GREMLIN Database
Q97UH1 - ABC transporter, permease
UniProt: Q97UH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (303)
Sequences: 17772 (11423)
Seq/√Len: 656.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_Q77_I3.5201.00
73_Q81_N3.3161.00
29_R78_Q3.2421.00
80_F84_K2.9371.00
84_K88_T2.8631.00
56_Q60_Q2.6371.00
64_Q72_Q2.6271.00
228_M254_A2.6171.00
21_I79_Y2.6081.00
119_P209_T2.4241.00
34_S63_V2.4171.00
241_R247_E2.4171.00
249_M252_S2.4111.00
112_W286_Y2.3751.00
237_M254_A2.2661.00
22_T79_Y2.2431.00
76_Y80_F2.1441.00
291_Y295_Q2.1411.00
105_I292_F2.0711.00
101_S104_T2.0371.00
267_S323_A2.0001.00
231_I236_Y1.9991.00
97_E105_I1.9911.00
59_I63_V1.9731.00
232_L254_A1.9681.00
20_G313_V1.9591.00
246_S249_M1.9511.00
131_L147_I1.9471.00
231_I234_E1.9211.00
177_F203_Y1.9181.00
58_E61_I1.8891.00
123_A213_I1.8781.00
177_F206_I1.8741.00
171_A179_T1.8271.00
126_F130_L1.8121.00
248_K251_A1.8031.00
263_F330_I1.8011.00
138_S141_K1.7951.00
77_I81_N1.7731.00
61_I65_Q1.7681.00
100_V104_T1.7551.00
144_D225_R1.7471.00
60_Q64_Q1.7341.00
55_V58_E1.7301.00
60_Q63_V1.7041.00
81_N84_K1.7021.00
142_I146_A1.6871.00
102_V307_G1.6421.00
239_Y243_M1.6311.00
85_E90_N1.6031.00
168_E173_D1.6021.00
182_Q286_Y1.5991.00
134_V138_S1.5831.00
143_S147_I1.5831.00
237_M250_V1.5831.00
103_S107_T1.5731.00
326_I329_I1.5621.00
245_V249_M1.5591.00
264_T327_Y1.5481.00
293_F308_I1.5181.00
13_Y317_V1.5131.00
17_W314_T1.5121.00
134_V143_S1.5031.00
11_I15_I1.5001.00
127_I130_L1.4941.00
138_S143_S1.4941.00
136_A228_M1.4911.00
86_I91_F1.4841.00
100_V108_E1.4541.00
209_T213_I1.4471.00
115_G182_Q1.4401.00
124_S216_S1.4361.00
169_V173_D1.4261.00
231_I258_A1.4211.00
166_L211_T1.4201.00
62_L66_L1.4191.00
231_I237_M1.4021.00
161_V165_I1.4011.00
112_W182_Q1.3981.00
236_Y257_L1.3961.00
127_I217_L1.3941.00
243_M253_K1.3831.00
18_F79_Y1.3701.00
133_R228_M1.3691.00
7_I11_I1.3681.00
77_I80_F1.3631.00
36_L59_I1.3601.00
18_F22_T1.3571.00
62_L65_Q1.3521.00
235_D238_N1.3331.00
81_N85_E1.3241.00
296_A304_L1.3221.00
105_I304_L1.3171.00
74_P77_I1.2991.00
169_V174_L1.2901.00
292_F304_L1.2871.00
128_G224_M1.2811.00
125_F266_F1.2801.00
34_S37_A1.2651.00
140_G144_D1.2601.00
213_I217_L1.2591.00
21_I82_Y1.2431.00
67_G73_Q1.2411.00
132_G136_A1.2381.00
93_V101_S1.2381.00
91_F307_G1.2341.00
121_I266_F1.2231.00
170_L174_L1.2181.00
157_F162_T1.2181.00
260_L327_Y1.2151.00
96_T299_G1.2101.00
100_V105_I1.2091.00
91_F103_S1.1981.00
115_G201_V1.1931.00
154_L218_A1.1891.00
108_E111_P1.1891.00
184_N204_H1.1841.00
225_R229_I1.1761.00
112_W115_G1.1711.00
18_F83_L1.1671.00
128_G220_W1.1661.00
37_A59_I1.1601.00
132_G224_M1.1501.00
13_Y321_F1.1371.00
22_T26_I1.1361.00
136_A229_I1.1341.00
224_M262_N1.1321.00
308_I312_L1.1291.00
294_N298_T1.1231.00
165_I169_V1.1231.00
67_G81_N1.1231.00
73_Q76_Y1.1111.00
325_I329_I1.1081.00
6_L325_I1.1061.00
115_G119_P1.1051.00
94_S301_D1.1011.00
166_L207_L1.1001.00
231_I254_A1.1001.00
17_W317_V1.0971.00
147_I221_I1.0961.00
319_S323_A1.0931.00
135_A147_I1.0901.00
137_L247_E1.0871.00
136_A232_L1.0831.00
10_G321_F1.0811.00
115_G205_A1.0791.00
104_T108_E1.0791.00
223_G265_S1.0741.00
211_T215_F1.0741.00
61_I64_Q1.0601.00
220_W269_S1.0481.00
131_L221_I1.0461.00
107_T111_P1.0381.00
105_I108_E1.0361.00
22_T75_L1.0351.00
183_Y204_H1.0321.00
79_Y83_L1.0291.00
177_F207_L1.0241.00
86_I310_F1.0221.00
26_I29_R1.0161.00
21_I310_F1.0141.00
202_I206_I1.0011.00
247_E250_V1.0011.00
29_R75_L0.9981.00
159_V280_I0.9971.00
295_Q299_G0.9961.00
19_V23_I0.9921.00
322_V326_I0.9861.00
271_G316_M0.9851.00
144_D229_I0.9821.00
245_V250_V0.9731.00
57_Q61_I0.9701.00
142_I145_Y0.9691.00
205_A209_T0.9661.00
40_I62_L0.9631.00
120_A213_I0.9631.00
139_R233_Q0.9601.00
163_G211_T0.9591.00
97_E100_V0.9581.00
104_T107_T0.9581.00
64_Q73_Q0.9571.00
123_A209_T0.9561.00
151_M221_I0.9511.00
185_T203_Y0.9511.00
117_V273_S0.9511.00
206_I210_L0.9501.00
224_M228_M0.9471.00
33_G300_L0.9441.00
26_I75_L0.9431.00
36_L40_I0.9231.00
130_L133_R0.9231.00
282_Y291_Y0.9201.00
10_G14_I0.9201.00
93_V99_P0.9181.00
118_I122_V0.9171.00
57_Q60_Q0.9171.00
263_F323_A0.9161.00
270_L319_S0.9151.00
140_G145_Y0.9101.00
109_A292_F0.8961.00
240_Y250_V0.8951.00
241_R250_V0.8941.00
137_L251_A0.8941.00
85_E88_T0.8921.00
84_K87_V0.8911.00
318_L322_V0.8881.00
15_I18_F0.8861.00
163_G283_L0.8831.00
106_I307_G0.8821.00
29_R302_Y0.8811.00
227_N258_A0.8761.00
120_A212_L0.8751.00
80_F83_L0.8721.00
251_A254_A0.8701.00
40_I54_N0.8691.00
170_L177_F0.8691.00
56_Q59_I0.8651.00
292_F296_A0.8641.00
162_T214_L0.8641.00
146_A150_L0.8631.00
95_L303_P0.8631.00
128_G132_G0.8591.00
228_M258_A0.8551.00
82_Y86_I0.8491.00
36_L63_V0.8481.00
121_I270_L0.8471.00
150_L154_L0.8401.00
118_I270_L0.8381.00
250_V254_A0.8351.00
240_Y245_V0.8351.00
83_L86_I0.8301.00
328_T334_T0.8291.00
258_A261_P0.8271.00
277_A280_I0.8191.00
210_L213_I0.8181.00
106_I308_I0.8151.00
132_G228_M0.8141.00
120_A124_S0.8131.00
24_D309_F0.8131.00
128_G221_I0.8061.00
130_L134_V0.8041.00
119_P286_Y0.8021.00
139_R229_I0.8021.00
125_F130_L0.8021.00
114_F118_I0.8001.00
36_L62_L0.7991.00
138_S247_E0.7941.00
113_T117_V0.7941.00
327_Y334_T0.7921.00
302_Y306_S0.7901.00
129_N224_M0.7891.00
145_Y148_L0.7881.00
325_I328_T0.7871.00
127_I131_L0.7861.00
182_Q205_A0.7841.00
148_L221_I0.7831.00
314_T318_L0.7811.00
143_S146_A0.7801.00
159_V214_L0.7721.00
182_Q201_V0.7721.00
84_K89_L0.7711.00
5_F328_T0.7641.00
131_L217_L0.7631.00
170_L176_I0.7591.00
217_L221_I0.7591.00
5_F336_Q0.7591.00
170_L207_L0.7571.00
115_G118_I0.7561.00
168_E172_I0.7551.00
111_P114_F0.7541.00
211_T280_I0.7531.00
116_I209_T0.7501.00
22_T76_Y0.7481.00
11_I14_I0.7401.00
154_L214_L0.7371.00
133_R255_Y0.7341.00
224_M227_N0.7341.00
87_V90_N0.7321.00
16_V317_V0.7291.00
306_S309_F0.7281.00
240_Y253_K0.7281.00
206_I209_T0.7271.00
9_R324_D0.7241.00
167_I179_T0.7211.00
58_E62_L0.7191.00
155_Y218_A0.7181.00
36_L66_L0.7161.00
180_G285_N0.7141.00
224_M258_A0.7141.00
102_V292_F0.7101.00
282_Y294_N0.7071.00
83_L87_V0.7061.00
60_Q72_Q0.7061.00
307_G311_M0.7061.00
26_I30_L0.7061.00
173_D176_I0.7051.00
295_Q298_T0.7011.00
54_N59_I0.7001.00
110_A114_F0.6991.00
39_I62_L0.6951.00
124_S213_I0.6941.00
181_G204_H0.6921.00
263_F326_I0.6911.00
129_N262_N0.6891.00
127_I213_I0.6891.00
201_V204_H0.6891.00
292_F308_I0.6841.00
287_A291_Y0.6831.00
216_S219_G0.6821.00
328_T335_S0.6811.00
316_M320_N0.6811.00
240_Y243_M0.6811.00
203_Y206_I0.6801.00
14_I18_F0.6801.00
109_A291_Y0.6791.00
293_F312_L0.6791.00
25_F29_R0.6771.00
293_F296_A0.6751.00
151_M218_A0.6751.00
183_Y201_V0.6731.00
113_T277_A0.6701.00
119_P123_A0.6651.00
184_N201_V0.6651.00
119_P206_I0.6641.00
178_P181_G0.6621.00
227_N231_I0.6601.00
42_S54_N0.6591.00
282_Y295_Q0.6591.00
147_I151_M0.6591.00
63_V72_Q0.6571.00
63_V68_L0.6561.00
37_A41_Y0.6561.00
146_A149_G0.6541.00
212_L277_A0.6511.00
224_M255_Y0.6501.00
135_A144_D0.6501.00
107_T110_A0.6481.00
111_P115_G0.6451.00
77_I84_K0.6441.00
105_I109_A0.6441.00
119_P205_A0.6401.00
178_P204_H0.6391.00
236_Y240_Y0.6381.00
166_L210_L0.6371.00
24_D28_P0.6331.00
28_P305_L0.6281.00
28_P31_I0.6271.00
106_I289_L0.6261.00
174_L177_F0.6251.00
75_L78_Q0.6231.00
94_S100_V0.6201.00
138_S144_D0.6201.00
246_S250_V0.6191.00
182_Q185_T0.6171.00
220_W262_N0.6161.00
323_A327_Y0.6141.00
267_S319_S0.6121.00
144_D148_L0.6121.00
54_N58_E0.6121.00
159_V215_F0.6111.00
29_R306_S0.6071.00
278_V294_N0.6061.00
13_Y16_V0.6051.00
123_A210_L0.6031.00
122_V126_F0.6011.00
312_L316_M0.6011.00
102_V304_L0.6011.00
65_Q99_P0.6001.00
97_E304_L0.6001.00
230_P234_E0.6001.00
133_R251_A0.5991.00
315_A319_S0.5971.00
149_G153_F0.5951.00
296_A305_L0.5931.00
141_K144_D0.5931.00
125_F220_W0.5931.00
260_L334_T0.5921.00
305_L309_F0.5911.00
245_V253_K0.5891.00
21_I83_L0.5891.00
271_G315_A0.5881.00
141_K146_A0.5861.00
121_I125_F0.5851.00
36_L39_I0.5851.00
269_S272_Y0.5841.00
133_R137_L0.5831.00
157_F161_V0.5831.00
218_A221_I0.5811.00
278_V282_Y0.5801.00
219_G265_S0.5791.00
117_V121_I0.5781.00
93_V97_E0.5721.00
141_K145_Y0.5701.00
251_A256_R0.5691.00
159_V162_T0.5691.00
136_A144_D0.5671.00
210_L214_L0.5661.00
8_K11_I0.5651.00
271_G319_S0.5631.00
259_L263_F0.5621.00
117_V277_A0.5601.00
36_L54_N0.5591.00
115_G286_Y0.5571.00
220_W224_M0.5561.00
259_L262_N0.5551.00
24_D29_R0.5551.00
304_L308_I0.5551.00
161_V164_E0.5541.00
219_G223_G0.5541.00
207_L211_T0.5511.00
237_M241_R0.5481.00
135_A148_L0.5471.00
251_A255_Y0.5461.00
35_A38_S0.5461.00
220_W265_S0.5431.00
321_F325_I0.5431.00
294_N297_I0.5421.00
171_A175_H0.5421.00
313_V317_V0.5421.00
238_N242_L0.5411.00
213_I216_S0.5411.00
75_L79_Y0.5391.00
219_G269_S0.5391.00
126_F129_N0.5391.00
327_Y331_D0.5381.00
125_F129_N0.5321.00
124_S220_W0.5290.99
328_T336_Q0.5280.99
303_P306_S0.5270.99
184_N203_Y0.5260.99
317_V320_N0.5250.99
117_V270_L0.5230.99
227_N230_P0.5200.99
332_P335_S0.5200.99
170_L173_D0.5190.99
15_I19_V0.5190.99
235_D239_Y0.5190.99
159_V163_G0.5190.99
20_G24_D0.5160.99
114_F274_V0.5150.99
12_Y16_V0.5140.99
137_L232_L0.5130.99
223_G227_N0.5130.99
297_I305_L0.5130.99
271_G323_A0.5110.99
263_F327_Y0.5110.99
55_V59_I0.5060.99
25_F75_L0.5060.99
35_A302_Y0.5050.99
18_F21_I0.5040.99
220_W266_F0.5040.99
135_A225_R0.5020.99
215_F218_A0.5020.99
177_F180_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6082 99.9 0.702 Contact Map
3rlfF 1 0.8012 99.8 0.725 Contact Map
4tquM 1 0.7895 99.8 0.727 Contact Map
4ymuD 2 0.6111 99.8 0.731 Contact Map
3d31C 2 0.7193 99.8 0.734 Contact Map
2onkC 2 0.7047 99.8 0.734 Contact Map
4tquN 1 0.7573 99.7 0.753 Contact Map
3rlfG 1 0.8129 99.7 0.766 Contact Map
4lz6A 1 0.2544 18.7 0.96 Contact Map
2yevC 1 0.0994 17 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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