GREMLIN Database
Q97UH7 - Uncharacterized protein
UniProt: Q97UH7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (226)
Sequences: 11297 (9220)
Seq/√Len: 613.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_G163_D3.2971.00
102_D115_T3.0321.00
114_G130_Y2.8561.00
199_G212_H2.7431.00
211_A221_W2.7331.00
193_E211_A2.6511.00
245_G248_E2.6401.00
96_G114_G2.6381.00
241_S255_T2.5101.00
113_A152_W2.4931.00
162_I172_F2.3211.00
222_N225_N2.3171.00
235_P254_I2.3041.00
143_K162_I2.2991.00
80_N83_T2.2631.00
219_S228_K2.2551.00
31_V41_N2.2101.00
30_W40_V2.1181.00
210_I220_R2.0961.00
161_L209_W2.0881.00
210_I244_F2.0551.00
131_K134_G2.0231.00
113_A129_L2.0071.00
161_L171_Q1.9791.00
161_L202_I1.9001.00
104_K151_G1.8401.00
219_S231_E1.8361.00
169_V211_A1.8001.00
221_W228_K1.7941.00
42_N45_T1.7741.00
63_I105_C1.7541.00
143_K164_T1.7301.00
22_D25_G1.7101.00
158_L171_Q1.7021.00
218_V254_I1.7001.00
153_D202_I1.6991.00
127_A162_I1.6851.00
210_I242_V1.6531.00
104_K150_L1.5651.00
113_A160_Y1.5581.00
39_I48_E1.5331.00
50_Y53_T1.5161.00
212_H239_V1.5061.00
245_G249_M1.4961.00
77_H86_I1.4781.00
186_I189_D1.4711.00
106_D152_W1.4611.00
18_S32_D1.4361.00
201_T243_T1.4341.00
193_E213_S1.4281.00
76_F114_G1.4221.00
63_I67_R1.4161.00
217_K231_E1.4161.00
106_D110_R1.4131.00
245_G251_Q1.4041.00
164_T168_K1.4031.00
163_D197_P1.4031.00
96_G116_M1.3601.00
128_S139_K1.3561.00
151_G201_T1.3481.00
170_F189_D1.3471.00
79_L86_I1.3451.00
245_G253_F1.3401.00
173_D176_K1.3401.00
203_D244_F1.3331.00
103_G114_G1.3251.00
115_T147_S1.3241.00
152_W174_F1.3221.00
101_N117_N1.3211.00
201_T242_V1.3151.00
113_A150_L1.3011.00
228_K231_E1.2881.00
30_W62_L1.2871.00
110_R133_E1.2851.00
208_L229_V1.2731.00
118_L126_T1.2611.00
204_E249_M1.2581.00
150_L162_I1.2531.00
198_D214_A1.2411.00
245_G250_N1.2241.00
22_D62_L1.2061.00
143_K166_L1.1991.00
32_D36_K1.1951.00
128_S136_R1.1891.00
244_F252_I1.1811.00
210_I252_I1.1691.00
130_Y136_R1.1661.00
63_I66_K1.1641.00
105_C112_W1.1621.00
203_D207_Y1.1611.00
41_N48_E1.1481.00
151_G200_M1.1311.00
153_D156_N1.1251.00
201_T244_F1.1221.00
96_G100_F1.1071.00
235_P239_V1.1041.00
107_I152_W1.0971.00
203_D206_G1.0961.00
116_M119_H1.0941.00
212_H242_V1.0851.00
148_N165_P1.0841.00
114_G128_S1.0831.00
143_K147_S1.0761.00
211_A219_S1.0731.00
256_T259_K1.0711.00
98_N117_N1.0691.00
168_K189_D1.0631.00
61_C104_K1.0621.00
68_I71_T1.0591.00
163_D200_M1.0551.00
59_S71_T1.0521.00
115_T150_L1.0491.00
153_D157_K1.0451.00
213_S217_K1.0401.00
31_V39_I1.0401.00
161_L200_M1.0331.00
86_I89_Y1.0321.00
164_T167_R1.0291.00
152_W160_Y1.0251.00
33_I37_K1.0211.00
203_D210_I1.0081.00
151_G202_I1.0021.00
154_P202_I0.9991.00
61_C103_G0.9911.00
70_V105_C0.9861.00
61_C105_C0.9831.00
30_W60_L0.9771.00
70_V79_L0.9771.00
22_D27_R0.9721.00
20_V61_C0.9711.00
214_A238_Y0.9681.00
234_L254_I0.9601.00
235_P256_T0.9511.00
154_P206_G0.9501.00
70_V78_T0.9401.00
106_D111_Y0.9371.00
170_F186_I0.9341.00
33_I36_K0.9341.00
200_M211_A0.9331.00
136_R139_K0.9301.00
76_F103_G0.9261.00
55_D73_R0.9241.00
157_K175_D0.9221.00
27_R42_N0.9201.00
64_D105_C0.9161.00
106_D109_D0.9141.00
213_S219_S0.9071.00
202_I209_W0.9041.00
110_R131_K0.9011.00
162_I170_F0.8991.00
217_K233_K0.8981.00
218_V242_V0.8971.00
28_L32_D0.8911.00
33_I39_I0.8911.00
243_T253_F0.8901.00
142_D172_F0.8891.00
193_E197_P0.8881.00
147_S162_I0.8831.00
240_S257_M0.8811.00
69_I78_T0.8791.00
146_R165_P0.8771.00
145_Y165_P0.8731.00
222_N229_V0.8681.00
107_I156_N0.8511.00
204_E244_F0.8501.00
256_T260_G0.8461.00
100_F116_M0.8441.00
255_T259_K0.8351.00
209_W223_P0.8331.00
207_Y220_R0.8321.00
184_K187_V0.8271.00
193_E221_W0.8261.00
198_D240_S0.8221.00
116_M128_S0.8091.00
20_V62_L0.8081.00
169_V200_M0.8081.00
208_L220_R0.8011.00
148_N198_D0.7961.00
186_I190_F0.7941.00
205_E249_M0.7931.00
242_V254_I0.7911.00
42_N47_E0.7891.00
196_R214_A0.7881.00
212_H216_G0.7841.00
37_K52_D0.7831.00
22_D26_N0.7811.00
49_K52_D0.7761.00
32_D35_G0.7741.00
88_P91_E0.7731.00
223_P226_G0.7731.00
102_D150_L0.7721.00
164_T170_F0.7641.00
193_E215_G0.7611.00
192_Y221_W0.7591.00
112_W132_L0.7581.00
62_L81_L0.7561.00
20_V60_L0.7561.00
169_V197_P0.7521.00
192_Y219_S0.7511.00
96_G128_S0.7471.00
101_N148_N0.7461.00
116_M126_T0.7411.00
38_V60_L0.7401.00
163_D167_R0.7391.00
126_T139_K0.7391.00
43_L46_N0.7341.00
23_R62_L0.7291.00
242_V252_I0.7281.00
151_G161_L0.7261.00
73_R77_H0.7241.00
35_G39_I0.7241.00
218_V232_I0.7231.00
20_V30_W0.7211.00
57_V60_L0.7181.00
111_Y137_L0.7181.00
222_N227_E0.7161.00
159_F202_I0.7131.00
213_S221_W0.7111.00
34_D56_L0.7071.00
166_L170_F0.7021.00
115_T119_H0.7011.00
184_K188_M0.7001.00
104_K152_W0.7001.00
147_S164_T0.6971.00
67_R80_N0.6961.00
149_G199_G0.6951.00
79_L84_G0.6941.00
132_L135_Q0.6911.00
81_L84_G0.6891.00
201_T210_I0.6881.00
111_Y114_G0.6871.00
199_G241_S0.6871.00
153_D159_F0.6841.00
29_F43_L0.6811.00
149_G200_M0.6781.00
234_L256_T0.6761.00
103_G112_W0.6761.00
100_F103_G0.6751.00
202_I223_P0.6731.00
171_Q202_I0.6731.00
238_Y257_M0.6721.00
96_G118_L0.6651.00
28_L40_V0.6641.00
95_N98_N0.6641.00
40_V62_L0.6581.00
30_W68_I0.6561.00
207_Y224_K0.6491.00
173_D185_R0.6481.00
95_N130_Y0.6471.00
215_G219_S0.6471.00
34_D37_K0.6381.00
75_G91_E0.6381.00
207_Y222_N0.6351.00
71_T79_L0.6341.00
102_D149_G0.6341.00
235_P258_S0.6331.00
30_W41_N0.6311.00
96_G130_Y0.6301.00
131_K173_D0.6261.00
59_S103_G0.6241.00
39_I50_Y0.6231.00
248_E251_Q0.6231.00
239_V254_I0.6221.00
105_C132_L0.6221.00
155_D158_L0.6181.00
171_Q185_R0.6161.00
141_L144_L0.6141.00
95_N128_S0.6141.00
240_S255_T0.6141.00
104_K113_A0.6121.00
67_R82_T0.6101.00
25_G28_L0.6101.00
127_A150_L0.6101.00
29_F32_D0.6101.00
53_T71_T0.6091.00
218_V239_V0.6061.00
221_W226_G0.6061.00
98_N116_M0.6041.00
80_N87_T0.6001.00
143_K170_F0.5981.00
153_D158_L0.5971.00
27_R44_D0.5961.00
72_L75_G0.5911.00
27_R31_V0.5901.00
62_L67_R0.5891.00
187_V190_F0.5871.00
118_L128_S0.5851.00
228_K232_I0.5831.00
197_P213_S0.5831.00
129_L152_W0.5821.00
213_S216_G0.5761.00
195_G214_A0.5751.00
203_D208_L0.5711.00
60_L71_T0.5701.00
72_L77_H0.5681.00
100_F114_G0.5641.00
244_F249_M0.5601.00
115_T127_A0.5591.00
21_Y43_L0.5591.00
23_R26_N0.5561.00
112_W130_Y0.5541.00
32_D60_L0.5541.00
85_E88_P0.5521.00
60_L70_V0.5521.00
212_H254_I0.5521.00
111_Y115_T0.5480.99
69_I105_C0.5470.99
27_R40_V0.5470.99
239_V256_T0.5440.99
67_R70_V0.5430.99
170_F184_K0.5380.99
63_I109_D0.5370.99
21_Y29_F0.5350.99
113_A127_A0.5310.99
129_L138_T0.5290.99
131_K135_Q0.5280.99
174_F184_K0.5270.99
168_K191_K0.5260.99
239_V242_V0.5260.99
254_I258_S0.5250.99
164_T172_F0.5220.99
77_H89_Y0.5220.99
131_K137_L0.5220.99
176_K184_K0.5210.99
176_K185_R0.5200.99
172_F186_I0.5200.99
185_R188_M0.5160.99
197_P200_M0.5130.99
197_P215_G0.5120.99
233_K238_Y0.5090.99
30_W69_I0.5070.99
202_I244_F0.5060.99
63_I78_T0.5050.99
60_L66_K0.5030.99
26_N43_L0.5030.99
64_D109_D0.5020.99
208_L212_H0.5010.99
19_P31_V0.5010.99
193_E219_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.9333 100 0.213 Contact Map
3dm0A 1 0.9263 100 0.224 Contact Map
4j73A 1 0.9333 100 0.224 Contact Map
4u1eI 1 0.9333 100 0.238 Contact Map
5a1uD 1 0.9333 100 0.239 Contact Map
4wjuA 1 0.8526 100 0.24 Contact Map
4lg9A 1 0.9158 100 0.24 Contact Map
3sfzA 1 0.9544 100 0.24 Contact Map
3ow8A 3 0.8596 100 0.241 Contact Map
3zey7 1 0.9333 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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