GLCD2 - SULSO - GREMLIN Contacts

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GLCD2 - Glucose 1-dehydrogenase 2

UniProt:	Q97UH6	Sequences: MKAIVVKPPNPGVEIKDVKDDENKLSNIGLVKVKILENGICGTDREIVSGKRTSVKPPIGKDELILGHEAIGIVEVGGYGFKEGELVMPINKRGCGKCLNCLIGRPDFCETGEGLVAGTKGLDGFMREYLYDDPKYLVKIPPAIKDIAILAQPLADIEKSVESILTSQKRIPIWTCDDGTLNCRKALVVGTGPTGILFSLVLRTYGFQVWIANRRELLDNEKEILDEPRILFYNSAKGYESLVKDVDKFDLIIDTTGASASIIQELVPLLQINGVLGLFGFPRYDNFSLDYKIVQDFVINNRIIIGLDNGQKPHFQQALIHLASWKSLWPKTASKMITKIISINDEREVISSLREKLPGEIKVKIVWE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	368 (298)
Sequences:	51491 (35183)
Seq/√Len:	2038.1

ECOLI - YBDR RSPB YGGP AHR YPHC YDJL YAHK TDH ADHP GATD FRMA YJJN IDND YDJJ ACUI YCJQ QOR1 CURA
BACSU - YJMD ADHB YOGA DHSO ADHA YYCR TDH BDHA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HR85 Q9HQS8
SULSO - GLCD2 GLCD1 Q97VV5 Q97YT7 Q7LXK1 Q97VW0 ADH GLCD3 Q97XR4 Q97ZV3 Q97V32 Q97WA1 Q97YM2 Q97TZ4 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
345_D	348_E	3.082	1.00
34_K	75_E	2.930	1.00
36_L	73_I	2.918	1.00
32_K	75_E	2.814	1.00
7_K	16_K	2.784	1.00
31_V	137_L	2.727	1.00
203_R	231_L	2.684	1.00
185_K	208_Q	2.652	1.00
86_L	140_I	2.605	1.00
82_K	85_E	2.513	1.00
85_E	139_K	2.484	1.00
341_I	352_S	2.421	1.00
70_A	125_F	2.405	1.00
223_E	227_E	2.391	1.00
34_K	73_I	2.382	1.00
242_L	245_D	2.345	1.00
146_D	340_I	2.334	1.00
20_D	129_Y	2.311	1.00
34_K	129_Y	2.243	1.00
181_L	184_R	2.236	1.00
222_K	226_D	2.178	1.00
80_G	134_P	2.177	1.00
208_Q	232_F	2.174	1.00
186_A	202_L	2.172	1.00
191_T	211_I	2.160	1.00
320_I	324_S	2.150	1.00
339_K	352_S	2.116	1.00
7_K	14_E	2.093	1.00
5_V	16_K	2.088	1.00
199_S	230_I	2.069	1.00
27_N	30_L	2.012	1.00
70_A	89_P	1.998	1.00
143_A	323_A	1.989	1.00
340_I	366_V	1.959	1.00
342_S	345_D	1.956	1.00
351_S	355_E	1.900	1.00
162_E	205_Y	1.887	1.00
216_E	223_E	1.877	1.00
187_L	212_A	1.872	1.00
187_L	249_F	1.867	1.00
22_E	76_V	1.864	1.00
210_W	249_F	1.847	1.00
32_K	131_Y	1.837	1.00
49_S	354_R	1.835	1.00
75_E	129_Y	1.834	1.00
355_E	358_P	1.825	1.00
348_E	351_S	1.820	1.00
184_R	275_V	1.808	1.00
223_E	226_D	1.808	1.00
250_D	271_Q	1.764	1.00
341_I	349_V	1.761	1.00
204_T	326_K	1.747	1.00
154_L	197_L	1.724	1.00
213_N	222_K	1.718	1.00
162_E	317_Q	1.708	1.00
222_K	233_Y	1.695	1.00
275_V	303_I	1.688	1.00
348_E	352_S	1.685	1.00
270_L	276_L	1.666	1.00
189_V	266_L	1.660	1.00
77_G	83_E	1.656	1.00
26_S	131_Y	1.616	1.00
81_F	139_K	1.593	1.00
81_F	85_E	1.591	1.00
86_L	142_P	1.587	1.00
224_I	227_E	1.573	1.00
4_I	346_E	1.571	1.00
126_M	350_I	1.565	1.00
208_Q	231_L	1.555	1.00
76_V	83_E	1.545	1.00
270_L	302_R	1.538	1.00
30_L	133_D	1.534	1.00
35_I	70_A	1.503	1.00
73_I	86_L	1.503	1.00
275_V	305_I	1.501	1.00
270_L	274_G	1.492	1.00
32_K	129_Y	1.486	1.00
140_I	148_A	1.447	1.00
199_S	211_I	1.426	1.00
214_R	236_A	1.424	1.00
180_T	184_R	1.417	1.00
29_G	133_D	1.415	1.00
232_F	246_V	1.415	1.00
146_D	366_V	1.415	1.00
48_V	350_I	1.410	1.00
30_L	131_Y	1.404	1.00
26_S	32_K	1.401	1.00
252_I	266_L	1.400	1.00
74_V	81_F	1.381	1.00
37_E	146_D	1.380	1.00
31_V	81_F	1.376	1.00
241_S	245_D	1.374	1.00
347_R	351_S	1.367	1.00
352_S	358_P	1.366	1.00
216_E	235_S	1.364	1.00
252_I	270_L	1.364	1.00
338_T	352_S	1.351	1.00
185_K	210_W	1.321	1.00
32_K	76_V	1.305	1.00
198_F	253_I	1.287	1.00
189_V	212_A	1.262	1.00
204_T	321_H	1.260	1.00
320_I	323_A	1.253	1.00
158_E	162_E	1.252	1.00
26_S	30_L	1.247	1.00
4_I	15_I	1.231	1.00
180_T	207_F	1.225	1.00
81_F	137_L	1.215	1.00
36_L	71_I	1.204	1.00
226_D	233_Y	1.198	1.00
3_A	18_V	1.194	1.00
36_L	86_L	1.178	1.00
185_K	250_D	1.176	1.00
20_D	32_K	1.176	1.00
242_L	246_V	1.169	1.00
215_R	220_N	1.159	1.00
33_V	72_G	1.154	1.00
211_I	230_I	1.148	1.00
37_E	366_V	1.144	1.00
9_P	12_G	1.134	1.00
35_I	130_L	1.130	1.00
29_G	134_P	1.127	1.00
200_L	328_L	1.125	1.00
342_S	366_V	1.109	1.00
132_D	137_L	1.108	1.00
75_E	83_E	1.098	1.00
40_I	349_V	1.094	1.00
184_R	250_D	1.094	1.00
238_G	242_L	1.091	1.00
48_V	354_R	1.087	1.00
317_Q	320_I	1.079	1.00
4_I	343_I	1.074	1.00
312_K	316_Q	1.069	1.00
222_K	235_S	1.068	1.00
215_R	235_S	1.065	1.00
37_E	364_K	1.050	1.00
268_P	296_D	1.049	1.00
33_V	87_V	1.047	1.00
321_H	326_K	1.042	1.00
15_I	344_N	1.042	1.00
226_D	232_F	1.036	1.00
41_C	69_E	1.034	1.00
224_I	360_E	1.026	1.00
316_Q	320_I	1.023	1.00
152_Q	156_D	1.021	1.00
346_E	365_I	1.016	1.00
41_C	68_H	1.014	1.00
147_I	328_L	1.013	1.00
191_T	213_N	1.011	1.00
238_G	241_S	1.002	1.00
210_W	232_F	0.999	1.00
157_I	161_V	0.990	1.00
22_E	26_S	0.987	1.00
214_R	222_K	0.975	1.00
240_E	244_K	0.975	1.00
126_M	346_E	0.971	1.00
202_L	207_F	0.969	1.00
5_V	18_V	0.968	1.00
5_V	65_I	0.966	1.00
254_D	257_G	0.965	1.00
199_S	209_V	0.960	1.00
162_E	314_H	0.952	1.00
157_I	201_V	0.947	1.00
214_R	237_K	0.947	1.00
153_P	156_D	0.944	1.00
38_N	125_F	0.941	1.00
38_N	126_M	0.941	1.00
188_V	198_F	0.937	1.00
210_W	234_N	0.929	1.00
20_D	76_V	0.928	1.00
201_V	318_A	0.927	1.00
352_S	363_V	0.925	1.00
235_S	238_G	0.920	1.00
29_G	78_G	0.920	1.00
126_M	365_I	0.915	1.00
216_E	222_K	0.914	1.00
45_R	353_L	0.914	1.00
154_L	318_A	0.914	1.00
351_S	354_R	0.912	1.00
34_K	128_E	0.906	1.00
188_V	202_L	0.905	1.00
264_Q	268_P	0.902	1.00
189_V	252_I	0.901	1.00
240_E	268_P	0.896	1.00
39_G	69_E	0.895	1.00
191_T	225_L	0.893	1.00
297_F	304_I	0.888	1.00
159_K	314_H	0.886	1.00
187_L	269_L	0.882	1.00
196_I	224_I	0.879	1.00
20_D	75_E	0.876	1.00
18_V	123_D	0.874	1.00
220_N	223_E	0.870	1.00
22_E	32_K	0.868	1.00
213_N	233_Y	0.868	1.00
185_K	249_F	0.863	1.00
82_K	139_K	0.859	1.00
79_Y	134_P	0.858	1.00
191_T	199_S	0.854	1.00
221_E	360_E	0.852	1.00
265_E	268_P	0.847	1.00
184_R	251_L	0.846	1.00
3_A	65_I	0.846	1.00
329_W	336_M	0.846	1.00
70_A	130_L	0.840	1.00
211_I	225_L	0.840	1.00
296_D	300_N	0.836	1.00
64_L	123_D	0.831	1.00
341_I	345_D	0.826	1.00
26_S	29_G	0.825	1.00
313_P	317_Q	0.821	1.00
160_S	279_F	0.820	1.00
26_S	78_G	0.818	1.00
157_I	198_F	0.818	1.00
317_Q	321_H	0.817	1.00
273_N	301_N	0.817	1.00
225_L	230_I	0.814	1.00
40_I	353_L	0.813	1.00
4_I	13_V	0.812	1.00
215_R	221_E	0.810	1.00
88_M	319_L	0.808	1.00
180_T	251_L	0.806	1.00
240_E	265_E	0.803	1.00
353_L	363_V	0.802	1.00
150_L	322_L	0.799	1.00
241_S	244_K	0.798	1.00
201_V	321_H	0.797	1.00
158_E	317_Q	0.797	1.00
243_V	249_F	0.797	1.00
159_K	163_S	0.791	1.00
71_I	86_L	0.789	1.00
7_K	12_G	0.788	1.00
144_I	148_A	0.785	1.00
216_E	220_N	0.785	1.00
41_C	44_D	0.782	1.00
157_I	194_T	0.781	1.00
266_L	276_L	0.779	1.00
27_N	131_Y	0.777	1.00
142_P	323_A	0.772	1.00
252_I	276_L	0.770	1.00
156_D	161_V	0.769	1.00
77_G	82_K	0.765	1.00
251_L	277_G	0.765	1.00
186_A	207_F	0.764	1.00
212_A	236_A	0.763	1.00
202_L	209_V	0.762	1.00
4_I	347_R	0.761	1.00
321_H	325_W	0.760	1.00
160_S	253_I	0.758	1.00
87_V	137_L	0.754	1.00
71_I	140_I	0.751	1.00
15_I	343_I	0.750	1.00
155_A	314_H	0.750	1.00
40_I	126_M	0.749	1.00
31_V	134_P	0.749	1.00
321_H	324_S	0.746	1.00
26_S	76_V	0.746	1.00
297_F	302_R	0.741	1.00
43_T	68_H	0.739	1.00
205_Y	317_Q	0.737	1.00
161_V	202_L	0.736	1.00
86_L	143_A	0.732	1.00
247_D	271_Q	0.731	1.00
313_P	316_Q	0.730	1.00
209_V	231_L	0.728	1.00
339_K	363_V	0.728	1.00
144_I	322_L	0.726	1.00
159_K	301_N	0.725	1.00
213_N	225_L	0.724	1.00
210_W	246_V	0.723	1.00
156_D	160_S	0.723	1.00
249_F	252_I	0.720	1.00
185_K	247_D	0.713	1.00
352_S	355_E	0.711	1.00
255_T	279_F	0.711	1.00
188_V	211_I	0.708	1.00
18_V	65_I	0.707	1.00
339_K	348_E	0.703	1.00
337_I	340_I	0.702	1.00
240_E	269_L	0.699	1.00
141_P	323_A	0.698	1.00
134_P	137_L	0.696	1.00
341_I	365_I	0.689	1.00
244_K	248_K	0.686	1.00
138_V	316_Q	0.686	1.00
272_I	300_N	0.683	1.00
157_I	160_S	0.683	1.00
341_I	363_V	0.679	1.00
278_L	304_I	0.678	1.00
138_V	315_F	0.676	1.00
6_V	12_G	0.676	1.00
210_W	243_V	0.676	1.00
71_I	149_I	0.672	1.00
297_F	306_G	0.672	1.00
207_F	251_L	0.672	1.00
239_Y	265_E	0.667	1.00
77_G	85_E	0.667	1.00
319_L	323_A	0.666	1.00
227_E	328_L	0.664	1.00
160_S	198_F	0.663	1.00
125_F	130_L	0.662	1.00
69_E	152_Q	0.661	1.00
27_N	78_G	0.661	1.00
186_A	251_L	0.660	1.00
231_L	234_N	0.659	1.00
249_F	269_L	0.659	1.00
85_E	142_P	0.656	1.00
179_G	303_I	0.654	1.00
158_E	161_V	0.653	1.00
37_E	71_I	0.652	1.00
41_C	153_P	0.649	1.00
11_P	351_S	0.649	1.00
224_I	228_P	0.648	1.00
31_V	74_V	0.646	1.00
203_R	209_V	0.644	1.00
222_K	225_L	0.643	1.00
263_I	276_L	0.642	1.00
80_G	139_K	0.642	1.00
88_M	140_I	0.639	1.00
80_G	312_K	0.637	1.00
41_C	152_Q	0.636	1.00
29_G	135_K	0.636	1.00
243_V	246_V	0.634	1.00
42_G	46_E	0.632	1.00
89_P	132_D	0.630	1.00
157_I	197_L	0.629	1.00
138_V	319_L	0.627	1.00
201_V	205_Y	0.625	1.00
215_R	222_K	0.625	1.00
198_F	279_F	0.624	1.00
145_K	148_A	0.623	1.00
179_G	305_I	0.622	1.00
28_I	78_G	0.621	1.00
251_L	275_V	0.619	1.00
80_G	83_E	0.618	1.00
243_V	269_L	0.618	1.00
264_Q	286_N	0.618	1.00
350_I	354_R	0.617	1.00
254_D	276_L	0.617	1.00
43_T	47_I	0.617	1.00
37_E	340_I	0.617	1.00
196_I	336_M	0.614	1.00
224_I	336_M	0.612	1.00
68_H	152_Q	0.611	1.00
21_D	131_Y	0.610	1.00
352_S	359_G	0.610	1.00
162_E	201_V	0.609	1.00
158_E	318_A	0.609	1.00
216_E	238_G	0.608	1.00
199_S	228_P	0.608	1.00
200_L	228_P	0.604	1.00
79_Y	82_K	0.603	1.00
286_N	290_D	0.602	1.00
21_D	32_K	0.601	1.00
252_I	269_L	0.598	1.00
290_D	296_D	0.598	1.00
213_N	236_A	0.594	1.00
238_G	265_E	0.593	1.00
33_V	89_P	0.593	1.00
179_G	275_V	0.590	1.00
301_N	311_Q	0.590	1.00
10_N	351_S	0.588	1.00
36_L	366_V	0.587	1.00
46_E	51_K	0.586	1.00
36_L	140_I	0.583	1.00
322_L	329_W	0.582	1.00
35_I	38_N	0.581	1.00
325_W	328_L	0.581	1.00
21_D	129_Y	0.579	1.00
179_G	184_R	0.579	1.00
264_Q	296_D	0.579	1.00
212_A	234_N	0.572	1.00
42_G	192_G	0.569	1.00
359_G	363_V	0.568	1.00
45_R	354_R	0.568	1.00
158_E	321_H	0.568	1.00
290_D	294_V	0.566	1.00
41_C	362_K	0.566	1.00
259_S	264_Q	0.563	1.00
33_V	137_L	0.560	1.00
67_G	126_M	0.559	1.00
35_I	89_P	0.559	1.00
90_I	138_V	0.558	1.00
315_F	319_L	0.558	1.00
153_P	193_P	0.556	1.00
163_S	303_I	0.555	1.00
43_T	46_E	0.553	1.00
20_D	26_S	0.552	1.00
197_L	201_V	0.551	1.00
254_D	280_G	0.551	1.00
187_L	252_I	0.550	1.00
213_N	235_S	0.549	1.00
200_L	327_S	0.548	1.00
264_Q	288_S	0.547	1.00
153_P	157_I	0.546	1.00
138_V	312_K	0.545	1.00
295_Q	298_V	0.545	1.00
20_D	131_Y	0.544	1.00
185_K	248_K	0.542	1.00
47_I	52_R	0.541	1.00
89_P	137_L	0.539	1.00
38_N	365_I	0.538	1.00
222_K	236_A	0.537	1.00
19_K	22_E	0.537	1.00
161_V	164_I	0.535	1.00
322_L	327_S	0.534	1.00
155_A	159_K	0.533	1.00
199_S	225_L	0.532	1.00
286_N	289_L	0.532	1.00
290_D	295_Q	0.531	1.00
81_F	134_P	0.530	1.00
160_S	163_S	0.530	1.00
213_N	221_E	0.529	1.00
77_G	81_F	0.529	1.00
12_G	347_R	0.529	1.00
182_N	205_Y	0.525	1.00
30_L	122_L	0.524	1.00
232_F	242_L	0.524	1.00
15_I	346_E	0.522	1.00
164_I	251_L	0.521	1.00
314_H	317_Q	0.520	1.00
150_L	154_L	0.518	1.00
234_N	239_Y	0.518	1.00
12_G	48_V	0.515	1.00
230_I	233_Y	0.514	1.00
355_E	359_G	0.511	1.00
277_G	307_L	0.510	1.00
182_N	206_G	0.510	1.00
151_A	154_L	0.510	1.00
248_K	271_Q	0.509	1.00
203_R	230_I	0.508	1.00
197_L	200_L	0.507	1.00
29_G	77_G	0.506	1.00
232_F	235_S	0.506	1.00
247_D	250_D	0.505	1.00
45_R	49_S	0.505	1.00
307_L	310_G	0.504	1.00
339_K	360_E	0.504	1.00
77_G	80_G	0.504	1.00
33_V	70_A	0.503	1.00
161_V	201_V	0.503	1.00
266_L	270_L	0.503	1.00
154_L	158_E	0.502	1.00
39_G	149_I	0.502	1.00
197_L	327_S	0.501	1.00
151_A	315_F	0.500	1.00
196_I	228_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cdcA	3	0.9674	100	0.179	Contact Map
4ej6A	1	0.8886	100	0.207	Contact Map
4gi2A	2	0.9158	100	0.21	Contact Map
4ilkA	2	0.8886	100	0.212	Contact Map
1vj0A	4	0.9022	100	0.213	Contact Map
2dq4A	4	0.8995	100	0.214	Contact Map
4cpdA	2	0.894	100	0.216	Contact Map
3ukoA	4	0.9049	100	0.218	Contact Map
1h2bA	4	0.8995	100	0.218	Contact Map
3widA	4	0.9565	100	0.218	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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