GREMLIN Database
Q97UI8 - Uncharacterized protein
UniProt: Q97UI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (231)
Sequences: 16575 (11769)
Seq/√Len: 774.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_K196_M3.0831.00
89_R131_I3.0721.00
21_K59_Y2.8551.00
53_K57_E2.7831.00
221_N224_E2.7651.00
122_A161_K2.6831.00
202_D216_G2.6031.00
30_Y235_V2.4461.00
93_E135_E2.4421.00
54_R58_K2.4001.00
138_I196_M2.3291.00
189_E228_A2.3001.00
93_E131_I2.2661.00
138_I168_K2.1021.00
15_D18_H2.0921.00
140_V196_M2.0841.00
17_E55_V2.0541.00
96_K135_E2.0171.00
118_I157_T1.9991.00
157_T161_K1.9571.00
130_D164_T1.9391.00
85_L127_S1.8911.00
102_Y140_V1.8891.00
55_V59_Y1.8641.00
156_R190_L1.8571.00
82_K86_Q1.8241.00
21_K25_E1.7631.00
156_R160_D1.7181.00
92_I135_E1.7081.00
55_V58_K1.6921.00
129_I167_V1.6681.00
48_E51_E1.6611.00
50_S97_K1.6581.00
56_V63_I1.6241.00
119_D161_K1.6091.00
182_T186_D1.6081.00
202_D218_G1.6031.00
131_I134_S1.6001.00
46_D97_K1.5881.00
95_S100_I1.5861.00
140_V170_L1.5811.00
223_K227_R1.5581.00
24_K59_Y1.5491.00
81_Y124_R1.5351.00
118_I161_K1.5341.00
248_D251_A1.5271.00
86_Q90_K1.5251.00
80_G83_E1.5051.00
113_E116_Y1.4911.00
49_F97_K1.4891.00
90_K93_E1.4791.00
122_A126_N1.4771.00
186_D190_L1.4591.00
133_Q166_W1.4401.00
231_G234_H1.4311.00
130_D134_S1.4271.00
131_I135_E1.4221.00
119_D123_E1.4121.00
22_V25_E1.3981.00
51_E54_R1.3961.00
123_E126_N1.3931.00
116_Y119_D1.3921.00
17_E58_K1.3901.00
198_L229_L1.3871.00
217_K255_E1.3821.00
92_I132_A1.3761.00
120_K123_E1.3681.00
173_P225_Q1.3541.00
18_H21_K1.3481.00
102_Y138_I1.3431.00
143_N176_A1.3231.00
89_R127_S1.3211.00
82_K127_S1.3161.00
21_K55_V1.3161.00
20_V59_Y1.3131.00
168_K194_D1.2961.00
86_Q89_R1.2691.00
129_I162_I1.2501.00
136_G166_W1.2481.00
153_K190_L1.2451.00
251_A255_E1.2431.00
89_R93_E1.2401.00
204_M213_M1.2351.00
51_E55_V1.2281.00
22_V250_E1.2281.00
54_R57_E1.2191.00
187_G191_I1.2131.00
157_T160_D1.2011.00
133_Q164_T1.1891.00
151_T154_E1.1851.00
85_L89_R1.1791.00
92_I137_V1.1711.00
126_N162_I1.1691.00
171_W176_A1.1661.00
92_I131_I1.1641.00
155_L169_V1.1601.00
224_E228_A1.1521.00
160_D194_D1.1491.00
122_A162_I1.1491.00
88_L128_A1.1461.00
50_S54_R1.1461.00
150_G154_E1.1451.00
126_N163_R1.1321.00
127_S130_D1.1311.00
63_I66_L1.1231.00
214_P217_K1.1201.00
17_E51_E1.1191.00
24_K60_G1.1191.00
133_Q165_K1.1051.00
156_R194_D1.1051.00
53_K97_K1.0991.00
20_V55_V1.0951.00
132_A139_L1.0931.00
89_R134_S1.0891.00
156_R191_I1.0831.00
78_E82_K1.0801.00
93_E97_K1.0731.00
22_V26_L1.0721.00
20_V56_V1.0721.00
188_Y192_K1.0551.00
28_A238_L1.0491.00
56_V61_L1.0341.00
17_E21_K1.0231.00
30_Y62_I1.0191.00
114_L154_E1.0161.00
49_F94_L1.0111.00
30_Y64_S1.0101.00
23_I28_A1.0091.00
118_I122_A1.0061.00
129_I164_T1.0051.00
46_D50_S0.9941.00
102_Y196_M0.9841.00
175_N201_K0.9811.00
104_R170_L0.9761.00
186_D189_E0.9741.00
83_E86_Q0.9701.00
159_L194_D0.9651.00
220_I225_Q0.9601.00
250_E254_R0.9581.00
101_A138_I0.9531.00
81_Y123_E0.9521.00
93_E96_K0.9511.00
126_N164_T0.9511.00
130_D133_Q0.9481.00
123_E127_S0.9471.00
66_L95_S0.9441.00
115_R157_T0.9411.00
172_D239_E0.9381.00
32_E197_H0.9261.00
174_G201_K0.9221.00
49_F53_K0.9141.00
95_S103_T0.9131.00
23_I31_V0.9131.00
56_V59_Y0.9131.00
24_K29_S0.9111.00
177_F219_M0.9091.00
33_V63_I0.9031.00
126_N130_D0.8991.00
89_R135_E0.8991.00
162_I167_V0.8971.00
62_I101_A0.8971.00
47_S51_E0.8971.00
226_F230_R0.8951.00
115_R119_D0.8821.00
129_I166_W0.8801.00
188_Y228_A0.8711.00
32_E65_N0.8701.00
169_V191_I0.8691.00
153_K157_T0.8681.00
152_G190_L0.8671.00
49_F98_L0.8661.00
14_Q22_V0.8641.00
81_Y120_K0.8611.00
201_K241_H0.8591.00
116_Y120_K0.8561.00
118_I154_E0.8551.00
201_K212_W0.8521.00
96_K137_V0.8371.00
125_F167_V0.8361.00
192_K195_I0.8331.00
45_L48_E0.8291.00
144_E147_C0.8271.00
224_E227_R0.8261.00
138_I166_W0.8241.00
142_E239_E0.8241.00
114_L117_Y0.8211.00
96_K136_G0.8191.00
25_E250_E0.8181.00
251_A254_R0.8131.00
198_L236_I0.8121.00
159_L169_V0.8031.00
120_K124_R0.8011.00
64_S235_V0.7981.00
247_N251_A0.7961.00
200_I222_Y0.7911.00
213_M217_K0.7901.00
152_G181_E0.7871.00
50_S53_K0.7821.00
197_H237_S0.7801.00
53_K99_D0.7741.00
94_L98_L0.7731.00
204_M219_M0.7631.00
21_K58_K0.7631.00
173_P222_Y0.7511.00
252_S255_E0.7441.00
62_I235_V0.7421.00
126_N161_K0.7361.00
81_Y85_L0.7351.00
32_E237_S0.7341.00
174_G203_A0.7291.00
121_L158_F0.7241.00
28_A253_T0.7231.00
170_L197_H0.7211.00
177_F220_I0.7181.00
85_L124_R0.7181.00
29_S62_I0.7141.00
154_E157_T0.7121.00
249_P252_S0.7071.00
125_F158_F0.7071.00
19_A23_I0.7021.00
90_K94_L0.6991.00
192_K228_A0.6971.00
127_S131_I0.6961.00
222_Y226_F0.6951.00
200_I236_I0.6931.00
128_A139_L0.6921.00
14_Q18_H0.6911.00
102_Y197_H0.6851.00
159_L167_V0.6831.00
129_I139_L0.6821.00
149_V155_L0.6781.00
63_I100_I0.6761.00
24_K61_L0.6751.00
91_V103_T0.6751.00
205_V219_M0.6731.00
163_R166_W0.6701.00
176_A187_G0.6701.00
20_V31_V0.6691.00
189_E192_K0.6691.00
20_V24_K0.6671.00
124_R127_S0.6651.00
171_W188_Y0.6631.00
188_Y195_I0.6611.00
122_A158_F0.6611.00
18_H22_V0.6551.00
87_I90_K0.6531.00
117_Y120_K0.6521.00
21_K24_K0.6511.00
105_I139_L0.6481.00
79_K83_E0.6461.00
17_E59_Y0.6451.00
152_G156_R0.6411.00
206_K219_M0.6361.00
163_R194_D0.6361.00
67_D106_F0.6341.00
149_V158_F0.6331.00
142_E175_N0.6331.00
20_V52_M0.6311.00
197_H235_V0.6311.00
66_L100_I0.6311.00
173_P200_I0.6291.00
159_L163_R0.6281.00
68_S91_V0.6281.00
142_E199_H0.6271.00
101_A136_G0.6261.00
78_E120_K0.6261.00
248_D252_S0.6251.00
129_I133_Q0.6241.00
143_N155_L0.6211.00
226_F236_I0.6171.00
45_L49_F0.6131.00
92_I103_T0.6041.00
229_L232_S0.6021.00
85_L128_A0.6021.00
140_V168_K0.6011.00
69_P72_K0.6001.00
103_T132_A0.6001.00
118_I158_F0.5991.00
79_K82_K0.5921.00
162_I165_K0.5911.00
121_L125_F0.5881.00
172_D201_K0.5851.00
187_G192_K0.5851.00
188_Y229_L0.5831.00
83_E87_I0.5811.00
119_D122_A0.5791.00
212_W215_V0.5761.00
110_Y113_E0.5751.00
164_T167_V0.5741.00
20_V61_L0.5721.00
81_Y127_S0.5721.00
52_M55_V0.5701.00
78_E81_Y0.5691.00
132_A137_V0.5691.00
130_D166_W0.5671.00
85_L131_I0.5661.00
57_E99_D0.5641.00
230_R236_I0.5621.00
198_L232_S0.5621.00
171_W187_G0.5601.00
199_H237_S0.5601.00
43_Q90_K0.5571.00
222_Y225_Q0.5561.00
171_W195_I0.5551.00
26_L254_R0.5551.00
144_E149_V0.5551.00
214_P252_S0.5531.00
93_E134_S0.5531.00
156_R159_L0.5521.00
46_D49_F0.5501.00
57_E97_K0.5491.00
143_N149_V0.5491.00
65_N104_R0.5491.00
25_E254_R0.5451.00
53_K56_V0.5441.00
197_H232_S0.5421.00
215_V218_G0.5411.00
201_K240_T0.5411.00
73_I76_D0.5381.00
152_G186_D0.5371.00
188_Y225_Q0.5371.00
106_F175_N0.5361.00
176_A181_E0.5351.00
64_S237_S0.5351.00
158_F162_I0.5351.00
95_S137_V0.5351.00
188_Y191_I0.5341.00
191_I195_I0.5341.00
106_F201_K0.5321.00
169_V195_I0.5301.00
104_R197_H0.5261.00
82_K85_L0.5261.00
125_F139_L0.5251.00
74_Y124_R0.5211.00
206_K209_H0.5211.00
99_D137_V0.5201.00
132_A135_E0.5141.00
173_P198_L0.5131.00
189_E224_E0.5111.00
19_A22_V0.5091.00
155_L159_L0.5061.00
199_H239_E0.5041.00
53_K98_L0.5031.00
29_S60_G0.5001.00
85_L88_L0.5001.00
16_F20_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zdsA 5 0.9851 100 0.231 Contact Map
3dx5A 2 0.9478 100 0.242 Contact Map
3cnyA 1 0.944 100 0.248 Contact Map
3cqjA 2 0.9813 100 0.248 Contact Map
1i60A 1 0.9813 100 0.249 Contact Map
3tvaA 1 0.9664 100 0.259 Contact Map
2qulA 2 0.944 100 0.263 Contact Map
2hk0A 3 0.9403 100 0.265 Contact Map
3wqoA 2 0.944 100 0.267 Contact Map
3kwsA 2 0.9328 100 0.269 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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