GREMLIN Database
Q97UI3 - Uncharacterized protein
UniProt: Q97UI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (184)
Sequences: 6932 (5139)
Seq/√Len: 378.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_K125_I3.1621.00
85_E125_I3.1141.00
159_G185_L3.0731.00
116_A153_E2.8601.00
20_E56_S2.7921.00
89_K129_Y2.7621.00
92_N129_Y2.3961.00
134_L185_L2.3481.00
123_N158_I2.1961.00
132_K185_L2.1361.00
50_K54_I2.1081.00
112_I153_E2.0961.00
149_K153_E2.0901.00
132_K159_G2.0621.00
82_K86_T2.0291.00
112_I149_K1.9821.00
14_S17_D1.9751.00
127_E157_D1.9671.00
148_V179_H1.9031.00
49_R53_E1.9031.00
20_E24_R1.8751.00
78_K82_K1.8541.00
98_G134_L1.8501.00
81_E121_R1.8121.00
125_I129_Y1.8001.00
125_I128_D1.7771.00
123_N154_L1.7411.00
145_D179_H1.7081.00
88_I129_Y1.7071.00
147_I160_F1.6811.00
159_G183_I1.6671.00
81_E85_E1.6481.00
91_A96_A1.6361.00
124_R128_D1.6131.00
152_Q183_I1.5871.00
173_C176_K1.5831.00
19_V56_S1.5681.00
51_A54_I1.5671.00
49_R93_S1.5011.00
148_V152_Q1.5011.00
85_E121_R1.4801.00
29_G61_S1.4681.00
113_H117_E1.4611.00
21_R24_R1.4391.00
77_R118_S1.4181.00
110_S113_H1.4081.00
51_A55_L1.4071.00
116_A120_N1.4061.00
86_T89_K1.3991.00
143_K146_N1.3891.00
78_K121_R1.3861.00
112_I116_A1.3781.00
82_K85_E1.3781.00
16_E55_L1.3371.00
47_I93_S1.3351.00
23_S56_S1.3341.00
76_E79_R1.3301.00
113_H153_E1.3261.00
21_R25_F1.3211.00
127_E156_E1.3211.00
130_S157_D1.3111.00
132_K157_D1.3091.00
148_V180_L1.3071.00
134_L161_V1.3061.00
148_V183_I1.2981.00
88_I126_A1.2951.00
88_I125_I1.2821.00
50_K53_E1.2761.00
117_E120_N1.2711.00
176_K179_H1.2391.00
84_L122_M1.2381.00
98_G132_K1.2261.00
22_V30_L1.2251.00
116_A154_L1.1851.00
13_L21_R1.1731.00
178_F184_I1.1711.00
49_R52_L1.1671.00
124_R127_E1.1581.00
115_I150_L1.1421.00
114_R117_E1.1381.00
19_V30_L1.1161.00
29_G59_K1.1091.00
50_K93_S1.1071.00
85_E89_K1.0911.00
144_K172_W1.0841.00
178_F181_K1.0831.00
88_I131_V1.0681.00
79_R82_K1.0671.00
49_R55_L1.0661.00
142_A146_N1.0551.00
77_R114_R1.0541.00
45_F48_N1.0521.00
43_P46_P1.0521.00
42_K46_P1.0461.00
151_L183_I1.0361.00
122_M133_I1.0361.00
16_E51_A1.0331.00
43_P47_I1.0331.00
74_E78_K1.0211.00
121_R124_R1.0211.00
71_F76_E1.0151.00
17_D20_E1.0141.00
81_E122_M1.0091.00
73_D76_E1.0081.00
126_A133_I1.0071.00
120_N124_R1.0041.00
31_E186_V1.0041.00
22_V27_F0.9801.00
123_N157_D0.9751.00
166_N190_R0.9741.00
149_K152_Q0.9691.00
89_K92_N0.9681.00
144_K179_H0.9641.00
23_S57_S0.9441.00
42_K45_F0.9431.00
162_Y178_F0.9301.00
44_E47_I0.9211.00
160_F180_L0.9171.00
75_S79_R0.8991.00
13_L17_D0.8991.00
144_K180_L0.8941.00
23_S28_D0.8931.00
77_R117_E0.8931.00
151_L160_F0.8911.00
165_A190_R0.8801.00
101_V133_I0.8801.00
109_K113_H0.8741.00
85_E128_D0.8721.00
16_E20_E0.8581.00
137_T147_I0.8551.00
81_E118_S0.8551.00
137_T167_V0.8331.00
37_D41_L0.8321.00
99_V126_A0.8281.00
162_Y167_V0.8241.00
117_E121_R0.8161.00
90_M94_L0.8111.00
120_N154_L0.8031.00
38_G41_L0.8011.00
52_L55_L0.8001.00
97_L132_K0.7901.00
164_P189_K0.7801.00
140_S170_R0.7781.00
120_N155_E0.7721.00
10_Y21_R0.7671.00
98_G185_L0.7621.00
110_S114_R0.7581.00
20_E55_L0.7561.00
116_A150_L0.7531.00
147_I151_L0.7531.00
118_S121_R0.7501.00
75_S78_K0.7491.00
180_L184_I0.7481.00
64_A67_T0.7451.00
18_V22_V0.7431.00
91_A99_V0.7421.00
10_Y25_F0.7401.00
60_I96_A0.7391.00
100_R138_H0.7371.00
154_L158_I0.7371.00
109_K149_K0.7351.00
136_E188_S0.7331.00
114_R118_S0.7331.00
69_F118_S0.7281.00
48_N51_A0.7261.00
15_L19_V0.7211.00
89_K93_S0.7171.00
162_Y177_L0.7121.00
16_E56_S0.7051.00
92_N97_L0.7041.00
63_L66_Y0.7030.99
102_Y138_H0.6960.99
62_D65_G0.6930.99
137_T160_F0.6910.99
161_V188_S0.6900.99
44_E48_N0.6870.99
141_L169_Y0.6870.99
84_L101_V0.6770.99
155_E183_I0.6770.99
10_Y13_L0.6740.99
146_N149_K0.6660.99
19_V58_I0.6660.99
62_D100_R0.6630.99
167_V177_L0.6630.99
97_L130_S0.6630.99
119_L150_L0.6580.99
68_R71_F0.6560.99
17_D21_R0.6540.99
100_R134_L0.6530.99
179_H182_D0.6500.99
107_S111_A0.6490.99
181_K184_I0.6460.99
121_R125_I0.6430.99
7_S18_V0.6430.99
119_L158_I0.6370.99
20_E23_S0.6360.99
151_L155_E0.6360.99
184_I187_L0.6350.99
162_Y184_I0.6320.99
23_S58_I0.6300.99
81_E125_I0.6290.99
145_D149_K0.6290.99
168_I172_W0.6270.99
64_A102_Y0.6260.99
83_A87_L0.6240.99
103_G115_I0.6230.99
161_V186_V0.6220.99
100_R161_V0.6220.99
41_L44_E0.6210.99
167_V170_R0.6190.99
15_L32_L0.6170.99
177_L180_L0.6150.99
69_F72_S0.6130.99
59_K97_L0.6110.99
135_I158_I0.6080.99
167_V172_W0.6070.99
112_I150_L0.6070.99
101_V104_G0.6050.98
8_L11_P0.6020.98
43_P48_N0.6000.98
85_E129_Y0.5990.98
178_F187_L0.5980.98
83_A86_T0.5980.98
19_V55_L0.5940.98
62_D66_Y0.5920.98
151_L158_I0.5910.98
150_L154_L0.5880.98
76_E80_N0.5880.98
82_K89_K0.5870.98
42_K48_N0.5860.98
92_N130_S0.5860.98
115_I119_L0.5800.98
71_F74_E0.5790.98
172_W176_K0.5790.98
119_L133_I0.5770.98
74_E77_R0.5710.98
65_G87_L0.5710.98
92_N131_V0.5700.98
7_S30_L0.5690.98
63_L96_A0.5690.98
148_V151_L0.5660.98
62_D67_T0.5660.98
104_G107_S0.5660.98
106_F111_A0.5650.98
120_N153_E0.5610.98
63_L91_A0.5580.97
56_S59_K0.5550.97
37_D40_H0.5550.97
77_R81_E0.5530.97
101_V119_L0.5520.97
34_V83_A0.5520.97
81_E84_L0.5520.97
41_L45_F0.5470.97
123_N127_E0.5440.97
168_I174_F0.5400.97
69_F80_N0.5380.97
47_I50_K0.5370.97
104_G108_E0.5340.97
138_H141_L0.5280.96
102_Y190_R0.5270.96
79_R83_A0.5260.96
72_S114_R0.5220.96
40_H45_F0.5200.96
152_Q179_H0.5190.96
161_V167_V0.5180.96
139_D169_Y0.5170.96
134_L159_G0.5140.96
138_H190_R0.5140.96
17_D24_R0.5120.96
70_H73_D0.5110.96
152_Q155_E0.5090.96
172_W177_L0.5090.96
87_L99_V0.5080.96
84_L133_I0.5040.95
70_H115_I0.5010.95
145_D148_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i60A 1 1 100 0.27 Contact Map
3wqoA 2 0.9895 100 0.276 Contact Map
3dx5A 2 0.9843 100 0.276 Contact Map
2zdsA 5 1 100 0.286 Contact Map
3kwsA 2 0.9738 100 0.287 Contact Map
4ovxA 1 0.9948 100 0.288 Contact Map
3qc0A 2 0.9738 100 0.291 Contact Map
3u0hA 3 0.9895 100 0.292 Contact Map
3vniA 4 0.9948 100 0.293 Contact Map
2q02A 2 0.9686 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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