GREMLIN Database
Q97UH3 - ABC transporter, ATP binding protein
UniProt: Q97UH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (271)
Sequences: 49097 (30874)
Seq/√Len: 1875.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K224_Y4.1591.00
93_V174_K3.5171.00
10_N27_N3.3911.00
7_S31_D3.2521.00
9_K69_S3.1881.00
13_V54_T2.9331.00
23_K26_R2.8991.00
38_I226_A2.8241.00
69_S77_D2.5861.00
238_K241_T2.5511.00
73_D174_K2.4751.00
39_G222_S2.4581.00
224_Y236_Y2.3991.00
33_P36_K2.3821.00
147_V150_M2.3791.00
226_A233_I2.3441.00
14_G23_K2.3371.00
26_R232_Q2.3301.00
7_S71_I2.3151.00
219_F240_N2.2481.00
8_V11_L2.1941.00
12_N67_R2.1861.00
77_D80_S2.1631.00
12_N27_N2.1361.00
34_E174_K2.0881.00
132_V135_N2.0741.00
52_A211_I2.0401.00
125_D128_A2.0201.00
136_T170_L2.0061.00
82_S85_E1.9841.00
132_V172_N1.9801.00
237_G242_L1.9421.00
15_Y50_T1.9381.00
9_K71_I1.8891.00
57_G86_L1.8121.00
39_G218_L1.7971.00
212_S218_L1.7911.00
52_A177_I1.7451.00
134_Y148_L1.7261.00
75_K85_E1.7201.00
12_N23_K1.7201.00
109_R113_E1.7061.00
15_Y24_V1.6761.00
150_M154_Q1.6441.00
13_V59_V1.6171.00
14_G66_E1.5991.00
135_N139_E1.5851.00
116_T133_V1.5741.00
198_K201_Q1.5701.00
226_A236_Y1.5651.00
116_T129_N1.5631.00
10_N29_S1.5511.00
14_G21_I1.5361.00
241_T245_E1.5321.00
13_V66_E1.5321.00
112_K149_D1.5291.00
200_I206_L1.5251.00
73_D93_V1.5201.00
16_L21_I1.5201.00
198_K220_Q1.5081.00
120_K129_N1.5051.00
11_L61_P1.5041.00
8_V30_I1.5041.00
147_V155_L1.5001.00
285_C291_C1.4591.00
81_M85_E1.4541.00
134_Y144_D1.4501.00
237_G241_T1.4331.00
112_K148_L1.4321.00
12_N26_R1.4231.00
37_I201_Q1.3861.00
130_I134_Y1.3621.00
110_K113_E1.3551.00
8_V55_I1.3501.00
178_M208_L1.3401.00
115_F137_L1.3211.00
97_V178_M1.3141.00
194_L217_M1.3101.00
127_Y131_D1.3061.00
32_I38_I1.2931.00
9_K31_D1.2811.00
197_L208_L1.2721.00
112_K116_T1.2681.00
36_K223_D1.2441.00
37_I208_L1.2341.00
30_I51_L1.2321.00
9_K29_S1.2301.00
155_L163_V1.2121.00
130_I148_L1.2041.00
57_G60_N1.1971.00
30_I226_A1.1941.00
40_V209_V1.1891.00
113_E116_T1.1821.00
110_K149_D1.1791.00
131_D135_N1.1711.00
108_I153_F1.1611.00
252_Y256_S1.1571.00
114_T167_I1.1501.00
112_K130_I1.1461.00
28_V51_L1.1431.00
38_I236_Y1.1401.00
81_M86_L1.1401.00
56_M96_Y1.1301.00
240_N244_E1.1301.00
71_I77_D1.1261.00
137_L148_L1.1221.00
37_I222_S1.1121.00
38_I224_Y1.1111.00
34_E73_D1.1021.00
54_T61_P1.0971.00
85_E88_K1.0871.00
75_K81_M1.0841.00
128_A131_D1.0751.00
139_E199_K1.0621.00
201_Q223_D1.0521.00
225_I239_Y1.0511.00
10_N67_R1.0421.00
32_I175_I1.0421.00
115_F170_L1.0411.00
116_T120_K1.0371.00
33_P224_Y1.0361.00
176_L206_L1.0311.00
141_G199_K1.0231.00
210_V221_I1.0201.00
201_Q208_L1.0101.00
34_E205_D1.0101.00
138_E144_D1.0051.00
143_T147_V1.0041.00
129_N133_V1.0011.00
53_T58_F0.9971.00
135_N138_E0.9961.00
283_K288_S0.9941.00
14_G26_R0.9911.00
109_R117_D0.9901.00
55_I209_V0.9831.00
176_L208_L0.9821.00
249_P252_Y0.9761.00
172_N206_L0.9741.00
51_L228_M0.9671.00
8_V70_I0.9661.00
112_K133_V0.9651.00
33_P207_T0.9621.00
119_L170_L0.9601.00
287_F291_C0.9571.00
288_S291_C0.9521.00
56_M177_I0.9511.00
5_S73_D0.9491.00
233_I236_Y0.9481.00
134_Y138_E0.9461.00
13_V50_T0.9431.00
284_G288_S0.9431.00
25_L54_T0.9231.00
46_S228_M0.9201.00
132_V136_T0.9141.00
126_Y129_N0.9131.00
241_T244_E0.9111.00
242_L251_T0.9011.00
5_S72_V0.8991.00
136_T139_E0.8961.00
138_E143_T0.8931.00
185_L193_I0.8921.00
282_P288_S0.8921.00
95_S168_S0.8901.00
109_R114_T0.8891.00
40_V226_A0.8821.00
83_R86_L0.8801.00
37_I198_K0.8771.00
128_A132_V0.8721.00
94_I175_I0.8721.00
232_Q286_V0.8691.00
116_T130_I0.8681.00
190_Q217_M0.8651.00
130_I149_D0.8631.00
122_K132_V0.8621.00
26_R286_V0.8621.00
24_V50_T0.8621.00
224_Y235_E0.8601.00
54_T70_I0.8591.00
141_G192_E0.8511.00
136_T166_A0.8491.00
118_I121_A0.8481.00
54_T59_V0.8481.00
217_M221_I0.8481.00
40_V51_L0.8471.00
198_K221_I0.8461.00
138_E145_R0.8461.00
260_T263_S0.8441.00
278_F281_Y0.8391.00
13_V25_L0.8361.00
286_V289_S0.8331.00
190_Q214_D0.8331.00
75_K93_V0.8331.00
84_D88_K0.8321.00
256_S269_P0.8321.00
285_C290_R0.8311.00
142_L147_V0.8281.00
41_A218_L0.8271.00
53_T59_V0.8251.00
222_S225_I0.8251.00
111_V163_V0.8241.00
97_V165_I0.8191.00
11_L54_T0.8191.00
118_I171_L0.8171.00
72_V93_V0.8161.00
110_K151_Y0.8151.00
281_Y286_V0.8111.00
105_L160_K0.8071.00
6_I55_I0.8061.00
287_F290_R0.8041.00
178_M197_L0.8021.00
284_G291_C0.8011.00
284_G287_F0.8001.00
16_L20_G0.7991.00
151_Y154_Q0.7971.00
25_L28_V0.7931.00
133_V148_L0.7831.00
275_F278_F0.7811.00
253_L257_S0.7791.00
106_N109_R0.7771.00
120_K126_Y0.7771.00
282_P289_S0.7761.00
118_I167_I0.7701.00
273_G276_E0.7701.00
249_P253_L0.7691.00
285_C288_S0.7671.00
32_I207_T0.7671.00
84_D87_N0.7641.00
136_T169_L0.7631.00
37_I221_I0.7611.00
125_D129_N0.7591.00
95_S173_P0.7561.00
28_V233_I0.7541.00
227_V246_A0.7531.00
10_N13_V0.7511.00
210_V222_S0.7491.00
243_L246_A0.7481.00
248_H251_T0.7481.00
27_N232_Q0.7461.00
175_I209_V0.7421.00
195_K220_Q0.7361.00
229_Y232_Q0.7341.00
198_K202_K0.7331.00
61_P66_E0.7301.00
194_L220_Q0.7291.00
127_Y130_I0.7241.00
239_Y243_L0.7241.00
155_L159_M0.7241.00
191_Y195_K0.7231.00
251_T255_L0.7221.00
152_P163_V0.7191.00
77_D81_M0.7191.00
37_I223_D0.7161.00
140_V166_A0.7161.00
111_V155_L0.7151.00
15_Y59_V0.7131.00
83_R88_K0.7131.00
144_D148_L0.7111.00
41_A227_V0.7101.00
180_E213_H0.7051.00
257_S260_T0.7051.00
196_L199_K0.7051.00
115_F133_V0.7041.00
182_T217_M0.6981.00
5_S175_I0.6981.00
222_S239_Y0.6961.00
229_Y234_V0.6921.00
285_C289_S0.6911.00
215_I243_L0.6911.00
278_F282_P0.6901.00
227_V242_L0.6901.00
276_E282_P0.6871.00
131_D138_E0.6871.00
177_I209_V0.6851.00
175_I207_T0.6831.00
14_G67_R0.6831.00
144_D147_V0.6811.00
122_K129_N0.6811.00
55_I70_I0.6801.00
32_I209_V0.6771.00
286_V290_R0.6761.00
134_Y145_R0.6751.00
276_E280_R0.6751.00
6_I175_I0.6721.00
272_P275_F0.6701.00
25_L51_L0.6701.00
195_K198_K0.6661.00
6_I72_V0.6661.00
272_P276_E0.6661.00
38_I209_V0.6661.00
69_S79_L0.6621.00
277_G280_R0.6621.00
280_R284_G0.6601.00
105_L163_V0.6571.00
49_S53_T0.6561.00
54_T66_E0.6531.00
271_I274_D0.6531.00
281_Y284_G0.6511.00
150_M155_L0.6501.00
195_K199_K0.6491.00
117_D121_A0.6441.00
119_L123_G0.6441.00
58_F98_P0.6431.00
147_V159_M0.6401.00
53_T96_Y0.6391.00
270_R274_D0.6391.00
56_M94_I0.6371.00
277_G281_Y0.6361.00
103_N160_K0.6351.00
72_V175_I0.6351.00
274_D278_F0.6341.00
282_P285_C0.6281.00
142_L159_M0.6271.00
116_T148_L0.6261.00
10_N68_G0.6261.00
124_M129_N0.6251.00
69_S80_S0.6251.00
82_S86_L0.6221.00
78_I94_I0.6201.00
105_L114_T0.6191.00
70_I79_L0.6171.00
281_Y285_C0.6171.00
5_S207_T0.6161.00
273_G277_G0.6151.00
234_V248_H0.6151.00
119_L122_K0.6141.00
278_F283_K0.6131.00
97_V168_S0.6121.00
278_F284_G0.6121.00
284_G289_S0.6101.00
110_K114_T0.6091.00
71_I74_S0.6071.00
34_E207_T0.6071.00
100_A103_N0.6051.00
35_S207_T0.6051.00
278_F286_V0.6031.00
112_K115_F0.6031.00
124_M128_A0.6021.00
269_P273_G0.6011.00
72_V78_I0.6001.00
283_K287_F0.5981.00
8_V51_L0.5981.00
95_S99_Q0.5941.00
126_Y130_I0.5941.00
239_Y250_Y0.5941.00
275_F289_S0.5931.00
283_K289_S0.5901.00
253_L256_S0.5871.00
273_G278_F0.5861.00
280_R283_K0.5861.00
122_K125_D0.5851.00
43_E46_S0.5811.00
27_N67_R0.5801.00
169_L206_L0.5801.00
271_I275_F0.5791.00
218_L222_S0.5781.00
114_T152_P0.5751.00
268_L271_I0.5751.00
267_K270_R0.5741.00
12_N66_E0.5741.00
165_I193_I0.5721.00
132_V139_E0.5711.00
130_I133_V0.5691.00
131_D134_Y0.5671.00
229_Y253_L0.5641.00
270_R275_F0.5641.00
274_D277_G0.5611.00
145_R150_M0.5591.00
277_G282_P0.5551.00
112_K134_Y0.5521.00
83_R87_N0.5521.00
270_R273_G0.5521.00
242_L246_A0.5511.00
241_T247_Y0.5501.00
218_L225_I0.5481.00
115_F118_I0.5451.00
250_Y254_L0.5411.00
237_G246_A0.5411.00
78_I86_L0.5401.00
119_L124_M0.5401.00
78_I81_M0.5401.00
216_A220_Q0.5371.00
237_G243_L0.5361.00
277_G288_S0.5361.00
133_V170_L0.5351.00
267_K271_I0.5341.00
36_K236_Y0.5341.00
232_Q236_Y0.5331.00
276_E279_I0.5301.00
282_P291_C0.5291.00
252_Y255_L0.5291.00
275_F279_I0.5281.00
137_L147_V0.5281.00
31_D236_Y0.5251.00
104_S164_V0.5211.00
258_V262_R0.5201.00
119_L171_L0.5201.00
161_Q184_G0.5191.00
250_Y253_L0.5181.00
99_Q157_G0.5151.00
276_E284_G0.5121.00
197_L221_I0.5121.00
279_I282_P0.5121.00
283_K286_V0.5111.00
279_I284_G0.5101.00
182_T193_I0.5061.00
269_P272_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9547 100 0.19 Contact Map
4fwiB 1 0.9305 100 0.192 Contact Map
4mkiB 2 0.852 100 0.222 Contact Map
1b0uA 2 0.7432 100 0.223 Contact Map
1g291 4 0.8671 100 0.224 Contact Map
4ry2A 2 0.719 100 0.224 Contact Map
4huqB 1 0.8308 100 0.226 Contact Map
2yyzA 1 0.9335 100 0.227 Contact Map
1v43A 2 0.8973 100 0.228 Contact Map
2it1A 1 0.9366 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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