Q97UI2 - SULSO - GREMLIN Contacts

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Q97UI2 - Dihydrodipicolinate synthase (DapA-2)

UniProt:	Q97UI2	Sequences: MDGVFLTNVTPFTKTLELDLEGLKRIVEFAQNSGYKYIVPLGTAGEFSSLTVEEKVRVVDHVRRALSKGEIIAGASSTSFLETGELCKKYKEIGVDKIMVLPPYYLKGNEKGLMEYFFKVAELCDSTMVLYNNPSSTGVDLSPQLIKRLNDMIPSFRVLKEARYNVVEFKEVVRLVGDKIDVIDGLEERALLGLVLGAKGFTTSMGSFSSLPLMIYESYEKKRNIDTAIRLYDLLLEYRSFIKLPLTMSHLAKLGAWLRGLISSYATRPPLPNLDDVVSEDVKRKMIEKINQIISFEKNTIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	302 (283)
Sequences:	10360 (6814)
Seq/√Len:	405.1

ECOLI - YAGE YJHH DAPA NANA
BACSU - DAPA KDGD
HALSA - DAPAL
SULSO - Q97UI2 Q97UF0 Q97WF2 KDGA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
224_N	227_T	3.963	1.00
13_T	17_E	3.256	1.00
114_M	148_R	3.217	1.00
258_L	283_K	3.137	1.00
20_L	57_R	2.781	1.00
20_L	61_H	2.733	1.00
24_K	61_H	2.725	1.00
91_K	125_D	2.693	1.00
56_V	89_K	2.563	1.00
75_A	87_C	2.559	1.00
218_S	227_T	2.549	1.00
24_K	64_R	2.546	1.00
193_G	198_A	2.512	1.00
87_C	98_I	2.323	1.00
63_R	66_L	2.210	1.00
227_T	230_R	2.187	1.00
28_E	68_K	2.184	1.00
28_E	64_R	2.115	1.00
118_F	153_I	2.111	1.00
218_S	224_N	2.091	1.00
217_E	222_K	2.088	1.00
122_E	153_I	2.060	1.00
213_L	217_E	2.051	1.00
29_F	33_S	2.026	1.00
110_E	142_S	2.018	1.00
194_L	219_Y	2.017	1.00
80_F	116_Y	2.014	1.00
5_F	37_Y	1.998	1.00
110_E	145_L	1.991	1.00
147_K	175_L	1.987	1.00
36_K	217_E	1.927	1.00
19_D	22_G	1.923	1.00
283_K	287_I	1.904	1.00
118_F	122_E	1.901	1.00
111_K	115_E	1.892	1.00
28_E	32_N	1.884	1.00
57_R	60_D	1.872	1.00
254_L	279_S	1.868	1.00
52_V	82_E	1.863	1.00
140_D	168_E	1.855	1.00
111_K	148_R	1.849	1.00
211_L	234_L	1.807	1.00
114_M	118_F	1.785	1.00
57_R	61_H	1.730	1.00
129_V	158_V	1.712	1.00
6_L	206_G	1.683	1.00
121_A	153_I	1.664	1.00
100_V	120_V	1.645	1.00
22_G	25_R	1.641	1.00
280_E	283_K	1.621	1.00
146_I	159_L	1.618	1.00
115_E	118_F	1.601	1.00
142_S	145_L	1.587	1.00
54_E	268_R	1.586	1.00
87_C	124_C	1.553	1.00
230_R	234_L	1.505	1.00
59_V	73_A	1.504	1.00
11_P	23_L	1.502	1.00
31_Q	69_G	1.473	1.00
23_L	58_V	1.470	1.00
214_M	218_S	1.418	1.00
91_K	124_C	1.412	1.00
9_V	256_A	1.407	1.00
83_T	120_V	1.404	1.00
115_E	119_K	1.401	1.00
244_L	281_D	1.399	1.00
280_E	284_R	1.396	1.00
276_D	279_S	1.393	1.00
91_K	126_S	1.373	1.00
276_D	280_E	1.370	1.00
36_K	213_L	1.363	1.00
89_K	92_E	1.356	1.00
5_F	39_V	1.349	1.00
214_M	227_T	1.339	1.00
257_W	264_S	1.337	1.00
254_L	258_L	1.328	1.00
275_D	278_V	1.326	1.00
52_V	85_E	1.323	1.00
171_E	175_L	1.320	1.00
77_S	83_T	1.302	1.00
98_I	124_C	1.296	1.00
56_V	85_E	1.283	1.00
79_S	82_E	1.283	1.00
2_D	220_E	1.279	1.00
84_G	119_K	1.277	1.00
24_K	63_R	1.272	1.00
53_E	57_R	1.260	1.00
129_V	202_T	1.260	1.00
31_Q	68_K	1.256	1.00
4_V	35_Y	1.255	1.00
257_W	262_I	1.255	1.00
72_I	97_K	1.249	1.00
52_V	89_K	1.238	1.00
56_V	60_D	1.236	1.00
173_V	182_V	1.236	1.00
284_R	288_E	1.233	1.00
29_F	261_L	1.230	1.00
46_E	253_K	1.224	1.00
191_L	228_A	1.222	1.00
219_Y	225_I	1.207	1.00
119_K	269_P	1.203	1.00
225_I	229_I	1.193	1.00
59_V	90_Y	1.187	1.00
121_A	155_S	1.184	1.00
41_L	58_V	1.176	1.00
17_E	81_L	1.172	1.00
181_D	199_K	1.169	1.00
60_D	89_K	1.160	1.00
216_Y	220_E	1.150	1.00
119_K	122_E	1.141	1.00
13_T	19_D	1.140	1.00
144_Q	175_L	1.138	1.00
226_D	229_I	1.135	1.00
255_G	286_M	1.134	1.00
284_R	287_I	1.129	1.00
88_K	92_E	1.127	1.00
21_E	24_K	1.126	1.00
254_L	257_W	1.124	1.00
20_L	24_K	1.111	1.00
56_V	92_E	1.105	1.00
12_F	50_L	1.105	1.00
61_H	64_R	1.099	1.00
24_K	28_E	1.093	1.00
22_G	263_S	1.092	1.00
119_K	123_L	1.089	1.00
88_K	123_L	1.088	1.00
72_I	129_V	1.086	1.00
60_D	93_I	1.082	1.00
254_L	283_K	1.080	1.00
73_A	95_V	1.079	1.00
214_M	217_E	1.061	1.00
75_A	90_Y	1.051	1.00
2_D	199_K	1.043	1.00
98_I	126_S	1.041	1.00
6_L	30_A	1.041	1.00
148_R	151_D	1.041	1.00
60_D	63_R	1.039	1.00
111_K	275_D	1.030	1.00
14_K	266_A	1.029	1.00
89_K	93_I	1.028	1.00
149_L	156_F	1.023	1.00
84_G	88_K	1.022	1.00
28_E	65_A	1.018	1.00
111_K	114_M	1.013	1.00
229_I	233_D	1.012	1.00
195_V	225_I	1.004	1.00
274_L	282_V	1.001	1.00
281_D	284_R	1.000	1.00
52_V	86_L	0.992	1.00
147_K	176_V	0.991	1.00
98_I	128_M	0.988	1.00
278_V	281_D	0.988	1.00
169_F	193_G	0.987	1.00
279_S	283_K	0.984	1.00
4_V	213_L	0.982	1.00
6_L	35_Y	0.979	1.00
171_E	240_S	0.978	1.00
39_V	99_M	0.971	1.00
227_T	231_L	0.971	1.00
274_L	278_V	0.971	1.00
76_S	101_L	0.970	1.00
121_A	128_M	0.962	1.00
16_L	81_L	0.960	1.00
26_I	256_A	0.960	1.00
150_N	180_I	0.958	1.00
114_M	145_L	0.952	1.00
110_E	148_R	0.948	1.00
27_V	61_H	0.947	1.00
205_M	239_R	0.944	1.00
130_L	146_I	0.944	1.00
53_E	85_E	0.943	1.00
85_E	89_K	0.941	1.00
8_N	30_A	0.931	1.00
71_I	95_V	0.929	1.00
84_G	123_L	0.927	1.00
55_K	86_L	0.927	1.00
77_S	82_E	0.926	1.00
195_V	229_I	0.924	1.00
237_E	288_E	0.924	1.00
75_A	98_I	0.921	1.00
257_W	279_S	0.920	1.00
147_K	151_D	0.919	1.00
194_L	216_Y	0.917	1.00
102_P	139_V	0.914	1.00
115_E	272_P	0.914	1.00
132_N	140_D	0.914	1.00
241_F	285_K	0.912	1.00
113_L	139_V	0.910	1.00
226_D	230_R	0.908	1.00
36_K	216_Y	0.907	1.00
22_G	262_I	0.904	1.00
85_E	88_K	0.901	1.00
277_V	280_E	0.898	1.00
209_S	238_Y	0.891	1.00
12_F	268_R	0.890	1.00
88_K	91_K	0.888	1.00
215_I	231_L	0.887	1.00
190_A	201_F	0.884	1.00
143_P	175_L	0.883	1.00
285_K	288_E	0.881	1.00
63_R	71_I	0.874	1.00
23_L	27_V	0.874	1.00
16_L	269_P	0.871	1.00
218_S	231_L	0.870	1.00
62_V	66_L	0.868	1.00
121_A	156_F	0.864	1.00
35_Y	210_S	0.861	1.00
203_T	206_G	0.860	1.00
183_I	200_G	0.856	1.00
40_P	58_V	0.854	1.00
195_V	219_Y	0.854	1.00
19_D	262_I	0.846	1.00
258_L	287_I	0.842	1.00
8_N	38_I	0.841	1.00
80_F	84_G	0.837	1.00
153_I	156_F	0.831	1.00
100_V	128_M	0.830	1.00
114_M	153_I	0.828	1.00
184_D	193_G	0.826	1.00
258_L	279_S	0.814	1.00
16_L	266_A	0.811	1.00
8_N	23_L	0.808	1.00
277_V	281_D	0.808	1.00
27_V	65_A	0.808	1.00
223_R	226_D	0.806	1.00
63_R	96_D	0.805	1.00
90_Y	95_V	0.805	1.00
25_R	261_L	0.802	1.00
21_E	25_R	0.802	1.00
59_V	95_V	0.799	1.00
143_P	168_E	0.794	1.00
192_L	195_V	0.791	1.00
143_P	147_K	0.791	1.00
33_S	210_S	0.789	1.00
24_K	65_A	0.789	1.00
66_L	71_I	0.788	1.00
53_E	56_V	0.787	1.00
59_V	93_I	0.786	1.00
209_S	235_L	0.782	1.00
4_V	206_G	0.779	1.00
115_E	269_P	0.776	1.00
81_L	85_E	0.774	1.00
50_L	58_V	0.773	1.00
41_L	73_A	0.770	1.00
70_E	96_D	0.769	1.00
4_V	201_F	0.764	1.00
232_Y	236_L	0.762	1.00
143_P	171_E	0.756	1.00
43_T	105_Y	0.756	1.00
176_V	199_K	0.755	1.00
236_L	240_S	0.754	1.00
257_W	263_S	0.752	1.00
13_T	16_L	0.742	1.00
18_L	23_L	0.742	1.00
94_G	126_S	0.737	1.00
27_V	66_L	0.736	1.00
131_Y	160_K	0.734	1.00
169_F	182_V	0.734	1.00
27_V	38_I	0.733	1.00
13_T	21_E	0.733	1.00
167_V	188_E	0.730	1.00
102_P	141_L	0.729	1.00
37_Y	72_I	0.727	1.00
192_L	196_L	0.722	1.00
31_Q	65_A	0.722	1.00
83_T	100_V	0.721	1.00
191_L	219_Y	0.718	1.00
110_E	144_Q	0.718	1.00
13_T	266_A	0.711	1.00
214_M	231_L	0.709	1.00
151_D	179_K	0.708	1.00
171_E	174_R	0.707	1.00
75_A	100_V	0.706	1.00
140_D	165_N	0.706	1.00
267_T	271_L	0.704	1.00
222_K	227_T	0.703	1.00
133_N	137_T	0.698	1.00
80_F	119_K	0.698	1.00
146_I	172_V	0.694	1.00
266_A	273_N	0.694	1.00
141_L	146_I	0.693	1.00
30_A	35_Y	0.692	1.00
211_L	214_M	0.685	1.00
56_V	86_L	0.683	1.00
56_V	93_I	0.682	1.00
244_L	278_V	0.681	1.00
41_L	50_L	0.680	0.99
144_Q	171_E	0.680	0.99
132_N	161_E	0.679	0.99
264_S	267_T	0.677	0.99
170_K	174_R	0.677	0.99
4_V	216_Y	0.675	0.99
29_F	259_R	0.675	0.99
245_P	278_V	0.675	0.99
280_E	287_I	0.673	0.99
118_F	148_R	0.673	0.99
52_V	56_V	0.673	0.99
150_N	176_V	0.669	0.99
256_A	259_R	0.666	0.99
18_L	58_V	0.666	0.99
47_F	74_G	0.666	0.99
60_D	92_E	0.660	0.99
30_A	33_S	0.659	0.99
56_V	90_Y	0.657	0.99
28_E	31_Q	0.653	0.99
173_V	176_V	0.651	0.99
170_K	196_L	0.649	0.99
26_I	30_A	0.649	0.99
215_I	219_Y	0.648	0.99
256_A	261_L	0.646	0.99
112_G	272_P	0.646	0.99
51_T	81_L	0.646	0.99
130_L	141_L	0.644	0.99
125_D	155_S	0.644	0.99
174_R	233_D	0.639	0.99
190_A	215_I	0.637	0.99
129_V	157_R	0.634	0.99
82_E	85_E	0.630	0.99
191_L	195_V	0.630	0.99
157_R	181_D	0.630	0.99
281_D	285_K	0.627	0.99
48_S	106_L	0.624	0.99
40_P	71_I	0.622	0.99
5_F	72_I	0.620	0.99
230_R	233_D	0.615	0.99
255_G	258_L	0.614	0.99
274_L	279_S	0.613	0.99
191_L	225_I	0.612	0.99
254_L	267_T	0.610	0.99
144_Q	147_K	0.610	0.99
14_K	264_S	0.607	0.99
173_V	199_K	0.606	0.99
109_N	245_P	0.605	0.99
176_V	179_K	0.601	0.99
14_K	263_S	0.600	0.99
145_L	148_R	0.600	0.99
161_E	169_F	0.598	0.99
109_N	112_G	0.595	0.99
158_V	181_D	0.594	0.99
62_V	71_I	0.592	0.99
177_G	180_I	0.590	0.99
258_L	286_M	0.589	0.99
267_T	272_P	0.589	0.99
41_L	55_K	0.588	0.99
18_L	61_H	0.586	0.99
38_I	69_G	0.585	0.98
191_L	232_Y	0.585	0.98
169_F	173_V	0.585	0.98
61_H	65_A	0.584	0.98
246_L	251_L	0.583	0.98
208_F	255_G	0.583	0.98
170_K	232_Y	0.582	0.98
35_Y	213_L	0.581	0.98
285_K	289_K	0.580	0.98
172_V	182_V	0.579	0.98
263_S	266_A	0.579	0.98
217_E	220_E	0.576	0.98
192_L	232_Y	0.575	0.98
218_S	222_K	0.569	0.98
73_A	90_Y	0.568	0.98
141_L	145_L	0.566	0.98
72_I	99_M	0.565	0.98
8_N	27_V	0.563	0.98
117_F	156_F	0.558	0.98
170_K	192_L	0.558	0.98
12_F	54_E	0.557	0.98
43_T	131_Y	0.555	0.98
102_P	117_F	0.555	0.98
39_V	72_I	0.553	0.98
60_D	64_R	0.552	0.98
174_R	237_E	0.551	0.98
63_R	67_S	0.550	0.98
122_E	155_S	0.550	0.98
40_P	62_V	0.549	0.98
34_G	213_L	0.548	0.98
9_V	252_A	0.547	0.98
65_A	68_K	0.545	0.98
53_E	89_K	0.543	0.98
7_T	204_S	0.543	0.98
151_D	177_G	0.543	0.98
116_Y	119_K	0.542	0.98
255_G	282_V	0.541	0.98
111_K	272_P	0.541	0.98
264_S	279_S	0.540	0.97
95_V	126_S	0.540	0.97
166_V	189_R	0.539	0.97
276_D	283_K	0.539	0.97
7_T	203_T	0.538	0.97
31_Q	66_L	0.538	0.97
129_V	181_D	0.536	0.97
208_F	252_A	0.534	0.97
231_L	234_L	0.533	0.97
190_A	212_P	0.532	0.97
100_V	117_F	0.531	0.97
109_N	249_S	0.527	0.97
190_A	216_Y	0.525	0.97
17_E	57_R	0.524	0.97
219_Y	228_A	0.524	0.97
26_I	262_I	0.523	0.97
208_F	256_A	0.522	0.97
211_L	231_L	0.522	0.97
165_N	168_E	0.521	0.97
218_S	228_A	0.520	0.97
97_K	157_R	0.519	0.97
102_P	113_L	0.517	0.97
83_T	87_C	0.513	0.97
26_I	29_F	0.512	0.97
107_K	135_S	0.512	0.97
77_S	86_L	0.511	0.97
86_L	90_Y	0.510	0.96
205_M	209_S	0.510	0.96
30_A	206_G	0.509	0.96
41_L	59_V	0.509	0.96
84_G	120_V	0.509	0.96
247_T	251_L	0.508	0.96
33_S	213_L	0.508	0.96
87_C	120_V	0.507	0.96
194_L	220_E	0.506	0.96
251_L	274_L	0.506	0.96
23_L	62_V	0.505	0.96
4_V	30_A	0.503	0.96
49_S	80_F	0.503	0.96
27_V	62_V	0.503	0.96
62_V	65_A	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3si9A	3	0.9603	100	0.073	Contact Map
3na8A	3	0.947	100	0.077	Contact Map
2ojpA	2	0.9503	100	0.079	Contact Map
4pfmA	2	0.9603	100	0.079	Contact Map
1xkyA	3	0.9503	100	0.079	Contact Map
4oe7A	3	0.9636	100	0.08	Contact Map
4i7wA	3	0.957	100	0.08	Contact Map
3qzeA	2	0.9536	100	0.081	Contact Map
3fluA	3	0.9536	100	0.081	Contact Map
3eb2A	3	0.9503	100	0.082	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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