GREMLIN Database
Q97UI2 - Dihydrodipicolinate synthase (DapA-2)
UniProt: Q97UI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (283)
Sequences: 10360 (6814)
Seq/√Len: 405.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_N227_T3.9631.00
13_T17_E3.2561.00
114_M148_R3.2171.00
258_L283_K3.1371.00
20_L57_R2.7811.00
20_L61_H2.7331.00
24_K61_H2.7251.00
91_K125_D2.6931.00
56_V89_K2.5631.00
75_A87_C2.5591.00
218_S227_T2.5491.00
24_K64_R2.5461.00
193_G198_A2.5121.00
87_C98_I2.3231.00
63_R66_L2.2101.00
227_T230_R2.1871.00
28_E68_K2.1841.00
28_E64_R2.1151.00
118_F153_I2.1111.00
218_S224_N2.0911.00
217_E222_K2.0881.00
122_E153_I2.0601.00
213_L217_E2.0511.00
29_F33_S2.0261.00
110_E142_S2.0181.00
194_L219_Y2.0171.00
80_F116_Y2.0141.00
5_F37_Y1.9981.00
110_E145_L1.9911.00
147_K175_L1.9871.00
36_K217_E1.9271.00
19_D22_G1.9231.00
283_K287_I1.9041.00
118_F122_E1.9011.00
111_K115_E1.8921.00
28_E32_N1.8841.00
57_R60_D1.8721.00
254_L279_S1.8681.00
52_V82_E1.8631.00
140_D168_E1.8551.00
111_K148_R1.8491.00
211_L234_L1.8071.00
114_M118_F1.7851.00
57_R61_H1.7301.00
129_V158_V1.7121.00
6_L206_G1.6831.00
121_A153_I1.6641.00
100_V120_V1.6451.00
22_G25_R1.6411.00
280_E283_K1.6211.00
146_I159_L1.6181.00
115_E118_F1.6011.00
142_S145_L1.5871.00
54_E268_R1.5861.00
87_C124_C1.5531.00
230_R234_L1.5051.00
59_V73_A1.5041.00
11_P23_L1.5021.00
31_Q69_G1.4731.00
23_L58_V1.4701.00
214_M218_S1.4181.00
91_K124_C1.4121.00
9_V256_A1.4071.00
83_T120_V1.4041.00
115_E119_K1.4011.00
244_L281_D1.3991.00
280_E284_R1.3961.00
276_D279_S1.3931.00
91_K126_S1.3731.00
276_D280_E1.3701.00
36_K213_L1.3631.00
89_K92_E1.3561.00
5_F39_V1.3491.00
214_M227_T1.3391.00
257_W264_S1.3371.00
254_L258_L1.3281.00
275_D278_V1.3261.00
52_V85_E1.3231.00
171_E175_L1.3201.00
77_S83_T1.3021.00
98_I124_C1.2961.00
56_V85_E1.2831.00
79_S82_E1.2831.00
2_D220_E1.2791.00
84_G119_K1.2771.00
24_K63_R1.2721.00
53_E57_R1.2601.00
129_V202_T1.2601.00
31_Q68_K1.2561.00
4_V35_Y1.2551.00
257_W262_I1.2551.00
72_I97_K1.2491.00
52_V89_K1.2381.00
56_V60_D1.2361.00
173_V182_V1.2361.00
284_R288_E1.2331.00
29_F261_L1.2301.00
46_E253_K1.2241.00
191_L228_A1.2221.00
219_Y225_I1.2071.00
119_K269_P1.2031.00
225_I229_I1.1931.00
59_V90_Y1.1871.00
121_A155_S1.1841.00
41_L58_V1.1761.00
17_E81_L1.1721.00
181_D199_K1.1691.00
60_D89_K1.1601.00
216_Y220_E1.1501.00
119_K122_E1.1411.00
13_T19_D1.1401.00
144_Q175_L1.1381.00
226_D229_I1.1351.00
255_G286_M1.1341.00
284_R287_I1.1291.00
88_K92_E1.1271.00
21_E24_K1.1261.00
254_L257_W1.1241.00
20_L24_K1.1111.00
56_V92_E1.1051.00
12_F50_L1.1051.00
61_H64_R1.0991.00
24_K28_E1.0931.00
22_G263_S1.0921.00
119_K123_L1.0891.00
88_K123_L1.0881.00
72_I129_V1.0861.00
60_D93_I1.0821.00
254_L283_K1.0801.00
73_A95_V1.0791.00
214_M217_E1.0611.00
75_A90_Y1.0511.00
2_D199_K1.0431.00
98_I126_S1.0411.00
6_L30_A1.0411.00
148_R151_D1.0411.00
60_D63_R1.0391.00
111_K275_D1.0301.00
14_K266_A1.0291.00
89_K93_I1.0281.00
149_L156_F1.0231.00
84_G88_K1.0221.00
28_E65_A1.0181.00
111_K114_M1.0131.00
229_I233_D1.0121.00
195_V225_I1.0041.00
274_L282_V1.0011.00
281_D284_R1.0001.00
52_V86_L0.9921.00
147_K176_V0.9911.00
98_I128_M0.9881.00
278_V281_D0.9881.00
169_F193_G0.9871.00
279_S283_K0.9841.00
4_V213_L0.9821.00
6_L35_Y0.9791.00
171_E240_S0.9781.00
39_V99_M0.9711.00
227_T231_L0.9711.00
274_L278_V0.9711.00
76_S101_L0.9701.00
121_A128_M0.9621.00
16_L81_L0.9601.00
26_I256_A0.9601.00
150_N180_I0.9581.00
114_M145_L0.9521.00
110_E148_R0.9481.00
27_V61_H0.9471.00
205_M239_R0.9441.00
130_L146_I0.9441.00
53_E85_E0.9431.00
85_E89_K0.9411.00
8_N30_A0.9311.00
71_I95_V0.9291.00
84_G123_L0.9271.00
55_K86_L0.9271.00
77_S82_E0.9261.00
195_V229_I0.9241.00
237_E288_E0.9241.00
75_A98_I0.9211.00
257_W279_S0.9201.00
147_K151_D0.9191.00
194_L216_Y0.9171.00
102_P139_V0.9141.00
115_E272_P0.9141.00
132_N140_D0.9141.00
241_F285_K0.9121.00
113_L139_V0.9101.00
226_D230_R0.9081.00
36_K216_Y0.9071.00
22_G262_I0.9041.00
85_E88_K0.9011.00
277_V280_E0.8981.00
209_S238_Y0.8911.00
12_F268_R0.8901.00
88_K91_K0.8881.00
215_I231_L0.8871.00
190_A201_F0.8841.00
143_P175_L0.8831.00
285_K288_E0.8811.00
63_R71_I0.8741.00
23_L27_V0.8741.00
16_L269_P0.8711.00
218_S231_L0.8701.00
62_V66_L0.8681.00
121_A156_F0.8641.00
35_Y210_S0.8611.00
203_T206_G0.8601.00
183_I200_G0.8561.00
40_P58_V0.8541.00
195_V219_Y0.8541.00
19_D262_I0.8461.00
258_L287_I0.8421.00
8_N38_I0.8411.00
80_F84_G0.8371.00
153_I156_F0.8311.00
100_V128_M0.8301.00
114_M153_I0.8281.00
184_D193_G0.8261.00
258_L279_S0.8141.00
16_L266_A0.8111.00
8_N23_L0.8081.00
277_V281_D0.8081.00
27_V65_A0.8081.00
223_R226_D0.8061.00
63_R96_D0.8051.00
90_Y95_V0.8051.00
25_R261_L0.8021.00
21_E25_R0.8021.00
59_V95_V0.7991.00
143_P168_E0.7941.00
192_L195_V0.7911.00
143_P147_K0.7911.00
33_S210_S0.7891.00
24_K65_A0.7891.00
66_L71_I0.7881.00
53_E56_V0.7871.00
59_V93_I0.7861.00
209_S235_L0.7821.00
4_V206_G0.7791.00
115_E269_P0.7761.00
81_L85_E0.7741.00
50_L58_V0.7731.00
41_L73_A0.7701.00
70_E96_D0.7691.00
4_V201_F0.7641.00
232_Y236_L0.7621.00
143_P171_E0.7561.00
43_T105_Y0.7561.00
176_V199_K0.7551.00
236_L240_S0.7541.00
257_W263_S0.7521.00
13_T16_L0.7421.00
18_L23_L0.7421.00
94_G126_S0.7371.00
27_V66_L0.7361.00
131_Y160_K0.7341.00
169_F182_V0.7341.00
27_V38_I0.7331.00
13_T21_E0.7331.00
167_V188_E0.7301.00
102_P141_L0.7291.00
37_Y72_I0.7271.00
192_L196_L0.7221.00
31_Q65_A0.7221.00
83_T100_V0.7211.00
191_L219_Y0.7181.00
110_E144_Q0.7181.00
13_T266_A0.7111.00
214_M231_L0.7091.00
151_D179_K0.7081.00
171_E174_R0.7071.00
75_A100_V0.7061.00
140_D165_N0.7061.00
267_T271_L0.7041.00
222_K227_T0.7031.00
133_N137_T0.6981.00
80_F119_K0.6981.00
146_I172_V0.6941.00
266_A273_N0.6941.00
141_L146_I0.6931.00
30_A35_Y0.6921.00
211_L214_M0.6851.00
56_V86_L0.6831.00
56_V93_I0.6821.00
244_L278_V0.6811.00
41_L50_L0.6800.99
144_Q171_E0.6800.99
132_N161_E0.6790.99
264_S267_T0.6770.99
170_K174_R0.6770.99
4_V216_Y0.6750.99
29_F259_R0.6750.99
245_P278_V0.6750.99
280_E287_I0.6730.99
118_F148_R0.6730.99
52_V56_V0.6730.99
150_N176_V0.6690.99
256_A259_R0.6660.99
18_L58_V0.6660.99
47_F74_G0.6660.99
60_D92_E0.6600.99
30_A33_S0.6590.99
56_V90_Y0.6570.99
28_E31_Q0.6530.99
173_V176_V0.6510.99
170_K196_L0.6490.99
26_I30_A0.6490.99
215_I219_Y0.6480.99
256_A261_L0.6460.99
112_G272_P0.6460.99
51_T81_L0.6460.99
130_L141_L0.6440.99
125_D155_S0.6440.99
174_R233_D0.6390.99
190_A215_I0.6370.99
129_V157_R0.6340.99
82_E85_E0.6300.99
191_L195_V0.6300.99
157_R181_D0.6300.99
281_D285_K0.6270.99
48_S106_L0.6240.99
40_P71_I0.6220.99
5_F72_I0.6200.99
230_R233_D0.6150.99
255_G258_L0.6140.99
274_L279_S0.6130.99
191_L225_I0.6120.99
254_L267_T0.6100.99
144_Q147_K0.6100.99
14_K264_S0.6070.99
173_V199_K0.6060.99
109_N245_P0.6050.99
176_V179_K0.6010.99
14_K263_S0.6000.99
145_L148_R0.6000.99
161_E169_F0.5980.99
109_N112_G0.5950.99
158_V181_D0.5940.99
62_V71_I0.5920.99
177_G180_I0.5900.99
258_L286_M0.5890.99
267_T272_P0.5890.99
41_L55_K0.5880.99
18_L61_H0.5860.99
38_I69_G0.5850.98
191_L232_Y0.5850.98
169_F173_V0.5850.98
61_H65_A0.5840.98
246_L251_L0.5830.98
208_F255_G0.5830.98
170_K232_Y0.5820.98
35_Y213_L0.5810.98
285_K289_K0.5800.98
172_V182_V0.5790.98
263_S266_A0.5790.98
217_E220_E0.5760.98
192_L232_Y0.5750.98
218_S222_K0.5690.98
73_A90_Y0.5680.98
141_L145_L0.5660.98
72_I99_M0.5650.98
8_N27_V0.5630.98
117_F156_F0.5580.98
170_K192_L0.5580.98
12_F54_E0.5570.98
43_T131_Y0.5550.98
102_P117_F0.5550.98
39_V72_I0.5530.98
60_D64_R0.5520.98
174_R237_E0.5510.98
63_R67_S0.5500.98
122_E155_S0.5500.98
40_P62_V0.5490.98
34_G213_L0.5480.98
9_V252_A0.5470.98
65_A68_K0.5450.98
53_E89_K0.5430.98
7_T204_S0.5430.98
151_D177_G0.5430.98
116_Y119_K0.5420.98
255_G282_V0.5410.98
111_K272_P0.5410.98
264_S279_S0.5400.97
95_V126_S0.5400.97
166_V189_R0.5390.97
276_D283_K0.5390.97
7_T203_T0.5380.97
31_Q66_L0.5380.97
129_V181_D0.5360.97
208_F252_A0.5340.97
231_L234_L0.5330.97
190_A212_P0.5320.97
100_V117_F0.5310.97
109_N249_S0.5270.97
190_A216_Y0.5250.97
17_E57_R0.5240.97
219_Y228_A0.5240.97
26_I262_I0.5230.97
208_F256_A0.5220.97
211_L231_L0.5220.97
165_N168_E0.5210.97
218_S228_A0.5200.97
97_K157_R0.5190.97
102_P113_L0.5170.97
83_T87_C0.5130.97
26_I29_F0.5120.97
107_K135_S0.5120.97
77_S86_L0.5110.97
86_L90_Y0.5100.96
205_M209_S0.5100.96
30_A206_G0.5090.96
41_L59_V0.5090.96
84_G120_V0.5090.96
247_T251_L0.5080.96
33_S213_L0.5080.96
87_C120_V0.5070.96
194_L220_E0.5060.96
251_L274_L0.5060.96
23_L62_V0.5050.96
4_V30_A0.5030.96
49_S80_F0.5030.96
27_V62_V0.5030.96
62_V65_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3si9A 3 0.9603 100 0.073 Contact Map
3na8A 3 0.947 100 0.077 Contact Map
2ojpA 2 0.9503 100 0.079 Contact Map
4pfmA 2 0.9603 100 0.079 Contact Map
1xkyA 3 0.9503 100 0.079 Contact Map
4oe7A 3 0.9636 100 0.08 Contact Map
4i7wA 3 0.957 100 0.08 Contact Map
3qzeA 2 0.9536 100 0.081 Contact Map
3fluA 3 0.9536 100 0.081 Contact Map
3eb2A 3 0.9503 100 0.082 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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