GREMLIN Database
GLCD2 - Glucose 1-dehydrogenase 2
UniProt: Q97UH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (298)
Sequences: 51491 (35183)
Seq/√Len: 2038.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
345_D348_E3.0821.00
34_K75_E2.9301.00
36_L73_I2.9181.00
32_K75_E2.8141.00
7_K16_K2.7841.00
31_V137_L2.7271.00
203_R231_L2.6841.00
185_K208_Q2.6521.00
86_L140_I2.6051.00
82_K85_E2.5131.00
85_E139_K2.4841.00
341_I352_S2.4211.00
70_A125_F2.4051.00
223_E227_E2.3911.00
34_K73_I2.3821.00
242_L245_D2.3451.00
146_D340_I2.3341.00
20_D129_Y2.3111.00
34_K129_Y2.2431.00
181_L184_R2.2361.00
222_K226_D2.1781.00
80_G134_P2.1771.00
208_Q232_F2.1741.00
186_A202_L2.1721.00
191_T211_I2.1601.00
320_I324_S2.1501.00
339_K352_S2.1161.00
7_K14_E2.0931.00
5_V16_K2.0881.00
199_S230_I2.0691.00
27_N30_L2.0121.00
70_A89_P1.9981.00
143_A323_A1.9891.00
340_I366_V1.9591.00
342_S345_D1.9561.00
351_S355_E1.9001.00
162_E205_Y1.8871.00
216_E223_E1.8771.00
187_L212_A1.8721.00
187_L249_F1.8671.00
22_E76_V1.8641.00
210_W249_F1.8471.00
32_K131_Y1.8371.00
49_S354_R1.8351.00
75_E129_Y1.8341.00
355_E358_P1.8251.00
348_E351_S1.8201.00
184_R275_V1.8081.00
223_E226_D1.8081.00
250_D271_Q1.7641.00
341_I349_V1.7611.00
204_T326_K1.7471.00
154_L197_L1.7241.00
213_N222_K1.7181.00
162_E317_Q1.7081.00
222_K233_Y1.6951.00
275_V303_I1.6881.00
348_E352_S1.6851.00
270_L276_L1.6661.00
189_V266_L1.6601.00
77_G83_E1.6561.00
26_S131_Y1.6161.00
81_F139_K1.5931.00
81_F85_E1.5911.00
86_L142_P1.5871.00
224_I227_E1.5731.00
4_I346_E1.5711.00
126_M350_I1.5651.00
208_Q231_L1.5551.00
76_V83_E1.5451.00
270_L302_R1.5381.00
30_L133_D1.5341.00
35_I70_A1.5031.00
73_I86_L1.5031.00
275_V305_I1.5011.00
270_L274_G1.4921.00
32_K129_Y1.4861.00
140_I148_A1.4471.00
199_S211_I1.4261.00
214_R236_A1.4241.00
180_T184_R1.4171.00
29_G133_D1.4151.00
232_F246_V1.4151.00
146_D366_V1.4151.00
48_V350_I1.4101.00
30_L131_Y1.4041.00
26_S32_K1.4011.00
252_I266_L1.4001.00
74_V81_F1.3811.00
37_E146_D1.3801.00
31_V81_F1.3761.00
241_S245_D1.3741.00
347_R351_S1.3671.00
352_S358_P1.3661.00
216_E235_S1.3641.00
252_I270_L1.3641.00
338_T352_S1.3511.00
185_K210_W1.3211.00
32_K76_V1.3051.00
198_F253_I1.2871.00
189_V212_A1.2621.00
204_T321_H1.2601.00
320_I323_A1.2531.00
158_E162_E1.2521.00
26_S30_L1.2471.00
4_I15_I1.2311.00
180_T207_F1.2251.00
81_F137_L1.2151.00
36_L71_I1.2041.00
226_D233_Y1.1981.00
3_A18_V1.1941.00
36_L86_L1.1781.00
185_K250_D1.1761.00
20_D32_K1.1761.00
242_L246_V1.1691.00
215_R220_N1.1591.00
33_V72_G1.1541.00
211_I230_I1.1481.00
37_E366_V1.1441.00
9_P12_G1.1341.00
35_I130_L1.1301.00
29_G134_P1.1271.00
200_L328_L1.1251.00
342_S366_V1.1091.00
132_D137_L1.1081.00
75_E83_E1.0981.00
40_I349_V1.0941.00
184_R250_D1.0941.00
238_G242_L1.0911.00
48_V354_R1.0871.00
317_Q320_I1.0791.00
4_I343_I1.0741.00
312_K316_Q1.0691.00
222_K235_S1.0681.00
215_R235_S1.0651.00
37_E364_K1.0501.00
268_P296_D1.0491.00
33_V87_V1.0471.00
321_H326_K1.0421.00
15_I344_N1.0421.00
226_D232_F1.0361.00
41_C69_E1.0341.00
224_I360_E1.0261.00
316_Q320_I1.0231.00
152_Q156_D1.0211.00
346_E365_I1.0161.00
41_C68_H1.0141.00
147_I328_L1.0131.00
191_T213_N1.0111.00
238_G241_S1.0021.00
210_W232_F0.9991.00
157_I161_V0.9901.00
22_E26_S0.9871.00
214_R222_K0.9751.00
240_E244_K0.9751.00
126_M346_E0.9711.00
202_L207_F0.9691.00
5_V18_V0.9681.00
5_V65_I0.9661.00
254_D257_G0.9651.00
199_S209_V0.9601.00
162_E314_H0.9521.00
157_I201_V0.9471.00
214_R237_K0.9471.00
153_P156_D0.9441.00
38_N125_F0.9411.00
38_N126_M0.9411.00
188_V198_F0.9371.00
210_W234_N0.9291.00
20_D76_V0.9281.00
201_V318_A0.9271.00
352_S363_V0.9251.00
235_S238_G0.9201.00
29_G78_G0.9201.00
126_M365_I0.9151.00
216_E222_K0.9141.00
45_R353_L0.9141.00
154_L318_A0.9141.00
351_S354_R0.9121.00
34_K128_E0.9061.00
188_V202_L0.9051.00
264_Q268_P0.9021.00
189_V252_I0.9011.00
240_E268_P0.8961.00
39_G69_E0.8951.00
191_T225_L0.8931.00
297_F304_I0.8881.00
159_K314_H0.8861.00
187_L269_L0.8821.00
196_I224_I0.8791.00
20_D75_E0.8761.00
18_V123_D0.8741.00
220_N223_E0.8701.00
22_E32_K0.8681.00
213_N233_Y0.8681.00
185_K249_F0.8631.00
82_K139_K0.8591.00
79_Y134_P0.8581.00
191_T199_S0.8541.00
221_E360_E0.8521.00
265_E268_P0.8471.00
184_R251_L0.8461.00
3_A65_I0.8461.00
329_W336_M0.8461.00
70_A130_L0.8401.00
211_I225_L0.8401.00
296_D300_N0.8361.00
64_L123_D0.8311.00
341_I345_D0.8261.00
26_S29_G0.8251.00
313_P317_Q0.8211.00
160_S279_F0.8201.00
26_S78_G0.8181.00
157_I198_F0.8181.00
317_Q321_H0.8171.00
273_N301_N0.8171.00
225_L230_I0.8141.00
40_I353_L0.8131.00
4_I13_V0.8121.00
215_R221_E0.8101.00
88_M319_L0.8081.00
180_T251_L0.8061.00
240_E265_E0.8031.00
353_L363_V0.8021.00
150_L322_L0.7991.00
241_S244_K0.7981.00
201_V321_H0.7971.00
158_E317_Q0.7971.00
243_V249_F0.7971.00
159_K163_S0.7911.00
71_I86_L0.7891.00
7_K12_G0.7881.00
144_I148_A0.7851.00
216_E220_N0.7851.00
41_C44_D0.7821.00
157_I194_T0.7811.00
266_L276_L0.7791.00
27_N131_Y0.7771.00
142_P323_A0.7721.00
252_I276_L0.7701.00
156_D161_V0.7691.00
77_G82_K0.7651.00
251_L277_G0.7651.00
186_A207_F0.7641.00
212_A236_A0.7631.00
202_L209_V0.7621.00
4_I347_R0.7611.00
321_H325_W0.7601.00
160_S253_I0.7581.00
87_V137_L0.7541.00
71_I140_I0.7511.00
15_I343_I0.7501.00
155_A314_H0.7501.00
40_I126_M0.7491.00
31_V134_P0.7491.00
321_H324_S0.7461.00
26_S76_V0.7461.00
297_F302_R0.7411.00
43_T68_H0.7391.00
205_Y317_Q0.7371.00
161_V202_L0.7361.00
86_L143_A0.7321.00
247_D271_Q0.7311.00
313_P316_Q0.7301.00
209_V231_L0.7281.00
339_K363_V0.7281.00
144_I322_L0.7261.00
159_K301_N0.7251.00
213_N225_L0.7241.00
210_W246_V0.7231.00
156_D160_S0.7231.00
249_F252_I0.7201.00
185_K247_D0.7131.00
352_S355_E0.7111.00
255_T279_F0.7111.00
188_V211_I0.7081.00
18_V65_I0.7071.00
339_K348_E0.7031.00
337_I340_I0.7021.00
240_E269_L0.6991.00
141_P323_A0.6981.00
134_P137_L0.6961.00
341_I365_I0.6891.00
244_K248_K0.6861.00
138_V316_Q0.6861.00
272_I300_N0.6831.00
157_I160_S0.6831.00
341_I363_V0.6791.00
278_L304_I0.6781.00
138_V315_F0.6761.00
6_V12_G0.6761.00
210_W243_V0.6761.00
71_I149_I0.6721.00
297_F306_G0.6721.00
207_F251_L0.6721.00
239_Y265_E0.6671.00
77_G85_E0.6671.00
319_L323_A0.6661.00
227_E328_L0.6641.00
160_S198_F0.6631.00
125_F130_L0.6621.00
69_E152_Q0.6611.00
27_N78_G0.6611.00
186_A251_L0.6601.00
231_L234_N0.6591.00
249_F269_L0.6591.00
85_E142_P0.6561.00
179_G303_I0.6541.00
158_E161_V0.6531.00
37_E71_I0.6521.00
41_C153_P0.6491.00
11_P351_S0.6491.00
224_I228_P0.6481.00
31_V74_V0.6461.00
203_R209_V0.6441.00
222_K225_L0.6431.00
263_I276_L0.6421.00
80_G139_K0.6421.00
88_M140_I0.6391.00
80_G312_K0.6371.00
41_C152_Q0.6361.00
29_G135_K0.6361.00
243_V246_V0.6341.00
42_G46_E0.6321.00
89_P132_D0.6301.00
157_I197_L0.6291.00
138_V319_L0.6271.00
201_V205_Y0.6251.00
215_R222_K0.6251.00
198_F279_F0.6241.00
145_K148_A0.6231.00
179_G305_I0.6221.00
28_I78_G0.6211.00
251_L275_V0.6191.00
80_G83_E0.6181.00
243_V269_L0.6181.00
264_Q286_N0.6181.00
350_I354_R0.6171.00
254_D276_L0.6171.00
43_T47_I0.6171.00
37_E340_I0.6171.00
196_I336_M0.6141.00
224_I336_M0.6121.00
68_H152_Q0.6111.00
21_D131_Y0.6101.00
352_S359_G0.6101.00
162_E201_V0.6091.00
158_E318_A0.6091.00
216_E238_G0.6081.00
199_S228_P0.6081.00
200_L228_P0.6041.00
79_Y82_K0.6031.00
286_N290_D0.6021.00
21_D32_K0.6011.00
252_I269_L0.5981.00
290_D296_D0.5981.00
213_N236_A0.5941.00
238_G265_E0.5931.00
33_V89_P0.5931.00
179_G275_V0.5901.00
301_N311_Q0.5901.00
10_N351_S0.5881.00
36_L366_V0.5871.00
46_E51_K0.5861.00
36_L140_I0.5831.00
322_L329_W0.5821.00
35_I38_N0.5811.00
325_W328_L0.5811.00
21_D129_Y0.5791.00
179_G184_R0.5791.00
264_Q296_D0.5791.00
212_A234_N0.5721.00
42_G192_G0.5691.00
359_G363_V0.5681.00
45_R354_R0.5681.00
158_E321_H0.5681.00
290_D294_V0.5661.00
41_C362_K0.5661.00
259_S264_Q0.5631.00
33_V137_L0.5601.00
67_G126_M0.5591.00
35_I89_P0.5591.00
90_I138_V0.5581.00
315_F319_L0.5581.00
153_P193_P0.5561.00
163_S303_I0.5551.00
43_T46_E0.5531.00
20_D26_S0.5521.00
197_L201_V0.5511.00
254_D280_G0.5511.00
187_L252_I0.5501.00
213_N235_S0.5491.00
200_L327_S0.5481.00
264_Q288_S0.5471.00
153_P157_I0.5461.00
138_V312_K0.5451.00
295_Q298_V0.5451.00
20_D131_Y0.5441.00
185_K248_K0.5421.00
47_I52_R0.5411.00
89_P137_L0.5391.00
38_N365_I0.5381.00
222_K236_A0.5371.00
19_K22_E0.5371.00
161_V164_I0.5351.00
322_L327_S0.5341.00
155_A159_K0.5331.00
199_S225_L0.5321.00
286_N289_L0.5321.00
290_D295_Q0.5311.00
81_F134_P0.5301.00
160_S163_S0.5301.00
213_N221_E0.5291.00
77_G81_F0.5291.00
12_G347_R0.5291.00
182_N205_Y0.5251.00
30_L122_L0.5241.00
232_F242_L0.5241.00
15_I346_E0.5221.00
164_I251_L0.5211.00
314_H317_Q0.5201.00
150_L154_L0.5181.00
234_N239_Y0.5181.00
12_G48_V0.5151.00
230_I233_Y0.5141.00
355_E359_G0.5111.00
277_G307_L0.5101.00
182_N206_G0.5101.00
151_A154_L0.5101.00
248_K271_Q0.5091.00
203_R230_I0.5081.00
197_L200_L0.5071.00
29_G77_G0.5061.00
232_F235_S0.5061.00
247_D250_D0.5051.00
45_R49_S0.5051.00
307_L310_G0.5041.00
339_K360_E0.5041.00
77_G80_G0.5041.00
33_V70_A0.5031.00
161_V201_V0.5031.00
266_L270_L0.5031.00
154_L158_E0.5021.00
39_G149_I0.5021.00
197_L327_S0.5011.00
151_A315_F0.5001.00
196_I228_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cdcA 3 0.9674 100 0.179 Contact Map
4ej6A 1 0.8886 100 0.207 Contact Map
4gi2A 2 0.9158 100 0.21 Contact Map
4ilkA 2 0.8886 100 0.212 Contact Map
1vj0A 4 0.9022 100 0.213 Contact Map
2dq4A 4 0.8995 100 0.214 Contact Map
4cpdA 2 0.894 100 0.216 Contact Map
3ukoA 4 0.9049 100 0.218 Contact Map
1h2bA 4 0.8995 100 0.218 Contact Map
3widA 4 0.9565 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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