_N	104_R	0.549	1.00
25_E	254_R	0.545	1.00
53_K	56_V	0.544	1.00
197_H	232_S	0.542	1.00
215_V	218_G	0.541	1.00
201_K	240_T	0.541	1.00
73_I	76_D	0.538	1.00
152_G	186_D	0.537	1.00
188_Y	225_Q	0.537	1.00
106_F	175_N	0.536	1.00
176_A	181_E	0.535	1.00
64_S	237_S	0.535	1.00
158_F	162_I	0.535	1.00
95_S	137_V	0.535	1.00
188_Y	191_I	0.534	1.00
191_I	195_I	0.534	1.00
106_F	201_K	0.532	1.00
169_V	195_I	0.530	1.00
104_R	197_H	0.526	1.00
82_K	85_L	0.526	1.00
125_F	139_L	0.525	1.00
74_Y	124_R	0.521	1.00
206_K	209_H	0.521	1.00
99_D	137_V	0.520	1.00
132_A	135_E	0.514	1.00
173_P	198_L	0.513	1.00
189_E	224_E	0.511	1.00
19_A	22_V	0.509	1.00
155_L	159_L	0.506	1.00
199_H	239_E	0.504	1.00
53_K	98_L	0.503	1.00
29_S	60_G	0.500	1.00
85_L	88_L	0.500	1.00
16_F	20_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zdsA	5	0.9851	100	0.231	Contact Map
3dx5A	2	0.9478	100	0.242	Contact Map
3cnyA	1	0.944	100	0.248	Contact Map
3cqjA	2	0.9813	100	0.248	Contact Map
1i60A	1	0.9813	100	0.249	Contact Map
3tvaA	1	0.9664	100	0.259	Contact Map
2qulA	2	0.944	100	0.263	Contact Map
2hk0A	3	0.9403	100	0.265	Contact Map
3wqoA	2	0.944	100	0.267	Contact Map
3kwsA	2	0.9328	100	0.269	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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