GREMLIN Database
Q97UH2 - ABC transporter, permease
UniProt: Q97UH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (253)
Sequences: 28261 (17608)
Seq/√Len: 1107.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V213_I2.8191.00
128_D183_R2.7721.00
199_D205_K2.5021.00
189_L194_Y2.4911.00
203_E207_S2.4601.00
207_S211_N2.4561.00
115_I131_L2.4241.00
189_L192_R2.3801.00
96_P241_Y2.3621.00
103_A167_L2.3561.00
107_I171_S2.3021.00
206_L210_F2.2801.00
204_S207_S2.2791.00
193_E196_L2.1871.00
195_I213_I2.0731.00
226_F291_N2.0411.00
195_I208_V2.0251.00
89_Q255_M2.0121.00
117_V186_V1.9941.00
122_Y205_K1.9441.00
118_T122_Y1.9391.00
122_Y127_I1.9241.00
73_P76_L1.9191.00
85_D88_S1.9141.00
110_L114_L1.8901.00
80_D84_H1.8311.00
59_N62_A1.8111.00
254_T263_E1.7991.00
121_L205_K1.7921.00
194_Y216_N1.7761.00
49_S94_G1.7461.00
189_L217_N1.7301.00
126_I130_I1.7231.00
120_G186_V1.7111.00
43_L47_V1.7071.00
87_F91_L1.6801.00
111_I175_W1.6661.00
77_L275_P1.6631.00
111_I114_L1.6621.00
86_I275_P1.6581.00
127_I131_L1.6541.00
82_Y89_Q1.6471.00
190_R213_I1.6441.00
99_G103_A1.6021.00
118_T127_I1.5821.00
108_G174_G1.5771.00
121_L209_I1.5641.00
167_L171_S1.5601.00
109_T225_F1.5551.00
64_N68_D1.5421.00
131_L179_A1.5381.00
185_L188_S1.5331.00
135_T179_A1.5261.00
35_S293_G1.5101.00
92_V95_F1.4981.00
75_H85_D1.4921.00
105_G225_F1.4681.00
84_H88_S1.4661.00
112_A178_G1.4481.00
188_S192_R1.4371.00
256_L276_P1.4231.00
38_G286_S1.4211.00
112_A182_L1.4161.00
133_A136_Q1.3991.00
197_S201_I1.3891.00
145_L149_L1.3641.00
116_G182_L1.3611.00
223_S295_D1.3541.00
116_G120_G1.3501.00
183_R187_L1.3481.00
189_L195_I1.3341.00
171_S175_W1.3301.00
120_G190_R1.3291.00
51_I54_F1.3161.00
45_I281_G1.3151.00
115_I179_A1.3031.00
77_L87_F1.2981.00
189_L213_I1.2951.00
47_V51_I1.2931.00
295_D299_N1.2881.00
65_F68_D1.2861.00
117_V209_I1.2821.00
33_R36_R1.2741.00
126_I129_R1.2731.00
270_W274_I1.2691.00
294_I297_V1.2601.00
181_V224_N1.2551.00
164_I168_L1.2481.00
72_S77_L1.2451.00
119_A131_L1.2371.00
150_I169_T1.2351.00
96_P99_G1.2291.00
36_R40_Y1.2291.00
198_S212_Q1.2101.00
90_L279_M1.2061.00
222_A298_A1.1941.00
178_G228_T1.1871.00
123_A190_R1.1851.00
117_V214_I1.1801.00
72_S75_H1.1781.00
84_H89_Q1.1711.00
293_G297_V1.1471.00
186_V217_N1.1431.00
198_S208_V1.1341.00
100_V236_F1.1341.00
138_F176_A1.1301.00
84_H92_V1.1201.00
182_L221_I1.1101.00
129_R133_A1.1071.00
77_L90_L1.1061.00
169_T173_T1.1051.00
42_L282_L1.1011.00
113_I182_L1.1001.00
198_S203_E1.0961.00
196_L199_D1.0951.00
45_I283_V1.0941.00
52_G92_V1.0911.00
182_L186_V1.0891.00
276_P280_I1.0821.00
114_L117_V1.0801.00
255_M272_W1.0781.00
38_G293_G1.0761.00
79_T85_D1.0761.00
56_T88_S1.0651.00
201_I212_Q1.0631.00
207_S210_F1.0571.00
40_Y44_G1.0471.00
185_L189_L1.0461.00
42_L286_S1.0441.00
132_S179_A1.0431.00
134_I138_F1.0411.00
141_I146_I1.0361.00
37_V40_Y1.0361.00
147_I169_T1.0341.00
175_W179_A1.0321.00
86_I255_M1.0181.00
164_I167_L1.0141.00
86_I272_W1.0131.00
104_V171_S1.0131.00
162_G165_T1.0101.00
128_D132_S1.0081.00
127_I130_I1.0041.00
69_L72_S1.0021.00
199_D208_V1.0001.00
128_D187_L1.0001.00
88_S92_V0.9971.00
123_A191_R0.9961.00
99_G163_Y0.9921.00
40_Y43_L0.9881.00
89_Q272_W0.9871.00
95_F99_G0.9861.00
64_N67_R0.9801.00
275_P278_L0.9781.00
124_E128_D0.9731.00
286_S290_I0.9701.00
38_G289_L0.9691.00
198_S201_I0.9681.00
44_G48_F0.9681.00
219_P295_D0.9681.00
130_I134_I0.9661.00
41_I282_L0.9661.00
104_V108_G0.9651.00
64_N69_L0.9651.00
38_G285_F0.9621.00
41_I286_S0.9511.00
116_G186_V0.9501.00
58_Y74_Q0.9471.00
93_G255_M0.9451.00
182_L217_N0.9431.00
271_W275_P0.9391.00
99_G102_F0.9331.00
90_L275_P0.9311.00
203_E208_V0.9281.00
68_D71_P0.9281.00
39_F43_L0.9211.00
129_R132_S0.9171.00
113_I221_I0.9121.00
205_K208_V0.9091.00
104_V170_L0.9091.00
72_S76_L0.9091.00
58_Y88_S0.9081.00
65_F69_L0.8921.00
143_G235_G0.8881.00
217_N220_F0.8821.00
222_A291_N0.8821.00
109_T113_I0.8801.00
154_L165_T0.8681.00
287_F291_N0.8661.00
170_L235_G0.8651.00
39_F290_I0.8601.00
48_F91_L0.8571.00
89_Q92_V0.8541.00
184_S187_L0.8501.00
135_T176_A0.8481.00
110_L113_I0.8451.00
124_E129_R0.8431.00
163_Y167_L0.8411.00
109_T178_G0.8401.00
50_L54_F0.8351.00
57_P88_S0.8351.00
88_S91_L0.8341.00
79_T83_G0.8321.00
168_L171_S0.8281.00
210_F213_I0.8271.00
54_F270_W0.8231.00
91_L95_F0.8221.00
66_P69_L0.8191.00
205_K209_I0.8191.00
192_R196_L0.8161.00
94_G283_V0.8141.00
143_G147_I0.8121.00
104_V232_G0.8111.00
64_N71_P0.8111.00
115_I175_W0.8061.00
114_L118_T0.8051.00
35_S39_F0.8001.00
109_T114_L0.7991.00
186_V190_R0.7961.00
35_S289_L0.7941.00
103_A241_Y0.7941.00
189_L216_N0.7881.00
265_Y268_G0.7861.00
165_T168_L0.7831.00
105_G228_T0.7741.00
196_L200_L0.7731.00
120_G187_L0.7721.00
295_D302_L0.7691.00
280_I284_A0.7681.00
203_E212_Q0.7681.00
255_M276_P0.7671.00
150_I165_T0.7671.00
274_I278_L0.7651.00
275_P279_M0.7651.00
257_Y266_L0.7621.00
263_E267_R0.7621.00
107_I167_L0.7591.00
48_F94_G0.7571.00
97_V101_G0.7571.00
76_L87_F0.7551.00
34_V38_G0.7541.00
103_A106_L0.7501.00
224_N228_T0.7481.00
119_A128_D0.7471.00
102_F106_L0.7461.00
226_F287_F0.7441.00
75_H79_T0.7341.00
296_R302_L0.7291.00
46_I278_L0.7271.00
111_I171_S0.7261.00
182_L185_L0.7241.00
206_L209_I0.7241.00
51_I55_Y0.7241.00
58_Y75_H0.7221.00
80_D269_L0.7201.00
257_Y263_E0.7181.00
91_L94_G0.7161.00
282_L286_S0.7121.00
72_S278_L0.7111.00
37_V41_I0.7091.00
130_I133_A0.7061.00
155_G165_T0.7021.00
70_P271_W0.7001.00
67_R70_P0.6991.00
290_I294_I0.6981.00
139_L176_A0.6941.00
185_L220_F0.6931.00
208_V213_I0.6921.00
112_A116_G0.6841.00
42_L287_F0.6821.00
108_G171_S0.6811.00
274_I277_G0.6791.00
45_I282_L0.6791.00
65_F71_P0.6781.00
185_L217_N0.6771.00
90_L276_P0.6771.00
111_I115_I0.6761.00
119_A132_S0.6721.00
38_G41_I0.6711.00
273_Y277_G0.6701.00
236_F240_Y0.6701.00
57_P87_F0.6661.00
76_L85_D0.6651.00
174_G177_W0.6651.00
284_A288_A0.6611.00
263_E266_L0.6571.00
173_T176_A0.6531.00
234_A237_T0.6521.00
132_S135_T0.6431.00
161_L164_I0.6411.00
166_I236_F0.6371.00
48_F52_G0.6271.00
203_E206_L0.6271.00
122_Y209_I0.6271.00
61_S65_F0.6261.00
131_L135_T0.6261.00
187_L190_R0.6241.00
62_A66_P0.6241.00
71_P271_W0.6231.00
143_G146_I0.6211.00
123_A126_I0.6181.00
178_G224_N0.6181.00
53_V95_F0.6181.00
178_G182_L0.6161.00
36_R39_F0.6131.00
123_A128_D0.6121.00
149_L153_Y0.6081.00
135_T175_W0.6071.00
235_G238_F0.6061.00
121_L210_F0.6061.00
121_L190_R0.6041.00
234_A238_F0.6031.00
101_G232_G0.5981.00
56_T92_V0.5961.00
58_Y268_G0.5911.00
237_T254_T0.5891.00
106_L110_L0.5881.00
152_A156_A0.5881.00
133_A137_I0.5821.00
123_A187_L0.5791.00
176_A179_A0.5791.00
289_L293_G0.5791.00
146_I173_T0.5791.00
109_T221_I0.5781.00
138_F175_W0.5781.00
256_L280_I0.5751.00
230_I284_A0.5741.00
98_I102_F0.5721.00
68_D269_L0.5721.00
49_S277_G0.5711.00
38_G42_L0.5681.00
46_I50_L0.5681.00
94_G98_I0.5661.00
112_A179_A0.5641.00
232_G235_G0.5621.00
69_L79_T0.5621.00
210_F215_P0.5621.00
233_I237_T0.5611.00
143_G172_L0.5591.00
65_F70_P0.5591.00
218_L222_A0.5551.00
33_R37_V0.5551.00
119_A183_R0.5551.00
103_A164_I0.5531.00
237_T257_Y0.5531.00
165_T169_T0.5521.00
64_N75_H0.5491.00
296_R303_R0.5491.00
181_V185_L0.5471.00
195_I199_D0.5461.00
95_F98_I0.5441.00
292_I295_D0.5421.00
41_I45_I0.5411.00
204_S208_V0.5391.00
168_L172_L0.5391.00
264_A268_G0.5381.00
45_I49_S0.5381.00
93_G254_T0.5331.00
117_V182_L0.5321.00
42_L290_I0.5321.00
271_W274_I0.5301.00
172_L175_W0.5241.00
100_V167_L0.5231.00
132_S136_Q0.5231.00
136_Q139_L0.5231.00
147_I238_F0.5221.00
223_S226_F0.5201.00
106_L109_T0.5191.00
115_I118_T0.5181.00
145_L148_E0.5161.00
89_Q93_G0.5161.00
100_V166_I0.5151.00
151_G155_G0.5141.00
105_G109_T0.5111.00
264_A272_W0.5091.00
174_G228_T0.5081.00
64_N70_P0.5071.00
53_V92_V0.5061.00
210_F214_I0.5031.00
194_Y198_S0.5011.00
229_A287_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.7914 99.9 0.657 Contact Map
3tuiA 2 0.638 99.9 0.687 Contact Map
3d31C 2 0.7239 99.9 0.688 Contact Map
2onkC 2 0.7423 99.9 0.699 Contact Map
3rlfF 1 0.8589 99.9 0.701 Contact Map
4tquN 1 0.8067 99.9 0.709 Contact Map
3rlfG 1 0.8129 99.9 0.712 Contact Map
4ymuD 2 0.6564 99.8 0.72 Contact Map
3j9pD 4 0.7822 81.1 0.938 Contact Map
3rvyA 3 0.6258 75.8 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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